RU94030812A - DERIVATIVES OF PHOSPHONOANATIC ACID, METHOD OF THEIR PRODUCTION AND CONTAINING THESE COMPOUNDS PHARMACEUTICAL COMPOSITIONS - Google Patents
DERIVATIVES OF PHOSPHONOANATIC ACID, METHOD OF THEIR PRODUCTION AND CONTAINING THESE COMPOUNDS PHARMACEUTICAL COMPOSITIONSInfo
- Publication number
- RU94030812A RU94030812A RU94030812/04A RU94030812A RU94030812A RU 94030812 A RU94030812 A RU 94030812A RU 94030812/04 A RU94030812/04 A RU 94030812/04A RU 94030812 A RU94030812 A RU 94030812A RU 94030812 A RU94030812 A RU 94030812A
- Authority
- RU
- Russia
- Prior art keywords
- lower alkyl
- compounds
- phosphonoanatic
- derivatives
- acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 3
- 239000002253 acid Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000003913 calcium metabolism Effects 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
в которой R обозначает в случае необходимости замещенную амино-группу общей формулы -NR1R2, причем R1 и R2, независимо друг от друга, смотря по обстоятельствам, обозначают водород, низший алкил, низший алкенил или низший алкинил; или R обозначает насыщенное, ненасыщенное или ароматическое гетероциклическое кольцо, которое в случае необходимости однократно или двукратно может быть замещено низшим алкилом или галогеном; "алк" обозначает валентный штрих, метиленовую группу, насыщенную или ненасыщенную, линейную или разветвленную алкиленовую цепь с 2 - 6 С-атомами; и R3, R4, R5, смотря по обстоятельствам независимо друг от друга обозначают водород, низший алкил или бензил, а также их фармакологически приемлемые соли и энантиомеры, причем в случае, когда R3-R4-R5-CH3 и "алк" обозначает валентный штрих, R не может обозначать диметиламино-группу; способ их получения и лекарственные средства, которые содержат эти соединения, для лечения заболеваний, связанных с кальциевым обменом.The proposed compounds of the formula
in which R denotes, if necessary, a substituted amino group of the general formula —NR 1 R 2 , and R 1 and R 2 independently of each other, depending on the circumstances, denote hydrogen, lower alkyl, lower alkenyl or lower alkynyl; or R is a saturated, unsaturated or aromatic heterocyclic ring which, if necessary, can be substituted once or twice by lower alkyl or halogen; “alk” refers to a valence stroke, a methylene group, a saturated or unsaturated, linear or branched alkylene chain with 2 to 6 C-atoms; and R 3 , R 4 , R 5 , depending on circumstances, independently of one another denote hydrogen, lower alkyl or benzyl, as well as their pharmacologically acceptable salts and enantiomers, moreover in the case when R 3 -R 4 -R 5 -CH 3 and “alk” refers to a valence dash, R cannot designate a dimethylamino group; the way they are received and drugs that contain these compounds for the treatment of diseases associated with calcium metabolism.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4141928A DE4141928A1 (en) | 1991-12-19 | 1991-12-19 | NEW PHOSPHON AMBER ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DEP4141928.6 | 1991-12-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94030812A true RU94030812A (en) | 1996-01-20 |
| RU2115656C1 RU2115656C1 (en) | 1998-07-20 |
Family
ID=6447460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94030812A RU2115656C1 (en) | 1991-12-19 | 1992-12-14 | Derivatives of phosphonesuccinic acid and their pharmacologically acceptable salts and composition based on thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5538957A (en) |
| EP (1) | EP0618920B1 (en) |
| JP (1) | JPH07507046A (en) |
| AT (1) | ATE141277T1 (en) |
| AU (1) | AU662790B2 (en) |
| CA (1) | CA2125867A1 (en) |
| CZ (1) | CZ151894A3 (en) |
| DE (2) | DE4141928A1 (en) |
| DK (1) | DK0618920T3 (en) |
| ES (1) | ES2093399T3 (en) |
| FI (1) | FI942910A0 (en) |
| GR (1) | GR3021110T3 (en) |
| HU (1) | HUT66771A (en) |
| IL (1) | IL104090A (en) |
| MX (1) | MX9207335A (en) |
| NO (1) | NO300546B1 (en) |
| NZ (1) | NZ246152A (en) |
| RU (1) | RU2115656C1 (en) |
| SK (1) | SK74694A3 (en) |
| TW (1) | TW222636B (en) |
| WO (1) | WO1993012122A1 (en) |
| ZA (1) | ZA929815B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5760021A (en) * | 1992-05-29 | 1998-06-02 | The Procter & Gamble Company | Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| DE4320223A1 (en) * | 1993-06-18 | 1994-12-22 | Boehringer Mannheim Gmbh | New phosphonosuccinic acid derivatives, processes for their preparation and medicaments containing these compounds |
| DE4336099A1 (en) * | 1993-10-22 | 1995-04-27 | Boehringer Mannheim Gmbh | New 2,4-diphosphonoglutaric acid derivatives, processes for their preparation and medicaments containing these compounds |
