SE398877B - PROCEDURE FOR THE PREPARATION OF 14-HYDROXY-MORPHINAND DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF 14-HYDROXY-MORPHINAND DERIVATIVES

Info

Publication number
SE398877B
SE398877B SE7211522A SE1152272A SE398877B SE 398877 B SE398877 B SE 398877B SE 7211522 A SE7211522 A SE 7211522A SE 1152272 A SE1152272 A SE 1152272A SE 398877 B SE398877 B SE 398877B
Authority
SE
Sweden
Prior art keywords
morphinand
hydroxy
derivatives
procedure
preparation
Prior art date
Application number
SE7211522A
Other languages
Swedish (sv)
Inventor
I J Pachter
B R Belleau
I Monkovic
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE398877B publication Critical patent/SE398877B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE7211522A 1971-09-08 1972-09-06 PROCEDURE FOR THE PREPARATION OF 14-HYDROXY-MORPHINAND DERIVATIVES SE398877B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17883771A 1971-09-08 1971-09-08
US00217633A US3819635A (en) 1971-09-08 1972-01-13 14-hydroxymorphinan derivatives

Publications (1)

Publication Number Publication Date
SE398877B true SE398877B (en) 1978-01-23

Family

ID=26874723

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7211522A SE398877B (en) 1971-09-08 1972-09-06 PROCEDURE FOR THE PREPARATION OF 14-HYDROXY-MORPHINAND DERIVATIVES
SE7506292A SE403286B (en) 1971-09-08 1975-06-02 INTERMEDIATES FOR THE PREPARATION OF 1,4-HYDROXIMORFINAND DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7506292A SE403286B (en) 1971-09-08 1975-06-02 INTERMEDIATES FOR THE PREPARATION OF 1,4-HYDROXIMORFINAND DERIVATIVES

Country Status (19)

Country Link
US (1) US3819635A (en)
JP (1) JPS5310596B2 (en)
AU (1) AU470102B2 (en)
BE (1) BE788478A (en)
CA (1) CA999578A (en)
CH (1) CH590845A5 (en)
CY (1) CY980A (en)
DD (1) DD100255A5 (en)
DE (3) DE2265255C2 (en)
DK (1) DK141624B (en)
FR (1) FR2154481B1 (en)
GB (2) GB1412130A (en)
HK (1) HK2679A (en)
IE (2) IE36688B1 (en)
KE (1) KE2911A (en)
MY (1) MY7900027A (en)
NL (1) NL162072C (en)
SE (2) SE398877B (en)
YU (1) YU45099B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910920A (en) * 1973-11-07 1975-10-07 Bristol Myers Co 3,14,17-Substituted-6,7-tetramethylenemorphinans
US3980641A (en) * 1975-07-31 1976-09-14 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinans
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4052389A (en) * 1976-03-23 1977-10-04 Bristol-Myers Company Derivatives of 9,10-dihydroxy-1-(p-alkoxybenzyl)-perhydroisoquinoline oxazine-3-one
US4139534A (en) * 1977-02-17 1979-02-13 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4058531A (en) * 1976-03-23 1977-11-15 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
JPS52136176A (en) * 1976-03-23 1977-11-14 Bristol Myers Co Method of improving 144hydroxymorphinan derivatives
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
US4338320A (en) * 1978-11-15 1982-07-06 The Board Of Regents Of The University Of Nebraska Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them
US4228285A (en) * 1979-02-28 1980-10-14 Bristol-Myers Company 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
DE69414085T2 (en) * 1993-07-19 1999-03-18 Toray Industries ACTIVE SUBSTANCE TO PROTECT BRAIN CELLS
JP3843456B2 (en) * 1993-07-23 2006-11-08 東レ株式会社 Morphinan derivatives and pharmaceutical applications
CZ281174B6 (en) * 1993-08-13 1996-07-17 Galena, A.S. Process for preparing 3,14beta-dihydroxy-17-normorphinan
ATE265846T1 (en) 1998-02-25 2004-05-15 Abbott Lab SUSTAINED RELEASE FORMULATIONS CONTAINING BUTORPHANOL
US20040167164A1 (en) * 1998-05-05 2004-08-26 Jose Pozuelo Compositions and methods for treating particular chemical addictions and mental illnesses
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2987788A1 (en) 2002-05-17 2016-02-24 Taiwanj Pharmaceuticals Co., Ltd. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN103073496B (en) * 2013-02-18 2015-08-26 苏州立新制药有限公司 The preparation method of Dextromethorphane Hbr
JP6464181B2 (en) 2014-10-14 2019-02-06 久光製薬株式会社 Patch

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3166559A (en) * 1965-01-19 J-lower alkoxy-x-phenyloxy-ix-hydroxy-
GB1028407A (en) * 1962-04-06 1966-05-04 Shionogi & Co Improvements in or relating to morphinan derivatives and their preparation
FR1362540A (en) * 1963-04-05 1964-06-05 Shionogi & Co Substituted n derivatives of morphinan and their production

