SG10201609933WA - New therapy for transthyretin-associated amyloidosis - Google Patents
New therapy for transthyretin-associated amyloidosisInfo
- Publication number
- SG10201609933WA SG10201609933WA SG10201609933WA SG10201609933WA SG10201609933WA SG 10201609933W A SG10201609933W A SG 10201609933WA SG 10201609933W A SG10201609933W A SG 10201609933WA SG 10201609933W A SG10201609933W A SG 10201609933WA SG 10201609933W A SG10201609933W A SG 10201609933WA
- Authority
- SG
- Singapore
- Prior art keywords
- transthyretin
- new therapy
- associated amyloidosis
- amyloidosis
- therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11382326 | 2011-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201609933WA true SG10201609933WA (en) | 2017-02-27 |
Family
ID=47076222
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201401215VA SG11201401215VA (en) | 2011-10-24 | 2012-10-23 | New therapy for transthyretin-associated amyloidosis |
SG10201609933WA SG10201609933WA (en) | 2011-10-24 | 2012-10-23 | New therapy for transthyretin-associated amyloidosis |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201401215VA SG11201401215VA (en) | 2011-10-24 | 2012-10-23 | New therapy for transthyretin-associated amyloidosis |
Country Status (20)
Country | Link |
---|---|
US (5) | US9610270B2 (en) |
EP (1) | EP2770988B1 (en) |
JP (1) | JP6068484B2 (en) |
KR (1) | KR102017354B1 (en) |
CN (1) | CN103889407B (en) |
AU (2) | AU2012327275B2 (en) |
BR (1) | BR112014009322B1 (en) |
CA (1) | CA2852808C (en) |
CL (1) | CL2014000893A1 (en) |
CY (1) | CY1118151T1 (en) |
ES (1) | ES2593038T3 (en) |
HK (1) | HK1198432A1 (en) |
IL (1) | IL231907B (en) |
MX (1) | MX347784B (en) |
PL (1) | PL2770988T3 (en) |
PT (1) | PT2770988T (en) |
RU (2) | RU2747536C2 (en) |
SG (2) | SG11201401215VA (en) |
WO (1) | WO2013060668A1 (en) |
ZA (1) | ZA201402546B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012327275B2 (en) * | 2011-10-24 | 2017-03-02 | Som Innovation Biotech, S.L. | New therapy for transthyretin-associated amyloidosis |
PT3185957T (en) * | 2014-08-29 | 2022-09-05 | Alnylam Pharmaceuticals Inc | Methods of treating transthyretin (ttr) mediated amyloidosis |
EP3275433A1 (en) | 2016-07-29 | 2018-01-31 | Som Innovation Biotech S.L. | Sustained release composition comprising micronized tolcapone |
US20210008209A1 (en) * | 2018-03-12 | 2021-01-14 | Corino Therapeutics, Inc. | Combination therapy for ttr amyloidosis |
CA3141998A1 (en) * | 2019-05-31 | 2020-12-03 | Plex Pharmaceuticals, Inc. | Pharmacological agents for treating protein aggregation diseases of the eye |
CN114324693B (en) * | 2022-01-14 | 2023-01-13 | 大连博源医学科技有限公司 | Pretreatment method and detection method for determination of concentration of transthyretin (TTR) tetramer in blood |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744368A (en) | 1993-11-04 | 1998-04-28 | Research Foundation Of State University Of New York | Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR) |
AU5727798A (en) | 1996-12-23 | 1998-07-17 | Texas A & M University, The | Anti-amyloidogenic agents |
FI20002044A0 (en) * | 2000-09-15 | 2000-09-15 | Orion Yhtymae Oyj | Naphthalene derivatives which inhibit Comt enzymes |
EP1372682B1 (en) | 2001-03-15 | 2012-05-02 | Proteotech Inc. | Catechins for the treatment of fibrillogenesis in alzheimer's disease, parkinson's disease, systemic aa amyloidosis, and other amyloid disorders |