| DE4410601A1 (en) * | 1994-03-26 | 1995-09-28 | Boehringer Mannheim Gmbh | New 2,4-diphosphonoglutaric acid derivatives, processes for their preparation and medicaments containing these compounds |
| US6011021A (en) * | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
| GB2313126A (en) * | 1996-05-14 | 1997-11-19 | Albright & Wilson Uk Ltd | Polymer compositions containing phosphorus |
| US5795877A (en) * | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US5902817A (en) * | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
| US6384022B1 (en) | 1996-06-17 | 2002-05-07 | Guilford Pharmaceuticals Inc. | Prodrugs of NAALAdase inhibitors |
| US5977090A (en) * | 1996-09-27 | 1999-11-02 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors |
| US5863536A (en) * | 1996-12-31 | 1999-01-26 | Guilford Pharmaceuticals Inc. | Phosphoramidate derivatives |
| US6054444A (en) * | 1997-04-24 | 2000-04-25 | Guilford Pharmaceuticals Inc. | Phosphonic acid derivatives |
| US6025345A (en) * | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US5672592A (en) * | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
| US6046180A (en) * | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
| HUP9903421A3 (en) | 1996-06-17 | 2001-08-28 | Guilford Pharmaceuticals Inc B | Use of phosphonic and phosphinic acid derivatives for producing pharmaceutical compositions having naaladase inhibitor activity |
| US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
| US6071965A (en) * | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
| US5962521A (en) * | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
| US5981209A (en) * | 1997-12-04 | 1999-11-09 | Guilford Pharmaceuticals Inc. | Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia |
| US6028216A (en) * | 1997-12-31 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives |
| US6121252A (en) * | 1998-03-30 | 2000-09-19 | Guilford Pharmaceuticals Inc. | Phosphinic acid derivatives |
| PL346762A1 (en) | 1998-07-06 | 2002-02-25 | Guilford Pharm Inc | Naaladase inhibitors useful as pharmaceutical compounds and compositions |
| US6395718B1 (en) | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
| US6265609B1 (en) | 1998-07-06 | 2001-07-24 | Guilford Pharmaceuticals Inc. | Thio-substituted pentanedioic acid derivatives |
| IT1303672B1 (en) | 1998-07-28 | 2001-02-23 | Nicox Sa | NITRATED SALTS OF DRUGS ACTIVE IN BONE DISORDERS |
| US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| EP1383511B1 (en) * | 2000-10-25 | 2006-10-25 | SmithKline Beecham Corporation | Calcilytic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2360797C2 (en) * | 1973-12-06 | 1985-05-23 | Henkel KGaA, 4000 Düsseldorf | Pharmaceutical preparations |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US5004549A (en) * | 1989-10-10 | 1991-04-02 | Olin Corporation | Method for inhibiting scale formation using calcium hypochlorite compositions |
-
1991
- 1991-12-19 DE DE4141928A patent/DE4141928A1/en not_active Withdrawn
-
1992
- 1992-12-01 TW TW081109635A patent/TW222636B/zh active
- 1992-12-14 HU HU9401834A patent/HUT66771A/en unknown
- 1992-12-14 JP JP5510624A patent/JPH07507046A/en active Pending
- 1992-12-14 DK DK93900042.8T patent/DK0618920T3/en active
- 1992-12-14 CA CA002125867A patent/CA2125867A1/en not_active Abandoned
- 1992-12-14 SK SK746-94A patent/SK74694A3/en unknown
- 1992-12-14 ES ES93900042T patent/ES2093399T3/en not_active Expired - Lifetime
- 1992-12-14 RU RU94030812A patent/RU2115656C1/en active
- 1992-12-14 CZ CZ941518A patent/CZ151894A3/en unknown
- 1992-12-14 IL IL104090A patent/IL104090A/en not_active IP Right Cessation
- 1992-12-14 NZ NZ246152A patent/NZ246152A/en unknown
- 1992-12-14 EP EP93900042A patent/EP0618920B1/en not_active Expired - Lifetime
- 1992-12-14 DE DE59206925T patent/DE59206925D1/en not_active Expired - Fee Related
- 1992-12-14 US US08/244,245 patent/US5538957A/en not_active Expired - Fee Related
- 1992-12-14 WO PCT/EP1992/002890 patent/WO1993012122A1/en not_active Application Discontinuation
- 1992-12-14 AT AT93900042T patent/ATE141277T1/en active
- 1992-12-14 AU AU31580/93A patent/AU662790B2/en not_active Ceased
- 1992-12-16 MX MX9207335A patent/MX9207335A/en not_active IP Right Cessation
- 1992-12-18 ZA ZA929815A patent/ZA929815B/en unknown
-
1994
- 1994-06-17 FI FI942910A patent/FI942910A0/en unknown
- 1994-06-17 NO NO942304A patent/NO300546B1/en not_active IP Right Cessation
-
1995
- 1995-06-05 US US08/465,360 patent/US5627170A/en not_active Expired - Fee Related
-
1996
- 1996-09-19 GR GR960402474T patent/GR3021110T3/en unknown
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