RU94046284A - Способ обнаружения антител, способ с-крекинга компонентов крови, набор для обнаружения антител к hcv - Google Patents

Способ обнаружения антител, способ с-крекинга компонентов крови, набор для обнаружения антител к hcv

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Publication number
RU94046284A
RU94046284A RU94046284/14A RU94046284A RU94046284A RU 94046284 A RU94046284 A RU 94046284A RU 94046284/14 A RU94046284/14 A RU 94046284/14A RU 94046284 A RU94046284 A RU 94046284A RU 94046284 A RU94046284 A RU 94046284A
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RU
Russia
Prior art keywords
antibodies
hcv
detecting
antigens
cracking
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RU94046284/14A
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English (en)
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RU2126158C1 (ru
Inventor
Й.Чиен Дэвид
Us]
Original Assignee
Чирон Корпорейшн (Us)
Чирон Корпорейшн
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Application filed by Чирон Корпорейшн (Us), Чирон Корпорейшн filed Critical Чирон Корпорейшн (Us)
Publication of RU94046284A publication Critical patent/RU94046284A/ru
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)

Abstract

Предлагаются методы иммуноанализа с использованием оболочечных антигенов HCV, которые содержат конформационные эпитопы, реактивные по отношению к антителам в сыворотке от инфицированных индивидов. Эти методы полезны для скрининга и диагностики. Эти антигены обнаруживают антитела, которые не обнаруживаются денатурированными оболочечными антигенами HCV. Кроме того, эти оболочечные антигены HCV, состоящие из конформационных эпитопов, гораздо более иммунологически реактивны, чем ряд других антигенов HCV, что свидетельствует о том, что конформационные эпитопы могут участвовать в иммунологической реакции на антигены HCV.

Claims (1)

  1. Предлагаются методы иммуноанализа с использованием оболочечных антигенов HCV, которые содержат конформационные эпитопы, реактивные по отношению к антителам в сыворотке от инфицированных индивидов. Эти методы полезны для скрининга и диагностики. Эти антигены обнаруживают антитела, которые не обнаруживаются денатурированными оболочечными антигенами HCV. Кроме того, эти оболочечные антигены HCV, состоящие из конформационных эпитопов, гораздо более иммунологически реактивны, чем ряд других антигенов HCV, что свидетельствует о том, что конформационные эпитопы могут участвовать в иммунологической реакции на антигены HCV.
RU94046284A 1992-07-07 1993-07-02 Способ обнаружения антител, способ скрининга компонентов крови, набор для обнаружения антител к hcv RU2126158C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91075992A 1992-07-07 1992-07-07
US910759 1992-07-07
US910.759 1992-07-07
PCT/US1993/006309 WO1994001778A1 (en) 1992-07-07 1993-07-02 Immunoassays for anti-hcv antibodies using antigens with conformational epitopes

Publications (2)

Publication Number Publication Date
RU94046284A true RU94046284A (ru) 1997-02-27
RU2126158C1 RU2126158C1 (ru) 1999-02-10

Family

ID=25429280

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046284A RU2126158C1 (ru) 1992-07-07 1993-07-02 Способ обнаружения антител, способ скрининга компонентов крови, набор для обнаружения антител к hcv

Country Status (19)

Country Link
US (1) US20020150883A1 (ru)
EP (1) EP0649537B2 (ru)
JP (2) JP3490085B2 (ru)
AT (1) ATE216779T1 (ru)
AU (1) AU685059B2 (ru)
CA (1) CA2139645C (ru)
CZ (1) CZ291951B6 (ru)
DE (1) DE69331845T3 (ru)
DK (1) DK0649537T4 (ru)
ES (1) ES2171414T5 (ru)
FI (1) FI110546B (ru)
HU (1) HUT70473A (ru)
NO (1) NO321185B1 (ru)
PL (1) PL174686B1 (ru)
PT (1) PT649537E (ru)
RU (1) RU2126158C1 (ru)
SK (1) SK284556B6 (ru)
UA (1) UA39944C2 (ru)
WO (1) WO1994001778A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
US7070790B1 (en) 1993-06-29 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5882852A (en) * 1993-06-29 1999-03-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
JPH09503396A (ja) 1994-07-29 1997-04-08 インノジェネティクス・エヌ・ブイ 診断用及び治療用の精製ｃ型肝炎ウイルスエンベロープ蛋白
DE4428705A1 (de) * 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
CA2223277A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories Method for detection of antibody to hepatitis c virus second envelope glycoprotein
US6514731B1 (en) 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
WO2000026673A1 (en) * 1998-11-03 2000-05-11 Abbott Laboratories Methods of detecting chronic infection caused by hcv
US6815160B1 (en) 1999-07-28 2004-11-09 Chiron Corporation Hepatitis C viral antigen immunoassay detection systems
CA2380777C (en) * 1999-07-28 2011-01-04 Chiron Corporation Hepatitis c viral antigen immunoassay detection systems
EP1829891B1 (en) 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Immunoassays for Anti-HCV Antibodies
US6630298B2 (en) 2000-06-15 2003-10-07 Chiron Corporation HCV antigen/antibody combination assay
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
ES2312806T3 (es) 2002-09-09 2009-03-01 Novartis Vaccines And Diagnostics, Inc. Ensayo de vhc.
WO2004071414A2 (en) * 2003-02-05 2004-08-26 Genzyme Corporation Therapeutic anti-hcv (al9) compounds
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
EP1802778B1 (en) 2004-08-27 2011-10-05 Novartis Vaccines and Diagnostics, Inc. Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof
CA2661492A1 (en) 2006-08-25 2008-02-28 Novartis Ag Hcv fusion polypeptides
US8815253B2 (en) 2007-12-07 2014-08-26 Novartis Ag Compositions for inducing immune responses
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
CN105228649B (zh) 2013-03-14 2019-01-18 雅培制药有限公司 Hcv抗原-抗体组合测定和方法以及用在其中的组合物
EP2970947A4 (en) 2013-03-14 2016-10-12 Abbott Lab RECOMBINANT HCV NS3 ANTIGENS AND THEIR MUTANTS FOR ENHANCED ANTIBODY DETECTION
EP3564384A1 (en) 2013-03-14 2019-11-06 Abbott Laboratories Hcv core lipid binding domain monoclonal antibodies
ES2832335T3 (es) 2015-03-27 2021-06-10 Ortho Clinical Diagnostics Inc Polipéptidos NS4A/NS3 modificado del VHC y usos de los mismos

