SG10201503394PA - Cyclopropyl Dicarboxamides And Analogs Exhibiting Anti-Cancer And Anti-Proliferative Activities - Google Patents

Cyclopropyl Dicarboxamides And Analogs Exhibiting Anti-Cancer And Anti-Proliferative Activities

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Publication number
SG10201503394PA
SG10201503394PA SG10201503394PA SG10201503394PA SG10201503394PA SG 10201503394P A SG10201503394P A SG 10201503394PA SG 10201503394P A SG10201503394P A SG 10201503394PA SG 10201503394P A SG10201503394P A SG 10201503394PA SG 10201503394P A SG10201503394P A SG 10201503394PA
Authority
SG
Singapore
Prior art keywords
cancer
proliferative activities
analogs exhibiting
dicarboxamides
cyclopropyl
Prior art date
Application number
SG10201503394PA
Inventor
Daniel L Flynn
Michael D Kaufman
Original Assignee
Deciphera Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deciphera Pharmaceuticals Llc filed Critical Deciphera Pharmaceuticals Llc
Publication of SG10201503394PA publication Critical patent/SG10201503394PA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
SG10201503394PA 2010-04-29 2011-04-29 Cyclopropyl Dicarboxamides And Analogs Exhibiting Anti-Cancer And Anti-Proliferative Activities SG10201503394PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32954810P 2010-04-29 2010-04-29

Publications (1)

Publication Number Publication Date
SG10201503394PA true SG10201503394PA (en) 2015-06-29

Family

ID=44260801

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012079760A SG185073A1 (en) 2010-04-29 2011-04-29 Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activites
SG10201503394PA SG10201503394PA (en) 2010-04-29 2011-04-29 Cyclopropyl Dicarboxamides And Analogs Exhibiting Anti-Cancer And Anti-Proliferative Activities

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Country Status (17)

Country Link
US (5) US20120058985A1 (en)
EP (1) EP2563362B1 (en)
JP (1) JP5795630B2 (en)
KR (1) KR20130109943A (en)
CN (1) CN103068384B (en)
AU (1) AU2011245248B2 (en)
BR (1) BR112012027743A2 (en)
CA (1) CA2800569A1 (en)
DK (1) DK2563362T3 (en)
ES (1) ES2475741T3 (en)
HK (1) HK1184392A1 (en)
IL (1) IL222728A0 (en)
MX (1) MX2012012571A (en)
PT (1) PT2563362E (en)
RU (1) RU2012151012A (en)
SG (2) SG185073A1 (en)
WO (1) WO2011137342A1 (en)

