SE9402332D0 - IGF-1 - Google Patents

IGF-1

Info

Publication number
SE9402332D0
SE9402332D0 SE9402332A SE9402332A SE9402332D0 SE 9402332 D0 SE9402332 D0 SE 9402332D0 SE 9402332 A SE9402332 A SE 9402332A SE 9402332 A SE9402332 A SE 9402332A SE 9402332 D0 SE9402332 D0 SE 9402332D0
Authority
SE
Sweden
Prior art keywords
igf
glycosylated
relates
truncated
amino acid
Prior art date
Application number
SE9402332A
Other languages
Swedish (sv)
Inventor
Rolf Eriksson
Stig Johansson
Harriet Roennholm
Anna Skottner
Karin Sonesson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to SE9402332A priority Critical patent/SE9402332D0/en
Publication of SE9402332D0 publication Critical patent/SE9402332D0/en
Priority to EP95925201A priority patent/EP0769022A1/en
Priority to IL11427095A priority patent/IL114270A0/en
Priority to JP8503823A priority patent/JPH10502623A/en
Priority to AU29406/95A priority patent/AU2940695A/en
Priority to CA002193399A priority patent/CA2193399A1/en
Priority to PCT/SE1995/000774 priority patent/WO1996001275A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to O-glycosylated authentic IGF-I, having three or more mannose residues to the Ser69 amino acid of the IGF-polypeptide chain or being truncated and having two mannose residues to the Thr29 amino acid of the truncated IGF-polypeptide chain. The O-glycosylated IGF-I according to the invention have substantially no insulin receptor affinity, which makes them valuable for use in therapeutic treatment. The invention also relates to a method of obtaining IGF-I as defined above by expressing IGF-I in yeast cells and isolating the claimed O-glycosylated IGF-I from the medium and to pharmaceutical composition containing these IGF-I together with a pharmaceutically acceptable carrier, diluent or excipient. It also relates to the use of the O-glycosylated IGF-I in the preparation of a medicament for the treatment of e.g. growth deficiency and insulin resistant states.
SE9402332A 1994-07-01 1994-07-01 IGF-1 SE9402332D0 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SE9402332A SE9402332D0 (en) 1994-07-01 1994-07-01 IGF-1
EP95925201A EP0769022A1 (en) 1994-07-01 1995-06-22 O-glycosylated authentic igf-i and truncated variants thereof, a method of preparation thereof and pharmaceutical compositions
IL11427095A IL114270A0 (en) 1994-07-01 1995-06-22 O-glycosylated authentic igf-i and truncated variants thereof a method of preparation thereof and pharmaceutical compositions
JP8503823A JPH10502623A (en) 1994-07-01 1995-06-22 O-glycosylated authentic IGF-I and truncated variants thereof, methods for their preparation, and pharmaceutical compositions
AU29406/95A AU2940695A (en) 1994-07-01 1995-06-22 O-glycosylated authentic igf-i and truncated variants thereof, a method of preparation thereof and pharmaceutical compositions
CA002193399A CA2193399A1 (en) 1994-07-01 1995-06-22 O-glycosylated authentic igf-i and truncated variants thereof, a method of preparation thereof and pharmaceutical compositions
PCT/SE1995/000774 WO1996001275A1 (en) 1994-07-01 1995-06-22 O-glycosylated authentic igf-i and truncated variants thereof, a method of preparation thereof and pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9402332A SE9402332D0 (en) 1994-07-01 1994-07-01 IGF-1

Publications (1)

Publication Number Publication Date
SE9402332D0 true SE9402332D0 (en) 1994-07-01

Family

ID=20394599

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9402332A SE9402332D0 (en) 1994-07-01 1994-07-01 IGF-1

Country Status (7)

Country Link
EP (1) EP0769022A1 (en)
JP (1) JPH10502623A (en)
AU (1) AU2940695A (en)
CA (1) CA2193399A1 (en)
IL (1) IL114270A0 (en)
SE (1) SE9402332D0 (en)
WO (1) WO1996001275A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9501472D0 (en) * 1995-04-21 1995-04-21 Pharmacia Ab Truncated IGF-I
SE9802938D0 (en) * 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
DK2241575T3 (en) 2005-01-07 2015-08-24 Regeneron Pharma IGF-1 fusion polypeptides and therapeutic uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819826D0 (en) * 1988-08-20 1988-09-21 Kabivitrum Ab Glycosylated igf-1
DK0597033T3 (en) * 1991-08-01 1997-06-02 Genentech Inc IGF-1 to improve the neural state

Also Published As

Publication number Publication date
WO1996001275A1 (en) 1996-01-18
JPH10502623A (en) 1998-03-10
CA2193399A1 (en) 1996-01-18
IL114270A0 (en) 1995-10-31
EP0769022A1 (en) 1997-04-23
AU2940695A (en) 1996-01-25

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