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855224A (en) * 1984-03-09 1989-08-08 Genentech, Inc. Molecularly cloned diagnostic product and method of use
DE3886363T3 (de) 1987-11-18 2004-09-09 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville NANBV-Diagnostika
WO1990011089A1 (en) 1989-03-17 1990-10-04 Chiron Corporation Nanbv diagnostics and vaccines
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
LU87861A1 (fr) * 1989-12-18 1991-10-08 Wellcome Found Agent viral
ZA912040B (en) * 1990-03-30 1991-12-24 Akzo Nv Peptides immunochemically reactive with antibodies directed against hepatitis non-a,non-b virus
KR100206150B1 (ko) * 1990-04-04 1999-07-01 로버트 피. 블랙버언 항-에이치씨브이 항체에 대한 면역분석용 씨형 간염 바이러스(에이치디브이)항원의 조합체
ES2152922T3 (es) * 1990-04-06 2001-02-16 Genelabs Tech Inc Epitopos del virus de la hepatitis c.
AU652941B2 (en) * 1990-06-25 1994-09-15 Research Foundation For Microbial Diseases Of Osaka University, The Non-A, Non-B hepatitis virus particles
EP0468657A3 (en) * 1990-07-09 1992-02-05 Tonen Corporation Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis
CZ289006B6 (cs) * 1990-11-08 2001-10-17 Chiron Corporation Asialoglykoprotein hepatitis C viru, farmaceutická kompozice s jeho obsahem a jeho pouľití
IT1249684B (it) * 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
JP3439209B2 (ja) * 1992-01-31 2003-08-25 アボツト・ラボラトリーズ Ｈｃｖ蛋白のための哺乳動物発現システム
US5587285A (en) * 1992-01-31 1996-12-24 University Of Texas System Generation serological assay for monitoring HIV exposure

Also Published As

Publication number Publication date
FI950002A (fi) 1995-02-27
US20020150883A1 (en) 2002-10-17
HU9500008D0 (en) 1995-03-28
JP3490085B2 (ja) 2004-01-26
NO950006L (no) 1995-02-24
FI110546B (fi) 2003-02-14
ATE216779T1 (de) 2002-05-15
SK495A3 (en) 1995-07-11
DE69331845T3 (de) 2006-10-05
PL307178A1 (en) 1995-05-02
ES2171414T3 (es) 2002-09-16
PT649537E (pt) 2002-09-30
CA2139645A1 (en) 1994-01-20
CZ291951B6 (cs) 2003-06-18
DK0649537T3 (da) 2002-06-17
RU2126158C1 (ru) 1999-02-10
SK284556B6 (sk) 2005-06-02
CZ695A3 (en) 1996-03-13
UA39944C2 (uk) 2001-07-16
DE69331845T2 (de) 2002-08-14
NO950006D0 (no) 1995-01-02
EP0649537B2 (en) 2006-02-22
ES2171414T5 (es) 2006-09-01
JPH07509060A (ja) 1995-10-05
NO321185B1 (no) 2006-04-03
AU685059B2 (en) 1998-01-15
JP2003329687A (ja) 2003-11-19
EP0649537A1 (en) 1995-04-26
DK0649537T4 (da) 2006-04-10
WO1994001778A1 (en) 1994-01-20
PL174686B1 (pl) 1998-08-31
DE69331845D1 (de) 2002-06-06
FI950002A0 (fi) 1995-01-02
EP0649537B1 (en) 2002-04-24
HUT70473A (en) 1995-10-30
CA2139645C (en) 2003-02-11
AU4662993A (en) 1994-01-31

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