SE8102047L - Inhibitorer av kolesterolbiosyntes, deras framstellning och anvendning - Google Patents

Inhibitorer av kolesterolbiosyntes, deras framstellning och anvendning

Info

Publication number: SE8102047L
Authority: SE; Sweden
Prior art keywords: hydrogen atom; inhibitors; preparation; compounds; cholesterol biosynthesis
Prior art date: 1980-03-31

Application number

SE8102047A

Other languages

Unknown language ( )

English (en)

Other versions

SE461590B (sv

Inventor

Terahara Akira

Sato Aiya

Tsujita Yoshio

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-03-31

Filing date

1981-03-31

Publication date

1981-10-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE8102047(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1981-03-31 Application filed by Sankyo Co filed Critical Sankyo Co

1981-10-01 Publication of SE8102047L publication Critical patent/SE8102047L/sv

1990-03-05 Publication of SE461590B publication Critical patent/SE461590B/sv

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
230000015572 biosynthetic process Effects 0.000 title abstract 2
235000012000 cholesterol Nutrition 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 3
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

SE8102047A 1980-03-31 1981-03-31 Derivat av 6-hexahydronaftyletyl-4-hydroxi-tetrahydropyren-2-on, foerfarande foer framstaellning av dessa och en farmaceutisk komposition till anvaendning foer haemning av kolesterol SE461590B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP55041292A JPH0692381B2 (ja)	1980-03-31	1980-03-31	Ｍｂ−５３０ａ誘導体

Publications (2)

Publication Number	Publication Date
SE8102047L true SE8102047L (sv)	1981-10-01
SE461590B SE461590B (sv)	1990-03-05

Family

ID=12604367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8102047A SE461590B (sv)	1980-03-31	1981-03-31	Derivat av 6-hexahydronaftyletyl-4-hydroxi-tetrahydropyren-2-on, foerfarande foer framstaellning av dessa och en farmaceutisk komposition till anvaendning foer haemning av kolesterol

Country Status (15)

Country	Link
JP (1)	JPH0692381B2 (sv)
AT (1)	ATA150781A (sv)
AU (1)	AU6893281A (sv)
BE (1)	BE888214A (sv)
CH (1)	CH646966A5 (sv)
DE (2)	DE3112566A1 (sv)
DK (3)	DK151273C (sv)
FI (1)	FI810991L (sv)
FR (1)	FR2479222A1 (sv)
GB (1)	GB2073193A (sv)
IE (1)	IE52367B1 (sv)
IT (1)	IT1144325B (sv)
MX (1)	MX9203567A (sv)
NL (1)	NL8101592A (sv)
SE (1)	SE461590B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4472426A (en) *	1982-12-22	1984-09-18	Merck & Co., Inc.	Antihypercholesterolemic compounds
EP0215665B1 (en) *	1985-09-13	1991-11-21	Sankyo Company Limited	Hydroxy-ml-236b derivatives, their preparation and use
US4997848A (en) *	1987-10-27	1991-03-05	Sankyo Company, Limited	Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) *	1988-08-10	1991-12-24	Hoffmann-La Roche Inc.	Antipsoriatic agents
US5021451A (en) *	1988-11-14	1991-06-04	Hoffman-La Roche Inc.	Method for inhibiting hyperproliferative diseases
US5200549A (en) *	1988-11-14	1993-04-06	Hoffman-La Roche Inc.	Antipsoriatic agents
US5073568A (en) *	1988-11-14	1991-12-17	Hoffmann-La Roche Inc.	Antipsoriatic agents
US5159104A (en) *	1991-05-01	1992-10-27	Merck & Co., Inc.	Process to simvastatin ester
FR2937537A1 (fr) *	2008-10-29	2010-04-30	Centre Nat Rech Scient	Nanoparticules de statine
KR101820099B1 (ko)	2013-01-18	2018-01-18	에스프린팅솔루션 주식회사	저항 발열체, 이를 채용한 가열 부재, 및 정착 장치
CN111788196A (zh) *	2018-01-09	2020-10-16	配体药物公司	缩醛化合物及其治疗用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (sv) *	1974-06-07	1981-03-18
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
GR69216B (sv) *	1979-06-15	1982-05-07	Merck & Co Inc
US4231938A (en) *	1979-06-15	1980-11-04	Merck & Co., Inc.	Hypocholesteremic fermentation products and process of preparation
US4282155A (en) *	1980-02-04	1981-08-04	Merck & Co., Inc.	Antihypercholesterolemic compounds
ZA81703B (en) *	1980-02-04	1982-09-29	Merck & Co Inc	New antihypercholesterolemic compounds,intermediates and processes
PT72394B (en) *	1980-02-04	1982-09-06	Merck & Co Inc	Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) *	1980-02-04	1986-01-09	Merck & Co., Inc.	Tetrahydro-2h-pyran-2-one derivatives

