SG10201506704XA - In vitro hepatic differentiation - Google Patents
In vitro hepatic differentiationInfo
- Publication number
- SG10201506704XA SG10201506704XA SG10201506704XA SG10201506704XA SG10201506704XA SG 10201506704X A SG10201506704X A SG 10201506704XA SG 10201506704X A SG10201506704X A SG 10201506704XA SG 10201506704X A SG10201506704X A SG 10201506704XA SG 10201506704X A SG10201506704X A SG 10201506704XA
- Authority
- SG
- Singapore
- Prior art keywords
- hepatic differentiation
- vitro hepatic
- vitro
- differentiation
- hepatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1014169.5A GB201014169D0 (en) | 2010-08-25 | 2010-08-25 | In vitro hepatic differentiation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201506704XA true SG10201506704XA (en) | 2015-10-29 |
Family
ID=42984593
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201506704XA SG10201506704XA (en) | 2010-08-25 | 2011-08-25 | In vitro hepatic differentiation |
| SG2013013818A SG188288A1 (en) | 2010-08-25 | 2011-08-25 | In vitro hepatic differentiation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013013818A SG188288A1 (en) | 2010-08-25 | 2011-08-25 | In vitro hepatic differentiation |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9284576B2 (en) |
| EP (1) | EP2609192B1 (en) |
| JP (1) | JP6063383B2 (en) |
| CN (1) | CN103180436B (en) |
| AU (1) | AU2011294869B2 (en) |
| CA (1) | CA2841641C (en) |
| DK (1) | DK2609192T3 (en) |
| GB (1) | GB201014169D0 (en) |
| SG (2) | SG10201506704XA (en) |
| WO (1) | WO2012025725A1 (en) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| GB201216796D0 (en) | 2012-09-20 | 2012-11-07 | Cambridge Entpr Ltd | In vitro pancreatic differentiation |
| KR20230154283A (en) * | 2012-11-01 | 2023-11-07 | 팩터 바이오사이언스 인크. | Methods and products for expressing proteins in cells |
| USD1009775S1 (en) | 2014-10-15 | 2024-01-02 | Maxeon Solar Pte. Ltd. | Solar panel |
| USD933584S1 (en) | 2012-11-08 | 2021-10-19 | Sunpower Corporation | Solar panel |
| JP6602288B2 (en) | 2013-04-03 | 2019-11-06 | フジフィルム セルラー ダイナミクス，インコーポレイテッド | Methods and compositions for culturing endoderm progenitor cells in suspension |
| WO2014182700A1 (en) * | 2013-05-10 | 2014-11-13 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| KR102580225B1 (en) | 2013-06-11 | 2023-09-20 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| GB201317869D0 (en) | 2013-10-09 | 2013-11-20 | Cambridge Entpr Ltd | In vitro production of foregut stem cells |
| US20150166952A1 (en) * | 2013-12-16 | 2015-06-18 | Industrial Technology Research Institute | Cultured hepatocyte and method for preparing the same |
| US9512406B2 (en) * | 2013-12-20 | 2016-12-06 | The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone | Generating hepatocytes |
| WO2015140257A1 (en) * | 2014-03-19 | 2015-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for inducing human cholangiocyte differentiation |
| AU2015261380B2 (en) | 2014-05-16 | 2021-04-15 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| CN105154386B (en) * | 2014-05-30 | 2018-04-24 | 中国人民解放军第二军医大学东方肝胆外科医院 | Human liver cell maintains for a long time and the special culture media and cultural method of propagation secondary culture |
| USD913210S1 (en) | 2014-10-15 | 2021-03-16 | Sunpower Corporation | Solar panel |
| USD999723S1 (en) | 2014-10-15 | 2023-09-26 | Sunpower Corporation | Solar panel |
| USD896747S1 (en) | 2014-10-15 | 2020-09-22 | Sunpower Corporation | Solar panel |
| USD933585S1 (en) | 2014-10-15 | 2021-10-19 | Sunpower Corporation | Solar panel |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
| CN107614678B (en) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | Method for producing stem cell-derived beta cells and method for using same |
| US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
| JPWO2016104541A1 (en) * | 2014-12-24 | 2017-10-05 | 国立大学法人京都大学 | Endodermal cell production method, liver cell production method, pancreatic cell production method, endoderm cell induction promoter, liver cell induction promotion kit, pancreatic cell induction promotion kit, and microfluidic device |
| CN106434535B (en) * | 2015-08-11 | 2021-05-14 | 中国科学院广州生物医药与健康研究院 | Method for controlling stem cell differentiation |
| CN106754636B (en) * | 2015-11-19 | 2019-08-30 | 中国人民解放军第二军医大学 | External evoked primary hepatocyte bile ductization and long-term cultivation, amplification and the method and its application of differentiation |
