SE7712430L - ANTIBIOTICS A 10 - Google Patents

ANTIBIOTICS A 10

Info

Publication number
SE7712430L
SE7712430L SE7712430A SE7712430A SE7712430L SE 7712430 L SE7712430 L SE 7712430L SE 7712430 A SE7712430 A SE 7712430A SE 7712430 A SE7712430 A SE 7712430A SE 7712430 L SE7712430 L SE 7712430L
Authority
SE
Sweden
Prior art keywords
gram
antibiotic
novel
lactamases
feedstuffs
Prior art date
Application number
SE7712430A
Other languages
Swedish (sv)
Other versions
SE433621B (en
Inventor
P J Cassidy
S B Zimmerman
J B Tunac
S Hernandez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7712430L publication Critical patent/SE7712430L/en
Publication of SE433621B publication Critical patent/SE433621B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The novel compound of the formula <IMAGE> and its pharmaceutically acceptable salts are prepared by culture of an appropriate strain of Streptomyces flavogriseus in aqueous nutrient medium which contains assimilable sources of carbon, nitrogen and inorganic salts, under submerged, aerobic conditions and isolation of the antibiotic formed. The novel antibiotic is active against various Gram-positive and Gram-negative bacteria and is a potent inhibitor of bacterial ss-lactamases. It can be used in human and veterinary medicine and is also suitable as an additive to animal feed owing to preservation of feedstuffs and foodstuffs and as a disinfectant.
SE7712430A 1976-11-17 1977-11-03 SET TO MAKE ANTIBIOTICS 890 A? 7110 BY CULTIVATING STREPTOMYCES FLAVOGRISEUS SE433621B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74295876A 1976-11-17 1976-11-17

Publications (2)

Publication Number Publication Date
SE7712430L true SE7712430L (en) 1978-05-18
SE433621B SE433621B (en) 1984-06-04

Family

ID=24986929

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7712430A SE433621B (en) 1976-11-17 1977-11-03 SET TO MAKE ANTIBIOTICS 890 A? 7110 BY CULTIVATING STREPTOMYCES FLAVOGRISEUS

Country Status (10)

Country Link
JP (1) JPS5363397A (en)
CH (1) CH634104A5 (en)
DE (1) DE2751303A1 (en)
DK (1) DK487977A (en)
ES (1) ES463973A1 (en)
FR (1) FR2371448A1 (en)
GB (1) GB1595233A (en)
NL (1) NL7712092A (en)
PT (1) PT67268B (en)
SE (1) SE433621B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16708A (en) 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1483142A (en) * 1975-03-15 1977-08-17 Beecham Group Ltd Streptomycetal antibiotic
CH633554A5 (en) * 1975-11-21 1982-12-15 Merck & Co Inc Process for the preparation of novel thienamycin derivatives.

Also Published As

Publication number Publication date
CH634104A5 (en) 1983-01-14
FR2371448B1 (en) 1980-03-14
GB1595233A (en) 1981-08-12
DE2751303A1 (en) 1978-05-18
NL7712092A (en) 1978-05-19
ES463973A1 (en) 1978-11-16
PT67268A (en) 1977-12-01
JPS5363397A (en) 1978-06-06
JPS6310998B2 (en) 1988-03-10
PT67268B (en) 1979-10-08
FR2371448A1 (en) 1978-06-16
SE433621B (en) 1984-06-04
DK487977A (en) 1978-05-18

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