EP1565172A2 (en) | 2002-01-29 | 2005-08-24 | Protemix Corporation Limited | Suppression of cytotoxic protein conformers |
US20040175382A1 (en) | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
CN1921856A (en) * | 2004-02-20 | 2007-02-28 | 诺瓦提斯公司 | Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders |
EP1732550A2 (en) | 2004-02-20 | 2006-12-20 | Novartis AG | Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders |
WO2005113523A1 (en) | 2004-05-20 | 2005-12-01 | Foldrx Pharmaceuticals, Inc. | 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
ES2339790T3 (en) | 2004-08-30 | 2010-05-25 | Seo Hong Yoo | NEUOPROTECTOR EFFECT OF UDCA SOLUBILIZED IN FOCAL ISCHEMICAL MODEL. |
GB2429645A (en) | 2006-03-10 | 2007-03-07 | Sekhsaria Chemicals Ltd | Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent |
US20120016037A1 (en) | 2006-07-24 | 2012-01-19 | Frank Toppo | Method for prevention and treatment of Alzheimers |
GB0718718D0 (en) | 2007-09-25 | 2007-11-07 | Pentraxin Therapeutics Ltd | Compound and use thereof |
DE102010010572A1 (en) | 2010-03-08 | 2011-09-08 | Mahle International Gmbh | Trockenseparator |
AU2012327275B2 (en) * | 2011-10-24 | 2017-03-02 | Som Innovation Biotech, S.L. | New therapy for transthyretin-associated amyloidosis |
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2012
- 2012-10-23 AU AU2012327275A patent/AU2012327275B2/en active Active
- 2012-10-23 WO PCT/EP2012/070945 patent/WO2013060668A1/en active Application Filing
- 2012-10-23 CN CN201280051812.8A patent/CN103889407B/en active Active
- 2012-10-23 US US14/353,459 patent/US9610270B2/en active Active
- 2012-10-23 RU RU2017119539A patent/RU2747536C2/en active
- 2012-10-23 SG SG11201401215VA patent/SG11201401215VA/en unknown
- 2012-10-23 SG SG10201609933WA patent/SG10201609933WA/en unknown
- 2012-10-23 JP JP2014536290A patent/JP6068484B2/en active Active
- 2012-10-23 MX MX2014004863A patent/MX347784B/en active IP Right Grant
- 2012-10-23 EP EP12778323.1A patent/EP2770988B1/en active Active
- 2012-10-23 PL PL12778323T patent/PL2770988T3/en unknown
- 2012-10-23 RU RU2014114930A patent/RU2623062C2/en active
- 2012-10-23 CA CA2852808A patent/CA2852808C/en active Active
- 2012-10-23 ES ES12778323.1T patent/ES2593038T3/en active Active
- 2012-10-23 PT PT127783231T patent/PT2770988T/en unknown
- 2012-10-23 KR KR1020147010767A patent/KR102017354B1/en active IP Right Grant
- 2012-10-23 BR BR112014009322-9A patent/BR112014009322B1/en active IP Right Grant
-
2014
- 2014-04-03 IL IL231907A patent/IL231907B/en active IP Right Grant
- 2014-04-08 ZA ZA2014/02546A patent/ZA201402546B/en unknown
- 2014-04-09 CL CL2014000893A patent/CL2014000893A1/en unknown
- 2014-11-26 HK HK14111954.5A patent/HK1198432A1/en unknown
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2016
- 2016-09-20 CY CY20161100934T patent/CY1118151T1/en unknown
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2017
- 2017-03-02 US US15/448,054 patent/US10045956B2/en active Active
- 2017-04-21 AU AU2017202670A patent/AU2017202670B2/en active Active
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2018
- 2018-08-13 US US16/101,882 patent/US10449169B2/en active Active
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2019
- 2019-09-12 US US16/569,055 patent/US10786473B2/en active Active
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2020
- 2020-08-28 US US17/005,893 patent/US11564899B2/en active Active
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