| WO2017093804A2 (en) * | 2015-12-01 | 2017-06-08 | Crispr Therapeutics Ag | Materials and methods for treatment of alpha-1 antitrypsin deficiency |
| JP6756493B2 (en) | 2016-02-29 | 2020-09-16 | 米満 吉和 | High-performance hepatocytes and their utilization |
| GB201603569D0 (en) * | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| CN106479957B (en) * | 2016-08-10 | 2019-11-19 | 上海爱萨尔生物科技有限公司 | Hepatocyte cultures liquid and cultural method |
| SG11201901364VA (en) | 2016-08-24 | 2019-03-28 | Sangamo Therapeutics Inc | Engineered target specific nucleases |
| MX2019002207A (en) | 2016-08-24 | 2019-07-15 | Sangamo Therapeutics Inc | Regulation of gene expression using engineered nucleases. |
| CA3051442A1 (en) * | 2017-02-14 | 2018-08-23 | Alejandro Soto-Gutierrez | Methods of engineering human induced pluripotent stem cells to produce liver tissue |
| WO2019073951A1 (en) * | 2017-10-12 | 2019-04-18 | 国立大学法人東京工業大学 | Method for inducing differentiation of pluripotent stem cells into hepatocytes |
| EP3710021A4 (en) | 2017-11-15 | 2021-08-11 | Semma Therapeutics, Inc. | Islet cell manufacturing compositions and methods of use |
| JP2019201584A (en) * | 2018-05-23 | 2019-11-28 | 国立大学法人神戸大学 | Diabetes preventive agent or therapeutic agent screening method, and cell used in the method |
| CA3108275A1 (en) | 2018-08-10 | 2020-02-13 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| CN111073843A (en) * | 2018-10-22 | 2020-04-28 | 立沃生物科技（深圳）有限公司 | Method for maturing and amplifying liver-like cells |
| MX2021006783A (en) | 2018-12-10 | 2021-07-15 | Amgen Inc | Mutated piggybac transposase. |
| CN111500525B (en) * | 2019-01-30 | 2023-05-02 | 中国科学院广州生物医药与健康研究院 | Composition and application thereof |
| BR112022018092A2 (en) | 2020-03-11 | 2022-11-22 | Bit Bio Ltd | METHOD OF GENERATING LIVER CELLS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2825579B1 (en) * | 2001-06-11 | 2004-07-23 | Rhobio | METHOD FOR OBTAINING MONOCOTYLEDONE PLANT CONTAINING A GENE OF INTEREST WITHOUT FOREIGN AUXILIARY SEQUENCE |
| EP2495310A3 (en) * | 2005-05-24 | 2013-03-27 | The Regents Of the University of California | Microscale micropatterned engineered in vitro tissue |
| EP1941029A2 (en) * | 2005-10-24 | 2008-07-09 | Agency for Science, Technology and Research | Methods of specifying mesodermal, endodermal and mesoendodermal cell fates |
| KR101555824B1 (en) | 2007-07-18 | 2015-09-25 | 라이프스캔, 인코포레이티드 | Differentiation of human embryonic stem cells |
| EP2195417A1 (en) * | 2007-08-24 | 2010-06-16 | University Court of the University of Edinburgh | Regionalised endoderm cells and uses thereof |
| WO2009090882A1 (en) | 2008-01-18 | 2009-07-23 | The University Of Tokyo | Diagnosis method for non-alcoholic fatty liver disease |
| WO2010014949A2 (en) * | 2008-07-31 | 2010-02-04 | The General Hospital Corporation | Compositions comprising hepatocyte-like cells and uses thereof |
| EP2362899A1 (en) | 2008-10-31 | 2011-09-07 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells |
-
2010
- 2010-08-25 GB GBGB1014169.5A patent/GB201014169D0/en not_active Ceased
-
2011
- 2011-08-25 DK DK11755098.8T patent/DK2609192T3/en active
- 2011-08-25 SG SG10201506704XA patent/SG10201506704XA/en unknown
- 2011-08-25 JP JP2013525350A patent/JP6063383B2/en active Active
- 2011-08-25 WO PCT/GB2011/001275 patent/WO2012025725A1/en active Application Filing
- 2011-08-25 CN CN201180051351.XA patent/CN103180436B/en active Active
- 2011-08-25 SG SG2013013818A patent/SG188288A1/en unknown
- 2011-08-25 EP EP11755098.8A patent/EP2609192B1/en active Active
- 2011-08-25 CA CA2841641A patent/CA2841641C/en active Active
- 2011-08-25 AU AU2011294869A patent/AU2011294869B2/en active Active
- 2011-08-25 US US13/818,515 patent/US9284576B2/en active Active
-
2012
- 2012-08-24 US US13/594,053 patent/US20130209426A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011294869B2 (en) | 2016-12-15 |
| EP2609192B1 (en) | 2017-12-20 |
| JP6063383B2 (en) | 2017-01-18 |
| DK2609192T3 (en) | 2018-03-05 |
| AU2011294869A1 (en) | 2013-03-21 |
| WO2012025725A1 (en) | 2012-03-01 |
| CA2841641C (en) | 2019-12-03 |
| US20130209426A1 (en) | 2013-08-15 |
| JP2013535980A (en) | 2013-09-19 |
| EP2609192A1 (en) | 2013-07-03 |
| SG188288A1 (en) | 2013-04-30 |
| US20130156743A1 (en) | 2013-06-20 |
| GB201014169D0 (en) | 2010-10-06 |
| CN103180436A (en) | 2013-06-26 |
| CN103180436B (en) | 2017-09-22 |
| CA2841641A1 (en) | 2012-03-01 |
| US9284576B2 (en) | 2016-03-15 |
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