RU94040150A - Стабильная лиофилизированная композиция тиотепа, способ ее получения - Google Patents

Стабильная лиофилизированная композиция тиотепа, способ ее получения

Info

Publication number
RU94040150A
RU94040150A RU94040150/14A RU94040150A RU94040150A RU 94040150 A RU94040150 A RU 94040150A RU 94040150/14 A RU94040150/14 A RU 94040150/14A RU 94040150 A RU94040150 A RU 94040150A RU 94040150 A RU94040150 A RU 94040150A
Authority
RU
Russia
Prior art keywords
preparing
composition
stable lyophilized
thiotepa
thiotepa composition
Prior art date
Application number
RU94040150/14A
Other languages
English (en)
Other versions
RU2134112C1 (ru
Inventor
С. КY Маннчинг
Us]
Велез Джордж
Хоффман Джо
Замора Лордес
Original Assignee
Американ Цианамид Компани (US)
Американ Цианамид Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Цианамид Компани (US), Американ Цианамид Компани filed Critical Американ Цианамид Компани (US)
Publication of RU94040150A publication Critical patent/RU94040150A/ru
Application granted granted Critical
Publication of RU2134112C1 publication Critical patent/RU2134112C1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В изобретении предлагается стабильная лиофилизированная композиция противоопухолевого алкилирующего агента тиотепа и способ получения такой композиции со-лиофилизацией активного ингредиента с фармацевтически приемлемым подщелачивающим агентом.

Claims (1)

  1. В изобретении предлагается стабильная лиофилизированная композиция противоопухолевого алкилирующего агента тиотепа и способ получения такой композиции со-лиофилизацией активного ингредиента с фармацевтически приемлемым подщелачивающим агентом.
RU94040150A 1993-11-09 1994-11-04 Стабильная лиофилизированная композиция тиотепа и способ ее получения RU2134112C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15050193A 1993-11-09 1993-11-09
US08/150,501 1993-11-09

Publications (2)

Publication Number Publication Date
RU94040150A true RU94040150A (ru) 1996-09-20
RU2134112C1 RU2134112C1 (ru) 1999-08-10

Family

ID=22534834

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94040150A RU2134112C1 (ru) 1993-11-09 1994-11-04 Стабильная лиофилизированная композиция тиотепа и способ ее получения

Country Status (29)

