SG10201403147SA - Diketopiperazine microparticles with defined isomer contents - Google Patents

Diketopiperazine microparticles with defined isomer contents

Info

Publication number: SG10201403147SA
Authority: SG; Singapore
Prior art keywords: diketopiperazine microparticles; isomer contents; defined isomer; contents; diketopiperazine
Prior art date: 2009-06-12

Application number

SG10201403147SA

Inventor

Kelly S Kraft

Karla Somerville

Original Assignee

Mannkind Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-12

Filing date

2010-06-11

Publication date

2014-10-30

2010-06-11 Application filed by Mannkind Corp filed Critical Mannkind Corp

2014-10-30 Publication of SG10201403147SA publication Critical patent/SG10201403147SA/en

Links

239000011859 microparticle Substances 0.000 title 1
BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

SG10201403147SA 2009-06-12 2010-06-11 Diketopiperazine microparticles with defined isomer contents SG10201403147SA (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18677909P	2009-06-12	2009-06-12

Publications (1)

Publication Number	Publication Date
SG10201403147SA true SG10201403147SA (en)	2014-10-30

Family

ID=43306942

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
SG10201403147SA SG10201403147SA (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents
SG2013076096A SG195546A1 (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents
SG10201706995VA SG10201706995VA (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents
SG2011091410A SG176778A1 (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
SG2013076096A SG195546A1 (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents
SG10201706995VA SG10201706995VA (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents
SG2011091410A SG176778A1 (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents

Country Status (17)

Country	Link
US (1)	US8227409B2 (en)
EP (2)	EP2440186B1 (en)
JP (2)	JP5859432B2 (en)
KR (1)	KR101782174B1 (en)
CN (1)	CN102458371B (en)
AR (1)	AR077087A1 (en)
AU (1)	AU2010259939B2 (en)
BR (1)	BRPI1010722B1 (en)
CA (1)	CA2765156C (en)
ES (2)	ES2880102T3 (en)
IL (1)	IL216910A (en)
MX (1)	MX2011013313A (en)
MY (1)	MY172858A (en)
RU (1)	RU2490026C1 (en)
SG (4)	SG10201403147SA (en)
TW (1)	TWI513692B (en)
WO (1)	WO2010144785A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9006175B2 (en)	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
ES2300568T3 (en)	2002-03-20	2008-06-16	Mannkind Corporation	INHALATION APPARATUS
US20070027063A1 (en) *	2004-01-12	2007-02-01	Mannkind Corporation	Method of preserving the function of insulin-producing cells
MX2007001903A (en)	2004-08-20	2007-08-02	Mannkind Corp	Catalysis of diketopiperazine synthesis.
KR101306384B1 (en)	2004-08-23	2013-09-09	맨카인드 코포레이션	Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery
JP5465878B2 (en)	2005-09-14	2014-04-09	マンカインドコーポレイション	Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
CN104383546B (en)	2006-02-22	2021-03-02	曼金德公司	Method for improving the pharmaceutical properties of microparticles comprising diketopiperazines and an active agent
ES2302448B1 (en) *	2006-10-20	2009-05-08	Vodafone España, S.A.	SYSTEM AND METHOD OF DISSEMINATION OF AREA INFORMATION IN LOCAL ENVIRONMENTS OF REDUCED SIZE WITHIN A MOBILE COMMUNICATIONS CELL SYSTEM.
US8485180B2 (en)	2008-06-13	2013-07-16	Mannkind Corporation	Dry powder drug delivery system
CN104689432B (en)	2008-06-13	2018-07-06	曼金德公司	Diskus and the system for drug conveying
JP5479465B2 (en)	2008-06-20	2014-04-23	マンカインドコーポレイション	Interactive device and method for profiling inhalation efforts in real time
TWI494123B (en)	2008-08-11	2015-08-01	Mannkind Corp	Use of ultrarapid acting insulin
US8314106B2 (en)	2008-12-29	2012-11-20	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (en)	2009-03-11	2014-04-30	Mannkind Corp	Apparatus, system and method for measuring resistance of an inhaler
EP2440184B1 (en)	2009-06-12	2023-04-05	MannKind Corporation	Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en)	2009-11-03	2011-05-12	Mannkind Corporation	An apparatus and method for simulating inhalation efforts
RU2571331C1 (en)	2010-06-21	2015-12-20	Маннкайнд Корпорейшн	Systems and methods for dry powder drug delivery
AU2011293294B2 (en)	2010-08-25	2016-03-24	Pangu Biopharma Limited	Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
DK2694402T3 (en)	2011-04-01	2017-07-03	Mannkind Corp	BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
EP2714094B1 (en)	2011-06-02	2016-02-24	The University of Louisville Research Foundation, Inc.	Anti-nucleolin agent-conjugated nanoparticles
WO2012174472A1 (en) *	2011-06-17	2012-12-20	Mannkind Corporation	High capacity diketopiperazine microparticles
AU2012328885B2 (en)	2011-10-24	2017-08-31	Mannkind Corporation	Methods and compositions for treating pain
AU2013289957B2 (en)	2012-07-12	2017-02-23	Mannkind Corporation	Dry powder drug delivery systems and methods
WO2014066856A1 (en)	2012-10-26	2014-05-01	Mannkind Corporation	Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) *	2013-03-15	2022-07-13	MannKind Corporation	Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
BR112016000937A8 (en)	2013-07-18	2021-06-22	Mannkind Corp	dry powder pharmaceutical formulations, method for making a dry powder formulation and use of a dry powder pharmaceutical formulation
JP2016530930A (en)	2013-08-05	2016-10-06	マンカインドコーポレイション	Ventilation device and method
WO2015148905A1 (en)	2014-03-28	2015-10-01	Mannkind Corporation	Use of ultrarapid acting insulin
US10561806B2 (en)	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
US9968125B2 (en)	2015-01-09	2018-05-15	Philip Morris Products S.A.	Nicotine—diketopiperazine microparticle formulations and methods of making the same
PT108368B (en) *	2015-03-31	2018-11-05	Hovione Farm S A	Continuous production of particles
SG11201806304PA (en) *	2016-01-29	2018-08-30	Mannkind Corp	Dry powder inhaler
WO2021202425A1 (en)	2020-03-28	2021-10-07	University Of Louisville Research Foundation, Inc.	Methods of inhibiting or treating coronavirus infection, and methods for delivering an anti-nucleolin agent

