SG10201601516QA - Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives - Google Patents
Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivativesInfo
- Publication number
- SG10201601516QA SG10201601516QA SG10201601516QA SG10201601516QA SG10201601516QA SG 10201601516Q A SG10201601516Q A SG 10201601516QA SG 10201601516Q A SG10201601516Q A SG 10201601516QA SG 10201601516Q A SG10201601516Q A SG 10201601516QA SG 10201601516Q A SG10201601516Q A SG 10201601516QA
- Authority
- SG
- Singapore
- Prior art keywords
- synthesis
- methods
- compounds useful
- fused aminodihydrothiazine
- aminodihydrothiazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161434849P | 2011-01-21 | 2011-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201601516QA true SG10201601516QA (en) | 2016-03-30 |
Family
ID=45563570
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013027461A SG191710A1 (en) | 2011-01-21 | 2012-01-20 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives |
| SG10201601516QA SG10201601516QA (en) | 2011-01-21 | 2012-01-20 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013027461A SG191710A1 (en) | 2011-01-21 | 2012-01-20 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8426584B2 (en) |
| EP (1) | EP2665716B1 (en) |
| JP (2) | JP5993875B2 (en) |
| CN (2) | CN103502231A (en) |
| BR (1) | BR112013016241A2 (en) |
| CA (1) | CA2814014A1 (en) |
| ES (1) | ES2624288T3 (en) |
| IL (1) | IL226405A0 (en) |
| MX (1) | MX2013005115A (en) |
| RU (1) | RU2013138226A (en) |
| SG (2) | SG191710A1 (en) |
| WO (1) | WO2012100179A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101910143B (en) | 2008-01-18 | 2013-08-21 | 卫材R&D管理有限公司 | Condensed aminodihydrothiazine derivative |
| GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| GB0912777D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
| GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101139D0 (en) * | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| UY34278A (en) | 2011-08-25 | 2013-04-05 | Novartis Ag | NEW NOXEDINE DERIVATIVES OF OXAZINE AND ITS USE IN THE TREATMENT OF DISEASES |
| GB201212816D0 (en) * | 2012-07-19 | 2012-09-05 | Eisai Ltd | Novel compounds |
| JO3318B1 (en) | 2013-06-18 | 2019-03-13 | Lilly Co Eli | Bace inhibitors |
| CA2963761C (en) * | 2014-10-10 | 2023-10-17 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition of fused aminodihydrothiazine derivative |
| SG11201903601QA (en) * | 2016-10-27 | 2019-05-30 | Eisai R&D Man Co Ltd | Composition comprising an anti-abeta protofibril antibody and a beta-secretase bace1 inhibitor for the treatment of alzheimer's disease |
| JP2021532126A (en) | 2018-07-24 | 2021-11-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | How to treat and prevent Alzheimer's disease |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3235551A (en) | 1966-02-15 | Novel derivatives of | ||
| US3227713A (en) | 1966-01-04 | Azine derivatives | ||
| JPH0967355A (en) | 1995-08-31 | 1997-03-11 | Tokyo Tanabe Co Ltd | Thiazine derivative, thiazole derivative and their production |
| CA2407088A1 (en) | 2000-05-19 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Beta-secretase inhibitors |
| US6562783B2 (en) | 2001-05-30 | 2003-05-13 | Neurologic, Inc. | Phosphinylmethyl and phosphorylmethyl succinic and glutauric acid analogs as β-secretase inhibitors |
| AU2003254844A1 (en) | 2002-08-09 | 2004-02-25 | Takeda Chemical Industries, Ltd. | Substituted amino compounds and use thereof |
| WO2004037212A2 (en) | 2002-10-24 | 2004-05-06 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| JP2004149429A (en) | 2002-10-29 | 2004-05-27 | Takeda Chem Ind Ltd | Indole compound and application thereof |
| US7109217B2 (en) | 2002-11-12 | 2006-09-19 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
| EP2153832B1 (en) | 2003-12-15 | 2016-03-09 | Merck Sharp & Dohme Corp. | Heterocyclic aspartyl protease inhibitors |
| JP2007530696A (en) | 2004-03-30 | 2007-11-01 | メルク エンド カムパニー インコーポレーテッド | 2-Aminothiazole compounds useful as aspartic protease inhibitors |
| PE20060664A1 (en) | 2004-09-15 | 2006-08-04 | Novartis Ag | BICYCLE AMIDAS AS KINASE INHIBITORS |
| EP1802588A4 (en) | 2004-10-15 | 2010-02-17 | Astrazeneca Ab | Substituted amino-pyrimidones and uses thereof |
| WO2006041404A1 (en) | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Substituted amino-compounds and uses thereof |
| JP2008526999A (en) | 2005-01-19 | 2008-07-24 | メルク エンド カムパニー インコーポレーテッド | Tertiary carbinamines containing substituted heterocycles active as beta-secretase inhibitors for the treatment of Alzheimer's disease |
| CA2609582A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
