SE8207474L - NEW HETEROCYCLIC CARBOXYLIC ACIDS AND A PROCEDURE FOR PREPARING THEREOF - Google Patents

NEW HETEROCYCLIC CARBOXYLIC ACIDS AND A PROCEDURE FOR PREPARING THEREOF

Info

Publication number
SE8207474L
SE8207474L SE8207474A SE8207474A SE8207474L SE 8207474 L SE8207474 L SE 8207474L SE 8207474 A SE8207474 A SE 8207474A SE 8207474 A SE8207474 A SE 8207474A SE 8207474 L SE8207474 L SE 8207474L
Authority
SE
Sweden
Prior art keywords
general formula
image
carboxylic acids
defined above
compound
Prior art date
Application number
SE8207474A
Other languages
Swedish (sv)
Other versions
SE8207474D0 (en
SE453082B (en
Inventor
K Lempert
G Doleschall
J Fetter
G Hornyak
P Huszthy
J Nyitrai
G Simig
K Zauer
T Gizur
K Harsanyi
G Fekete
L Szporny
G Hajos
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8207474D0 publication Critical patent/SE8207474D0/en
Publication of SE8207474L publication Critical patent/SE8207474L/en
Publication of SE453082B publication Critical patent/SE453082B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New heterocyclic carboxylic acids of the general formula (I), <IMAGE> wherein Y<1> and Y<2> form together a removable carbonyl protecting group and R is a removable amido protecting group, are prepared in such a way that a compound of the general formula (IV), <IMAGE> wherein Z is a C1-5 alkyl group and R is as defined above, is reacted with a compound capable for the temporary protection of the carbonyl group, the resulting compound of the general formula (III), <IMAGE> wherein R, Z, Y<1> and Y<2> are as defined above, is treated with an alkali metal halide, and the resulting compound of the general formula (II), <IMAGE> wherein Z, R, Y<1> and Y<2> are as defined above, is either hydrolysed selectively or separated into its isomers and the trans isomer is then hydrolysed. The resulting compounds of the general formula (I) are valuable intermediates of the synthesis of thienamycin and thienamycin analogues.
SE8207474A 1981-12-30 1982-12-29 AZETIDINON CARBOXYLIC ACIDS AND PROCEDURES FOR PREPARING THEREOF SE453082B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814011A HU184494B (en) 1981-12-30 1981-12-30 Process for producing new azetidinone-caraoxylic acids

Publications (3)

Publication Number Publication Date
SE8207474D0 SE8207474D0 (en) 1982-12-29
SE8207474L true SE8207474L (en) 1983-07-01
SE453082B SE453082B (en) 1988-01-11

Family

ID=10966500

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8207474A SE453082B (en) 1981-12-30 1982-12-29 AZETIDINON CARBOXYLIC ACIDS AND PROCEDURES FOR PREPARING THEREOF

Country Status (19)

Country Link
JP (1) JPS58118565A (en)
AT (1) AT378769B (en)
AU (1) AU556905B2 (en)
BE (1) BE895493A (en)
CA (1) CA1189864A (en)
CH (1) CH655927A5 (en)
DE (1) DE3248671A1 (en)
ES (1) ES518719A0 (en)
FI (1) FI824515L (en)
FR (1) FR2518997B1 (en)
GB (1) GB2112392B (en)
GR (1) GR78430B (en)
HU (1) HU184494B (en)
IT (1) IT1210967B (en)
LU (1) LU84566A1 (en)
NL (1) NL8205069A (en)
PL (1) PL137738B1 (en)
SE (1) SE453082B (en)
ZA (1) ZA829592B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111463A (en) * 1979-02-21 1980-08-28 Sankyo Co Ltd Beta-lactam compound and its preparation
EP0018594B1 (en) * 1979-04-27 1985-08-21 Merck & Co. Inc. Process for the preparation of 3-(1-hydroxyethyl)-azetidinones
JPS56142259A (en) * 1980-03-11 1981-11-06 Sankyo Co Ltd Beta-lactam compound and its preparation

Also Published As

Publication number Publication date
IT1210967B (en) 1989-09-29
AT378769B (en) 1985-09-25
IT8225059A0 (en) 1982-12-30
JPS58118565A (en) 1983-07-14
NL8205069A (en) 1983-07-18
GR78430B (en) 1984-09-27
PL137738B1 (en) 1986-07-31
FI824515A0 (en) 1982-12-30
FR2518997A1 (en) 1983-07-01
ZA829592B (en) 1983-10-26
PL239884A1 (en) 1984-01-02
AU9196782A (en) 1983-07-07
GB2112392A (en) 1983-07-20
ES8504119A1 (en) 1985-04-16
ATA450682A (en) 1985-02-15
GB2112392B (en) 1985-08-14
ES518719A0 (en) 1985-04-16
FI824515L (en) 1983-07-01
SE8207474D0 (en) 1982-12-29
AU556905B2 (en) 1986-11-27
FR2518997B1 (en) 1985-09-06
HU184494B (en) 1984-08-28
BE895493A (en) 1983-06-28
CA1189864A (en) 1985-07-02
CH655927A5 (en) 1986-05-30
LU84566A1 (en) 1984-10-22
DE3248671A1 (en) 1983-07-07
SE453082B (en) 1988-01-11

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