SE7503724L - PROCEDURE FOR MANUFACTURE OF ANTIBIOTICS. - Google Patents
PROCEDURE FOR MANUFACTURE OF ANTIBIOTICS.Info
- Publication number
- SE7503724L SE7503724L SE7503724A SE7503724A SE7503724L SE 7503724 L SE7503724 L SE 7503724L SE 7503724 A SE7503724 A SE 7503724A SE 7503724 A SE7503724 A SE 7503724A SE 7503724 L SE7503724 L SE 7503724L
- Authority
- SE
- Sweden
- Prior art keywords
- ethanol
- antibiotic
- chloroform
- absorption
- soluble
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Feed For Specific Animals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1479063 Antibiotics PFIZER Inc 16 April 1975 [16 April 1974 17 Jan 1975] 15748/75 Heading C2A A synergistic antibiotic mixture comprises compounds 35, 763, 36, 926, 37, 277 and 37, 932 and miscellaneous lesser antibiotic components produced by cultivating Actinoplanes auranticolor ATCC 31011 under submerged aerobic conditions in an aqueous nutrient medium containing an assimilable source of carbon and nitrogen until substantial antibiotic activity is obtained and separating the antibiotic mixture therefrom. Antibiotic compound 37, 277 is in crystalline form and has an optical rotation of [α] D <SP>25‹</SP>= + 11‹ at a concentration of 1% in ethanol, absorption maxima in ethanol in the ultra-violet region at 225, 274, 282, 303 and 355 mÁ with E<SP>1%</SP> 1cm values of 309À3, 36.67, 45.01, 70 and 20, an average composition by weight of 60.91% C, 5.98% H, 10.45% N and 22.66% O, when dissolved in chloroform exhibits the absorption characteristics indicated in Fig. 1 (not shown), on heating decomposes between 145‹ and 150‹ C., is insoluble in diethyl ether, Lexane, treptane and water, slightly soluble in acetone and leuzene, and readily soluble in methanol ethanol, chloroform and methylene chloride. Antibiotic compound 36, 926 has an average composition by weight of 57.89% C, 6.78% H, 8.04% N and 27.29% O, a molecular formula C 26 H 35 N 3 0 7 , an optical rotation of [α] D <SP>25‹</SP>=-130‹ at a concentration of 1% in ethanol, absorption maximum in ethanol in the ultra-violet region of the spectrum at 214 mÁ. with E<SP>1%</SP> 1cm of 723À8, 8 when spectrum at 214 mÁ with E<SP>1%</SP> 1cm of 723À8, when pelleted on KBr exhibits the absorption characteristics indicated in Fig. 2 (not shown), and on heating, decomposition commences at 100‹ C., is soluble in ethanol, methanol, chloroform and methylene chloride and insoluble in diethyl ether, hexane and heptane. Antibiotic compound 35, 763 has the molecular formula C 26 H 27 N 3 O 7 , an optical rotation of [α] D <SP>25‹</SP>=-114‹ at a concentration of 1% in ethanol, absorption maximum in ethanol in the ultra violet region at 218 mÁ with E<SP>1%</SP> 1cm of 668.9, when pelleted in KBr exhibits the absorption characteristic indicated in Fig. 3 (not shown), is soluble in methanol, ethanol, chloroform and methylene chloride, insouble in diethyl ether, heptane and hexane, on heating decomposition commences at 100‹ C., has a M.Wt of 503 and an average composition by weight of 61À29% C, 6À73% H, 8À83% N and 23À15% O. Antibiotic compound 37, 932 is in crystalline form and has an optical rotation of [α] D <SP>25‹</SP> = + 5.0‹ at a concentration of 0.25% in chloroform, absorption maxima in ethanol in the ultra-violet region of the spectrum at 226, 276, 283, 305 and 355 mÁ with E<SP>1%</SP> 1cm values of 304.4, 36.8, 43.49, 70.25 and 20.07, an average composition by weight of 59.41% C, 6À01% H, 10À66% N and 23.92% O when pelleted in KBr exhibits the absorption characteristics indicated on Fig. 4 (not shown) and is soluble in methanol, ethanol, chloroform and methylene chloride, is insoluble in diethyl ether, hexane, heptane and water and on heating decomposition commences at 185‹ C. The antibiotic mixture or one or more of the antibiotics may be admixed with a pharmaceutically acceptable carrier to form a pharmaceutical composition. The antibiotic mixture or one or more of the antibiotics may be incorporated in an animal feed composition.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46129874A | 1974-04-16 | 1974-04-16 | |
