RU94046297A - Новое бензодиазепиновое производное, способ его получения фармкомпозиция - Google Patents
Новое бензодиазепиновое производное, способ его получения фармкомпозицияInfo
- Publication number
- RU94046297A RU94046297A RU94046297/04A RU94046297A RU94046297A RU 94046297 A RU94046297 A RU 94046297A RU 94046297/04 A RU94046297/04 A RU 94046297/04A RU 94046297 A RU94046297 A RU 94046297A RU 94046297 A RU94046297 A RU 94046297A
- Authority
- RU
- Russia
- Prior art keywords
- cck
- benzodiazepine derivative
- receptor
- pharmcomposition
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Предлагается новое бензодиазепиновое производное, представляемое формулой, приведенной в формуле изобретения, или его фармацевтически приемлемые соли. Эти соединения являются полезными в качестве медицинских препаратов, в частности при лечении и предупреждении заболеваний, связанных с функционированием CCK-B-рецептора и гастринового рецептора, поскольку они обладают CCK-B-рецепторным антагонизмом, гастриновым рецепторным антагонизмом и оказывают ингибирующее действие на секрецию желудочного сока.
Claims (1)
- Предлагается новое бензодиазепиновое производное, представляемое формулой, приведенной в формуле изобретения, или его фармацевтически приемлемые соли. Эти соединения являются полезными в качестве медицинских препаратов, в частности при лечении и предупреждении заболеваний, связанных с функционированием CCK-B-рецептора и гастринового рецептора, поскольку они обладают CCK-B-рецепторным антагонизмом, гастриновым рецепторным антагонизмом и оказывают ингибирующее действие на секрецию желудочного сока.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPHEI-4-189826 | 1992-06-24 | ||
JP18982692 | 1992-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU94046297A true RU94046297A (ru) | 1996-11-27 |
Family
ID=16247861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94046297/04A RU94046297A (ru) | 1992-06-24 | 1993-06-22 | Новое бензодиазепиновое производное, способ его получения фармкомпозиция |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0647632A1 (ru) |
KR (1) | KR950702191A (ru) |
AU (1) | AU670597B2 (ru) |
CA (1) | CA2138129A1 (ru) |
FI (1) | FI945989A0 (ru) |
HU (1) | HUT68208A (ru) |
RU (1) | RU94046297A (ru) |
WO (1) | WO1994000438A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2282594A (en) * | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
GB2282595A (en) * | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6506782B1 (en) | 1998-02-27 | 2003-01-14 | Athena Neurosciences, Inc. | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6774125B2 (en) | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
FR2782997A1 (fr) * | 1998-09-08 | 2000-03-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la benzodiazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicaments et compositions pharmaceutiques les renfermant |
EP1142868A4 (en) * | 1998-12-22 | 2004-09-29 | Mitsubishi Chem Corp | amide derivatives |
ATE275403T1 (de) | 1999-12-02 | 2004-09-15 | Zeria Pharm Co Ltd | Kalziumsalze von 1,5-benzodiazepin-derivaten, verfahren zu deren herstellung und diese enthaltende medikamente |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8430455D0 (en) * | 1984-12-03 | 1985-01-09 | Fujisawa Pharmaceutical Co | Fr-900506 substance |
CA1332410C (en) * | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
EP0358508A3 (en) * | 1988-09-08 | 1991-03-20 | Merck & Co. Inc. | Novel immunosuppressant compound |
GB2225576B (en) * | 1988-11-29 | 1992-07-01 | Sandoz Ltd | Substituted azatricyclo derivatives and metabolites,their preparation and pharmaceutical compositions containing them |
CA2099672A1 (en) * | 1990-12-25 | 1992-06-26 | Masato Satoh | Benzodiazepine derivatives |
WO1993008175A1 (en) * | 1991-10-24 | 1993-04-29 | Glaxo Group Limited | Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin |
-
1993
- 1993-06-22 AU AU43570/93A patent/AU670597B2/en not_active Ceased
- 1993-06-22 CA CA002138129A patent/CA2138129A1/en not_active Abandoned
- 1993-06-22 RU RU94046297/04A patent/RU94046297A/ru unknown
- 1993-06-22 HU HU9403785A patent/HUT68208A/hu unknown
- 1993-06-22 EP EP93913562A patent/EP0647632A1/en not_active Ceased
- 1993-06-22 WO PCT/JP1993/000844 patent/WO1994000438A1/ja not_active Application Discontinuation
-
1994
- 1994-12-21 FI FI945989A patent/FI945989A0/fi unknown
- 1994-12-23 KR KR1019940704699A patent/KR950702191A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUT68208A (en) | 1995-06-28 |
AU670597B2 (en) | 1996-07-25 |
AU4357093A (en) | 1994-01-24 |
HU9403785D0 (en) | 1995-02-28 |
EP0647632A4 (ru) | 1995-04-19 |
FI945989A (fi) | 1994-12-21 |
WO1994000438A1 (en) | 1994-01-06 |
CA2138129A1 (en) | 1994-01-06 |
EP0647632A1 (en) | 1995-04-12 |
FI945989A0 (fi) | 1994-12-21 |
KR950702191A (ko) | 1995-06-19 |
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