SG10201403703XA - Methods of producing humanized non-human mammals - Google Patents

Methods of producing humanized non-human mammals

Info

Publication number
SG10201403703XA
SG10201403703XA SG10201403703XA SG10201403703XA SG10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA SG 10201403703X A SG10201403703X A SG 10201403703XA
Authority
SG
Singapore
Prior art keywords
methods
human mammals
producing humanized
humanized non
producing
Prior art date
Application number
SG10201403703XA
Inventor
Qingfeng Chen
Jianzhu Chen
Original Assignee
Qingfeng Chen
Jianzhu Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingfeng Chen, Jianzhu Chen filed Critical Qingfeng Chen
Publication of SG10201403703XA publication Critical patent/SG10201403703XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG10201403703XA 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals SG10201403703XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22143809P 2009-06-29 2009-06-29

Publications (1)

Publication Number Publication Date
SG10201403703XA true SG10201403703XA (en) 2014-10-30

Family

ID=43411395

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2011084647A SG176118A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals
SG10201403703XA SG10201403703XA (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2011084647A SG176118A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Country Status (6)

Country Link
US (1) US20120157667A1 (en)
EP (1) EP2449094A4 (en)
JP (1) JP2012531896A (en)
CN (1) CN102725400A (en)
SG (2) SG176118A1 (en)
WO (1) WO2011002727A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3417701T (en) 2009-10-06 2022-03-16 Univ Yale Genetically modified mice and engraftment
FI3375284T3 (en) 2011-02-15 2023-06-15 Regeneron Pharma Humanized m-csf mice and uses thereof
SG11201402112RA (en) * 2011-12-06 2014-09-26 Massachusetts Inst Technology Use of humanized mice to determine toxicity
CN103387955B (en) * 2012-05-10 2015-04-29 上海南方模式生物科技发展有限公司 Making method and use of non-human mammal B lymphocyte defect animal model
WO2014039733A1 (en) * 2012-09-05 2014-03-13 University Of Southern California Methods and compositions for detecting, imaging, and treating small cell lung cancer utilizing post-translationally modified residues and higher molecular weight antigenic complexes in proteins
KR102340059B1 (en) * 2012-09-07 2021-12-17 예일 유니버시티 Genetically modified non-human animals and methods of use thereof
ES2748662T3 (en) 2012-11-05 2020-03-17 Institute For Res In Biomedicine Irb Genetically modified immunodeficient rodents and methods of using them
WO2014121840A1 (en) * 2013-02-07 2014-08-14 Medizinische Hochschule Hannover Induced dendritic cells and uses thereof
SG11201509981WA (en) * 2013-06-05 2016-01-28 Agency Science Tech & Res A humanized mouse model for study of bona fide hepatitis virus infection and use thereof
NO2785538T3 (en) * 2014-05-07 2018-08-04
FI3841877T3 (en) * 2014-05-19 2023-12-01 Regeneron Pharma Genetically modified mice expressing human epo
CN113424798B (en) 2015-04-13 2023-01-13 再生元制药公司 Humanized SIRP alpha-IL 15 knock-in mice and methods of use thereof
JP6654001B2 (en) * 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 Human IL-15 secreting immunodeficient mouse
JP2019508014A (en) * 2015-11-30 2019-03-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Generation of human macrophages in an immunodeficient non-human host
WO2019098362A1 (en) * 2017-11-17 2019-05-23 国立大学法人筑波大学 Non-human animal and method for producing same
CN111172190B (en) * 2018-12-25 2021-07-30 百奥赛图江苏基因生物技术有限公司 Construction method and application of humanized cell factor CSF2 gene modified non-human animal
CN111304248B (en) * 2018-12-25 2021-08-24 百奥赛图江苏基因生物技术有限公司 Construction method and application of humanized cytokine IL15 gene modified non-human animal
EP3900529B1 (en) 2019-01-28 2024-01-10 Central Institute For Experimental Animals Rodent having a human il-34 gene and human cd34-positive hematopoietic stem cells, and use therefor
WO2020168029A1 (en) * 2019-02-13 2020-08-20 The Jackson Laboratory Transgenic mouse models supporting innate immune function
CN113614238A (en) * 2019-03-28 2021-11-05 公益财团法人实验动物中央研究所 Immunodeficient mice
CN111485001A (en) * 2020-04-14 2020-08-04 澎立生物医药技术（上海）有限公司 Construction method of humanized immune system mouse with NK (Natural killer) cell and ADCC (advanced Charge coupled device) capabilities
EP4179080A1 (en) * 2020-07-08 2023-05-17 The Jackson Laboratory Transgenic mouse models supporting human innate immune function
CN112042597B (en) * 2020-07-22 2022-04-29 南京普恩瑞生物科技有限公司 Construction method of double humanized tumor xenograft model
CN114853871B (en) * 2021-04-20 2024-04-05 百奥赛图(北京)医药科技股份有限公司 Humanized non-human animal of CSF1 and/or CSF1R gene, construction method and application thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322240B1 (en) * 1987-12-23 1995-03-01 The Board Of Trustees Of The Leland Stanford Junior University Chimeric immunocompromised mammals and their use
US5639939A (en) * 1987-12-23 1997-06-17 The Board Of Trustees For The Leland Stanford Junior University Chimeric immunocompromised mammal comprosing vascularized fetal organ tissue
CA2174729A1 (en) * 1993-12-17 1995-06-22 Benjamin P. Chen A method of preventing depletion of non-autologous hematopoietic cells and animal model systems for use thereof
US6015554A (en) * 1995-06-07 2000-01-18 Systemix, Inc. Method of reconstituting human lymphoid and dendritic cells
US6060643A (en) * 1995-08-04 2000-05-09 Emory University Mouse model with human immune system
US20070021364A1 (en) * 1995-12-13 2007-01-25 Hans Herweijer Methods for genetic immunization
WO1999061589A2 (en) * 1998-05-28 1999-12-02 St. Jude Children's Research Hospital Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof
EP1084227A4 (en) * 1998-05-29 2002-06-12 Univ Jefferson Compositions and methods for use in affecting hematopoietic stem cell populations in mammals
JP2006501177A (en) * 2002-06-24 2006-01-12 ジェンザイム・コーポレイション Methods for delivering gene therapy drugs
GB0406728D0 (en) * 2004-03-25 2004-04-28 Hydrodynamic Gene Delivery Ltd Gene therapy
KR20070099550A (en) * 2004-10-25 2007-10-09 셀러랜트 세라퓨틱스 인코퍼레이티드 Methods of expanding myeloid cell populations and uses thereof
WO2007120811A2 (en) * 2006-04-14 2007-10-25 Advanced Cell Technology, Inc. Hemangio-colony forming cells
KR20090130236A (en) * 2007-03-13 2009-12-21 내셔날 쥬이쉬 헬스 Methods for generation of antibodies
US20090215875A1 (en) * 2008-02-25 2009-08-27 Deneault Eric Methods and kits for expanding hematopoietic stem cells
WO2010115115A1 (en) * 2009-04-03 2010-10-07 Inserm ( Institut National De La Sante Et De La Recherche) Dendritic cell-boosted humanized immune system mice
EP2448967B1 (en) * 2009-06-29 2015-04-15 Ilya B. Leskov Non-human mammal model of human hematopoietic cancer
PT3417701T (en) * 2009-10-06 2022-03-16 Univ Yale Genetically modified mice and engraftment