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT83613B (en)	1985-10-28	1988-11-21	Lilly Co Eli	Process for the selective chemical removal of a protein amino-terminal residue
US6331318B1 (en)	1994-09-30	2001-12-18	Emisphere Technologies Inc.	Carbon-substituted diketopiperazine delivery systems
US5693338A (en)	1994-09-29	1997-12-02	Emisphere Technologies, Inc.	Diketopiperazine-based delivery systems
US5352461A (en)	1992-03-11	1994-10-04	Pharmaceutical Discovery Corporation	Self assembling diketopiperazine drug delivery system
US5888477A (en)	1993-01-29	1999-03-30	Aradigm Corporation	Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5506203C1 (en)	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5547929A (en)	1994-09-12	1996-08-20	Eli Lilly And Company	Insulin analog formulations
US6428771B1 (en)	1995-05-15	2002-08-06	Pharmaceutical Discovery Corporation	Method for drug delivery to the pulmonary system
US5874064A (en)	1996-05-24	1999-02-23	Massachusetts Institute Of Technology	Aerodynamically light particles for pulmonary drug delivery
HUP0101912A2 (en)	1998-04-09	2001-10-28	Axiva Gmbh	Particulate active agent support for pulmonary application
US9006175B2 (en) *	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
AU779986B2 (en)	1999-06-29	2005-02-24	Mannkind Corporation	Purification and stabilization of peptide and protein pharmaceutical agents
US7464706B2 (en)	1999-07-23	2008-12-16	Mannkind Corporation	Unit dose cartridge and dry powder inhaler
ES2300568T3 (en)	2002-03-20	2008-06-16	Mannkind Corporation	INHALATION APPARATUS
WO2005092301A1 (en)	2004-03-26	2005-10-06	Universita' Degli Studi Di Parma	Insulin highly respirable microparticles
MX2007001903A (en)	2004-08-20	2007-08-02	Mannkind Corp	Catalysis of diketopiperazine synthesis.
KR101306384B1 (en)	2004-08-23	2013-09-09	맨카인드 코포레이션	Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery
JP2008526893A (en) *	2005-01-10	2008-07-24	マンカインドコーポレイション	Methods and compositions for minimizing the natural increase of inhalable insulin in the lung
JP5465878B2 (en)	2005-09-14	2014-04-09	マンカインドコーポレイション	Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
CN104383546B (en)	2006-02-22	2021-03-02	曼金德公司	Method for improving the pharmaceutical properties of microparticles comprising diketopiperazines and an active agent
MX2008013216A (en)	2006-04-14	2008-10-27	Mannkind Corp	Glucagon-like peptide 1(glp-1) pharmaceutical formulations.
MX2010004510A (en) *	2007-10-24	2010-07-02	Mannkind Corp	Method of preventing adverse effects by glp-1.
AU2008316636B2 (en) *	2007-10-24	2014-02-06	Mannkind Corporation	Delivery of active agents
CN104689432B (en) *	2008-06-13	2018-07-06	曼金德公司	Diskus and the system for drug conveying

