SA515361251B1 - طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتين - Google Patents
طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتينInfo
- Publication number
- SA515361251B1 SA515361251B1 SA515361251A SA515361251A SA515361251B1 SA 515361251 B1 SA515361251 B1 SA 515361251B1 SA 515361251 A SA515361251 A SA 515361251A SA 515361251 A SA515361251 A SA 515361251A SA 515361251 B1 SA515361251 B1 SA 515361251B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- glutamic acid
- pyro
- protein
- increasing
- acid formation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
يتعلق الاختراع الحالي بطريقة لتحويل جلوتامين عند الطرف- N N-terminal glutamine و/أو وحدة بنائية من حمض جلوتاميك glutamic acid residue من البروتين protein إلى حمض بيرو –جلوتاميك pyro-glutamic acid في عملية تنقية purification process
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13162241 | 2013-04-04 | ||
PCT/EP2014/056700 WO2014161940A1 (en) | 2013-04-04 | 2014-04-03 | A method for increasing pyro-glutamic acid formation of a protein |
Publications (1)
Publication Number | Publication Date |
---|---|
SA515361251B1 true SA515361251B1 (ar) | 2018-07-01 |
Family
ID=48044678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA515361251A SA515361251B1 (ar) | 2013-04-04 | 2015-10-01 | طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتين |
Country Status (18)
Country | Link |
---|---|
US (1) | US10400042B2 (ar) |
EP (1) | EP2981553A1 (ar) |
JP (1) | JP2016523812A (ar) |
KR (1) | KR20150138273A (ar) |
CN (1) | CN105121469A (ar) |
AR (1) | AR095977A1 (ar) |
AU (1) | AU2014247034B2 (ar) |
BR (1) | BR112015025106A2 (ar) |
CA (1) | CA2907766A1 (ar) |
EC (1) | ECSP15043422A (ar) |
HK (1) | HK1221472A1 (ar) |
MX (1) | MX2015014038A (ar) |
RU (1) | RU2015147187A (ar) |
SA (1) | SA515361251B1 (ar) |
SG (2) | SG11201507815XA (ar) |
TW (1) | TW201444863A (ar) |
UY (1) | UY35517A (ar) |
WO (1) | WO2014161940A1 (ar) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3300500T1 (sl) | 2015-05-20 | 2020-07-31 | Amgen Inc. | Triazolni agonisti receptorja APJ |
US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
EP3541810B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
EP3541804A1 (en) | 2016-11-16 | 2019-09-25 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
US11191762B2 (en) | 2016-11-16 | 2021-12-07 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the APJ Receptor |
EP3541805B1 (en) | 2016-11-16 | 2020-10-14 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
JOP20190100A1 (ar) * | 2016-11-19 | 2019-05-01 | Potenza Therapeutics Inc | بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها |
US11964998B2 (en) * | 2017-08-30 | 2024-04-23 | Fresenius Kabi Deutschland Gmbh | Method for purifying anti-IL-6 receptor antibodies |
EP3704122B1 (en) | 2017-11-03 | 2021-09-01 | Amgen Inc. | Fused triazole agonists of the apj receptor |
WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
EP3643322A1 (en) * | 2018-10-26 | 2020-04-29 | Mabion SA | Low aggregate anti cd20 ligand formulation |
CN112110983A (zh) * | 2019-06-21 | 2020-12-22 | 正大天晴药业集团股份有限公司 | 蛋白质的纯化方法 |
