RU94036773A - Домен i ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена i - Google Patents
Домен i ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена iInfo
- Publication number
- RU94036773A RU94036773A RU94036773/13A RU94036773A RU94036773A RU 94036773 A RU94036773 A RU 94036773A RU 94036773/13 A RU94036773/13 A RU 94036773/13A RU 94036773 A RU94036773 A RU 94036773A RU 94036773 A RU94036773 A RU 94036773A
- Authority
- RU
- Russia
- Prior art keywords
- phe
- cys
- amino acid
- glu
- domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Вариант домена 1 ингибитора протеазы человека типа Кунитца, а именно ингибитора метаболизма тканевого фактора (TFP1), где указанный вариант содержит следующую аминокислотную последовательность: Х, Суs, Аlа, Phe, Lуs, Аlа, Аsр, Х, Gly, Х, Суs, Х, Х, Х, Х, Х, Х, Phe, Phe, Phe, Asn, Ile, Phe, Thr, Arg, Gln, Cys, Glu, Glu, Phe, X, Туr, Gly, Gly, Cys, X, X, X, Gln, Asn, Arg, Phe, X, Ser, Leu, Glu, Glu, Cys, X, X, Met, Cys, Thr, Arg, X(SEQ D N 1), где Х- Н или 1 - 7 натуральных аминокислотных остатков, за исключением Суs; каждый из Х- Х- независимо натуральный аминокислотный остаток, а Х- OH или 1 - 5 натуральных аминокислотных остатков, за исключением Суs; при условии, что по крайней мере один из аминокислотных остатков Х- Хотличается от соответствующего аминокислотного остатка нативной последовательности.
Claims (1)
- Вариант домена 1 ингибитора протеазы человека типа Кунитца, а именно ингибитора метаболизма тканевого фактора (TFP1), где указанный вариант содержит следующую аминокислотную последовательность: Х1, Суs, Аlа, Phe, Lуs, Аlа, Аsр, Х2, Gly, Х3, Суs, Х4, Х5, Х6, Х7, Х8, Х9, Phe, Phe, Phe, Asn, Ile, Phe, Thr, Arg, Gln, Cys, Glu, Glu, Phe, X10, Туr, Gly, Gly, Cys, X11, X12, X13, Gln, Asn, Arg, Phe, X14, Ser, Leu, Glu, Glu, Cys, X15, X16, Met, Cys, Thr, Arg, X17 (SEQ D N 1), где Х1 - Н или 1 - 7 натуральных аминокислотных остатков, за исключением Суs; каждый из Х2 - Х16 - независимо натуральный аминокислотный остаток, а Х17 - OH или 1 - 5 натуральных аминокислотных остатков, за исключением Суs; при условии, что по крайней мере один из аминокислотных остатков Х1 - Х17 отличается от соответствующего аминокислотного остатка нативной последовательности.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU94036770/13A RU94036770A (ru) | 1992-01-07 | 1993-01-07 | Домен ингибитора протеазы, днк, вектор, клетка, способ получения домена, фармацевтическая композиция, применение домена |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKDK92/00002 | 1992-01-07 | ||
| DK9200002 | 1992-01-07 | ||
| DKDK92/00340 | 1992-11-16 | ||
| DK9200340 | 1992-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU94036773A true RU94036773A (ru) | 1996-09-27 |
Family
ID=26068350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94036773/13A RU94036773A (ru) | 1992-01-07 | 1993-01-07 | Домен i ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена i |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0621872A1 (ru) |
| JP (1) | JPH07504891A (ru) |
| AU (1) | AU675926B2 (ru) |
| CA (1) | CA2127246A1 (ru) |
| CZ (1) | CZ164494A3 (ru) |
| FI (1) | FI943234A0 (ru) |
| HU (1) | HUT70293A (ru) |
| IL (1) | IL104324A0 (ru) |
