SE378110B - - Google Patents
Info
- Publication number
- SE378110B SE378110B SE7206645A SE664572A SE378110B SE 378110 B SE378110 B SE 378110B SE 7206645 A SE7206645 A SE 7206645A SE 664572 A SE664572 A SE 664572A SE 378110 B SE378110 B SE 378110B
- Authority
- SE
- Sweden
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7206645A SE378110B (fr) | 1972-05-19 | 1972-05-19 | |
ZA732956A ZA732956B (en) | 1972-05-19 | 1973-05-01 | A process for the separation of stereoisomeric mixtures into their components and components obtained hereby |
IL42154A IL42154A (en) | 1972-05-19 | 1973-05-01 | Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby |
AU55252/73A AU478324B2 (en) | 1972-05-19 | 1973-05-04 | A process for the separation of stereoisomeric mixtures into their components and components obtained hereby |
CY1012A CY1012A (en) | 1972-05-19 | 1973-05-09 | Process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtainned thereby |
GB2219573A GB1428416A (en) | 1972-05-19 | 1973-05-09 | Process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtained thereby |
DE2323216A DE2323216C3 (de) | 1972-05-19 | 1973-05-09 | Verfahren zur Auftrennung von Stereoisomerengemischen von Pregna-1,4dien-11 -ol-33-dionen |
US359913A US3928326A (en) | 1972-05-19 | 1973-05-14 | Process for the separation of stereoisomeric mixtures into their components and components obtained hereby |
FI731543A FI50711C (fi) | 1972-05-19 | 1973-05-14 | Menetelmä kortikosteroidien stereoisomeeriseosten jakamiseksi stereois omeerikomponenteikseen. |
DK277073A DK133249C (da) | 1972-05-19 | 1973-05-17 | Fremgangsmade til opspaltning af stereoisomerblandinger af 16alfa,17alfa-alkylidendioxypregnan-11beta,21-diol-3,20-dioner |
NLAANVRAGE7306979,A NL175917C (nl) | 1972-05-19 | 1973-05-18 | Werkwijze voor het splitsen van isomere mengsels van steroiden, werkwijze voor het bereiden van een farmaceutisch preparaat en aldus verkregen gevormd farmaceutisch preparaat. |
SU1918554A SU468408A3 (ru) | 1972-05-19 | 1973-05-18 | Способ разделени стереоизомерных смесей |
FR7318126A FR2185406B1 (fr) | 1972-05-19 | 1973-05-18 | |
CA171,781A CA1003402A (en) | 1972-05-19 | 1973-05-18 | Process for the separation of steroisomeric mixtures into their components and components obtained hereby |
BE131271A BE799728A (fr) | 1972-05-19 | 1973-05-18 | Procede pour la separation de steredoisomeres de certains steroides |
JP5623473A JPS547794B2 (fr) | 1972-05-19 | 1973-05-19 | |
US05/629,390 US3992534A (en) | 1972-05-19 | 1975-11-06 | Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods |
US05/629,493 US3996359A (en) | 1972-05-19 | 1975-11-06 | Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith |
KE2969A KE2969A (en) | 1972-05-19 | 1979-06-20 | A process for the separation of sterioisomeric mixtures of steroid acetalsinto, their components and components obtained thereby |
HK490/79A HK49079A (en) | 1972-05-19 | 1979-07-19 | A process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtained thereby |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7206645A SE378110B (fr) | 1972-05-19 | 1972-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
SE378110B true SE378110B (fr) | 1975-08-18 |
Family
ID=20269238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7206645A SE378110B (fr) | 1972-05-19 | 1972-05-19 |
Country Status (17)
Country | Link |
---|---|
US (1) | US3928326A (fr) |
JP (1) | JPS547794B2 (fr) |
BE (1) | BE799728A (fr) |
