SE8700589D0 - NOVEL PROCESS - Google Patents

NOVEL PROCESS

Info

Publication number
SE8700589D0
SE8700589D0 SE8700589A SE8700589A SE8700589D0 SE 8700589 D0 SE8700589 D0 SE 8700589D0 SE 8700589 A SE8700589 A SE 8700589A SE 8700589 A SE8700589 A SE 8700589A SE 8700589 D0 SE8700589 D0 SE 8700589D0
Authority
SE
Sweden
Prior art keywords
methoxy
naphthyl
effected
formula
novel process
Prior art date
Application number
SE8700589A
Other languages
Swedish (sv)
Other versions
SE8700589L (en
Inventor
E A Faruk
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of SE8700589D0 publication Critical patent/SE8700589D0/en
Publication of SE8700589L publication Critical patent/SE8700589L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4-(6-Methoxy-5-Q-2-naphthyl) -4-hydroxy- 3-buten-2-ones of formula (I) and 2-acetyl- 6-methoxy-5 -Q-naphthalenes of formula (II) are new: Q is a protecting gp., esp halogen. Prodn. of 4-(6-methoxy-2-naphthyl) -2-butanone (III) is effected by catalytic hydrogenation of (I) or its Na salts. Pref. hydrogenation is effected at 0-70 deg.C and low or moderate H2 pressure in an inert organic solvent using a Pd catalyst.
SE8700589A 1986-02-15 1987-02-13 NEW PROCEDURE SE8700589L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868603766A GB8603766D0 (en) 1986-02-15 1986-02-15 Process

Publications (2)

Publication Number Publication Date
SE8700589D0 true SE8700589D0 (en) 1987-02-13
SE8700589L SE8700589L (en) 1987-08-16

Family

ID=10593122

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8700589A SE8700589L (en) 1986-02-15 1987-02-13 NEW PROCEDURE

Country Status (8)

Country Link
JP (1) JPS62215545A (en)
CH (1) CH670631A5 (en)
DK (1) DK74987A (en)
ES (1) ES2004876A6 (en)
GB (1) GB8603766D0 (en)
GR (1) GR870253B (en)
NL (1) NL8700353A (en)
SE (1) SE8700589L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1285567B1 (en) 1996-02-21 1998-06-18 Alfa Chem Ital NEW PROCESS FOR THE SYNTHESIS OF NABUMETONE
US5756851A (en) * 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2014993B (en) * 1977-11-03 1982-05-12 Beecham Group Ltd Chemical compounds
JPS6045621B2 (en) * 1978-01-27 1985-10-11 ビ−チヤム・グル−プ・リミテツド Method for producing butanone derivatives

Also Published As

Publication number Publication date
NL8700353A (en) 1987-09-01
ES2004876A6 (en) 1989-02-16
SE8700589L (en) 1987-08-16
DK74987A (en) 1987-08-16
GR870253B (en) 1987-06-16
CH670631A5 (en) 1989-06-30
DK74987D0 (en) 1987-02-13
JPS62215545A (en) 1987-09-22
GB8603766D0 (en) 1986-03-19

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