RU93043621A - METHODS FOR PRODUCING НСV Glycoproteins, METHOD OF CLEANING, ANALYTICAL KIT, METHOD FOR IDENTIFICATION OF НСV, METHOD OF ELIMINATION OF НСV, METHOD OF INDUCTION OF IMMUNITY, GYCLOPROTEIN, IMGENTO - Google Patents

METHODS FOR PRODUCING НСV Glycoproteins, METHOD OF CLEANING, ANALYTICAL KIT, METHOD FOR IDENTIFICATION OF НСV, METHOD OF ELIMINATION OF НСV, METHOD OF INDUCTION OF IMMUNITY, GYCLOPROTEIN, IMGENTO

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Publication number
RU93043621A
RU93043621A RU93043621/13A RU93043621A RU93043621A RU 93043621 A RU93043621 A RU 93043621A RU 93043621/13 A RU93043621/13 A RU 93043621/13A RU 93043621 A RU93043621 A RU 93043621A RU 93043621 A RU93043621 A RU 93043621A
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RU
Russia
Prior art keywords
нсv
glycoproteins
imgento
gycloprotein
immunity
Prior art date
Application number
RU93043621/13A
Other languages
Russian (ru)
Other versions
RU2123528C1 (en
Inventor
О. Рэлстон Роберт
Маркус ФРЭНК
Б.Тудьюм Кент
А.Гервэйс Барбара
А.Холл Джон
Original Assignee
Чирон Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Чирон Корпорейшн filed Critical Чирон Корпорейшн
Publication of RU93043621A publication Critical patent/RU93043621A/en
Application granted granted Critical
Publication of RU2123528C1 publication Critical patent/RU2123528C1/en

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Claims (1)

Два белка оболочки гепатита С (Е1 и Е2) экспрессируются без сиалилирования. Рекомбинантная экспрессия этих протеинов в низших вукариотах или в клетках млекопитающих, у которых блокировано терминальное глюкозилирование, дает рекомбинантные белки, которые имеют большее сходство с естественными гликопротеинами ВГС. Когда их выделяют при помощи сродства к локтину GNA, протеины Е1 и Е2 соединяются в вирусоподобные частицы. Клетки, несущие рецептор маинозы или рецептор асиалогликопротеина, можно инфицировать ВГС и использовать для культивирования вируса.Two hepatitis C envelope proteins (E1 and E2) are expressed without sialylation. The recombinant expression of these proteins in lower vukaryotes or in mammalian cells in which terminal glucosylation is blocked gives recombinant proteins that are more similar to natural HCV glycoproteins. When they are secreted by the affinity for the elbow GNA, the E1 and E2 proteins combine into virus-like particles. Cells carrying the mainoza receptor or the asialoglycoprotein receptor can be infected with HCV and used to cultivate the virus.
RU93043621A 1990-11-08 1991-11-07 Method of preparing hcv proteins useful for using in vaccine or immune analysis, asialoglycoprotein (variants), composition for using in vaccine or in immune analysis (variants), method of asialoglycoprotein purification and a method of hcv content decrease or elimination RU2123528C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US61141990A 1990-11-08 1990-11-08
US611,419 1990-11-08
US611,965 1990-11-08
US611419 1990-11-08
US758,880 1991-09-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU97115378A Division RU2175657C2 (en) 1990-11-08 1991-11-07 Hepatitis c virus (hcv) asialoglycoprotein, immunogenic composition, method of induction of immune response, method of immune assay

Publications (2)

Publication Number Publication Date
RU93043621A true RU93043621A (en) 1997-02-10
RU2123528C1 RU2123528C1 (en) 1998-12-20

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Family Applications (2)

Application Number Title Priority Date Filing Date
RU93043621A RU2123528C1 (en) 1990-11-08 1991-11-07 Method of preparing hcv proteins useful for using in vaccine or immune analysis, asialoglycoprotein (variants), composition for using in vaccine or in immune analysis (variants), method of asialoglycoprotein purification and a method of hcv content decrease or elimination
RU97115378A RU2175657C2 (en) 1990-11-08 1991-11-07 Hepatitis c virus (hcv) asialoglycoprotein, immunogenic composition, method of induction of immune response, method of immune assay

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU97115378A RU2175657C2 (en) 1990-11-08 1991-11-07 Hepatitis c virus (hcv) asialoglycoprotein, immunogenic composition, method of induction of immune response, method of immune assay

Country Status (2)

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IE (1) IE20060502A1 (en)
RU (2) RU2123528C1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103063840A (en) * 2011-10-18 2013-04-24 中国科学院武汉病毒研究所 Application of cellular target liver X receptor in preparation of drugs treating hepatitis C virus
AU2017235278C1 (en) 2016-03-14 2022-03-10 F. Hoffmann-La Roche Ag Oligonucleotides for reduction of PD-L1 expression

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