RU95108245A - Method of preparing and/or purification of clavulanic acid or its esters from clavulanic acid salt and tert-octylamine
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Method of preparing and/or purification of clavulanic acid or its esters from clavulanic acid salt and tert-octylamine
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RU95108245A
RU95108245ARU95108245/04ARU95108245ARU95108245ARU 95108245 ARU95108245 ARU 95108245ARU 95108245/04 ARU95108245/04 ARU 95108245/04ARU 95108245 ARU95108245 ARU 95108245ARU 95108245 ARU95108245 ARU 95108245A
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Priority claimed from GB929222841Aexternal-prioritypatent/GB9222841D0/en
Priority claimed from GB929226061Aexternal-prioritypatent/GB9226061D0/en
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
FIELD: organic chemistry, chemical technology. SUBSTANCE: method involves: i) contact of unpurified clavulanic acid or its labile derivative in organic solvent with tert.-octylamine; ii) isolation of clavulanic acid salt formed with tert.-octylamine; iii) conversion of the obtained salt to clavulanic acid or its pharmaceutically acceptable salt or ester. EFFECT: improved method of preparing and purification.
Claims (1)
Предложен способ получения и/или очистки клавулановой кислоты или ее фармацевтически приемлемых солей или эфиров, который включает: контактирование неочищенной клавулановой кислоты или ее лабильного производного в органическом растворителе с трет-октиламином; выделение соли клавулановой кислоты, образованной с трет-октиламином; превращение образованной таким образом соли в клавулановую кислоту или ее фармацевтически приемлемые соль или эфир.A method for the preparation and / or purification of clavulanic acid or its pharmaceutically acceptable salts or esters, which includes: contacting the crude clavulanic acid or its labile derivative in an organic solvent with tert-octylamine; isolation of a clavulanic acid salt formed with tert-octylamine; the conversion of the salt thus formed into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.
RU9595108245A1992-10-311993-06-07Method of preparing clavulanic acid or its pharmaceutically acceptable salts or esters
RU2088586C1
(en)
Derivatives of 1,3-substituted cycloalkane and cycloalkene, mixture of isomers or individual isomers, their hydrates and salts, method of their synthesis and pharmaceutical composition