Country Link
US (1) US5561121A (ru)
EP (1) EP0656211B1 (ru)
JP (1) JP3726255B2 (ru)
KR (1) KR100348382B1 (ru)
CN (1) CN1111130A (ru)
AR (1) AR023045A2 (ru)
AT (1) ATE180670T1 (ru)
AU (1) AU690143B2 (ru)
CA (1) CA2135265A1 (ru)
CZ (1) CZ287052B6 (ru)
DE (1) DE69418832T2 (ru)
DK (1) DK0656211T3 (ru)
ES (1) ES2133152T3 (ru)
FI (1) FI116036B (ru)
GR (1) GR3031122T3 (ru)
HK (1) HK1011283A1 (ru)
HU (1) HU218216B (ru)
IL (1) IL111534A (ru)
NO (1) NO305274B1 (ru)
NZ (1) NZ264861A (ru)
PE (1) PE22995A1 (ru)
PH (1) PH31219A (ru)
PL (1) PL176984B1 (ru)
RU (1) RU2134112C1 (ru)
SG (1) SG63584A1 (ru)
SI (1) SI0656211T1 (ru)
SK (1) SK280840B6 (ru)
TW (1) TW344662B (ru)
ZA (1) ZA948833B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726343D0 (en) * 1997-12-13 1998-02-11 Auffret Anthony The use of excipients to accelerate freeze-drying
JP2004532277A (ja) * 2001-06-08 2004-10-21 パウダージェクト ワクチンズ，インコーポレーテッド 噴霧凍結乾燥組成物
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
CN102164579B (zh) 2008-09-25 2014-10-15 赛福伦公司 苯达莫司汀的液体配制品
CN102281877B (zh) 2009-01-15 2014-07-23 赛福伦公司 苯达莫司汀的游离碱形式
JP2014528953A (ja) * 2011-09-29 2014-10-30 ヤンセン ファーマシューティカ エヌ．ベー． スルファミド誘導体の調製プロセス
CN104349417B (zh) * 2013-08-07 2017-11-21 中国科学院声学研究所 基于短生命周期的区域性水下通信网的组网方法
WO2018227112A1 (en) 2017-06-09 2018-12-13 The Trustees Of Columbia University In The City Of New York Short tat oligomers for drug delivery
CN109956972A (zh) * 2017-12-22 2019-07-02 四川科瑞德凯华制药有限公司 塞替派晶型i及其制备方法和用途
CN110917146A (zh) * 2019-12-03 2020-03-27 黑龙江福和制药集团股份有限公司 一种塞替派粉针及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670347A (en) * 1952-01-08 1954-02-23 American Cyanamid Co Thiophosphoric acid derivatives and method of preparing the same
GB845823A (en) * 1957-09-19 1960-08-24 Sumitomo Chemical Co Stabilised compositions comprising therapeutic imine derivatives and the preparation thereof
DE1951822C3 (de) * 1969-10-14 1980-12-11 Kowa Co., Ltd., Nagoya, Aichi (Japan) Pharmazeutisches Präparat zur Krebsbehandlung
DE2925009A1 (de) * 1979-06-21 1981-01-08 Basf Ag Zubereitung fuer substanzen, verfahren zu deren herstellung und deren verwendung
EP0120907A1 (en) * 1982-10-13 1984-10-10 Aston Molecules Limited Pharmaceutical preparations for use in antitumour therapy
DE3484584D1 (de) * 1983-10-14 1991-06-20 Sumitomo Pharma Injektionen mit verzoegerter abgabe.
CH676508A5 (ru) * 1986-10-13 1991-01-31 Anawa Lab Ag
US4918199A (en) * 1988-01-21 1990-04-17 American Cyanamid Company Process for producing thiotepa
US5122367A (en) * 1989-03-31 1992-06-16 Massachusetts Institute Of Technology Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
EP0419890A3 (en) * 1989-09-29 1991-05-29 American Cyanamid Company Stable pharmaceutical formulations for antineoplastic compounds having more than one ethyleneimine group, and method

Also Published As

Publication number Publication date
HUT70762A (en) 1995-10-30
SK135294A3 (en) 1996-01-10
EP0656211B1 (en) 1999-06-02
SG63584A1 (en) 1999-03-30
CN1111130A (zh) 1995-11-08
US5561121A (en) 1996-10-01
JP3726255B2 (ja) 2005-12-14
JPH07196517A (ja) 1995-08-01
HU9403210D0 (en) 1995-01-30
CA2135265A1 (en) 1995-05-10
ES2133152T3 (es) 1999-09-01
HU218216B (hu) 2000-06-28
SI0656211T1 (en) 1999-08-31
PH31219A (en) 1998-05-05
KR100348382B1 (ko) 2002-11-23
NO944256D0 (no) 1994-11-08
AU690143B2 (en) 1998-04-23
AR023045A2 (es) 2002-09-04
AU7768994A (en) 1995-05-18
CZ271894A3 (en) 1995-07-12
CZ287052B6 (en) 2000-08-16
ATE180670T1 (de) 1999-06-15
DE69418832D1 (de) 1999-07-08
NO944256L (no) 1995-05-10
PL305752A1 (en) 1995-05-15
RU2134112C1 (ru) 1999-08-10
EP0656211A1 (en) 1995-06-07
ZA948833B (en) 1995-07-14
SK280840B6 (sk) 2000-08-14
PL176984B1 (pl) 1999-08-31
HK1011283A1 (en) 1999-07-09
FI945252A (fi) 1995-05-10
IL111534A (en) 1999-06-20
FI945252A0 (fi) 1994-11-08
DK0656211T3 (da) 1999-11-15
IL111534A0 (en) 1995-01-24
DE69418832T2 (de) 1999-09-23
FI116036B (fi) 2005-09-15
NZ264861A (en) 1995-10-26
NO305274B1 (no) 1999-05-03
PE22995A1 (es) 1995-09-08
GR3031122T3 (en) 1999-12-31
TW344662B (en) 1998-11-11

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Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20061105