CA (1) | CA1003402A (fr) |
CY (1) | CY1012A (fr) |
DE (1) | DE2323216C3 (fr) |
DK (1) | DK133249C (fr) |
FI (1) | FI50711C (fr) |
FR (1) | FR2185406B1 (fr) |
GB (1) | GB1428416A (fr) |
HK (1) | HK49079A (fr) |
IL (1) | IL42154A (fr) |
KE (1) | KE2969A (fr) |
NL (1) | NL175917C (fr) |
SE (1) | SE378110B (fr) |
SU (1) | SU468408A3 (fr) |
ZA (1) | ZA732956B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4404200A (en) * | 1980-12-04 | 1983-09-13 | Aktiebolaget Draco | 4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL188581C (nl) * | 1974-07-15 | 1992-08-03 | Akzo Nv | Werkwijze voor het bereiden van 11beta-hydroxy-18-alkylestraanverbindingen. |
ZA763131B (en) * | 1975-05-27 | 1978-01-25 | Syntex Inc | Use of flunisolide to treat respiratory diseases |
IT1196142B (it) * | 1984-06-11 | 1988-11-10 | Sicor Spa | Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti |
SE8604059D0 (sv) * | 1986-09-25 | 1986-09-25 | Astra Pharma Prod | A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
PL178307B1 (pl) * | 1993-01-08 | 2000-04-28 | Astra Ab | Nowe pochodne steroidowe, sposób wytwarzania nowych pochodnych steroidowych i preparat farmaceutyczny do leczenia stanu zapalnego śluzówki jelita |
DE19635498A1 (de) * | 1996-09-03 | 1998-03-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Epimerenanreicherung |
IT1291288B1 (it) | 1997-04-30 | 1999-01-07 | Farmabios Srl | Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22. |
US6266556B1 (en) | 1998-04-27 | 2001-07-24 | Beth Israel Deaconess Medical Center, Inc. | Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation |
IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
EP1663999A2 (fr) * | 2003-08-29 | 2006-06-07 | Ranbaxy Laboratories, Ltd. | Inhibiteurs de la phosphodiesterase de type iv |
EP1694655A2 (fr) * | 2003-11-26 | 2006-08-30 | Ranbaxy Laboratories Limited | Inhibiteurs de la phosphodiesterase |
CA2561315A1 (fr) | 2004-04-09 | 2005-10-27 | Merck & Co., Inc. | Inhibiteurs de l'activite d'akt |
WO2006123182A2 (fr) | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Sulfones de cyclohexyle pour le traitement du cancer |
EP1934219A1 (fr) | 2005-09-16 | 2008-06-25 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridines substituees en tant qu'inhibiteurs de la phosphodiesterase |
US20090221664A1 (en) | 2005-10-19 | 2009-09-03 | Abhijit Ray | Pharmaceutical compositions of muscarinic receptor antagonists |
EP1948167A1 (fr) * | 2005-10-19 | 2008-07-30 | Ranbaxy Laboratories, Ltd. | Compositions d'inhibiteurs de la phosphodiesterase de type iv |
US20110021473A1 (en) * | 2006-09-22 | 2011-01-27 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-iv |
WO2008035316A2 (fr) * | 2006-09-22 | 2008-03-27 | Ranbaxy Laboratories Limited | Inhibiteurs de phosphodiestérase |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
JP2010514777A (ja) | 2006-12-26 | 2010-05-06 | ファーマサイクリックス,インク. | 併用療法においてヒストンデアセチラーゼ阻害剤を使用し、バイオマーカーをモニタする方法 |
AU2008204380B2 (en) | 2007-01-10 | 2013-08-15 | Msd Italia S.R.L. | Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors |
EP1958947A1 (fr) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibiteurs de la phosphodiestérase de type 4 |
EP2124944B1 (fr) | 2007-03-14 | 2012-02-15 | Ranbaxy Laboratories Limited | Dérivés de pyrazolo[3,4-b]pyridine comme inhibiteurs de phosphodiestérase |
