SE302132B - Förfarande för framställning av derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan - Google Patents

Förfarande för framställning av derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan

Info

Publication number: SE302132B
Authority: SE; Sweden
Prior art keywords: indolyl; alpha; derivatives; preparation; inflammatory effect
Prior art date: 1963-02-01

Application number

SE88867A

Other languages

English (en)

Inventor

G Gal

M Sletzinger

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1963-02-01

Filing date

1967-01-20

Publication date

1968-07-08

1967-01-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1968-07-08 Publication of SE302132B publication Critical patent/SE302132B/sv

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE88867A 1963-02-01 1967-01-20 Förfarande för framställning av derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan SE302132B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25564263A	1963-02-01	1963-02-01

Publications (1)

Publication Number	Publication Date
SE302132B true SE302132B (sv)	1968-07-08

Family

ID=22969254

Family Applications (12)

Application Number	Title	Priority Date	Filing Date
SE89267A SE302463B (sv)	1963-02-01	1964-01-31
SE123764A SE307948B (sv)	1963-02-01	1964-01-31
SE88967A SE317975B (sv)	1963-02-01	1964-01-31
SE89367A SE302133B (sv)	1963-02-01	1967-01-20	Förfarande för framställning av derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan
SE88667A SE302130B (sv)	1963-02-01	1967-01-20	Sätt att framställning derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan
SE88867A SE302132B (sv)	1963-02-01	1967-01-20	Förfarande för framställning av derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan
SE891/67A SE304995B (sv)	1963-02-01	1967-01-20
SE894/67A SE320367B (sv)	1963-02-01	1967-01-20
SE890/67A SE307133B (sv)	1963-02-01	1967-01-20
SE895/67A SE320069B (sv)	1963-02-01	1967-01-20
SE896/67A SE320666B (sv)	1963-02-01	1967-01-20
SE88767A SE302131B (sv)	1963-02-01	1967-01-31

Family Applications Before (5)

Application Number	Title	Priority Date	Filing Date
SE89267A SE302463B (sv)	1963-02-01	1964-01-31
SE123764A SE307948B (sv)	1963-02-01	1964-01-31
SE88967A SE317975B (sv)	1963-02-01	1964-01-31
SE89367A SE302133B (sv)	1963-02-01	1967-01-20	Förfarande för framställning av derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan
SE88667A SE302130B (sv)	1963-02-01	1967-01-20	Sätt att framställning derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan

Family Applications After (6)

Application Number	Title	Priority Date
SE891/67A SE304995B (sv)	1963-02-01	1967-01-20
SE894/67A SE320367B (sv)	1963-02-01	1967-01-20
SE890/67A SE307133B (sv)	1963-02-01	1967-01-20
SE895/67A SE320069B (sv)	1963-02-01	1967-01-20
SE896/67A SE320666B (sv)	1963-02-01	1967-01-20
SE88767A SE302131B (sv)	1963-02-01	1967-01-31

Country Status (11)

Country	Link
AT (1)	AT277992B (sv)
BE (1)	BE643268A (sv)
BR (1)	BR6456479D0 (sv)
CH (16)	CH457435A (sv)
DE (16)	DE1695492A1 (sv)
DK (11)	DK112238B (sv)
FI (9)	FI46955C (sv)
FR (1)	FR1559559A (sv)
GB (13)	GB1050738A (sv)
NL (1)	NL6400813A (sv)
SE (12)	SE302463B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU163233B (sv) *	1970-07-31	1973-07-28
WO1989012436A1 (fr) *	1988-06-21	1989-12-28	Vita Zahnfabrik H. Rauter Gmbh & Co. Kg	Masse ceramique dispersee
GB9518994D0 (en) *	1995-09-16	1995-11-15	Agrevo Uk Ltd	Fungicides