| US8211904B2 (en) | 2005-07-18 | 2012-07-03 | Merck, Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| EP2612854B1 (en) | 2005-10-25 | 2015-04-29 | Shionogi&Co., Ltd. | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors |
| CN101460480A (en) | 2006-04-05 | 2009-06-17 | 阿斯利康(瑞典)有限公司 | 2-aminopyrimidin-4-ones and their use for treating or preventing a beta-related pathologies |
| RU2466994C2 (en) | 2006-05-31 | 2012-11-20 | Дайити Санкё Компани, Лимитед | 7-membered cyclic compounds, methods of their obtaining and their pharmaceutical application |
| US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
| JP5383483B2 (en) * | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | Pharmaceutical composition for the treatment of Alzheimer's disease |
| TW200902526A (en) | 2007-04-24 | 2009-01-16 | Shionogi & Amp Co Ltd | Aminodihydrothiazin derivative substituted with a cyclic group |
| BRPI0811262A2 (en) | 2007-05-29 | 2014-11-04 | Santen Pharmaceutical Co Ltd | COMPOUND, COMPOUND OR SALT THEREOF, PHARMACEUTICAL COMPOSITION, GLYCORTICOID RECEIVER MODULATOR, METHOD FOR PREVENTION AND / OR TREATMENT OF METABOLIC DISEASES, INFLAMMATORY DISEASES, NURSES, ALPHERE CARE DISEASES WITH HOMEOSTASE OR GLAUCOMA, AND USE AT LEAST ONE COMPOUND OR SALT OF THE SAME |
| PE20091236A1 (en) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | PYRIMIDINE DERIVATIVES AS IMMUNOMODULATORS OF TLR7 |
| CN101910143B (en) * | 2008-01-18 | 2013-08-21 | 卫材R&D管理有限公司 | Condensed aminodihydrothiazine derivative |
| TWI431004B (en) | 2008-05-02 | 2014-03-21 | Lilly Co Eli | Bace inhibitors |
| WO2010013794A1 (en) | 2008-07-28 | 2010-02-04 | Eisai R&D Management Co., Ltd. | Spiroaminodihydrothiazine derivatives |
| WO2010013302A1 (en) | 2008-07-28 | 2010-02-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Spiroaminodihydrothiazine derivative |
| ES2539859T3 (en) | 2008-09-30 | 2015-07-06 | Eisai R&D Management Co., Ltd. | New condensed aminodihydrotiazine derivative |
| AR077277A1 (en) | 2009-07-09 | 2011-08-17 | Lilly Co Eli | BICYCLE COMPOUNDS (1,3) TIAZIN-2-AMINA PHARMACEUTICAL FORMULATION THAT INCLUDES IT AND ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| GB0912777D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
| GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| WO2012003274A1 (en) | 2010-07-01 | 2012-01-05 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of pi3k activity |
| GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
-
2012
- 2012-01-20 BR BR112013016241A patent/BR112013016241A2/en not_active IP Right Cessation
- 2012-01-20 MX MX2013005115A patent/MX2013005115A/en active IP Right Grant
- 2012-01-20 US US13/355,030 patent/US8426584B2/en active Active
- 2012-01-20 SG SG2013027461A patent/SG191710A1/en unknown
- 2012-01-20 SG SG10201601516QA patent/SG10201601516QA/en unknown
- 2012-01-20 JP JP2013550622A patent/JP5993875B2/en not_active Expired - Fee Related
- 2012-01-20 ES ES12702690.4T patent/ES2624288T3/en active Active
- 2012-01-20 CN CN201280004193.7A patent/CN103502231A/en active Pending
- 2012-01-20 EP EP12702690.4A patent/EP2665716B1/en active Active
- 2012-01-20 CN CN201610875412.9A patent/CN106632401B/en active Active
- 2012-01-20 WO PCT/US2012/022053 patent/WO2012100179A1/en active Application Filing
- 2012-01-20 RU RU2013138226/04A patent/RU2013138226A/en not_active Application Discontinuation
- 2012-01-20 CA CA2814014A patent/CA2814014A1/en not_active Abandoned
-
2013
- 2013-03-12 US US13/795,308 patent/US8802871B2/en active Active
- 2013-05-16 IL IL226405A patent/IL226405A0/en unknown
-
2014
- 2014-06-26 US US14/316,321 patent/US8962858B2/en not_active Expired - Fee Related
-
2016
- 2016-03-03 JP JP2016041508A patent/JP6087005B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014503001A (en) | 2014-02-06 |
| BR112013016241A2 (en) | 2016-07-12 |
| ES2624288T3 (en) | 2017-07-13 |
| CA2814014A1 (en) | 2012-07-26 |
| MX2013005115A (en) | 2013-06-03 |
| US20120190848A1 (en) | 2012-07-26 |
| EP2665716B1 (en) | 2017-03-08 |
| SG191710A1 (en) | 2013-08-30 |
| EP2665716A1 (en) | 2013-11-27 |
| JP6087005B2 (en) | 2017-03-01 |
| CN106632401B (en) | 2020-12-29 |
| JP2016121177A (en) | 2016-07-07 |
| RU2013138226A (en) | 2015-02-27 |
| US8426584B2 (en) | 2013-04-23 |
| WO2012100179A1 (en) | 2012-07-26 |
| CN103502231A (en) | 2014-01-08 |
| US20130197244A1 (en) | 2013-08-01 |
| JP5993875B2 (en) | 2016-09-14 |
| IL226405A0 (en) | 2013-07-31 |
| CN106632401A (en) | 2017-05-10 |
| US8962858B2 (en) | 2015-02-24 |
| US8802871B2 (en) | 2014-08-12 |
| US20140309429A1 (en) | 2014-10-16 |
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