2010
- 2010-06-11 MY MYPI2011006016A patent/MY172858A/en unknown
- 2010-06-11 JP JP2012515175A patent/JP5859432B2/en active Active
- 2010-06-11 SG SG10201403147SA patent/SG10201403147SA/en unknown
- 2010-06-11 SG SG2013076096A patent/SG195546A1/en unknown
- 2010-06-11 TW TW099119045A patent/TWI513692B/en active
- 2010-06-11 BR BRPI1010722 patent/BRPI1010722B1/en active IP Right Grant
- 2010-06-11 ES ES19175215T patent/ES2880102T3/en active Active
- 2010-06-11 EP EP10724973.2A patent/EP2440186B1/en active Active
- 2010-06-11 SG SG10201706995VA patent/SG10201706995VA/en unknown
- 2010-06-11 CN CN201080026117.7A patent/CN102458371B/en active Active
- 2010-06-11 AU AU2010259939A patent/AU2010259939B2/en active Active
- 2010-06-11 WO PCT/US2010/038287 patent/WO2010144785A2/en active Application Filing
- 2010-06-11 EP EP19175215.3A patent/EP3556356B1/en active Active
- 2010-06-11 MX MX2011013313A patent/MX2011013313A/en active IP Right Grant
- 2010-06-11 CA CA2765156A patent/CA2765156C/en active Active
- 2010-06-11 US US12/813,839 patent/US8227409B2/en active Active
- 2010-06-11 ES ES10724973T patent/ES2751107T3/en active Active
- 2010-06-11 KR KR1020127000804A patent/KR101782174B1/en active IP Right Grant
- 2010-06-11 RU RU2012100785/15A patent/RU2490026C1/en active
- 2010-06-11 SG SG2011091410A patent/SG176778A1/en unknown
- 2010-06-14 AR ARP100102093A patent/AR077087A1/en not_active Application Discontinuation
2011
- 2011-12-12 IL IL216910A patent/IL216910A/en active IP Right Grant
2015
- 2015-09-07 JP JP2015176164A patent/JP6101326B2/en active Active

Also Published As

Publication number	Publication date
RU2490026C1 (en)	2013-08-20
AU2010259939B2 (en)	2012-07-05
BRPI1010722A2 (en)	2016-03-15
SG176778A1 (en)	2012-01-30
ES2880102T3 (en)	2021-11-23
AU2010259939A1 (en)	2011-12-15
ES2751107T3 (en)	2020-03-30
JP2016028068A (en)	2016-02-25
MY172858A (en)	2019-12-12
WO2010144785A3 (en)	2011-03-03
TW201113259A (en)	2011-04-16
JP6101326B2 (en)	2017-03-22
KR20120044971A (en)	2012-05-08
EP2440186A2 (en)	2012-04-18
IL216910A (en)	2016-05-31
RU2012100785A (en)	2013-07-20
SG10201706995VA (en)	2017-09-28
AR077087A1 (en)	2011-08-03
CN102458371B (en)	2015-08-05
EP2440186B1 (en)	2019-08-07
BRPI1010722B1 (en)	2019-12-10
TWI513692B (en)	2015-12-21
CA2765156C (en)	2018-04-10
CN102458371A (en)	2012-05-16
EP3556356A1 (en)	2019-10-23
WO2010144785A2 (en)	2010-12-16
US8227409B2 (en)	2012-07-24
IL216910A0 (en)	2012-02-29
EP3556356B1 (en)	2021-05-05
CA2765156A1 (en)	2010-12-16
JP5859432B2 (en)	2016-02-10
JP2012530062A (en)	2012-11-29
US20100317574A1 (en)	2010-12-16
SG195546A1 (en)	2013-12-30
KR101782174B1 (en)	2017-09-26
MX2011013313A (en)	2012-01-25

Publication	Publication Date	Title
SG10201706995VA (en)	2017-09-28	Diketopiperazine microparticles with defined isomer contents
IL216911A0 (en)	2012-02-29	Diketopiperazine microparticles with defined specific surface areas
GB2457110B (en)	2012-05-30	Sifting containers
IL215191A0 (en)	2011-12-29	Improved containers
PL2323911T3 (en)	2017-05-31	Large container
TWI561435B (en)	2016-12-11	Bottle
ZA201209432B (en)	2014-02-26	Oval-neck bottle
EP2623427A4 (en)	2014-03-26	Bottle
EP2623426A4 (en)	2014-03-26	Bottle
GB201116695D0 (en)	2011-11-09	Container assembly
SI2390185T1 (en)	2018-10-30	Container transporter
PL2328814T3 (en)	2016-03-31	Large container
EP2317989A4 (en)	2013-08-28	Microparticles
GB2478109B (en)	2012-06-20	Containers
GB201120324D0 (en)	2012-01-04	Improved containers and assembly thereof
PL2216467T3 (en)	2013-03-29	Large container
GB0911958D0 (en)	2009-08-19	Improved microparticles
AP2008000293S (en)	2015-12-17	Pet bottle design
GB201019900D0 (en)	2011-01-05	Improved containers and assembly thereof
AU337552S (en)	2011-07-11	Bottle
TWM389080U (en)	2010-09-21	Bicycle hanging container
AU335071S (en)	2011-02-11	Bottle
GB201002584D0 (en)	2010-03-31	Improved Bottle
AU334040S (en)	2010-12-08	Bottle
AP2008000287S (en)	2015-12-17	Bottle Design