Also Published As

Publication number Publication date
DD100255A5 (en) 1973-09-12
DE2243961A1 (en) 1973-04-05
SE7506292L (en) 1975-06-02
YU227772A (en) 1982-02-28
GB1412130A (en) 1975-10-29
BE788478A (en) 1973-03-06
FR2154481A1 (en) 1973-05-11
YU45099B (en) 1992-07-20
DE2265256C2 (en) 1985-10-24
NL162072C (en) 1980-04-15
IE36688B1 (en) 1977-02-02
AU4622872A (en) 1974-03-07
DE2265256A1 (en) 1977-01-27
CA999578A (en) 1976-11-09
NL162072B (en) 1979-11-15
DK141624B (en) 1980-05-12
JPS4834864A (en) 1973-05-22
KE2911A (en) 1979-01-26
AU470102B2 (en) 1976-03-04
DE2243961C2 (en) 1988-07-21
DE2265255C2 (en) 1986-06-05
JPS5310596B2 (en) 1978-04-14
CH590845A5 (en) 1977-08-31
GB1412129A (en) 1975-10-29
IE36687B1 (en) 1977-02-02
IE36687L (en) 1973-03-08
US3819635A (en) 1974-06-25
DK141624C (en) 1980-10-13
FR2154481B1 (en) 1976-04-23
SE403286B (en) 1978-08-07
MY7900027A (en) 1979-12-31
NL7212176A (en) 1973-03-12
HK2679A (en) 1979-01-19
DE2265255A1 (en) 1977-01-27
CY980A (en) 1979-03-23

Similar Documents

Publication Publication Date Title
SE392269B (en) PROCEDURE FOR THE PREPARATION OF CERTAIN INDANYLOXITETRAZOLES
SE398877B (en) PROCEDURE FOR THE PREPARATION OF 14-HYDROXY-MORPHINAND DERIVATIVES
SE398229B (en) PROCEDURE FOR THE PREPARATION OF 4-PHENOXI-PHENOXIAL CANCARBONIC ACID DERIVATIVES
SE406197B (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4-AMINOKINAZOLINE DERIVATIVES
SE400292B (en) PROCEDURE FOR THE PREPARATION OF BENZHYDRYL-3-CARBAMOYLOXIMETHYL-7-THIENYLACETAMIDO-7-METHOXIDE CEFALOSPORANATE
SE392615B (en) PROCEDURE FOR THE PREPARATION OF 2-NITRO-5-IMIDAZOLALDEHYDE DERIVATIVES
SE380273B (en) PROCEDURE FOR THE PREPARATION OF THIOPYRIMIDINE DERIVATIVES
SE384686B (en) PROCEDURE FOR THE PREPARATION OF LINKOMYCIN DERIVATIVES
SE397090B (en) PROCEDURE FOR THE PREPARATION OF HYDROXIPYRIMIDINES
SE405478B (en) PROCEDURE FOR THE PREPARATION OF ALFA-SULFOACYLCEPHALOSPORINES
SE417318B (en) PROCEDURE FOR THE PREPARATION OF PENICILLIN OXOFURYL ESTERATE DERIVATIVES
SE399069B (en) ANALOGICAL PROCEDURE FOR THE PREPARATION OF TRIAZOLO-PYRIDINO-ISOKINOLINE DERIVATIVES
SE408177B (en) PROCEDURE FOR THE PREPARATION OF 4-HYDROXIMETHYL-1-PHTHALAZONE DERIVATIVES
SE387936B (en) PROCEDURE FOR THE PREPARATION OF SUBSTITUTED METHOXYAMINES
SE380520B (en) PROCEDURE FOR THE PREPARATION OF 1-CINNAMYLIDENAMINO-3-BENZYLIDENAMINOGUANIDINE
SE409866B (en) PROCEDURE FOR THE PREPARATION OF ADENOSIN DERIVATIVES
SE394680B (en) PROCEDURE FOR THE PREPARATION OF CYCLIC PHOSPHAMID DERIVATIVES
SE384210B (en) PROCEDURE FOR THE PREPARATION OF NEW NITROSOCARBAMIDE DERIVATIVES
SE405730B (en) PROCEDURE FOR THE PREPARATION OF CHINAZOLINE DERIVATIVES
SE397350B (en) PROCEDURE FOR THE PREPARATION OF TIENO-DIAZEPINE DERIVATIVES
SE392902B (en) PROCEDURE FOR THE PREPARATION OF PHENYLIMIDAZOLIDINONES
SE386897B (en) PROCEDURE FOR THE PREPARATION OF N-ACYL- (PIPERAZINOETHYL) -PYRAZOLES
SE7510790L (en) PROCEDURE FOR THE PREPARATION OF 2- OR 3-CEFEM DERIVATIVES
SE407061B (en) PROCEDURE FOR THE PREPARATION OF BENZYLPYRIMIDINES
SE387948B (en) PROCEDURE FOR THE PREPARATION OF TIOFEN