Also Published As

Publication number Publication date
EP2449094A4 (en) 2013-07-10
EP2449094A1 (en) 2012-05-09
CN102725400A (en) 2012-10-10
WO2011002727A9 (en) 2011-02-24
JP2012531896A (en) 2012-12-13
SG176118A1 (en) 2011-12-29
WO2011002727A1 (en) 2011-01-06
US20120157667A1 (en) 2012-06-21

Similar Documents

Publication Publication Date Title
SG10201403703XA (en) Methods of producing humanized non-human mammals
HK1154463A1 (en) Antibody producing non-human mammals
EP2346994A4 (en) Non-human mammals for the production of chimeric antibodies
IL229118A0 (en) Method for producing phenylacetamide compound
IL248217B (en) Method of producing ingenol-3-angelate
EP2646879A4 (en) Method of producing toner
IL217919A0 (en) Humanized anti-cdcp1 antibodies
EP2528864A4 (en) Method of producing cyclohexasilane compounds
EP2418227A4 (en) Method for producing stabilized fluoropolymer
HUE052073T2 (en) Method for producing phosgene
GB2469158B (en) Base-assisted formation of tin-sucrose adducts
EP2474560A4 (en) Method for producing 11-sugar sialyloligosaccharide-peptide
PL2432877T3 (en) Method for producing (+) -zizaene
EP2612748A4 (en) Method for producing molded gasket
IL214287A0 (en) Method for producing 2-aminobiphenylene
GB2465047B (en) Prediction of signals
HRP20130605T1 (en) Method for producing die-cast parts
PT2760619T (en) Structure producing method
EP2694461A4 (en) Manufacture of methanol
EP2494028A4 (en) Methods of increasing yields of pleuromutilins
EP2420492A4 (en) Method for producing 2-halogeno-6-substituted-4-trifluoromethylpyridine
PL386122A1 (en) Method of producing styrofoam with high thermoisolation
GB0900522D0 (en) Method of producing archtectural moulding
PL387300A1 (en) Method of manufacturing oligocarbonatediols from dimethyl carbonate
GB0909872D0 (en) Method of producing presentations