SG10201606493XA - Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies - Google Patents

Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies

Info

Publication number
SG10201606493XA
SG10201606493XA SG10201606493XA SG10201606493XA SG10201606493XA SG 10201606493X A SG10201606493X A SG 10201606493XA SG 10201606493X A SG10201606493X A SG 10201606493XA SG 10201606493X A SG10201606493X A SG 10201606493XA SG 10201606493X A SG10201606493X A SG 10201606493XA
Authority
SG
Singapore
Prior art keywords
antibodies
removal
affinity chromatography
chromatography media
novel affinity
Prior art date
Application number
SG10201606493XA
Inventor
Bian Nanying
Sun Chia-Yun
Holstein Melissa
Cotoni Kristen
T Stone Matthew
Rahane Santosh
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56920532&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201606493X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG10201606493XA publication Critical patent/SG10201606493XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
SG10201606493XA 2015-09-08 2016-08-05 Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies SG10201606493XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562215401P 2015-09-08 2015-09-08

Publications (1)

Publication Number Publication Date
SG10201606493XA true SG10201606493XA (en) 2017-04-27

Family

ID=56920532

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201606493XA SG10201606493XA (en) 2015-09-08 2016-08-05 Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies

Country Status (9)

Country Link
US (2) US20170066839A1 (en)
EP (1) EP3141558B2 (en)
JP (1) JP6494572B2 (en)
KR (1) KR101952228B1 (en)
CN (1) CN106995496B (en)
AU (1) AU2016219569B2 (en)
CA (1) CA2938544C (en)
ES (1) ES2737731T5 (en)
SG (1) SG10201606493XA (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3035799B1 (en) * 2015-05-06 2017-05-05 Elicityl SUPPORT FOR THE PURIFICATION OF BIOLOGICAL LIQUIDS
FR3035794B1 (en) * 2015-05-06 2017-05-05 Elicityl PROCESS FOR THE PURIFICATION OF TOTAL BLOOD OR A PRODUCT FROM BLOOD
US11253794B2 (en) * 2015-05-28 2022-02-22 Proprietary Technology Assets, Llc Universal blood product and methods of preparing and using same
KR20230041082A (en) 2017-01-30 2023-03-23 리제너론 파마슈티칼스 인코포레이티드 Method for reducing bioburden in chromatography
JP2021506925A (en) * 2017-12-21 2021-02-22 ジェンザイム・コーポレーション How to facilitate the removal of impurities during protein A chromatography
CN108101981B (en) * 2018-01-15 2019-06-04 四川远大蜀阳药业有限责任公司 A kind of production technology of intravenous immunoglobulin
JP2022509734A (en) * 2018-12-05 2022-01-24 サイトソーベンツ・コーポレーション Cross-linked polysaccharide-based absorber for removing anti-A and / or anti-B antibodies from human plasma and whole blood
FR3106064A1 (en) 2020-01-14 2021-07-16 Maco Pharma System for the selective removal of a target substance in a biological fluid
CN112794425B (en) * 2021-02-05 2022-02-18 广东省科学院生物工程研究所 Method for improving flocculation capacity of dextran
EP4382914A1 (en) * 2022-10-18 2024-06-12 Tianjin Dexiang Biotechnology Co., Ltd. Use of blood group antigen trisaccharide conjugate in blood group antibody detection
WO2024082390A1 (en) * 2022-10-18 2024-04-25 天津德祥生物技术股份有限公司 Use of blood group antigen trisaccharide conjugate in blood group antibody detection

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1554084A (en) † 1968-01-19 1969-01-17
SE9303790D0 (en) † 1993-11-17 1993-11-17 Pharmacia Lkb Biotech A method for separation and synthetic polymers that can be used as separation media in the method
AU1074601A (en) * 1999-10-08 2001-04-23 V.I. Technologies, Inc. Isoagglutinin-depleted blood compositions and methods of making same
FR2895263B1 (en) * 2005-12-26 2008-05-30 Lab Francais Du Fractionnement CONCENTRATE OF IMMUNOGLOBIN G (LG) DEPLETED ANTI-A AND ANTI-B ANTIBODIES, AND POLYREACTIVE IGG
EP2556848A1 (en) * 2011-08-08 2013-02-13 Gambro Lundia AB Separation material comprising saccharide ligands
EP2771087A4 (en) * 2011-10-28 2015-06-10 Glycorex Transplantation Ab A method for extracorporeal elimination of one or more components from blood
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US10611826B2 (en) * 2013-07-05 2020-04-07 Laboratoire Français Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
FR3008098B1 (en) * 2013-07-05 2016-09-16 Lab Francais Du Fractionnement AFFINITY CHROMATOGRAPHY MATRIX WITH REDUCED LIGAND DENSITY
FR3008097B1 (en) * 2013-07-05 2016-11-04 Lab Francais Du Fractionnement AFFINITY CHROMATOGRAPHY MATRIX
KR102058067B1 (en) * 2013-09-04 2019-12-20 이엠디 밀리포어 코포레이션 Methods of cleaning a protein a based affinity chromatography coloumn
RU2016117052A (en) * 2013-10-01 2017-11-10 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед COMPOUNDS FOR AFFINITY CHROMATOGRAPHY AND FOR EXTENDING THE HALF-TIME OF A THERAPEUTIC MEDICINE
FR3035794B1 (en) 2015-05-06 2017-05-05 Elicityl PROCESS FOR THE PURIFICATION OF TOTAL BLOOD OR A PRODUCT FROM BLOOD

Also Published As

Publication number Publication date
AU2016219569B2 (en) 2018-05-17
ES2737731T3 (en) 2020-01-15
CA2938544C (en) 2020-03-24
KR20170030033A (en) 2017-03-16
US20170066839A1 (en) 2017-03-09
CA2938544A1 (en) 2017-03-08
JP2017053846A (en) 2017-03-16
ES2737731T5 (en) 2022-05-09
US20210047430A1 (en) 2021-02-18
AU2016219569A1 (en) 2017-03-23
CN106995496B (en) 2021-05-07
KR101952228B1 (en) 2019-02-26
EP3141558B1 (en) 2019-05-22
EP3141558B2 (en) 2022-02-16
JP6494572B2 (en) 2019-04-03
EP3141558A1 (en) 2017-03-15
CN106995496A (en) 2017-08-01

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