0
- GB GB1050740D patent/GB1050740A/en active Active
- GB GB1050729D patent/GB1050729A/en active Active
- GB GB1050728D patent/GB1050728A/en active Active
- GB GB1050730D patent/GB1050730A/en active Active
- GB GB1050732D patent/GB1050732A/en active Active
- GB GB1050733D patent/GB1050733A/en active Active
- GB GB1050736D patent/GB1050736A/en active Active
- GB GB1050739D patent/GB1050739A/en active Active
- GB GB1050731D patent/GB1050731A/en active Active
- GB GB1050737D patent/GB1050737A/en active Active
- GB GB1050735D patent/GB1050735A/en active Active
- GB GB1050734D patent/GB1050734A/en active Active
- GB GB1050738D patent/GB1050738A/en active Active
1964
- 1964-01-14 DE DE19641695492 patent/DE1695492A1/de active Pending
- 1964-01-24 DE DE19641770802 patent/DE1770802A1/de active Pending
- 1964-01-24 DE DE19641793561 patent/DE1793561A1/de active Pending
- 1964-01-24 DE DE19641695489 patent/DE1695489A1/de active Pending
- 1964-01-24 DE DE19641770116 patent/DE1770116A1/de active Pending
- 1964-01-24 DE DE19641695490 patent/DE1695490A1/de active Pending
- 1964-01-24 DE DE19641695485 patent/DE1695485A1/de active Pending
- 1964-01-24 DE DE19641470059D patent/DE1470059B1/de active Pending
- 1964-01-24 DE DE19641695491 patent/DE1695491A1/de active Pending
- 1964-01-24 DE DE19641695487 patent/DE1695487A1/de active Pending
- 1964-01-24 DE DE19641695488 patent/DE1695488A1/de active Pending
- 1964-01-24 DE DE19641695493 patent/DE1695493A1/de active Pending
- 1964-01-24 DE DE19641770134 patent/DE1770134A1/de active Pending
- 1964-01-24 DE DE19641695484 patent/DE1695484A1/de active Pending
- 1964-01-24 DE DE19641695486 patent/DE1695486A1/de active Pending
- 1964-01-24 DE DE19641770132 patent/DE1770132A1/de active Pending
- 1964-01-28 BR BR15647964A patent/BR6456479D0/pt unknown
- 1964-01-28 AT AT01821/67A patent/AT277992B/de not_active IP Right Cessation
- 1964-01-29 FI FI16964A patent/FI46955C/sv active
- 1964-01-31 CH CH236068A patent/CH457435A/de unknown
- 1964-01-31 CH CH235868A patent/CH457434A/de unknown
- 1964-01-31 DK DK48964A patent/DK112238B/da unknown
- 1964-01-31 CH CH236168A patent/CH464202A/de unknown
- 1964-01-31 CH CH419468A patent/CH466284A/de unknown
- 1964-01-31 CH CH236368A patent/CH457436A/de unknown
- 1964-01-31 CH CH490268A patent/CH466286A/de unknown
- 1964-01-31 FR FR1559559D patent/FR1559559A/fr not_active Expired
- 1964-01-31 DK DK598265A patent/DK109562C/da active
- 1964-01-31 SE SE89267A patent/SE302463B/xx unknown
- 1964-01-31 DK DK598765A patent/DK109334C/da active
- 1964-01-31 DK DK598565A patent/DK109514C/da active
- 1964-01-31 SE SE123764A patent/SE307948B/xx unknown
- 1964-01-31 CH CH1674568A patent/CH466289A/de unknown
- 1964-01-31 NL NL6400813A patent/NL6400813A/xx unknown
- 1964-01-31 CH CH1674468A patent/CH466288A/de unknown
- 1964-01-31 CH CH236468A patent/CH466283A/de unknown
- 1964-01-31 SE SE88967A patent/SE317975B/xx unknown
- 1964-01-31 BE BE643268D patent/BE643268A/xx unknown
- 1964-01-31 CH CH236268A patent/CH557815A/de not_active IP Right Cessation
- 1964-01-31 CH CH1674768A patent/CH466290A/de unknown
- 1964-01-31 CH CH444166A patent/CH466285A/de unknown
- 1964-01-31 CH CH236668A patent/CH457437A/de unknown
- 1964-01-31 CH CH236568A patent/CH464203A/de unknown
- 1964-01-31 CH CH490368A patent/CH466287A/de unknown
1965
- 1965-11-22 DK DK598965A patent/DK112314B/da unknown
- 1965-11-22 DK DK598665A patent/DK112239B/da unknown
- 1965-11-22 DK DK598365A patent/DK113501B/da unknown
- 1965-11-22 DK DK598865A patent/DK112313B/da unknown
- 1965-11-22 DK DK598465A patent/DK111751B/da unknown
1966
- 1966-02-23 DK DK93366A patent/DK112447B/da unknown
- 1966-02-23 DK DK93266A patent/DK112446B/da unknown
1967
- 1967-01-20 SE SE89367A patent/SE302133B/sv unknown
- 1967-01-20 SE SE88667A patent/SE302130B/sv unknown
- 1967-01-20 SE SE88867A patent/SE302132B/sv unknown
- 1967-01-20 SE SE891/67A patent/SE304995B/xx unknown
- 1967-01-20 SE SE894/67A patent/SE320367B/xx unknown
- 1967-01-20 SE SE890/67A patent/SE307133B/xx unknown
- 1967-01-20 SE SE895/67A patent/SE320069B/xx unknown
- 1967-01-20 SE SE896/67A patent/SE320666B/xx unknown
- 1967-01-31 SE SE88767A patent/SE302131B/xx unknown
- 1967-02-23 CH CH115364A patent/CH489495A/de not_active IP Right Cessation
1970
- 1970-09-21 FI FI257470A patent/FI47100C/sv active
- 1970-09-21 FI FI257070A patent/FI47097B/fi active
- 1970-09-21 FI FI256870A patent/FI47096C/sv active
- 1970-09-21 FI FI257370A patent/FI47185C/sv active
- 1970-09-21 FI FI257570A patent/FI47101C/sv active
- 1970-09-21 FI FI257270A patent/FI47099C/sv active
- 1970-09-21 FI FI702570A patent/FI47097C/sv active
- 1970-09-21 FI FI257170A patent/FI47098C/sv active

