RU94007350A - DERIVATIVES OF BENZOXAZINE, METHOD FOR THEIR PRODUCTION, PHARMACEUTICALS, INTERMEDIATE CONNECTION - Google Patents

DERIVATIVES OF BENZOXAZINE, METHOD FOR THEIR PRODUCTION, PHARMACEUTICALS, INTERMEDIATE CONNECTION

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Publication number
RU94007350A
RU94007350A RU94007350/04A RU94007350A RU94007350A RU 94007350 A RU94007350 A RU 94007350A RU 94007350/04 A RU94007350/04 A RU 94007350/04A RU 94007350 A RU94007350 A RU 94007350A RU 94007350 A RU94007350 A RU 94007350A
Authority
RU
Russia
Prior art keywords
group
tetrahydroisoquinolin
methoxy
phenyl
dimethoxy
Prior art date
Application number
RU94007350/04A
Other languages
Russian (ru)
Other versions
RU2130020C1 (en
Inventor
Ховард Уильямз Пол
Зард Лидия
Эндрю Парселль Томас
Гальтье Даниель
Мюллер Жан-Клод
Жорж Паскаль
Фрост Джонатан
Пазо Патрик
Русселль Корин
Бартш Режин
Original Assignee
Синтелябо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9302659A external-priority patent/FR2702477B1/en
Application filed by Синтелябо filed Critical Синтелябо
Publication of RU94007350A publication Critical patent/RU94007350A/en
Application granted granted Critical
Publication of RU2130020C1 publication Critical patent/RU2130020C1/en

Links

Claims (1)

Предложены производные бензоксазина общей формулы
Figure 00000001

где Y - атом водорода, фтора или хлора или метильная или метокси-группа, R1 - либо фенильная группа, замещенная атомом фтора или группой, выбранной из метильной, метокси-, трифторметильной и фенильной групп, либо тиен-2-ильная группа, R2 - метильная группа, R3 - либо (С1-С4)алкильная группа, либо фенил (С1-С2)алкильная группа, в которой кольцо, при необходимости, замещено 2-3 метокси-группами, либо 2-(пиридин-2-ил)этильная группа, или R2 и R3 образуют вместе с азотом либо 4-фенил(пиперидин-1-ильную)группу, либо 4-фенилметил(пиперидин-1-ильную)группу, либо 1,2,3,4-тетрагидроизохинолин-2-ильную группу, либо 6-метокси-1,2,3,4-тетрагидроизохинолин-2-ильную группу, либо 5,8-диметокси-1,2,3,4-тетрагидроизохинолин-2-ильную группу, либо 6,7-диметокси-1,2,3,4-тетрагидроизохинолин-2-ильную группу, либо 2,3,4,5-тетрагидро-1Н-3-бензазепин-3-ильную группу, либо 7,8-диметокси-2,3,4,5-тетрагидро-1Н-3-бензазепин-3-ильную группу, а Х - либо карбонильная группа, либо сульфонильная группа, обладают высокой фармацевтической активностью и применяются в терапии.Proposed benzoxazine derivatives of the general formula
Figure 00000001

where Y is a hydrogen, fluorine or chlorine atom or a methyl or methoxy group, R 1 is either a phenyl group substituted by a fluorine atom or a group selected from a methyl, methoxy, trifluoromethyl and phenyl groups, or a thien-2-yl group, R 2 is a methyl group, R 3 is either a (C 1 -C 4 ) alkyl group, or a phenyl (C 1 -C 2 ) alkyl group in which the ring is optionally substituted by 2-3 methoxy groups, or 2- ( a pyridin-2-yl) ethyl group, or R 2 and R 3 form together with nitrogen either a 4-phenyl (piperidin-1-yl) group, or 4-phenylmethyl (piperidin-1-yl) group, or 1,2, 3 , 4-tetrahydroisoquinolin-2-yl group, or 6-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ilen group, or 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ilen group, or 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl group, or 2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl group, or 7.8 -dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl group, and X - either a carbonyl group or a sulfonyl group, has high pharmaceutical activity and is used in therapy.
RU94007350A 1993-03-08 1994-03-05 Derivatives of benzoxazine, methods of their synthesis, a pharmaceutical preparation RU2130020C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9302659 1993-03-08
FR02659 1993-03-08
FR9302659A FR2702477B1 (en) 1993-03-08 1993-03-08 Benzoxazine derivatives, their preparation and their therapeutic application.

Publications (2)

Publication Number Publication Date
RU94007350A true RU94007350A (en) 1995-11-10
RU2130020C1 RU2130020C1 (en) 1999-05-10

Family

ID=9444751

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94007350A RU2130020C1 (en) 1993-03-08 1994-03-05 Derivatives of benzoxazine, methods of their synthesis, a pharmaceutical preparation

Country Status (20)

Country Link
US (1) US5447928A (en)
EP (1) EP0614893B1 (en)
JP (1) JPH0710852A (en)
CN (1) CN1099032A (en)
AT (1) ATE166648T1 (en)
AU (1) AU673226B2 (en)
CA (1) CA2117122A1 (en)
CZ (1) CZ284789B6 (en)
DE (1) DE69410509T2 (en)
DK (1) DK0614893T3 (en)
ES (1) ES2119099T3 (en)
FI (1) FI941068A (en)
FR (1) FR2702477B1 (en)
HU (1) HUT70539A (en)
IL (1) IL108885A (en)
NO (1) NO300542B1 (en)
NZ (1) NZ260039A (en)
RU (1) RU2130020C1 (en)
SK (1) SK27494A3 (en)
TW (1) TW302362B (en)

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Publication number Priority date Publication date Assignee Title
CN1109880A (en) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-aminoethyl)-4-[3-(trifluoromethyl) benzoyl]-3,4-dihydro-1,4-benzoxazine derivative and preparation of same
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
WO1999038500A2 (en) * 1998-01-30 1999-08-05 The Brigham And Women's Hospital, Inc. The human calcium-sensing receptor in the detection and treatment of cancer
TW472491B (en) * 1999-03-19 2002-01-11 Seiko Epson Corp Projection system and projector
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
AU2005292314B2 (en) * 2004-09-29 2011-11-03 Portola Pharmaceuticals, Inc. Substituted 2H-1,3-benzoxazin-4(3H)-ones
AR051780A1 (en) * 2004-11-29 2007-02-07 Japan Tobacco Inc FUSIONED RING COMPOUNDS CONTAINING NITROGEN AND USING THEMSELVES
HU230826B1 (en) 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Process for preparation of benzazepine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1287584B (en) * 1962-07-04 1969-01-23 Thomae Gmbh Dr K Process for the preparation of 2, 3-dihydro-1, 4-benzoxazine derivatives
GB8803419D0 (en) * 1988-02-15 1988-03-16 Erba Carlo Spa 1 4-benzoxazine & 1 4-benzothiazine derivatives & process for their preparation
AU638154B2 (en) * 1990-10-04 1993-06-17 Suntory Limited Benzoxazine derivative and herbicide containing same as an active ingredient
DE4037427A1 (en) * 1990-11-24 1992-05-27 Kali Chemie Pharma Gmbh HETEROCYCLICALLY SUBSTITUTED PIPERAZINOALKYLBENZAZAZINE AND -THIAZIN COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF, AND THE MEDICAMENTS CONTAINING SUCH COMPOUNDS

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