US54180075A | 1975-01-17 | 1975-01-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7503724L true SE7503724L (en) | 1975-10-17 |
SE423246B SE423246B (en) | 1982-04-26 |
Family
ID=27039975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7503724A SE423246B (en) | 1974-04-16 | 1975-04-01 | CULTIVATION OF A. AURANTICOLOR ATCC 31011 FOR THE PREPARATION OF ANTIBIOTICS |
Country Status (26)
Country | Link |
---|---|
JP (2) | JPS548760B2 (en) |
AR (1) | AR207359A1 (en) |
AU (1) | AU475745B2 (en) |
BG (1) | BG28268A3 (en) |
CA (1) | CA1045568A (en) |
CH (1) | CH606423A5 (en) |
CS (1) | CS196262B2 (en) |
DD (2) | DD118119A5 (en) |
DE (1) | DE2516020A1 (en) |
DK (1) | DK138758B (en) |
ES (1) | ES436615A1 (en) |
FI (1) | FI54326C (en) |
FR (1) | FR2287915A1 (en) |
GB (1) | GB1479063A (en) |
HU (1) | HU171026B (en) |
IE (1) | IE40906B1 (en) |
IL (1) | IL47004A (en) |
IT (1) | IT1053258B (en) |
LU (1) | LU72292A1 (en) |
NL (1) | NL159436B (en) |
NO (1) | NO143107C (en) |
PH (4) | PH14603A (en) |
RO (1) | RO68835A (en) |
SE (1) | SE423246B (en) |
SU (1) | SU552907A3 (en) |
YU (1) | YU90275A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6147714A (en) * | 1984-08-14 | 1986-03-08 | Agency Of Ind Science & Technol | Graft polymerization process |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE37892B1 (en) * | 1972-07-31 | 1977-11-09 | Lilly Co Eli | Antibiotic a-2315 and process for preparation thereof |
-
1975
- 1975-01-01 AR AR258391A patent/AR207359A1/en active
- 1975-04-01 SE SE7503724A patent/SE423246B/en not_active IP Right Cessation
- 1975-04-03 NO NO751149A patent/NO143107C/en unknown
- 1975-04-03 IL IL47004A patent/IL47004A/en unknown
- 1975-04-03 IE IE745/75A patent/IE40906B1/en unknown
- 1975-04-04 AU AU79833/75A patent/AU475745B2/en not_active Expired
- 1975-04-07 PH PH17024A patent/PH14603A/en unknown
- 1975-04-09 YU YU00902/75A patent/YU90275A/en unknown
- 1975-04-12 DE DE19752516020 patent/DE2516020A1/en active Pending
- 1975-04-12 BG BG7529639A patent/BG28268A3/en unknown
- 1975-04-15 SU SU2137352A patent/SU552907A3/en active
- 1975-04-15 NL NL7504453.A patent/NL159436B/en not_active IP Right Cessation
- 1975-04-15 HU HU75PI00000464A patent/HU171026B/en not_active IP Right Cessation
- 1975-04-15 DD DD185452A patent/DD118119A5/xx unknown
- 1975-04-15 ES ES436615A patent/ES436615A1/en not_active Expired
- 1975-04-15 FI FI751107A patent/FI54326C/en not_active IP Right Cessation
- 1975-04-15 DD DD191038A patent/DD122778A5/xx unknown
- 1975-04-15 CA CA224,595A patent/CA1045568A/en not_active Expired
- 1975-04-15 IT IT49091/75A patent/IT1053258B/en active
- 1975-04-15 DK DK161075AA patent/DK138758B/en not_active IP Right Cessation
- 1975-04-16 JP JP4629375A patent/JPS548760B2/ja not_active Expired
- 1975-04-16 RO RO7582003A patent/RO68835A/en unknown
- 1975-04-16 GB GB15748/75A patent/GB1479063A/en not_active Expired
- 1975-04-16 LU LU72292A patent/LU72292A1/xx unknown
- 1975-04-16 CS CS752641A patent/CS196262B2/en unknown
- 1975-04-16 FR FR7511848A patent/FR2287915A1/en active Granted
- 1975-04-16 CH CH487675A patent/CH606423A5/xx not_active IP Right Cessation
- 1975-05-30 JP JP50065248A patent/JPS5831919B2/en not_active Expired
-
1977
- 1977-11-24 PH PH20484A patent/PH15618A/en unknown
- 1977-11-24 PH PH20483A patent/PH13383A/en unknown
- 1977-11-24 PH PH20482A patent/PH13963A/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
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NUG | Patent has lapsed |
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