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BRPI0920765A2 (en) * 2008-10-29 2015-08-18 Deciphera Pharmaceuticals Llc Cilopropane amides and analogs that exhibit anticancer and antiproliferative activities
CA2800569A1 (en) * 2010-04-29 2011-11-03 Deciphera Pharmaceuticals, Llc Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities
CN102702120A (en) * 2012-04-06 2012-10-03 浙江工业大学 New compound o-hydroxyphenyl tetrazine dicarbonamide, preparation and application thereof
CN102702121B (en) * 2012-04-06 2016-04-13 浙江工业大学 Hydroxy phenyl tetrazine diformamide and Synthesis and applications between a kind of compound
WO2013169907A1 (en) 2012-05-08 2013-11-14 The Regents Of The University Of California Alpha 7 nicotinic acetylcholine allosteric modulators, their derivatives and uses thereof
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
EP3696276A1 (en) 2013-02-25 2020-08-19 Novartis AG Novel androgen receptor mutation
US9193719B2 (en) * 2013-03-15 2015-11-24 Deciphera Pharmaceuticals, Llc 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities
WO2016061231A1 (en) * 2014-10-14 2016-04-21 Deciphera Pharmaceuticals, Llc Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression
WO2016061228A1 (en) * 2014-10-14 2016-04-21 Deciphera Pharmaceuticals, Llc Inhibition of trk kinase mediated tumor growth and disease progression
US20170079966A1 (en) * 2014-10-14 2017-03-23 Deciphera Pharmaceuticals, Llc Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression
WO2017157885A1 (en) 2016-03-16 2017-09-21 Bayer Cropscience Aktiengesellschaft N-(cyanobenzyl)-6-(cyclopropyl-carbonylamino)-4-(phenyl)-pyridine-2-carboxamide derivatives and related compounds as pesticides and plant protection agents
CN106349158B (en) * 2016-08-03 2020-02-28 杭州市西溪医院 C-Met small molecule inhibitor, pharmaceutical composition containing same and pharmaceutical application thereof
CN107793363B (en) * 2016-09-06 2021-02-26 上海医药工业研究院 Substituted arylamino aromatic heterocyclic compound and application thereof as antitumor drug
CN106831707B (en) * 2016-12-28 2019-09-20 杭州市西溪医院 Benzheterocycle analog derivative and its medical application as c-Met kinase inhibitor
US10180422B1 (en) 2017-08-22 2019-01-15 Scripps Health Methods of treating a neuroendocrine tumor
CN109988108B (en) * 2017-12-29 2022-04-29 江苏豪森药业集团有限公司 Preparation method of cabozantinib
DK3902547T3 (en) 2018-12-28 2023-12-18 Deciphera Pharmaceuticals Llc CSF1R INHIBITORS FOR USE IN CANCER TREATMENT
LT3966206T (en) 2019-05-10 2023-11-10 Deciphera Pharmaceuticals, Llc Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
EP3966207B1 (en) 2019-05-10 2023-11-01 Deciphera Pharmaceuticals, LLC Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
EP3983081A1 (en) 2019-06-17 2022-04-20 Deciphera Pharmaceuticals, LLC Aminopyrimidine amide autophagy inhibitors and methods of use thereof
MX2022001863A (en) 2019-08-12 2022-05-30 Deciphera Pharmaceuticals Llc Ripretinib for treating gastrointestinal stromal tumors.
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
BR112022013169A2 (en) 2019-12-30 2022-09-13 Deciphera Pharmaceuticals Llc COMPOSITIONS OF 1-(4-BROMO-5-(1-ETHYL-7-(METHYLAMINO)-2-OXO-1,2-DIHYDRO-1,6-NAFTIRIDIN-3-YL)-2-FLUOROFEYL)-3- PHENYLUREA
RS65058B1 (en) 2019-12-30 2024-02-29 Deciphera Pharmaceuticals Llc Amorphous kinase inhibitor formulations and methods of use thereof
US11912668B2 (en) 2020-11-18 2024-02-27 Deciphera Pharmaceuticals, Llc GCN2 and perk kinase inhibitors and methods of use thereof
CN114394940B (en) * 2022-01-26 2024-01-16 武汉工程大学 Cyclopropyl-1, 1 diamide compound and preparation method and application thereof
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

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BRPI0920765A2 (en) * 2008-10-29 2015-08-18 Deciphera Pharmaceuticals Llc Cilopropane amides and analogs that exhibit anticancer and antiproliferative activities
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Also Published As

Publication number Publication date
EP2563362B1 (en) 2014-03-12
JP2013525458A (en) 2013-06-20
US20140194405A1 (en) 2014-07-10
DK2563362T3 (en) 2014-06-23
IL222728A0 (en) 2012-12-31
RU2012151012A (en) 2014-06-10
SG185073A1 (en) 2012-12-28
ES2475741T3 (en) 2014-07-11
HK1184392A1 (en) 2014-01-24
CN103068384B (en) 2015-03-11
MX2012012571A (en) 2013-04-05
CN103068384A (en) 2013-04-24
AU2011245248A1 (en) 2012-12-20
US20120322834A1 (en) 2012-12-20
PT2563362E (en) 2014-07-11
EP2563362A1 (en) 2013-03-06
US20120252849A1 (en) 2012-10-04
AU2011245248B2 (en) 2016-01-07
CA2800569A1 (en) 2011-11-03
US8637672B2 (en) 2014-01-28
WO2011137342A1 (en) 2011-11-03
JP5795630B2 (en) 2015-10-14
US20150218130A1 (en) 2015-08-06
BR112012027743A2 (en) 2017-03-14
KR20130109943A (en) 2013-10-08
US20120058985A1 (en) 2012-03-08

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