SA515361251B1 - طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتين - Google Patents

طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتين

Info

Publication number
SA515361251B1
SA515361251B1 SA515361251A SA515361251A SA515361251B1 SA 515361251 B1 SA515361251 B1 SA 515361251B1 SA 515361251 A SA515361251 A SA 515361251A SA 515361251 A SA515361251 A SA 515361251A SA 515361251 B1 SA515361251 B1 SA 515361251B1
Authority
SA
Saudi Arabia
Prior art keywords
glutamic acid
pyro
protein
increasing
acid formation
Prior art date
Application number
SA515361251A
Other languages
English (en)
Inventor
برابرا ثورين،
شرافينديجك، ماري روز فان
ستيفن واجه،
Original Assignee
مابكسينس اس. ايه
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by مابكسينس اس. ايه filed Critical مابكسينس اس. ايه
Publication of SA515361251B1 publication Critical patent/SA515361251B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

يتعلق الاختراع الحالي بطريقة لتحويل جلوتامين عند الطرف- ‏N‏ ‏N-terminal glutamine‏ ‏و/أو وحدة بنائية من حمض جلوتاميك ‏glutamic acid residue‏ من البروتين ‏protein‏ إلى ‏حمض بيرو –جلوتاميك ‏pyro-glutamic acid‏ في عملية تنقية ‏purification process
SA515361251A 2013-04-04 2015-10-01 طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتين SA515361251B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13162241 2013-04-04
PCT/EP2014/056700 WO2014161940A1 (en) 2013-04-04 2014-04-03 A method for increasing pyro-glutamic acid formation of a protein

Publications (1)

Publication Number Publication Date
SA515361251B1 true SA515361251B1 (ar) 2018-07-01

Family

ID=48044678

Family Applications (1)

Application Number Title Priority Date Filing Date
SA515361251A SA515361251B1 (ar) 2013-04-04 2015-10-01 طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتين

Country Status (18)

Country Link
US (1) US10400042B2 (ar)
EP (1) EP2981553A1 (ar)
JP (1) JP2016523812A (ar)
KR (1) KR20150138273A (ar)
CN (1) CN105121469A (ar)
AR (1) AR095977A1 (ar)
AU (1) AU2014247034B2 (ar)
BR (1) BR112015025106A2 (ar)
CA (1) CA2907766A1 (ar)
EC (1) ECSP15043422A (ar)
HK (1) HK1221472A1 (ar)
MX (1) MX2015014038A (ar)
RU (1) RU2015147187A (ar)
SA (1) SA515361251B1 (ar)
SG (2) SG11201507815XA (ar)
TW (1) TW201444863A (ar)
UY (1) UY35517A (ar)
WO (1) WO2014161940A1 (ar)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3300500T1 (sl) 2015-05-20 2020-07-31 Amgen Inc. Triazolni agonisti receptorja APJ
US9988369B2 (en) 2016-05-03 2018-06-05 Amgen Inc. Heterocyclic triazole compounds as agonists of the APJ receptor
EP3541810B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole phenyl compounds as agonists of the apj receptor
EP3541792B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
EP3541804A1 (en) 2016-11-16 2019-09-25 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the apj receptor
US11191762B2 (en) 2016-11-16 2021-12-07 Amgen Inc. Alkyl substituted triazole compounds as agonists of the APJ Receptor
EP3541805B1 (en) 2016-11-16 2020-10-14 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
JOP20190100A1 (ar) * 2016-11-19 2019-05-01 Potenza Therapeutics Inc بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها
US11964998B2 (en) * 2017-08-30 2024-04-23 Fresenius Kabi Deutschland Gmbh Method for purifying anti-IL-6 receptor antibodies
EP3704122B1 (en) 2017-11-03 2021-09-01 Amgen Inc. Fused triazole agonists of the apj receptor
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor
EP3643322A1 (en) * 2018-10-26 2020-04-29 Mabion SA Low aggregate anti cd20 ligand formulation
CN112110983A (zh) * 2019-06-21 2020-12-22 正大天晴药业集团股份有限公司 蛋白质的纯化方法
US11598116B1 (en) 2020-10-01 2023-03-07 Florida Aluminum Systems, Llc Mounting system for separating and connecting fencing slabs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
DE602004032379D1 (de) 2003-12-19 2011-06-01 Novo Nordisk As Prozessierung von peptiden und proteinen
US20060286629A1 (en) * 2003-12-19 2006-12-21 Norby Inga S N Processing of Peptides and Proteins
ATE443870T1 (de) 2004-07-20 2009-10-15 Symphogen As Verfahren zur charakterisierung einer polyklonalen zellinie
KR20070072510A (ko) 2004-08-30 2007-07-04 론자 바이올로직스 피엘씨 항체 정제를 위한 친화도- 및 이온 교환- 크로마토그래피
WO2007064911A1 (en) 2005-12-02 2007-06-07 Biogen Idec Inc. Anti-mouse cd20 antibodies and uses thereof
SI2215117T2 (en) 2007-10-30 2018-04-30 Genentech, Inc. Purification of the antibody by cation exchange chromatography
US8815242B2 (en) 2009-05-27 2014-08-26 Synageva Biopharma Corp. Avian derived antibodies
CN102492040B (zh) * 2011-12-29 2014-06-25 嘉和生物药业有限公司 一种抗her2或/和抗her3抗体蛋白的纯化方法

Also Published As

Publication number Publication date
BR112015025106A2 (pt) 2017-10-10
MX2015014038A (es) 2016-06-02
AU2014247034B2 (en) 2018-08-23
CN105121469A (zh) 2015-12-02
ECSP15043422A (es) 2017-03-31
KR20150138273A (ko) 2015-12-09
AU2014247034A1 (en) 2015-10-01
US10400042B2 (en) 2019-09-03
SG10201708088WA (en) 2017-10-30
JP2016523812A (ja) 2016-08-12
TW201444863A (zh) 2014-12-01
RU2015147187A (ru) 2017-05-23
RU2015147187A3 (ar) 2018-02-28
SG11201507815XA (en) 2015-10-29
AR095977A1 (es) 2015-11-25
EP2981553A1 (en) 2016-02-10
US20160060349A1 (en) 2016-03-03
UY35517A (es) 2014-10-31
CA2907766A1 (en) 2014-10-09
WO2014161940A1 (en) 2014-10-09
HK1221472A1 (zh) 2017-06-02

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