SG10201505503WA - Dry-coated tablet containing tegafur, gimeracil and oteracil potassium - Google Patents

Dry-coated tablet containing tegafur, gimeracil and oteracil potassium

Info

Publication number
SG10201505503WA
SG10201505503WA SG10201505503WA SG10201505503WA SG10201505503WA SG 10201505503W A SG10201505503W A SG 10201505503WA SG 10201505503W A SG10201505503W A SG 10201505503WA SG 10201505503W A SG10201505503W A SG 10201505503WA SG 10201505503W A SG10201505503W A SG 10201505503WA
Authority
SG
Singapore
Prior art keywords
gimeracil
dry
coated tablet
tablet containing
oteracil potassium
Prior art date
Application number
SG10201505503WA
Inventor
Takumi Okamoto
Takashi Yoshizawa
Yoshito Ohnishi
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of SG10201505503WA publication Critical patent/SG10201505503WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
SG10201505503WA 2011-05-25 2012-05-24 Dry-coated tablet containing tegafur, gimeracil and oteracil potassium SG10201505503WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011116884 2011-05-25

Publications (1)

Publication Number Publication Date
SG10201505503WA true SG10201505503WA (en) 2015-09-29

Family

ID=47217314

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201505503WA SG10201505503WA (en) 2011-05-25 2012-05-24 Dry-coated tablet containing tegafur, gimeracil and oteracil potassium
SG2013083829A SG194922A1 (en) 2011-05-25 2012-05-24 Dry-coated tablet containing tegafur, gimeracil and oteracil potassium

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013083829A SG194922A1 (en) 2011-05-25 2012-05-24 Dry-coated tablet containing tegafur, gimeracil and oteracil potassium

Country Status (15)

Country Link
US (1) US20140335174A1 (en)
EP (1) EP2716290B1 (en)
JP (2) JP5689173B2 (en)
KR (2) KR20170072959A (en)
AU (1) AU2012259803B2 (en)
BR (1) BR112013030093B1 (en)
CA (1) CA2836865C (en)
ES (1) ES2671926T3 (en)
IL (1) IL229372B (en)
MX (1) MX353289B (en)
MY (1) MY167883A (en)
RU (1) RU2601620C2 (en)
SG (2) SG10201505503WA (en)
TW (2) TWI488659B (en)
WO (1) WO2012161240A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013030093B1 (en) * 2011-05-25 2019-12-10 Taiho Pharmaceutical Co Ltd oral disintegrating dry coated tablet containing tegafur, gimeracil and potassium oteracil
CN107837273A (en) * 2016-09-18 2018-03-27 江苏金甙生物技术有限公司 A kind of enteric tegafur, gimeracil and oteracil potassium sustained release preparation and preparation method thereof
CN107865871B (en) * 2016-09-23 2021-09-03 江苏恒瑞医药股份有限公司 Tegiloi composition and preparation method thereof
CN106619689B (en) * 2016-12-30 2018-05-01 陈晓华 It is a kind of for the pharmaceutical composition for the treatment of cancer, kit and its application
WO2023238929A1 (en) * 2022-06-10 2023-12-14 大鵬薬品工業株式会社 Pharmaceutical composition containing pimitespib

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122011100040I2 (en) * 1991-05-27 2012-08-09 Taiho Pharmaceutical Co Ltd Composition, method and instrument for potentiating antitumor activity and treating tumors.
NZ507271A (en) * 1998-03-06 2003-03-28 Eurand Internat S Fast disintegrating tablets
DE60116758T2 (en) * 2000-05-18 2006-11-02 Therics, Inc. Encapsulation of a toxic to a non-toxic region in an oral formulation
JPWO2003028706A1 (en) 2001-09-28 2005-01-13 株式会社三和化学研究所 Nucleated fast-disintegrating molded product
ES2256544T3 (en) * 2001-11-07 2006-07-16 Synthon B.V. TAMSULOSINE TABLETS.
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
US20030215502A1 (en) * 2002-03-20 2003-11-20 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
PT1604991E (en) * 2003-03-14 2008-10-27 Taiho Pharmaceutical Co Ltd Antitumor effect potentiator and antitumor agent
CA2540488A1 (en) * 2003-09-29 2005-04-07 Cipla Limited Pharmaceutical formulation with improved stability
CN100333726C (en) 2004-12-23 2007-08-29 鲁南制药集团股份有限公司 Disintegration piece taken through oral cavity containing Gimeracil and Oteracil Potassium with fluorine being added
TWI434700B (en) * 2005-04-01 2014-04-21 Taiho Pharmaceutical Co Ltd Radiotherapy enhancer
JP4994618B2 (en) * 2005-08-11 2012-08-08 学校法人北里研究所 Chemoradiation with TS-1 / camptothecins
EP2223683B1 (en) * 2007-12-27 2014-06-18 Taiho Pharmaceutical Co., Ltd. Oral particulate antitumor preparation
TWI468188B (en) * 2008-01-30 2015-01-11 Univ Tokushima Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation
KR100934876B1 (en) 2008-01-31 2010-01-06 성균관대학교산학협력단 Plating method for liga process
CN101380327B (en) * 2008-10-09 2011-01-26 北京恒瑞康达医药科技发展有限公司 Anti-cancer composite sustained-release composition and preparation method thereof
JP5553522B2 (en) 2009-03-31 2014-07-16 大鵬薬品工業株式会社 Pharmaceutical composition for oral administration
CA2761243A1 (en) * 2009-05-12 2010-11-18 Taiho Pharmaceutical Co., Ltd. Anti-tumor agent containing tegafur-gimeracil-oteracil potassium combination drug and oxaliplatin
CN101711765B (en) * 2009-10-31 2011-03-23 山东新时代药业有限公司 Dispersing tablet containing tegafur, gimeracil and oteracil potassium
BR112013030093B1 (en) * 2011-05-25 2019-12-10 Taiho Pharmaceutical Co Ltd oral disintegrating dry coated tablet containing tegafur, gimeracil and potassium oteracil
CN102614183B (en) * 2012-03-05 2013-10-30 齐鲁制药(海南)有限公司 Oral preparation containing tegafur, gimeracil and oteracil potassium

Also Published As

Publication number Publication date
IL229372A0 (en) 2014-01-30
TW201300141A (en) 2013-01-01
EP2716290A1 (en) 2014-04-09
TW201529100A (en) 2015-08-01
US20140335174A1 (en) 2014-11-13
KR20170072959A (en) 2017-06-27
IL229372B (en) 2018-12-31
TWI488659B (en) 2015-06-21
EP2716290A4 (en) 2014-11-26
KR20140037879A (en) 2014-03-27
KR101869127B1 (en) 2018-06-19
MX353289B (en) 2018-01-05
EP2716290B1 (en) 2018-03-14
JP5689173B2 (en) 2015-03-25
ES2671926T3 (en) 2018-06-11
AU2012259803B2 (en) 2016-03-17
NZ617625A (en) 2015-10-30
BR112013030093B1 (en) 2019-12-10
RU2601620C2 (en) 2016-11-10
CA2836865A1 (en) 2012-11-29
MX2013013563A (en) 2013-12-16
JP2014218523A (en) 2014-11-20
MY167883A (en) 2018-09-26
BR112013030093A2 (en) 2016-09-20
CA2836865C (en) 2018-02-27
JPWO2012161240A1 (en) 2014-07-31
JP5769853B2 (en) 2015-08-26
RU2013157528A (en) 2015-06-27
WO2012161240A1 (en) 2012-11-29
SG194922A1 (en) 2013-12-30
TWI566787B (en) 2017-01-21

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