Also Published As

Publication number	Publication date
DK109562C (da)	1968-05-13
DK112239B (da)	1968-11-25
DK112313B (da)	1968-12-02
FI47096C (sv)	1973-09-10
FI47097B (sv)	1973-05-31
SE302463B (sv)	1968-07-22
DE1770134A1 (de)	1971-09-30
CH466288A (de)	1968-12-15
AT277992B (de)	1970-01-12
DE1770802A1 (de)	1972-02-17
GB1050728A (sv)
CH464202A (de)	1968-10-31
GB1050732A (sv)
GB1050734A (sv)
SE317975B (sv)	1969-12-01
DE1695487A1 (de)	1970-10-01
DE1770132A1 (de)	1971-09-30
CH464203A (de)	1968-10-31
CH557815A (de)	1975-01-15
GB1050733A (sv)
CH466290A (de)	1968-12-15
SE320666B (sv)	1970-02-16
GB1050729A (sv)
FI47097C (sv)	1973-09-10
GB1050731A (sv)
SE320069B (sv)	1970-02-02
FI46955B (sv)	1973-05-02
FI47100C (sv)	1973-09-10
DE1695484A1 (de)	1971-04-15
DE1695493A1 (de)	1971-04-01
GB1050736A (sv)
SE307948B (sv)	1969-01-27
SE304995B (sv)	1968-10-14
CH466286A (de)	1968-12-15
FI47185B (sv)	1973-07-02
FI47096B (sv)	1973-05-31
FR1559559A (sv)	1969-03-14
DE1695492A1 (de)	1971-04-01
DK112446B (da)	1968-12-16
NL6400813A (sv)	1964-08-03
GB1050738A (sv)
SE320367B (sv)	1970-02-09
BE643268A (sv)	1964-07-31
CH466289A (de)	1968-12-15
FI47185C (sv)	1973-10-10
DE1695489A1 (de)	1970-08-13
GB1050730A (sv)
DE1470059B1 (de)	1970-01-29
SE307133B (sv)	1968-12-23
SE302133B (sv)	1968-07-08
FI47099B (sv)	1973-05-31
SE302131B (sv)	1968-07-08
SE302130B (sv)	1968-07-08
DK112314B (da)	1968-12-02
CH457434A (de)	1968-06-15
FI47101C (sv)	1973-09-10
DE1695488A1 (de)	1970-09-17
DE1770116A1 (de)	1971-10-14
DE1695485A1 (de)	1971-04-15
FI46955C (sv)	1973-08-10
DK109514C (da)	1968-05-06
CH457435A (de)	1968-06-15
DE1695491A1 (de)	1971-04-15
GB1050739A (sv)
CH489495A (de)	1970-04-30
DK112447B (da)	1968-12-16
GB1050740A (sv)
CH466285A (de)	1968-12-15
DE1695486A1 (de)	1971-04-15
CH466284A (de)	1968-12-15
CH457436A (de)	1968-06-15
DE1793561A1 (de)	1972-01-20
DK111751B (da)	1968-10-07
CH466287A (de)	1968-12-15
CH457437A (de)	1968-06-15
CH466283A (de)	1968-12-15
DK109334C (da)	1968-04-16
BR6456479D0 (pt)	1973-09-20
FI47101B (sv)	1973-05-31
FI47098B (sv)	1973-05-31
DK112238B (da)	1968-11-25
DE1695490A1 (de)	1971-04-15
FI47099C (sv)	1973-09-10
FI47098C (sv)	1973-09-10
DK113501B (da)	1969-03-31
FI47100B (sv)	1973-05-31
GB1050737A (sv)
GB1050735A (sv)

