SE8007133L - BENSO (IJ) QUINOLIZIN-2-CARBOXYLIC ACID DERIVATIVES, THERAPEUTIC COMPOSITION CONTAINING THIS SUBSTANCE AND PREPARATION OF THEM - Google Patents

BENSO (IJ) QUINOLIZIN-2-CARBOXYLIC ACID DERIVATIVES, THERAPEUTIC COMPOSITION CONTAINING THIS SUBSTANCE AND PREPARATION OF THEM

Info

Publication number
SE8007133L
SE8007133L SE8007133A SE8007133A SE8007133L SE 8007133 L SE8007133 L SE 8007133L SE 8007133 A SE8007133 A SE 8007133A SE 8007133 A SE8007133 A SE 8007133A SE 8007133 L SE8007133 L SE 8007133L
Authority
SE
Sweden
Prior art keywords
group substituted
group
benso
quinolizin
substance
Prior art date
Application number
SE8007133A
Other languages
Swedish (sv)
Other versions
SE445917B (en
Inventor
H Ishikawa
F Tabusa
K Nagagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of SE8007133L publication Critical patent/SE8007133L/en
Publication of SE445917B publication Critical patent/SE445917B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Benzo[ij]quinolizine-2-carboxylic acids of the formula:- <IMAGE> wherein R<1> represents a hydrogen atom or a lower alkyl group; R<2> represents a hydrogen atom or a halogen atom; R<3> represents a lower alkyl group substituted with one or more of a halogen atom and a hydroxy group, a lower alkanoyl group substituted with one or more halogen atoms, a phenylalkyl group substituted with one or more lower alkoxy groups on the phenyl ring, a lower alkanesulfonyl group substituted with one or more halogen atoms, a lower alkenyl group or a lower alkynyl group; or pharmaceutically acceptable salts thereof, have antimicrobial activity. They are particularly effective on those bacteria resistant to conventional antibiotics and can be maintained at high concentration levels in blood for extended periods of time.
SE8007133A 1979-10-11 1980-10-10 BENSO (IJ) QUINOLIZIN-2-CARBOXYLIC ACID DERIVATIVES, PREPARING THEREOF AND THERAPEUTIC COMPOSITION SE445917B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54131630A JPS6019910B2 (en) 1979-10-11 1979-10-11 Benzo[ij]quinolidine-2-carboxylic acid derivative and method for producing the same

Publications (2)

Publication Number Publication Date
SE8007133L true SE8007133L (en) 1981-04-12
SE445917B SE445917B (en) 1986-07-28

Family

ID=15062532

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8007133A SE445917B (en) 1979-10-11 1980-10-10 BENSO (IJ) QUINOLIZIN-2-CARBOXYLIC ACID DERIVATIVES, PREPARING THEREOF AND THERAPEUTIC COMPOSITION

Country Status (12)

Country Link
JP (1) JPS6019910B2 (en)
AU (1) AU536230B2 (en)
BE (1) BE885605A (en)
CA (1) CA1156232A (en)
CH (1) CH644859A5 (en)
DE (1) DE3037103A1 (en)
ES (1) ES496312A0 (en)
FR (1) FR2467205A1 (en)
GB (1) GB2062627B (en)
IT (1) IT1143997B (en)
NL (1) NL187020C (en)
SE (1) SE445917B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO156828C (en) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd ANALOGY PROCEDURE FOR THE PREPARATION OF ANTIBACTERYLY EFFECTIVE BENZOHETEROCYCLIC COMPOUNDS.
JPS57176987A (en) * 1981-04-24 1982-10-30 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
US4400386A (en) * 1981-11-06 1983-08-23 Riker Laboratories, Inc. Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine
US4472406A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
JPS59137482A (en) * 1983-01-26 1984-08-07 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1,-ij)quinoline-5-carboxylic acid derivative
JPS59155381A (en) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd Benzoquinolizinecarboxylic acid derivative and its preparation
DE3333719A1 (en) * 1983-09-17 1985-04-04 Bayer Ag SOLUTIONS MILK ACID SALTS OF PIPERAZINYL CHINOLONIC AND PIPERAZINYL AZACHINOLONE CARBONIC ACIDS
JPS60161987A (en) * 1984-01-31 1985-08-23 Otsuka Pharmaceut Co Ltd Benzoheterocyclic ring derivative
DE3517709A1 (en) * 1985-01-05 1986-07-10 Bayer Ag BASIC PREPARATIONS OF CHINOLON CARBON ACIDS
AU585981B2 (en) * 1985-05-24 1989-06-29 Tokyo Tanabe Company Limited Benzo (IJ) quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and processes for preparing the same
DE3741026A1 (en) * 1987-12-03 1989-06-15 Muetek Laser Und Opto Elektron METHOD AND SYSTEM FOR (TRACK) GAS ANALYSIS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793524A (en) * 1971-12-30 1973-06-29 Riker Laboratories Inc BENZOQUINOLIZINE-CARBOXYLIC ACIDS AND THEIR DERIVATIVES
JPS6034957B2 (en) * 1978-04-12 1985-08-12 大塚製薬株式会社 penicillanic acid derivatives

Also Published As

Publication number Publication date
BE885605A (en) 1981-02-02
FR2467205B1 (en) 1983-10-07
FR2467205A1 (en) 1981-04-17
CH644859A5 (en) 1984-08-31
DE3037103C2 (en) 1989-06-15
AU6309080A (en) 1981-04-16
NL187020C (en) 1991-05-01
JPS6019910B2 (en) 1985-05-18
GB2062627B (en) 1983-12-07
AU536230B2 (en) 1984-05-03
SE445917B (en) 1986-07-28
CA1156232A (en) 1983-11-01
NL187020B (en) 1990-12-03
JPS5655389A (en) 1981-05-15
IT8049851A0 (en) 1980-10-09
DE3037103A1 (en) 1981-05-07
ES8106903A1 (en) 1981-10-01
ES496312A0 (en) 1981-10-01
GB2062627A (en) 1981-05-28
IT1143997B (en) 1986-10-29
NL8005613A (en) 1981-04-14

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