EP2124943A1 (fr) * | 2007-03-14 | 2009-12-02 | Ranbaxy Laboratories Limited | Dérivés de pyrazolo[3,4-b]pyridine comme inhibiteurs de phosphodiestérases |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
ITMI20080645A1 (it) | 2008-04-11 | 2009-10-12 | Ind Chimica Srl | Procedimento per la preparazione di budesonide |
EP2111861A1 (fr) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions d'inhibiteurs de type IV de la phosphodiestérase |
GB0900484D0 (en) | 2009-01-13 | 2009-02-11 | Angeletti P Ist Richerche Bio | Therapeutic agent |
EP2413932A4 (fr) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | Inhibiteurs de l'activité akt |
US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
EP2475676B1 (fr) * | 2009-09-11 | 2020-05-27 | Chiesi Farmaceutici S.p.A. | Dérivés des prégnanes condensés en position 16,17 par un cycle isoxazolidine N-substitué pour le traitement de l'inflammation |
GB0916608D0 (en) | 2009-09-22 | 2009-11-04 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
BR112012008849A2 (pt) | 2009-10-14 | 2015-09-22 | Schering Corp | composto, composição farmacêutica, e, uso de um composto |
EP2534145A4 (fr) | 2010-02-08 | 2013-09-11 | Kinagen Inc | Methodes therapeutiques et compositions impliquant l'inhibition de la kinase allosterique |
EP2584903B1 (fr) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk |
JP6043285B2 (ja) | 2010-08-02 | 2016-12-14 | サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
HUE044815T2 (hu) | 2010-08-17 | 2019-11-28 | Sirna Therapeutics Inc | Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával |
EP2608669B1 (fr) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | Nouveaux dérivés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de mtor |
EP2613782B1 (fr) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk |
WO2012036997A1 (fr) | 2010-09-16 | 2012-03-22 | Schering Corporation | Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
WO2012087772A1 (fr) | 2010-12-21 | 2012-06-28 | Schering Corporation | Dérivés d'indazole utiles en tant qu'inhibiteurs de erk |
US20140045847A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
US9492423B2 (en) | 2011-09-13 | 2016-11-15 | Pharmacyclics Llc | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
WO2013063214A1 (fr) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Nouveaux composés qui sont des inhibiteurs d'erk |
EP3919620A1 (fr) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Compositions d'acide nucléique interférent court (sina) |
JP6453218B2 (ja) | 2012-08-24 | 2019-01-16 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 疾患を治療するためのhif活性の複素環式修飾物質 |
US9155747B2 (en) * | 2012-09-13 | 2015-10-13 | Chiesi Farmaceutici S.P.A. | Isoxazolidine derivatives |
US9233979B2 (en) | 2012-09-28 | 2016-01-12 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
BR112015012295A8 (pt) | 2012-11-28 | 2023-03-14 | Merck Sharp & Dohme | Uso de um inibidor de wee1, e, kit para identificar um paciente com câncer |
BR112015013611A2 (pt) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | composto, e, composição farmacêutica |
EP2951180B1 (fr) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2 |
EP3041938A1 (fr) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Polynucléotides circulaires |
EP3475275B1 (fr) | 2016-06-23 | 2024-04-10 | Merck Sharp & Dohme LLC | 5-trifluorométhyl-oxadiazoles substitués en 3-aryle et hétéroaryle en tant qu'inhibiteurs de l'histone désacétylase 6 (hdac6) |
AU2017359043B2 (en) | 2016-11-08 | 2022-06-16 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
