RU94046284A - Способ обнаружения антител, способ с-крекинга компонентов крови, набор для обнаружения антител к hcv - Google Patents
Способ обнаружения антител, способ с-крекинга компонентов крови, набор для обнаружения антител к hcvInfo
- Publication number
- RU94046284A RU94046284A RU94046284/14A RU94046284A RU94046284A RU 94046284 A RU94046284 A RU 94046284A RU 94046284/14 A RU94046284/14 A RU 94046284/14A RU 94046284 A RU94046284 A RU 94046284A RU 94046284 A RU94046284 A RU 94046284A
- Authority
- RU
- Russia
- Prior art keywords
- antibodies
- hcv
- detecting
- antigens
- cracking
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Abstract
Предлагаются методы иммуноанализа с использованием оболочечных антигенов HCV, которые содержат конформационные эпитопы, реактивные по отношению к антителам в сыворотке от инфицированных индивидов. Эти методы полезны для скрининга и диагностики. Эти антигены обнаруживают антитела, которые не обнаруживаются денатурированными оболочечными антигенами HCV. Кроме того, эти оболочечные антигены HCV, состоящие из конформационных эпитопов, гораздо более иммунологически реактивны, чем ряд других антигенов HCV, что свидетельствует о том, что конформационные эпитопы могут участвовать в иммунологической реакции на антигены HCV.
Claims (1)
- Предлагаются методы иммуноанализа с использованием оболочечных антигенов HCV, которые содержат конформационные эпитопы, реактивные по отношению к антителам в сыворотке от инфицированных индивидов. Эти методы полезны для скрининга и диагностики. Эти антигены обнаруживают антитела, которые не обнаруживаются денатурированными оболочечными антигенами HCV. Кроме того, эти оболочечные антигены HCV, состоящие из конформационных эпитопов, гораздо более иммунологически реактивны, чем ряд других антигенов HCV, что свидетельствует о том, что конформационные эпитопы могут участвовать в иммунологической реакции на антигены HCV.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91075992A | 1992-07-07 | 1992-07-07 | |
US910759 | 1992-07-07 | ||
US910.759 | 1992-07-07 | ||
PCT/US1993/006309 WO1994001778A1 (en) | 1992-07-07 | 1993-07-02 | Immunoassays for anti-hcv antibodies using antigens with conformational epitopes |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94046284A true RU94046284A (ru) | 1997-02-27 |
RU2126158C1 RU2126158C1 (ru) | 1999-02-10 |
Family
ID=25429280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94046284A RU2126158C1 (ru) | 1992-07-07 | 1993-07-02 | Способ обнаружения антител, способ скрининга компонентов крови, набор для обнаружения антител к hcv |
Country Status (19)
Country | Link |
---|---|
US (1) | US20020150883A1 (ru) |
EP (1) | EP0649537B2 (ru) |
JP (2) | JP3490085B2 (ru) |
AT (1) | ATE216779T1 (ru) |
AU (1) | AU685059B2 (ru) |
CA (1) | CA2139645C (ru) |
CZ (1) | CZ291951B6 (ru) |
DE (1) | DE69331845T3 (ru) |
DK (1) | DK0649537T4 (ru) |
ES (1) | ES2171414T5 (ru) |
FI (1) | FI110546B (ru) |
HU (1) | HUT70473A (ru) |
NO (1) | NO321185B1 (ru) |
PL (1) | PL174686B1 (ru) |
PT (1) | PT649537E (ru) |
RU (1) | RU2126158C1 (ru) |
SK (1) | SK284556B6 (ru) |
UA (1) | UA39944C2 (ru) |
WO (1) | WO1994001778A1 (ru) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274148B1 (en) * | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
US7070790B1 (en) | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
US5882852A (en) * | 1993-06-29 | 1999-03-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates |
JPH09503396A (ja) | 1994-07-29 | 1997-04-08 | インノジェネティクス・エヌ・ブイ | 診断用及び治療用の精製c型肝炎ウイルスエンベロープ蛋白 |
DE4428705A1 (de) * | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus |
US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
CA2223277A1 (en) * | 1995-06-07 | 1996-12-19 | Abbott Laboratories | Method for detection of antibody to hepatitis c virus second envelope glycoprotein |
US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
WO2000026673A1 (en) * | 1998-11-03 | 2000-05-11 | Abbott Laboratories | Methods of detecting chronic infection caused by hcv |
US6815160B1 (en) | 1999-07-28 | 2004-11-09 | Chiron Corporation | Hepatitis C viral antigen immunoassay detection systems |
CA2380777C (en) * | 1999-07-28 | 2011-01-04 | Chiron Corporation | Hepatitis c viral antigen immunoassay detection systems |
EP1829891B1 (en) | 2000-06-15 | 2012-12-26 | Novartis Vaccines and Diagnostics, Inc. | Immunoassays for Anti-HCV Antibodies |
US6630298B2 (en) | 2000-06-15 | 2003-10-07 | Chiron Corporation | HCV antigen/antibody combination assay |
AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
ES2312806T3 (es) | 2002-09-09 | 2009-03-01 | Novartis Vaccines And Diagnostics, Inc. | Ensayo de vhc. |
WO2004071414A2 (en) * | 2003-02-05 | 2004-08-26 | Genzyme Corporation | Therapeutic anti-hcv (al9) compounds |
US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
EP1802778B1 (en) | 2004-08-27 | 2011-10-05 | Novartis Vaccines and Diagnostics, Inc. | Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof |
CA2661492A1 (en) | 2006-08-25 | 2008-02-28 | Novartis Ag | Hcv fusion polypeptides |
US8815253B2 (en) | 2007-12-07 | 2014-08-26 | Novartis Ag | Compositions for inducing immune responses |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
CN105228649B (zh) | 2013-03-14 | 2019-01-18 | 雅培制药有限公司 | Hcv抗原-抗体组合测定和方法以及用在其中的组合物 |
EP2970947A4 (en) | 2013-03-14 | 2016-10-12 | Abbott Lab | RECOMBINANT HCV NS3 ANTIGENS AND THEIR MUTANTS FOR ENHANCED ANTIBODY DETECTION |
EP3564384A1 (en) | 2013-03-14 | 2019-11-06 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
ES2832335T3 (es) | 2015-03-27 | 2021-06-10 | Ortho Clinical Diagnostics Inc | Polipéptidos NS4A/NS3 modificado del VHC y usos de los mismos |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855224A (en) * | 1984-03-09 | 1989-08-08 | Genentech, Inc. | Molecularly cloned diagnostic product and method of use |
DE3886363T3 (de) | 1987-11-18 | 2004-09-09 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | NANBV-Diagnostika |
WO1990011089A1 (en) | 1989-03-17 | 1990-10-04 | Chiron Corporation | Nanbv diagnostics and vaccines |
US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
LU87861A1 (fr) * | 1989-12-18 | 1991-10-08 | Wellcome Found | Agent viral |
ZA912040B (en) * | 1990-03-30 | 1991-12-24 | Akzo Nv | Peptides immunochemically reactive with antibodies directed against hepatitis non-a,non-b virus |
KR100206150B1 (ko) * | 1990-04-04 | 1999-07-01 | 로버트 피. 블랙버언 | 항-에이치씨브이 항체에 대한 면역분석용 씨형 간염 바이러스(에이치디브이)항원의 조합체 |
ES2152922T3 (es) * | 1990-04-06 | 2001-02-16 | Genelabs Tech Inc | Epitopos del virus de la hepatitis c. |
AU652941B2 (en) * | 1990-06-25 | 1994-09-15 | Research Foundation For Microbial Diseases Of Osaka University, The | Non-A, Non-B hepatitis virus particles |
EP0468657A3 (en) * | 1990-07-09 | 1992-02-05 | Tonen Corporation | Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis |
CZ289006B6 (cs) * | 1990-11-08 | 2001-10-17 | Chiron Corporation | Asialoglykoprotein hepatitis C viru, farmaceutická kompozice s jeho obsahem a jeho pouľití |
IT1249684B (it) * | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
JP3439209B2 (ja) * | 1992-01-31 | 2003-08-25 | アボツト・ラボラトリーズ | Hcv蛋白のための哺乳動物発現システム |
US5587285A (en) * | 1992-01-31 | 1996-12-24 | University Of Texas System | Generation serological assay for monitoring HIV exposure |
-
1993
- 1993-02-07 UA UA95028108A patent/UA39944C2/uk unknown
- 1993-07-02 JP JP50344094A patent/JP3490085B2/ja not_active Expired - Lifetime
- 1993-07-02 CA CA002139645A patent/CA2139645C/en not_active Expired - Lifetime
- 1993-07-02 CZ CZ19956A patent/CZ291951B6/cs not_active IP Right Cessation
- 1993-07-02 RU RU94046284A patent/RU2126158C1/ru active
- 1993-07-02 PL PL93307178A patent/PL174686B1/pl unknown
- 1993-07-02 AU AU46629/93A patent/AU685059B2/en not_active Expired
- 1993-07-02 DK DK93916942T patent/DK0649537T4/da active
- 1993-07-02 PT PT93916942T patent/PT649537E/pt unknown
- 1993-07-02 SK SK4-95A patent/SK284556B6/sk not_active IP Right Cessation
- 1993-07-02 DE DE69331845T patent/DE69331845T3/de not_active Expired - Lifetime
- 1993-07-02 AT AT93916942T patent/ATE216779T1/de active
- 1993-07-02 EP EP93916942A patent/EP0649537B2/en not_active Expired - Lifetime
- 1993-07-02 ES ES93916942T patent/ES2171414T5/es not_active Expired - Lifetime
- 1993-07-02 WO PCT/US1993/006309 patent/WO1994001778A1/en active IP Right Grant
- 1993-07-02 HU HU9500008A patent/HUT70473A/hu not_active Application Discontinuation
-
1995
- 1995-01-02 FI FI950002A patent/FI110546B/fi not_active IP Right Cessation
- 1995-01-02 NO NO19950006A patent/NO321185B1/no not_active IP Right Cessation
-
2001
- 2001-08-02 US US09/920,879 patent/US20020150883A1/en not_active Abandoned
-
2003
- 2003-04-14 JP JP2003109573A patent/JP2003329687A/ja not_active Withdrawn
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Legal Events
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PD4A | Correction of name of patent owner |