US11598116B1 (en) | 2020-10-01 | 2023-03-07 | Florida Aluminum Systems, Llc | Mounting system for separating and connecting fencing slabs |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
DE602004032379D1 (de) | 2003-12-19 | 2011-06-01 | Novo Nordisk As | Prozessierung von peptiden und proteinen |
US20060286629A1 (en) * | 2003-12-19 | 2006-12-21 | Norby Inga S N | Processing of Peptides and Proteins |
ATE443870T1 (de) | 2004-07-20 | 2009-10-15 | Symphogen As | Verfahren zur charakterisierung einer polyklonalen zellinie |
KR20070072510A (ko) | 2004-08-30 | 2007-07-04 | 론자 바이올로직스 피엘씨 | 항체 정제를 위한 친화도- 및 이온 교환- 크로마토그래피 |
WO2007064911A1 (en) | 2005-12-02 | 2007-06-07 | Biogen Idec Inc. | Anti-mouse cd20 antibodies and uses thereof |
SI2215117T2 (en) | 2007-10-30 | 2018-04-30 | Genentech, Inc. | Purification of the antibody by cation exchange chromatography |
US8815242B2 (en) | 2009-05-27 | 2014-08-26 | Synageva Biopharma Corp. | Avian derived antibodies |
CN102492040B (zh) * | 2011-12-29 | 2014-06-25 | 嘉和生物药业有限公司 | 一种抗her2或/和抗her3抗体蛋白的纯化方法 |
-
2014
- 2014-03-31 UY UY0001035517A patent/UY35517A/es not_active Application Discontinuation
- 2014-04-01 AR ARP140101455A patent/AR095977A1/es unknown
- 2014-04-02 TW TW103112224A patent/TW201444863A/zh unknown
- 2014-04-03 WO PCT/EP2014/056700 patent/WO2014161940A1/en active Application Filing
- 2014-04-03 AU AU2014247034A patent/AU2014247034B2/en not_active Expired - Fee Related
- 2014-04-03 RU RU2015147187A patent/RU2015147187A/ru not_active Application Discontinuation
- 2014-04-03 CN CN201480019372.7A patent/CN105121469A/zh active Pending
- 2014-04-03 MX MX2015014038A patent/MX2015014038A/es unknown
- 2014-04-03 US US14/780,964 patent/US10400042B2/en active Active
- 2014-04-03 SG SG11201507815XA patent/SG11201507815XA/en unknown
- 2014-04-03 CA CA2907766A patent/CA2907766A1/en not_active Abandoned
- 2014-04-03 EP EP14718533.4A patent/EP2981553A1/en not_active Ceased
- 2014-04-03 JP JP2016505823A patent/JP2016523812A/ja active Pending
- 2014-04-03 KR KR1020157030512A patent/KR20150138273A/ko not_active Application Discontinuation
- 2014-04-03 SG SG10201708088WA patent/SG10201708088WA/en unknown
- 2014-04-03 BR BR112015025106A patent/BR112015025106A2/pt not_active IP Right Cessation
-
2015
- 2015-10-01 SA SA515361251A patent/SA515361251B1/ar unknown
- 2015-10-14 EC ECIEPI201543422A patent/ECSP15043422A/es unknown
-
2016
- 2016-08-09 HK HK16109481.9A patent/HK1221472A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BR112015025106A2 (pt) | 2017-10-10 |
MX2015014038A (es) | 2016-06-02 |
AU2014247034B2 (en) | 2018-08-23 |
CN105121469A (zh) | 2015-12-02 |
ECSP15043422A (es) | 2017-03-31 |
KR20150138273A (ko) | 2015-12-09 |
AU2014247034A1 (en) | 2015-10-01 |
US10400042B2 (en) | 2019-09-03 |
SG10201708088WA (en) | 2017-10-30 |
JP2016523812A (ja) | 2016-08-12 |
TW201444863A (zh) | 2014-12-01 |
RU2015147187A (ru) | 2017-05-23 |
RU2015147187A3 (ar) | 2018-02-28 |
SG11201507815XA (en) | 2015-10-29 |
AR095977A1 (es) | 2015-11-25 |
EP2981553A1 (en) | 2016-02-10 |
US20160060349A1 (en) | 2016-03-03 |
UY35517A (es) | 2014-10-31 |
CA2907766A1 (en) | 2014-10-09 |
WO2014161940A1 (en) | 2014-10-09 |
HK1221472A1 (zh) | 2017-06-02 |
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