SE9201966D0 - INTERLEUKIN-1BETA DELETION MUTANT - Google Patents

INTERLEUKIN-1BETA DELETION MUTANT

Info

Publication number
SE9201966D0
SE9201966D0 SE9201966A SE9201966A SE9201966D0 SE 9201966 D0 SE9201966 D0 SE 9201966D0 SE 9201966 A SE9201966 A SE 9201966A SE 9201966 A SE9201966 A SE 9201966A SE 9201966 D0 SE9201966 D0 SE 9201966D0
Authority
SE
Sweden
Prior art keywords
interleukin
beta
deletion
deletion mutant
receptors
Prior art date
Application number
SE9201966A
Other languages
Swedish (sv)
Inventor
T Bartfai
Original Assignee
Trion Forskning & Utveckling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trion Forskning & Utveckling filed Critical Trion Forskning & Utveckling
Priority to SE9201966A priority Critical patent/SE9201966D0/en
Publication of SE9201966D0 publication Critical patent/SE9201966D0/en
Priority to AU45191/93A priority patent/AU4519193A/en
Priority to PCT/SE1993/000562 priority patent/WO1994000491A1/en
Priority to JP6502266A priority patent/JPH07508408A/en
Priority to EP93915072A priority patent/EP0647238A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

An Interleukin-1(beta) deletion mutant, which has a quasi conserved sequence of three amino acids deleted from the amino acid sequence of an endogenous mammalian Interleukin-1(beta) is disclosed. The deletion is Ser Asn Asp (numbers 52-54 of mature human IL-1(beta)) in the case of human, mouse, rat and rabbit, and Arg Asp Asn in the case of bovine and sheep Interleukin-1(beta). The Interleukin-1(beta) deletion mutant is shown to be an Interleukin-1 receptor ligand which binds to both Interleukin-1 type I receptors and Interleukin-1 type II receptors with substantially different binding-affinities. The ligand may have additional amino acid deletion(s) and/or point mutation(s). The Interleukin-1(beta) deletion mutants may be used as carriers and adjuvants for biologically active molecules as well as in therapeutic and/or prophylactic agent.
SE9201966A 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT SE9201966D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SE9201966A SE9201966D0 (en) 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT
AU45191/93A AU4519193A (en) 1992-06-25 1993-06-23 Interleukin-1beta deletion mutant
PCT/SE1993/000562 WO1994000491A1 (en) 1992-06-25 1993-06-23 INTERLEUKIN-1β DELETION MUTANT
JP6502266A JPH07508408A (en) 1992-06-25 1993-06-23 Interleukin-1β deletion mutant
EP93915072A EP0647238A1 (en) 1992-06-25 1993-06-23 INTERLEUKIN-1$g(b) DELETION MUTANT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9201966A SE9201966D0 (en) 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT

Publications (1)

Publication Number Publication Date
SE9201966D0 true SE9201966D0 (en) 1992-06-25

Family

ID=20386611

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9201966A SE9201966D0 (en) 1992-06-25 1992-06-25 INTERLEUKIN-1BETA DELETION MUTANT

Country Status (5)

Country Link
EP (1) EP0647238A1 (en)
JP (1) JPH07508408A (en)
AU (1) AU4519193A (en)
SE (1) SE9201966D0 (en)
WO (1) WO1994000491A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114163514A (en) * 2021-12-13 2022-03-11 青岛瑞斯凯尔生物科技有限公司 IL-10 mutants and uses thereof

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4408890A1 (en) * 1994-03-16 1995-09-21 Knoll Ag Use of Il-1 antagonists as a medicine for the treatment of diseases with an increased interleukin-6 serum level
US5986059A (en) 1996-06-14 1999-11-16 Bayer Corporation T-cell selective interleukin-4 agonists
US6335426B1 (en) 1996-06-14 2002-01-01 Bayer Corporation T-cell selective interleukin-4 agonists
US6028176A (en) * 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
US5978749A (en) * 1997-06-30 1999-11-02 Pile Dynamics, Inc. Pile installation recording system
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
EP3371311B1 (en) 2015-11-06 2021-07-21 Orionis Biosciences BV Bi-functional chimeric proteins and uses thereof
EP3998281A1 (en) 2016-02-05 2022-05-18 Orionis Biosciences BV Cd8 binding agents
EP3426278B1 (en) 2016-03-07 2024-01-03 Vib Vzw Cd20 binding single domain antibodies
WO2017194782A2 (en) 2016-05-13 2017-11-16 Orionis Biosciences Nv Therapeutic targeting of non-cellular structures
JP7105200B2 (en) 2016-05-13 2022-07-22 オリオニス バイオサイエンシズ ビーブイ Targeted mutant interferon-beta and its uses
ES2917000T3 (en) 2016-10-24 2022-07-06 Orionis Biosciences BV Target mutant interferon-gamma and uses thereof
KR102642385B1 (en) 2017-02-06 2024-03-04 오리오니스 바이오사이언시스 엔브이 Targeted chimeric proteins and uses thereof
US10906985B2 (en) 2017-02-06 2021-02-02 Orionis Biosciences, Inc. Targeted engineered interferon and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2591615B2 (en) * 1986-03-14 1997-03-19 大塚製薬株式会社 Interleukin-1β derivative and pharmaceutical
FR2667601A1 (en) * 1990-10-05 1992-04-10 Rhone Poulenc Sante POLYPEPTIDES DERIVED FROM INTERLEUKIN-1 BETA, PROCESS FOR THE PREPARATION AND USE THEREOF, PARTICULARLY IN THE CONTEXT OF OSTEOARTICULAR PATHOLOGIES.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114163514A (en) * 2021-12-13 2022-03-11 青岛瑞斯凯尔生物科技有限公司 IL-10 mutants and uses thereof
CN114163514B (en) * 2021-12-13 2023-05-26 青岛瑞斯凯尔生物科技有限公司 IL-10 mutants and uses thereof

Also Published As

Publication number Publication date
AU4519193A (en) 1994-01-24
EP0647238A1 (en) 1995-04-12
JPH07508408A (en) 1995-09-21
WO1994000491A1 (en) 1994-01-06

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