SE0203747D0 - New use - Google Patents

New use

Info

Publication number
SE0203747D0
SE0203747D0 SE0203747A SE0203747A SE0203747D0 SE 0203747 D0 SE0203747 D0 SE 0203747D0 SE 0203747 A SE0203747 A SE 0203747A SE 0203747 A SE0203747 A SE 0203747A SE 0203747 D0 SE0203747 D0 SE 0203747D0
Authority
SE
Sweden
Prior art keywords
new use
deoxypodophyllotoxin
picropodophyllin
glioblastoma
neuroblastoma
Prior art date
Application number
SE0203747A
Other languages
Swedish (sv)
Inventor
Magnus Axelsson
Olle Larsson
Original Assignee
Karolinska Innovations Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab filed Critical Karolinska Innovations Ab
Priority to SE0203747A priority Critical patent/SE0203747D0/en
Publication of SE0203747D0 publication Critical patent/SE0203747D0/en
Priority to PCT/SE2003/002012 priority patent/WO2004055022A1/en
Priority to AU2003288858A priority patent/AU2003288858A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention refers to the use of certain cyclolignans as specific inhibitors of the insulin-like growth factor-1 receptor for treatment of the malignant diseases neuroblastoma, myeloma, glioblastoma and lung cancer, as well as benign tumours. Preferred compounds are picropodophyllin and deoxypodophyllotoxin.
SE0203747A 2002-12-18 2002-12-18 New use SE0203747D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE0203747A SE0203747D0 (en) 2002-12-18 2002-12-18 New use
PCT/SE2003/002012 WO2004055022A1 (en) 2002-12-18 2003-12-18 Use of cyclolignans as inhibitors of igf-1 receptor for treatment of malignat diseases
AU2003288858A AU2003288858A1 (en) 2002-12-18 2003-12-18 Use of cyclolignans as inhibitors of igf-1 receptor for treatment of malignat diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0203747A SE0203747D0 (en) 2002-12-18 2002-12-18 New use

Publications (1)

Publication Number Publication Date
SE0203747D0 true SE0203747D0 (en) 2002-12-18

Family

ID=20289900

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0203747A SE0203747D0 (en) 2002-12-18 2002-12-18 New use

Country Status (3)

Country Link
AU (1) AU2003288858A1 (en)
SE (1) SE0203747D0 (en)
WO (1) WO2004055022A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080171318A1 (en) * 2004-09-30 2008-07-17 Epigenomics Ag Epigenetic Methods and Nucleic Acids for the Detection of Lung Cell Proliferative Disorders
WO2009100349A1 (en) 2008-02-09 2009-08-13 The Trustees Of Columbia University In The City Of New York Analogues of (-)-picropodophyllin, synthesis and uses thereof
WO2010146059A2 (en) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarkers for igf-1r inhibitor therapy
US20130331445A1 (en) * 2010-10-08 2013-12-12 Axelar Ab Picropodophyllin Monohydrate or Polymorph A in Cancer Therapy
CN103269700A (en) 2010-10-08 2013-08-28 阿克塞拉公司 Picropodophyllin polymorphs b or c for use in cancer therapy
WO2013132263A1 (en) * 2012-03-09 2013-09-12 Axelar Ab Picropodophyllin derivatives for use in therapy
KR102090554B1 (en) * 2018-04-13 2020-03-18 한국원자력의학원 Radiosensitizer containing β-Apopicropodophyllin as an active ingredient

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102168D0 (en) * 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds

Also Published As

Publication number Publication date
AU2003288858A1 (en) 2004-07-09
WO2004055022A1 (en) 2004-07-01

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