SE9003706L - METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS - Google Patents
METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODSInfo
- Publication number
- SE9003706L SE9003706L SE9003706A SE9003706A SE9003706L SE 9003706 L SE9003706 L SE 9003706L SE 9003706 A SE9003706 A SE 9003706A SE 9003706 A SE9003706 A SE 9003706A SE 9003706 L SE9003706 L SE 9003706L
- Authority
- SE
- Sweden
- Prior art keywords
- liposomes
- proteoliposomes
- gel
- lipids
- methods
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/291—Gel sorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28016—Particle form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28047—Gels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Cosmetics (AREA)
Abstract
This invention relates to methods of immobilizing liposomes or proteoliposomes in cross-linked or non-cross-linked materials with a three-dimensional network, like gel beads or gel particles, or beads or particles of similar materials. The liposomes are trapped within the matrix or pores of the gel or material by formation of sufficiently large liposomes from a liposome suspension or an emulsion of lipids. The methods comprise preparing a suspension of liposomes and/or proteoliposomes, or an emulsion of lipids, or lipids and protein(s), and water in organic solvent; mixing the material with the suspension or the emulsion; increasing the average size of the liposomes and/or proteoliposomes which have entered the material, or effect uptake and association of emulsified lipids [and protein(s)] in the material by evaporating the organic solvent, whereby liposomes and/or proteoliposomes are formed; and removing non-immobilized liposomes and/or proteoliposomes. The used gel beads show an immobilization capacity corresponding to at least 20 mu mol of phospholipids per ml packed gel, or a total internal liposome volume of at least 50 mu mol per ml gel. The invention comprises gel beads or similar materials with immobilized liposomes, proteoliposomes and/or liposomes with included or inserted drugs, substances or macromolecules, and their use for chromatographic, medical, veterinary, biotechnological, synthetic, analytical and/or cosmetic purposes.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003706A SE9003706L (en) | 1990-11-21 | 1990-11-21 | METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS |
PCT/SE1991/000788 WO1992009267A1 (en) | 1990-11-21 | 1991-11-20 | Methods of immobilizing liposomes in gel beads and similar materials, gel beads and similar materials with immobilized liposomes prepared by such methods and uses thereof |
EP19910920486 EP0559698A1 (en) | 1990-11-21 | 1991-11-20 | Methods of immobilizing liposomes in gel beads and similar materials, gel beads and similar materials with immobilized liposomes prepared by such methods and uses thereof |
JP4500582A JPH06505913A (en) | 1990-11-21 | 1991-11-20 | Methods of immobilizing liposomes in gel beads and similar materials, immobilized liposomes prepared by such methods, and uses thereof |
AU89268/91A AU8926891A (en) | 1990-11-21 | 1991-11-20 | Methods of immobilizing liposomes in gel beads and similar materials, gel beads and similar materials with immobilized liposomes prepared by such methods and uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003706A SE9003706L (en) | 1990-11-21 | 1990-11-21 | METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS |
Publications (2)
Publication Number | Publication Date |
---|---|
SE9003706D0 SE9003706D0 (en) | 1990-11-21 |
SE9003706L true SE9003706L (en) | 1992-05-22 |
Family
ID=20380966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9003706A SE9003706L (en) | 1990-11-21 | 1990-11-21 | METHODS FOR IMMOBILIZATION OF LIPOSOMES IN GELBULS, AND GELBULS WITH LIPOSOMES WHICH ARE IMMOBILIZED USING THESE METHODS |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0559698A1 (en) |
JP (1) | JPH06505913A (en) |
AU (1) | AU8926891A (en) |
SE (1) | SE9003706L (en) |
WO (1) | WO1992009267A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003074691A1 (en) * | 2002-03-01 | 2003-09-12 | National Institute Of Advanced Industrial Science And Technology | Immobilized cells and liposomes and method of immobilizing the same |
AU2012261730B2 (en) * | 2005-08-04 | 2014-05-08 | Intendis Gmbh | Anhydrous multiphase gel system |
DE102005037844A1 (en) * | 2005-08-04 | 2007-04-05 | Intendis Gmbh | Anhydrous multi-phase gel system |
JP6522387B2 (en) * | 2015-03-27 | 2019-05-29 | 株式会社キレートジャパン | Hydrogel-containing cosmetic |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4708861A (en) * | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
JPS60231609A (en) * | 1984-04-28 | 1985-11-18 | Terumo Corp | Liposome pharmaceutical |
US4921757A (en) * | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
GB8522963D0 (en) * | 1985-09-17 | 1985-10-23 | Biocompatibles Ltd | Microcapsules |
-
1990
- 1990-11-21 SE SE9003706A patent/SE9003706L/en not_active Application Discontinuation
-
1991
- 1991-11-20 JP JP4500582A patent/JPH06505913A/en active Pending
- 1991-11-20 WO PCT/SE1991/000788 patent/WO1992009267A1/en not_active Application Discontinuation
- 1991-11-20 AU AU89268/91A patent/AU8926891A/en not_active Abandoned
- 1991-11-20 EP EP19910920486 patent/EP0559698A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0559698A1 (en) | 1993-09-15 |
SE9003706D0 (en) | 1990-11-21 |
WO1992009267A1 (en) | 1992-06-11 |
JPH06505913A (en) | 1994-07-07 |
AU8926891A (en) | 1992-06-25 |
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