| NO (1) | NO942549L (ru) |
| NZ (1) | NZ246570A (ru) |
| RU (1) | RU94036773A (ru) |
| WO (1) | WO1993014122A1 (ru) |
| ZA (1) | ZA9396B (ru) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| ATE529444T1 (de) | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| ATE275583T1 (de) * | 1994-01-11 | 2004-09-15 | Dyax Corp | KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| ATE226249T1 (de) * | 1994-08-05 | 2002-11-15 | Chiron Corp | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| ATE239501T1 (de) * | 1995-06-07 | 2003-05-15 | Chiron Corp | Regulierung der neutrophil elastase synthese und freisetzung |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| EP1105423B1 (en) * | 1998-08-25 | 2004-06-16 | Kleesiek, Knut, Prof. Dr. | A mutant of tissue factor pathway inhibitor, dna sequence and use for detecting thrombotic disorders |
| CN1325889A (zh) * | 2000-05-26 | 2001-12-12 | 上海博德基因开发有限公司 | 一种新的多肽——人Kazal型抑制因子11和编码这种多肽的多核苷酸 |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
| DK2386310T3 (en) * | 2002-08-28 | 2019-02-25 | Dyax Corp | Methods of preserving organs and tissues |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| WO2005021557A2 (en) | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| AU2009327338B2 (en) | 2008-12-19 | 2015-07-02 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| SI2521568T1 (sl) | 2010-01-06 | 2019-01-31 | Dyax Corp. | Proteini, ki vežejo plazemski kalikrein |
| NZ603028A (en) | 2010-03-19 | 2014-11-28 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | KALLIKREIN PLASMA BINDING PROTEINS |
| NZ724133A (en) | 2012-03-21 | 2020-07-31 | Baxalta Inc | Tfpi inhibitors and methods of use |
| JP7003354B2 (ja) | 2015-12-11 | 2022-03-04 | 武田薬品工業株式会社 | 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
-
1993
- 1993-01-06 IL IL104324A patent/IL104324A0/xx unknown
- 1993-01-07 CZ CZ941644A patent/CZ164494A3/cs unknown
- 1993-01-07 ZA ZA9396A patent/ZA9396B/xx unknown
- 1993-01-07 JP JP5511993A patent/JPH07504891A/ja active Pending
- 1993-01-07 NZ NZ246570A patent/NZ246570A/en unknown
- 1993-01-07 CA CA002127246A patent/CA2127246A1/en not_active Abandoned
- 1993-01-07 HU HU9401990A patent/HUT70293A/hu unknown
- 1993-01-07 EP EP93902106A patent/EP0621872A1/en not_active Withdrawn
- 1993-01-07 RU RU94036773/13A patent/RU94036773A/ru unknown
- 1993-01-07 AU AU33460/93A patent/AU675926B2/en not_active Ceased
- 1993-01-07 WO PCT/DK1993/000005 patent/WO1993014122A1/en not_active Application Discontinuation
-
1994
- 1994-07-06 FI FI943234A patent/FI943234A0/fi unknown
- 1994-07-06 NO NO942549A patent/NO942549L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2127246A1 (en) | 1993-07-22 |
| JPH07504891A (ja) | 1995-06-01 |
| WO1993014122A1 (en) | 1993-07-22 |
| NZ246570A (en) | 1996-09-25 |
| FI943234A (fi) | 1994-07-06 |
| EP0621872A1 (en) | 1994-11-02 |
| CZ164494A3 (en) | 1994-12-15 |
| HU9401990D0 (en) | 1994-09-28 |
| NO942549D0 (no) | 1994-07-06 |
| AU3346093A (en) | 1993-08-03 |
| IL104324A0 (en) | 1993-05-13 |
| ZA9396B (en) | 1993-08-10 |
| NO942549L (no) | 1994-09-07 |
| HUT70293A (en) | 1995-09-28 |
| FI943234A0 (fi) | 1994-07-06 |
| AU675926B2 (en) | 1997-02-27 |
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