RU94031165A - Use of arylindole-derivatives for psychosis treatment and a method of treatment - Google Patents
Use of arylindole-derivatives for psychosis treatment and a method of treatmentInfo
- Publication number
- RU94031165A RU94031165A RU94031165/14A RU94031165A RU94031165A RU 94031165 A RU94031165 A RU 94031165A RU 94031165/14 A RU94031165/14 A RU 94031165/14A RU 94031165 A RU94031165 A RU 94031165A RU 94031165 A RU94031165 A RU 94031165A
- Authority
- RU
- Russia
- Prior art keywords
- hydrogen
- alkyl
- cycloalkylmethyl
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Abstract
FIELD: organic chemistry. SUBSTANCE: product: 6- and/or 2-substituted 1-arylindole-derivative of the general formula (I) where Ar is nonobligatory substituted phenyl or heteroaromatic group; X and X' are hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, alkylsulfonyl, alkyl- or dialkylamino, cyano, trifluoromethyl or trifluoromethylthio; or X and X' were combined to 5-7-membered carbocyclic ring; Ris hydrogen or lower alkyl at condition that if X - hydrogen or fluorine then Rdoes not hydrogen; Y is nitrogen or carbon; R is hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkylmethyl or R - a substituent of the formula (Ia) or (Iв) where n - whole number = 2, 6; W is oxygen or sulfur; U is nitrogen or carbon; Z is -/CH/-, -CH=CH-, -COCH-,-CSCH- or 1,2-phenylene; V is oxygen, sulfur, CHor NR; Vis -O-R,-S-R,-CHRRor -NRRand R,Rand Rare hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkylmethyl. Synthesized compounds inhibit the spontaneous activity of dopamine neurons excitement in ventricle brain region and can be used for human psychosis treatment. EFFECT: improved method of synthesis, psychosis treatment.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK2065/91 | 1991-12-23 | ||
DK912065A DK206591D0 (en) | 1991-12-23 | 1991-12-23 | TREATMENT OF PSYCHOSIS |
Publications (1)
Publication Number | Publication Date |
---|---|
RU94031165A true RU94031165A (en) | 1996-06-20 |
Family
ID=8109829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94031165/14A RU94031165A (en) | 1991-12-23 | 1992-12-21 | Use of arylindole-derivatives for psychosis treatment and a method of treatment |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0618799A1 (en) |
JP (1) | JPH07502517A (en) |
AU (1) | AU668537B2 (en) |
CA (1) | CA2126571A1 (en) |
CZ (1) | CZ153994A3 (en) |
DK (1) | DK206591D0 (en) |
NO (1) | NO942378L (en) |
RU (1) | RU94031165A (en) |
SK (1) | SK75794A3 (en) |
WO (1) | WO1993012790A1 (en) |
ZA (1) | ZA9210001B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5554030A (en) * | 1994-06-30 | 1996-09-10 | Minnesota Mining And Manufacturing Company | Method for bonding non-amalgam restorative materials to dental surfaces |
UA44838C2 (en) * | 1996-03-25 | 2002-03-15 | Елі Ліллі Енд Компані | METHOD OF TREATMENT OF MIGRAINE |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
GB8908085D0 (en) * | 1989-04-11 | 1989-05-24 | Lundbeck & Co As H | New therapeutic use |
DK158590D0 (en) * | 1990-07-02 | 1990-07-02 | Lundbeck & Co As H | indole derivatives |
DK238190D0 (en) * | 1990-10-03 | 1990-10-03 | Lundbeck & Co As H | DEPOT DERIVATIVES |
DK8492D0 (en) * | 1992-01-23 | 1992-01-23 | Lundbeck & Co As H | TREATMENT OF PSYCHOSIS |
-
1991
- 1991-12-23 DK DK912065A patent/DK206591D0/en not_active Application Discontinuation
-
1992
- 1992-12-21 CA CA002126571A patent/CA2126571A1/en not_active Abandoned
- 1992-12-21 EP EP93902096A patent/EP0618799A1/en not_active Ceased
- 1992-12-21 JP JP5511365A patent/JPH07502517A/en active Pending
- 1992-12-21 AU AU33452/93A patent/AU668537B2/en not_active Ceased
- 1992-12-21 SK SK757-94A patent/SK75794A3/en unknown
- 1992-12-21 CZ CZ941539A patent/CZ153994A3/en unknown
- 1992-12-21 WO PCT/DK1992/000390 patent/WO1993012790A1/en not_active Application Discontinuation
- 1992-12-21 RU RU94031165/14A patent/RU94031165A/en unknown
- 1992-12-23 ZA ZA9210001A patent/ZA9210001B/en unknown
-
1994
- 1994-06-22 NO NO942378A patent/NO942378L/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA9210001B (en) | 1994-01-13 |
DK206591D0 (en) | 1991-12-23 |
EP0618799A1 (en) | 1994-10-12 |
JPH07502517A (en) | 1995-03-16 |
SK75794A3 (en) | 1995-04-12 |
NO942378D0 (en) | 1994-06-22 |
CZ153994A3 (en) | 1995-06-14 |
NO942378L (en) | 1994-06-22 |
WO1993012790A1 (en) | 1993-07-08 |
CA2126571A1 (en) | 1993-07-08 |
AU668537B2 (en) | 1996-05-09 |
AU3345293A (en) | 1993-07-28 |
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