RU93005013A - 1-аминоспиро[изохинолин-4(1н)3-пирролидин-1,2,3,5'(2н)-тетроны] и их аналоги, способ их получения и фармацевтическая композиция - Google Patents
1-аминоспиро[изохинолин-4(1н)3-пирролидин-1,2,3,5'(2н)-тетроны] и их аналоги, способ их получения и фармацевтическая композицияInfo
- Publication number
- RU93005013A RU93005013A RU93005013/04A RU93005013A RU93005013A RU 93005013 A RU93005013 A RU 93005013A RU 93005013/04 A RU93005013/04 A RU 93005013/04A RU 93005013 A RU93005013 A RU 93005013A RU 93005013 A RU93005013 A RU 93005013A
- Authority
- RU
- Russia
- Prior art keywords
- tetrons
- izohinolin
- aminospiro
- pyrrolidin
- analogues
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Изобретение относится к 1-аминоспиро[изохинолин-4(1Н) 3-пирролидин-1,2,3,5'(2Н)-тетронам и их фармацевтически приемлемым солям, к способам их получения, способам использования этих соединений и фармацевтическим препаратам на их основе. Указанные соединения обладают фармацевтическими свойствами, которые делают их полезными для предотвращения или лечения осложнений, связанных с сахарным диабетом.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/596,266 US5102886A (en) | 1990-10-12 | 1990-10-12 | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
US596266 | 1990-10-12 | ||
US596.266 | 1990-10-12 | ||
PCT/US1991/007473 WO1992006975A1 (en) | 1990-10-12 | 1991-10-10 | 1'-aminospiro[isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93005013A true RU93005013A (ru) | 1996-05-10 |
RU2110518C1 RU2110518C1 (ru) | 1998-05-10 |
Family
ID=24386645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93005013A RU2110518C1 (ru) | 1990-10-12 | 1991-10-10 | Производные спиро[изохинолин-4(1н),3-пирролидин]-1,2',3,5'[2н]тетрона, способ их получения и фармацевтическая композиция для предотвращения или лечения осложнений, связанных с сахарным диабетом |
Country Status (19)
Country | Link |
---|---|
US (1) | US5102886A (ru) |
EP (1) | EP0553263B1 (ru) |
JP (1) | JP3115598B2 (ru) |
KR (1) | KR100228842B1 (ru) |
AT (1) | ATE169300T1 (ru) |
AU (1) | AU645865B2 (ru) |
CA (1) | CA2093794C (ru) |
DE (1) | DE69129941T2 (ru) |
DK (1) | DK0553263T3 (ru) |
ES (1) | ES2120966T3 (ru) |
FI (1) | FI103045B1 (ru) |
HK (1) | HK1009601A1 (ru) |
HU (2) | HU214874B (ru) |
MX (1) | MX9101543A (ru) |
PT (1) | PT99179B (ru) |
RU (1) | RU2110518C1 (ru) |
SG (1) | SG47809A1 (ru) |
TW (1) | TW200484B (ru) |
WO (1) | WO1992006975A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69218626T2 (de) * | 1991-11-25 | 1997-07-03 | American Home Prod | 1'-amino-2[(benzothiazolyl)methyl] spiro [isochinolin-4(1h), 3'-pyrrolidine]-1,2',3,5'-tetrone und analoge davon verwendbar als aldosereduktase luhibitoren |
US5189168A (en) * | 1991-11-25 | 1993-02-23 | American Home Products Corporation | 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
EP1400244A1 (en) | 2002-09-17 | 2004-03-24 | Warner-Lambert Company LLC | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4200642A (en) * | 1978-08-21 | 1980-04-29 | Pfizer Inc. | Spiro-oxazolidindiones |
IE52879B1 (en) * | 1981-05-12 | 1988-03-30 | Ici Plc | Pharmaceutical spiro-hydantoin derivatives |
US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
JPH0426510A (ja) * | 1990-05-18 | 1992-01-29 | Tonen Corp | 炭素系粒子、その製造方法及びその用途 |
US5068332A (en) * | 1990-10-12 | 1991-11-26 | American Home Products Corporation | Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
-
1990
- 1990-10-12 US US07/596,266 patent/US5102886A/en not_active Expired - Lifetime
-
1991
- 1991-10-08 TW TW080107927A patent/TW200484B/zh active
- 1991-10-09 PT PT99179A patent/PT99179B/pt not_active IP Right Cessation
- 1991-10-10 AT AT91920029T patent/ATE169300T1/de not_active IP Right Cessation
- 1991-10-10 DK DK91920029T patent/DK0553263T3/da active
- 1991-10-10 JP JP03518368A patent/JP3115598B2/ja not_active Expired - Fee Related
- 1991-10-10 DE DE69129941T patent/DE69129941T2/de not_active Expired - Fee Related
- 1991-10-10 HU HU9301042A patent/HU214874B/hu not_active IP Right Cessation
- 1991-10-10 EP EP91920029A patent/EP0553263B1/en not_active Expired - Lifetime
- 1991-10-10 WO PCT/US1991/007473 patent/WO1992006975A1/en active IP Right Grant
- 1991-10-10 RU RU93005013A patent/RU2110518C1/ru not_active IP Right Cessation
- 1991-10-10 ES ES91920029T patent/ES2120966T3/es not_active Expired - Lifetime
- 1991-10-10 KR KR1019930701086A patent/KR100228842B1/ko not_active IP Right Cessation
- 1991-10-10 SG SG1996004510A patent/SG47809A1/en unknown
- 1991-10-10 AU AU89026/91A patent/AU645865B2/en not_active Ceased
- 1991-10-10 CA CA002093794A patent/CA2093794C/en not_active Expired - Fee Related
- 1991-10-11 MX MX9101543A patent/MX9101543A/es unknown
-
1993
- 1993-04-08 FI FI931601A patent/FI103045B1/fi not_active IP Right Cessation
-
1995
- 1995-06-27 HU HU95P/P00451P patent/HU211601A9/hu unknown
-
1998
- 1998-09-04 HK HK98110467A patent/HK1009601A1/xx not_active IP Right Cessation
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