WO2018213077A1 (fr) | 2017-05-18 | 2018-11-22 | Regeneron Pharmaceuticals, Inc. | Conjugués médicamenteux protéiques à base de cyclodextrine |
WO2019217591A1 (fr) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-msr1 et leurs procédés d'utilisation |
EP3833667B1 (fr) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Inhibiteurs de prmt5 |
WO2020033282A1 (fr) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Inhibiteurs de prmt5 |
US20230108452A1 (en) | 2019-12-17 | 2023-04-06 | Merck Sharp & Dohme Llc | Prmt5 inhibitors |
WO2024049931A1 (fr) | 2022-09-02 | 2024-03-07 | Merck Sharp & Dohme Llc | Compositions pharmaceutiques à base d'inhibiteurs de la topoisomérase-1 dérivés de l'exatécan, et leurs utilisations |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3133940A (en) * | 1956-04-10 | 1964-05-19 | Glaxo Group Ltd | Process for the separation of delta-1, 4-3-keto steroid compounds from mixtures thereof with other 3-keto steroids |
US3197469A (en) * | 1958-08-06 | 1965-07-27 | Pharmaceutical Res Products In | 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor |
US3048581A (en) * | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
US3128238A (en) * | 1962-09-14 | 1964-04-07 | Lilly Co Eli | delta1-dehydrogenation of steroids by fermentation with actinoplanaceae |
-
1972
- 1972-05-19 SE SE7206645A patent/SE378110B/xx unknown
-
1973
- 1973-05-01 ZA ZA732956A patent/ZA732956B/xx unknown
- 1973-05-01 IL IL42154A patent/IL42154A/en unknown
- 1973-05-09 GB GB2219573A patent/GB1428416A/en not_active Expired
- 1973-05-09 CY CY1012A patent/CY1012A/xx unknown
- 1973-05-09 DE DE2323216A patent/DE2323216C3/de not_active Expired
- 1973-05-14 FI FI731543A patent/FI50711C/fi active
- 1973-05-14 US US359913A patent/US3928326A/en not_active Expired - Lifetime
- 1973-05-17 DK DK277073A patent/DK133249C/da not_active IP Right Cessation
- 1973-05-18 NL NLAANVRAGE7306979,A patent/NL175917C/xx not_active IP Right Cessation
- 1973-05-18 FR FR7318126A patent/FR2185406B1/fr not_active Expired
- 1973-05-18 BE BE131271A patent/BE799728A/fr not_active IP Right Cessation
- 1973-05-18 SU SU1918554A patent/SU468408A3/ru active
- 1973-05-18 CA CA171,781A patent/CA1003402A/en not_active Expired
- 1973-05-19 JP JP5623473A patent/JPS547794B2/ja not_active Expired
-
1979
- 1979-06-20 KE KE2969A patent/KE2969A/xx unknown
- 1979-07-19 HK HK490/79A patent/HK49079A/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4404200A (en) * | 1980-12-04 | 1983-09-13 | Aktiebolaget Draco | 4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions |
Also Published As
Publication number | Publication date |
---|---|
DE2323216B2 (de) | 1977-11-03 |
BE799728A (fr) | 1973-09-17 |
NL7306979A (fr) | 1973-11-21 |
FI50711B (fr) | 1976-03-01 |
IL42154A (en) | 1976-12-31 |
DK133249B (da) | 1976-04-12 |
GB1428416A (en) | 1976-03-17 |
JPS547794B2 (fr) | 1979-04-10 |
HK49079A (en) | 1979-07-27 |
CA1003402A (en) | 1977-01-11 |
CY1012A (en) | 1979-11-23 |
DE2323216A1 (de) | 1973-11-29 |
FR2185406B1 (fr) | 1976-12-31 |
NL175917C (nl) | 1985-01-16 |
AU5525273A (en) | 1974-11-07 |
FI50711C (fi) | 1976-06-10 |
IL42154A0 (en) | 1973-07-30 |
JPS4941379A (fr) | 1974-04-18 |
US3928326A (en) | 1975-12-23 |
KE2969A (en) | 1979-07-20 |
NL175917B (nl) | 1984-08-16 |
DE2323216C3 (de) | 1978-06-22 |
ZA732956B (en) | 1974-04-24 |
SU468408A3 (ru) | 1975-04-25 |
DK133249C (da) | 1976-09-13 |
FR2185406A1 (fr) | 1974-01-04 |