SE422685B - Forfarande for framstellning av 2-(4-(tetrahydro-2-furoyl)-piperazin)-4-amino-6,7-dimetoxikinazolin - Google Patents
Forfarande for framstellning av 2-(4-(tetrahydro-2-furoyl)-piperazin)-4-amino-6,7-dimetoxikinazolinInfo
- Publication number
- SE422685B SE422685B SE7611379A SE7611379A SE422685B SE 422685 B SE422685 B SE 422685B SE 7611379 A SE7611379 A SE 7611379A SE 7611379 A SE7611379 A SE 7611379A SE 422685 B SE422685 B SE 422685B
- Authority
- SE
- Sweden
- Prior art keywords
- dimetoxicinazoline
- furoyl
- tetrahydro
- piperazine
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/621,980 US4026894A (en) | 1975-10-14 | 1975-10-14 | Antihypertensive agents |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7611379L SE7611379L (sv) | 1977-04-15 |
SE422685B true SE422685B (sv) | 1982-03-22 |
Family
ID=24492453
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7611379A SE422685B (sv) | 1975-10-14 | 1976-10-13 | Forfarande for framstellning av 2-(4-(tetrahydro-2-furoyl)-piperazin)-4-amino-6,7-dimetoxikinazolin |
SE8008533A SE431208B (sv) | 1975-10-14 | 1980-12-04 | Forfarande for framstellning av 2-(4-(tetrahydropyran-2-karbonyl)piperazinyl)-4-amino-6,7-dimetoxikinazolin |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8008533A SE431208B (sv) | 1975-10-14 | 1980-12-04 | Forfarande for framstellning av 2-(4-(tetrahydropyran-2-karbonyl)piperazinyl)-4-amino-6,7-dimetoxikinazolin |
Country Status (10)
Country | Link |
---|---|
US (2) | US4026894A (sv) |
JP (1) | JPS5248678A (sv) |
AU (1) | AU498925B2 (sv) |
CA (1) | CA1057754A (sv) |
CH (1) | CH602712A5 (sv) |
DE (1) | DE2646186A1 (sv) |
FR (1) | FR2327787A1 (sv) |
GB (1) | GB1517403A (sv) |
MX (1) | MX3620E (sv) |
SE (2) | SE422685B (sv) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
FR2421888A1 (fr) * | 1978-02-06 | 1979-11-02 | Synthelabo | Amides d'alkylene-diamines et leur application en therapeutique |
US4197301A (en) * | 1978-10-16 | 1980-04-08 | Allergan Pharmaceuticals, Inc. | Topical ophthalmic use of Prazosin |
US4287341A (en) * | 1979-11-01 | 1981-09-01 | Pfizer Inc. | Alkoxy-substituted-6-chloro-quinazoline-2,4-diones |
DK121080A (da) * | 1979-04-25 | 1980-10-26 | Pfizer | Fremgangsmaade til fremstilling af 2-piperazinoquinazolinderivater |
EP0022481A1 (en) * | 1979-06-21 | 1981-01-21 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions |
HU180708B (en) * | 1979-10-11 | 1983-04-29 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 1,2,4-oxadiazine derivatives |
US4351940A (en) * | 1980-03-03 | 1982-09-28 | Pfizer Inc. | Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
DE3346675A1 (de) * | 1983-12-23 | 1985-07-04 | Beiersdorf Ag, 2000 Hamburg | Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte |
FI79107C (sv) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Förfarande för framställning av stabil -form av prazosinhydroklorid. |
US4734418A (en) * | 1984-12-14 | 1988-03-29 | Mitsui Petrochemical Industries, Ltd. | Quinazoline compounds and antihypertensives |
ATE72244T1 (de) * | 1986-03-21 | 1992-02-15 | Heumann Pharma Gmbh & Co | Kristalline, wasserfreie sigma -form von 2-(4-(2furoyl-(2-piperazin)-1-yl>-4-amino-6,7- dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung. |
YU70890A (en) * | 1989-04-21 | 1992-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for obtaining quinazoline derivatives |
JPH03286800A (ja) * | 1990-04-03 | 1991-12-17 | Gunze Ltd | 衣類の折畳み装置 |
US5212176A (en) * | 1990-06-29 | 1993-05-18 | Abbott Laboratories | R(+)-terazosin |
NZ241979A (en) * | 1991-03-20 | 1996-01-26 | Merck & Co Inc | Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker |
CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
IT1270993B (it) * | 1994-03-18 | 1997-05-26 | Recordati Chem Pharm | Derivati chinzolilamminici attivi come alfa-antagonisti |
US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
JPH11512710A (ja) * | 1995-09-29 | 1999-11-02 | メルク エンド カンパニー インコーポレーテッド | アルファ1bアドレナリンレセプターアンタゴニスト |
US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
US6177430B1 (en) | 1997-03-27 | 2001-01-23 | Pfizer Inc | Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
CA2173408C (en) * | 1996-04-03 | 2001-09-04 | K.S. Keshava Murthy | Process for the manufacture of intermediates suitable to make doxazosin,terazosin, prazosin, tiodazosin and related antihypertensive medicines |
US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
IT1286790B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridrato anidro |
IT1286789B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridato anidro |
GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
US6248888B1 (en) | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
NZ510685A (en) | 1998-09-30 | 2003-10-31 | Takeda Chemical Industries Ltd | Drugs for improving vesical excretory strength |
