SE9603467D0 - New compounds - Google Patents

New compounds

Info

Publication number
SE9603467D0
SE9603467D0 SE9603467A SE9603467A SE9603467D0 SE 9603467 D0 SE9603467 D0 SE 9603467D0 SE 9603467 A SE9603467 A SE 9603467A SE 9603467 A SE9603467 A SE 9603467A SE 9603467 D0 SE9603467 D0 SE 9603467D0
Authority
SE
Sweden
Prior art keywords
group
monomer
polysulphide
amino acid
formula
Prior art date
Application number
SE9603467A
Other languages
Swedish (sv)
Inventor
Haakan Bergstrand
Tomas Eriksson
Magnus Lindvall
Bengt Saernstrand
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9603467A priority Critical patent/SE9603467D0/en
Publication of SE9603467D0 publication Critical patent/SE9603467D0/en
Priority to AU44062/97A priority patent/AU4406297A/en
Priority to PCT/SE1997/001553 priority patent/WO1998012218A1/en
Priority to ZA9708475A priority patent/ZA978475B/en
Priority to ARP970104370A priority patent/AR009806A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A physiologically active tri- or polysulphide linked peptide homo- or heterodimer or cyclised monomer, derived from one or more monomers of formula (I): A-R2-R3-B (SEQ ID NO:1) wherein R2 is a residue of an amino acid selected from proline (Pro), isoleucine (Ile), alanine (Ala), tyrosine (Tyr), pipecolic acid (Pec), threonine (Thr), arginine (Arg), glycine (Gly), or R8, R3 is R8, and each R8 is independently an amino acid residue of formula (II) or formula (III), wherein each of R5 and R6 is independently selected from H, alkyl, e.g. methyl, aryl and alkoxy, n is selected from 0, 1, 2, 3 and 4, and m is selected from 0, 1, 2, 3 and 4; the entire peptide sequence of each monomer containing 3 to 30 amino acid residues; the dimer being formed by linking of the sulphide group of at least one R8 group of one monomer to the sulphide group of an R8 group of the other monomer via an -(S)p- wherein p is an integer of at least 1, so that a trisulphide or polysulphide link is provided, and the monomer being cyclised by linking of the sulphide group of one R8 group to the sulphide group of another R8 group via an -(S)p-, wherein p is an integer of at least 1, so that a trisulphide or polysulphide cyclising link is provided, is absorbable by the epithelial cell lining in a mammal resulting in a modulated immune response and thereby a therapeutic effect against disease.
SE9603467A 1996-09-23 1996-09-23 New compounds SE9603467D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SE9603467A SE9603467D0 (en) 1996-09-23 1996-09-23 New compounds
AU44062/97A AU4406297A (en) 1996-09-23 1997-09-15 Tri- or polysulphide containing peptides having immunomodulating activity
PCT/SE1997/001553 WO1998012218A1 (en) 1996-09-23 1997-09-15 Tri- or polysulphide containing peptides having immunomodulating activity
ZA9708475A ZA978475B (en) 1996-09-23 1997-09-19 Sulphide containing peptides.
ARP970104370A AR009806A1 (en) 1996-09-23 1997-09-23 PEPTIDES WITH SULFIDE CONTENT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9603467A SE9603467D0 (en) 1996-09-23 1996-09-23 New compounds

Publications (1)

Publication Number Publication Date
SE9603467D0 true SE9603467D0 (en) 1996-09-23

Family

ID=20403989

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9603467A SE9603467D0 (en) 1996-09-23 1996-09-23 New compounds

Country Status (5)

Country Link
AR (1) AR009806A1 (en)
AU (1) AU4406297A (en)
SE (1) SE9603467D0 (en)
WO (1) WO1998012218A1 (en)
ZA (1) ZA978475B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9800932D0 (en) 1998-03-20 1998-03-20 Astra Ab New compunds
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
CN114276411B (en) * 2020-09-27 2024-02-09 北京大学深圳研究生院 Solid phase synthesis method of cyclic peptide compound containing trithioether bond

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402253D0 (en) * 1994-06-27 1994-06-27 Pharmacia Ab Process
US5811391A (en) * 1994-08-25 1998-09-22 Cytel Corporation Cyclic CS-1 peptidomimetics, compositions and methods of using same
SE9403526D0 (en) * 1994-10-14 1994-10-14 Astra Ab New Peptides

Also Published As

Publication number Publication date
ZA978475B (en) 1998-03-23
AU4406297A (en) 1998-04-14
WO1998012218A1 (en) 1998-03-26
AR009806A1 (en) 2000-05-03

Similar Documents

Publication Publication Date Title
US5910569A (en) Iodothyronine polymers
SE9603467D0 (en) New compounds
ES2095255T3 (en) ANALOGS OF SUBSTITUTION OF PEPTIDES MAGAININA.
PT87537B (en) PROCESS FOR THE PREPARATION OF ANTICOAGULANT CYCLIC PEPTIDES
DK0579363T3 (en) Treatment of tropical spastic paresis with peptide T
CA2133205C (en) Stable polypeptide composition
EP0655463B1 (en) Cyclic hexapeptides having endothelin antagonistic activity
DK0564972T3 (en) Peptides with modifications at the N-terminal with bradykinin antagonistic effect
SE9603465D0 (en) New compounds
GB2120253A (en) Immune modulator peptides
US3803309A (en) Growth hormone release stimulating pharmaceutical preparations of n-acetyl-10-17 aminoacid acth-sequence peptides
SE9603468D0 (en) New compounds
EP0249394A3 (en) Small peptides wich inhibit binding to t-4 receptors and act as immunogens
ES8707740A1 (en) Vasopressin antagonists.
KR920012114A (en) Selected peptides of group-specific antigens (gaa) of human immunodeficiency virus (HIV), their preparation and use
KR920701180A (en) 4H-3,1-benzoxazin-4-one compound and pharmaceutical composition for inhibiting elastase thereof
WO1994004565A3 (en) Ipnv vaccine
SE9603461D0 (en) New compounds
Ohno et al. Ribonuclease T1 Peptides. I. Synthesis of a Protected N-Terminal Undecapeptide Containing Asparagine Residue in Third Position
SE9603466D0 (en) New compounds
SE9603462D0 (en) New compounds
RU96118282A (en) Peptides for inhibition of pepsin release
SE9603463D0 (en) New compounds