1980
- 1980-03-31 JP JP55041292A patent/JPH0692381B2/ja not_active Expired - Lifetime
1981
- 1981-03-27 IE IE698/81A patent/IE52367B1/en not_active IP Right Cessation
- 1981-03-30 IT IT67438/81A patent/IT1144325B/it active
- 1981-03-30 DE DE19813112566 patent/DE3112566A1/de active Granted
- 1981-03-30 DE DE3153666A patent/DE3153666C2/de not_active Expired - Lifetime
- 1981-03-30 CH CH215381A patent/CH646966A5/de not_active IP Right Cessation
- 1981-03-31 BE BE0/204328A patent/BE888214A/fr not_active IP Right Cessation
- 1981-03-31 AT AT0150781A patent/ATA150781A/de not_active IP Right Cessation
- 1981-03-31 FI FI810991A patent/FI810991L/fi not_active Application Discontinuation
- 1981-03-31 DK DK145481A patent/DK151273C/da not_active IP Right Cessation
- 1981-03-31 SE SE8102047A patent/SE461590B/sv not_active Application Discontinuation
- 1981-03-31 FR FR8106403A patent/FR2479222A1/fr active Granted
- 1981-03-31 NL NL8101592A patent/NL8101592A/nl not_active Application Discontinuation
- 1981-03-31 AU AU68932/81A patent/AU6893281A/en not_active Abandoned
- 1981-03-31 GB GB8110075A patent/GB2073193A/en not_active Withdrawn
1990
- 1990-02-07 DK DK032290A patent/DK32290D0/da not_active Application Discontinuation
- 1990-02-07 DK DK032190A patent/DK167805B1/da not_active IP Right Cessation
1992
- 1992-06-26 MX MX9203567A patent/MX9203567A/es unknown

Also Published As

Publication number	Publication date
MX9203567A (es)	1992-09-01
ATA150781A (de)	1983-03-15
JPS56138181A (en)	1981-10-28
DK32190A (da)	1990-02-07
CH646966A5 (de)	1984-12-28
IE810698L (en)	1981-09-30
DE3153666C2 (de)	1993-11-11
AU6893281A (en)	1981-10-08
SE461590B (sv)	1990-03-05
DK32290A (da)	1990-02-07
DK167805B1 (da)	1993-12-20
FI810991L (fi)	1981-10-01
FR2479222B1 (sv)	1983-08-26
DK32190D0 (da)	1990-02-07
GB2073193A (en)	1981-10-14
JPH0692381B2 (ja)	1994-11-16
DK145481A (da)	1981-10-01
IT1144325B (it)	1986-10-29
DK151273C (da)	1988-07-04
DK151273B (da)	1987-11-16
DK32290D0 (da)	1990-02-07
BE888214A (fr)	1981-09-30
DE3112566A1 (de)	1982-03-11
IT8167438A0 (it)	1981-03-30
DE3112566C2 (sv)	1990-04-05
FR2479222A1 (fr)	1981-10-02
NL8101592A (nl)	1981-10-16
IE52367B1 (en)	1987-09-30

Legal Events

Date	Code	Title	Description
1995-09-25	NAV	Patent application has lapsed	Ref document number: 8102047-1

Publication	Publication Date	Title
JPS5412381A (en)	1979-01-30	N-alkylpiperidine derivative
MX9204661A (es)	1994-02-28	Compuestos intermedios derivados de eter y procedimiento para su preparacion.
BG92804A (bg)	1993-12-24	4-бензоилизоксазолови производни
FI853625L (fi)	1986-03-23	Tetralinderivat, deras framstaellning och anvaendning.
NO914091D0 (no)	1991-10-17	Fremgangsmaate for fremstilling av hydroksylerte inhibitorer for hiv-reverstranskriptase
FI914723A0 (fi)	1991-10-07	17b-substituerade 4-aza-5a-androstan -3-jon-derivat och foerfarande foer framstaellning av desamma.
BR8801410A (pt)	1988-11-01	Composicao fotoendurecivel
NO912630L (no)	1992-01-06	Fremgangsmaate for fremstilling av nye 2,6-dialkyl-4-silyl-fenoler som antiarteriosklerotiske midler
SE8102047L (sv)	1981-10-01	Inhibitorer av kolesterolbiosyntes, deras framstellning och anvendning
YU96291A (sh)	1994-06-10	Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini
IT8221296A0 (it)	1982-05-14	Procedimento di trattamento di legumi per la loro presentazione alla vendita.
IT7825074A0 (it)	1978-06-28	Procedimento per l'eliminazione di impurita' di carbonile da idrocarburi.
FI891986A (fi)	1989-04-26	Farmaceutiska sammansaettningar foer behandling av psoriasis.
NO820820L (no)	1982-03-12	Fremgangsmaate ved fremstilling av 2,9-dioxatricyclo (4,3,1,0 3,7)decaner
ES2074992T3 (es)	1995-10-01	Derivados fungicidas de azolilo.
IT7826768A0 (it)	1978-08-14	Procedimento per l'eliminazione di nitrosammine delle dinitro-aniline.
IT8020763A0 (it)	1980-03-19	Procedimento per il trattamento d'olio greggio.
DK0596326T3 (da)	1996-01-15	Aryliden-1-azacycloalkaner og arylalkyl-1-azacycloalkaner og salte deraf, lægemidler indeholdende forbindelserne og forbindelsernes anvendelse samt fremgangsmåde til fremstilling af forbindelserne
ES8201993A1 (es)	1982-01-16	Un procedimiento para la preparacion de tiazoles
NO880405D0 (no)	1988-01-29	Fremgangsmaate til fremstilling av 3-fenyl-7h-tiazolo-/3,2-b//1,2,4/-tiazine-7-oner.
JPS5424856A (en)	1979-02-24	1-(3 or 4-methyl-3-cyclohexenyl)-2-methyl-1-penten-3-ol
JPS5387330A (en)	1978-08-01	Novel thiohydroxymate derivative, its preparation and bactericideand herbicide containing the same
IL67272A (en)	1986-04-29	Alkylcycloalkyl imidazolylmethyl ketones and their preparation
JPS5321132A (en)	1978-02-27	Propanol derivatives and their preparation
JPS53147017A (en)	1978-12-21	Compound of acylketene-s.n-acetal and its preparation