US20020065286A1 (en) * | 2000-08-21 | 2002-05-30 | Davies Michael John | Treatment of wounds |
US20020091129A1 (en) * | 2000-11-20 | 2002-07-11 | Mitradev Boolell | Treatment of premature ejaculation |
US20030060513A1 (en) * | 2001-09-27 | 2003-03-27 | Arneric Stephen P. | Pharmaceutical composition |
GB0130219D0 (en) * | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Compounds for the treatment of sexual dysfunction |
US20030229001A1 (en) * | 2002-01-31 | 2003-12-11 | Pfizer Inc. | Treatment of male sexual dysfunction |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
GB0219961D0 (en) | 2002-08-28 | 2002-10-02 | Pfizer Ltd | Oxytocin inhibitors |
US7323462B2 (en) * | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
WO2004054560A1 (en) | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
PA8597401A1 (es) * | 2003-03-14 | 2005-05-24 | Pfizer | Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep |
US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
US20050065158A1 (en) * | 2003-07-16 | 2005-03-24 | Pfizer Inc. | Treatment of sexual dysfunction |
US20050059744A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
US20050058696A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
CN102657664A (zh) | 2003-09-12 | 2012-09-12 | 阿勒根公司 | 用于治疗疼痛和其它α2肾上腺素能介导疾病的方法及组合物 |
US7291640B2 (en) * | 2003-09-22 | 2007-11-06 | Pfizer Inc. | Substituted triazole derivatives as oxytocin antagonists |
US20050267096A1 (en) * | 2004-05-26 | 2005-12-01 | Pfizer Inc | New indazole and indolone derivatives and their use pharmaceuticals |
US20050288270A1 (en) * | 2004-05-27 | 2005-12-29 | Pfizer Inc | New aminopyridine derivatives and their use as pharmaceuticals |
CA2500676A1 (en) * | 2005-03-11 | 2006-09-11 | Apotex Pharmachem Inc. | Preparation of acid addition salts of amine bases by solid phase-gas phase reactions |
WO2006100557A1 (en) * | 2005-03-21 | 2006-09-28 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
EP1863484A1 (en) * | 2005-03-21 | 2007-12-12 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
US20060264442A1 (en) * | 2005-05-18 | 2006-11-23 | Allergan, Inc. | Methods for the treatment of ocular and neurodegenerative conditions in a mammal |
CA2618103A1 (en) * | 2005-08-10 | 2007-02-15 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
US20070086958A1 (en) * | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Formation of medically useful gels comprising microporous particles and methods of use |
US20070161791A1 (en) * | 2006-01-09 | 2007-07-12 | Narsimha Reddy Penthala | Process for the preparation of terazosin hydrocloride dihydrate |
CN101190890B (zh) * | 2006-11-30 | 2011-04-27 | 江苏豪森药业股份有限公司 | 5-[(2r)-[2-[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2-甲氧基苯磺酰胺 |
EP2162444B1 (en) * | 2007-07-11 | 2014-06-04 | Hetero Drugs Limited | An improved process for the preparation of erlotinib hydrochloride |
CN103739596A (zh) * | 2013-12-10 | 2014-04-23 | 刘磊 | 用于心脑血管疾病的喹唑啉衍生物 |
US11224572B1 (en) | 2020-08-17 | 2022-01-18 | Novitium Pharma LLC | Stable oral liquid composition of terazosin |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
US3669968A (en) * | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
JPS4966691A (sv) * | 1972-10-30 | 1974-06-27 |
-
1975
- 1975-10-14 US US05/621,980 patent/US4026894A/en not_active Expired - Lifetime
-
1976
- 1976-08-02 CA CA258,274A patent/CA1057754A/en not_active Expired
- 1976-08-04 AU AU16557/76A patent/AU498925B2/en not_active Expired
- 1976-08-11 MX MX762894U patent/MX3620E/es unknown
- 1976-10-05 JP JP51119041A patent/JPS5248678A/ja active Granted
- 1976-10-12 CH CH1288876A patent/CH602712A5/xx not_active IP Right Cessation
- 1976-10-13 SE SE7611379A patent/SE422685B/sv not_active IP Right Cessation
- 1976-10-13 DE DE19762646186 patent/DE2646186A1/de active Granted
- 1976-10-13 FR FR7630803A patent/FR2327787A1/fr active Granted
- 1976-10-14 GB GB42802/76A patent/GB1517403A/en not_active Expired
-
1977
- 1977-01-21 US US05/760,895 patent/US4112097A/en not_active Expired - Lifetime
-
1980
- 1980-12-04 SE SE8008533A patent/SE431208B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SE8008533L (sv) | 1980-12-04 |
US4026894A (en) | 1977-05-31 |
SE431208B (sv) | 1984-01-23 |
FR2327787B1 (sv) | 1980-10-10 |
DE2646186C2 (sv) | 1987-10-29 |
AU1655776A (en) | 1978-02-09 |
DE2646186A1 (de) | 1977-04-28 |
US4112097A (en) | 1978-09-05 |
AU498925B2 (en) | 1979-03-29 |
CH602712A5 (sv) | 1978-07-31 |
JPS5248678A (en) | 1977-04-18 |
SE7611379L (sv) | 1977-04-15 |
CA1057754A (en) | 1979-07-03 |
FR2327787A1 (fr) | 1977-05-13 |
JPS5543474B2 (sv) | 1980-11-06 |
MX3620E (es) | 1981-04-02 |
GB1517403A (en) | 1978-07-12 |
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