Publication	Publication Date	Title
FI45953C (sv)	1972-11-10	Förfarande för framställning av (3-bensoyl-fenyl)-ättiksyraderivat.
FI49414C (sv)	1975-06-10	Förfarande för framställning av nya, anti-inflammatoriska salter av su bstituerade 3-fenyl-2,3-epoxismörsyror.
FI44619C (sv)	1971-12-10	Förfarande för framställning av nya terapeutiskt aktiva substituerade fenylättiksyror.
SE403911B (sv)	1978-09-11	Forfarande for framstellning av aroylsubstituerade fenylettiksyraderivat med anti-inflammatorisk verkan
FI49290C (sv)	1975-05-12	Förfarande för framställning av nya terapeutiskt användbara bensenderi vat.
FI48082C (sv)	1974-06-10	Förfarande för framställning av blodtrycksnedsättande 2-arylhydrazinoi midazoliner-(2)
DK124612B (da)	1972-11-06	Analogifremgangsmåde til fremstilling af indolderivater.
FI50409C (sv)	1976-03-10	Förfarande för framställning av pyridin-karboxylsyror
FI50410C (sv)	1976-03-10	Förfarande för framställning av inflammationshämmande substituerade am inopyridiner
FI49971C (sv)	1975-11-10	Förfarande för framställning av mikrobicida-2-nitrofurfurylidenindanon derivat.
FI45041C (sv)	1972-03-10	Förfarande för framställning av terapeutiskt användbara pyrrol-derivat .
SE302133B (sv)	1968-07-08	Förfarande för framställning av derivat av alpha-(3-indolyl)-ättiksyror med inflammationshämmande verkan
CH476726A (de)	1969-08-15	Verfahren zur Herstellung von Indolderivaten
CH458384A (de)	1968-06-30	Verfahren zum Herstellen von Derivaten der Essigsäure
FI51587C (sv)	1977-02-10	Förfarande för framställning av sulfamyl-m-aminobensoesyror med terape utisk verkan.
SE380271B (sv)	1975-11-03	Forfarande for framstellning av nya derivat av tiazolin-pyrimidin-5-oner
FI46727C (sv)	1973-06-11	Förfarande för framställning av pyridazolderivat.
CH462813A (de)	1968-09-30	Verfahren zur Herstellung von Indolderivaten
FI45045C (sv)	1972-03-10	Förfarande för framställning av nya terapeutiskt verksamma 5-nitro-2-f uryl-isoxazolderivat.
SE327405B (no)	1970-08-24	Förfarande för framställning av nya iminodibensylderivat
SE380526B (sv)	1975-11-10	Forfarande for framstellning av derivat av tienobensopyran och tiopyranobensopyran
SE373363B (sv)	1975-02-03	Forfarande for framstellning av kromon-2-karbonsyror och derivat derav
FI49162C (sv)	1975-04-10	Förfarande för framställning av terapeutiskt användbara 3-indolyl-alif atisk-syra-derivat.
IT1056701B (it)	1982-02-20	Procedimento per prepare acidi oromon 2 carbossilici e loro derivati
FI48081C (sv)	1974-06-10	Förfarande för framställning av farmakologiskt aktiva 1-sulfanilyl-2-i mino-3-R-imidazolidiner