RU93004698A - AMINO-SUBSTITUTED BENZOILGUANIDINES, METHOD FOR THEIR PRODUCTION AND USE - Google Patents
AMINO-SUBSTITUTED BENZOILGUANIDINES, METHOD FOR THEIR PRODUCTION AND USEInfo
- Publication number
- RU93004698A RU93004698A RU93004698/04A RU93004698A RU93004698A RU 93004698 A RU93004698 A RU 93004698A RU 93004698/04 A RU93004698/04 A RU 93004698/04A RU 93004698 A RU93004698 A RU 93004698A RU 93004698 A RU93004698 A RU 93004698A
- Authority
- RU
- Russia
- Prior art keywords
- well
- denotes
- amino
- substituted
- ischemia
- Prior art date
Links
- 206010061255 Ischaemia Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- -1 Amino-substituted benzoylguanidines Chemical class 0.000 claims 1
- 206010002383 Angina pectoris Diseases 0.000 claims 1
- 206010003119 Arrhythmia Diseases 0.000 claims 1
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- AJDQRQQNNLZLPM-UHFFFAOYSA-N N-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000003288 anthiarrhythmic Effects 0.000 claims 1
- 239000003416 antiarrhythmic agent Substances 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000003293 cardioprotective Effects 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000035778 pathophysiological process Effects 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Claims (1)
в которой R (1) или R (2) обозначают амино-группу - R (3)R(4), где R(3) и R(4) обозначают Н, (цикло) - алкил, или R(3) обозначает фенил - (СН2)р - с р = 0,1,2,3 или 4, или фенил, или R(3) и R(4) также вместе могут представлять собой метиленовую цепь; в которой, смотря по обстоятельствам, другой заместитель R(1) или R(2) обозначает Н, F, С1, алкил, алкоксил, CF3, СmF2 m + 1 - СН2-, бензил или фенокси, а также их фармацевтически совместимые соли. Предлагаемые в изобретении соединения обладают очень хорошими антиаритмическими свойствами, например, помогающими при явлениях кислородной недостаточности. Соединения служат в качестве антиаритмических лекарственных средств с кардиозащитной компонентой для профилактики и лечения инфаркта, а также для лечения стенокардии, причем они также предохранительно ингибируют или сильно уменьшают патофизиологические процессы при возникновении ишемически индуцированных повреждений, в особенности при провоцировании ишемически индуцированных аритмий сердца.Amino-substituted benzoylguanidines, method for their preparing, their use as a medicine, as well as a medicine containing them. Benzoylguanidines of the formula I are described:
in which R (1) or R (2) denotes an amino group - R (3) R (4), where R (3) and R (4) denote H, (cyclo) - alkyl, or R (3) denotes phenyl - (CH 2 ) p - with p = 0,1,2,3 or 4, or phenyl, or R (3) and R (4) can also be a methylene chain; in which, depending on the circumstances, the other substituent R (1) or R (2) denotes H, F, C1, alkyl, alkoxy, CF 3 , C m F 2 m + 1 - CH 2 -, benzyl or phenoxy, as well as their pharmaceutically compatible salts. The compounds according to the invention have very good antiarrhythmic properties, for example, which help in the course of oxygen deficiency. The compounds serve as antiarrhythmic drugs with a cardioprotective component for the prevention and treatment of infarction, as well as for the treatment of angina pectoris, and they also inhibit or greatly reduce the pathophysiological processes in the event of ischemia-induced damage, especially in provoking ischemia-induced heart arrhythmias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4204577 | 1992-02-15 | ||
DEP4204577.0 | 1992-02-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93004698A true RU93004698A (en) | 1995-09-27 |
RU2085555C1 RU2085555C1 (en) | 1997-07-27 |
Family
ID=6451809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93004698/04A RU2085555C1 (en) | 1992-02-15 | 1993-02-12 | Amino-substituted benzoylguanidines and method of their synthesis |
Country Status (24)
Country | Link |
---|---|
US (1) | US5364868A (en) |
EP (1) | EP0556672B1 (en) |
JP (1) | JP3321473B2 (en) |
KR (1) | KR100275603B1 (en) |
AT (1) | ATE156485T1 (en) |
AU (1) | AU658261B2 (en) |
CA (1) | CA2089442C (en) |
CZ (1) | CZ284456B6 (en) |
DE (1) | DE59307039D1 (en) |
DK (1) | DK0556672T3 (en) |
ES (1) | ES2104971T3 (en) |
FI (1) | FI930603A (en) |
GR (1) | GR3024731T3 (en) |
HU (1) | HU215851B (en) |
IL (1) | IL104715A (en) |
MA (1) | MA22798A1 (en) |
MX (1) | MX9300784A (en) |
NO (1) | NO302029B1 (en) |
NZ (1) | NZ245896A (en) |
PH (1) | PH30940A (en) |
RO (1) | RO114131B1 (en) |
RU (1) | RU2085555C1 (en) |
TW (1) | TW224455B (en) |
ZA (1) | ZA93986B (en) |
Families Citing this family (35)
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TW250479B (en) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
DE59403818D1 (en) * | 1993-02-20 | 1997-10-02 | Hoechst Ag | Substituted benzoylguanidines, processes for their preparation, their use as medicaments, as inhibitors of cellular Na + / H + exchange or as diagnostic agents and medicaments containing them |
US6190894B1 (en) | 1993-03-19 | 2001-02-20 | The Regents Of The University Of California | Method and compositions for disrupting the epithelial barrier function |
US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4318658A1 (en) * | 1993-06-04 | 1994-12-08 | Hoechst Ag | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them |
DE4318756A1 (en) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them |
DE4325822A1 (en) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them |
DE4337611A1 (en) * | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | New benzoylguanidines, their preparation and their use in medicines |
TW415937B (en) * | 1994-01-25 | 2000-12-21 | Hoechst Ag | Phenyl-substituted alkylcarboxylic acid guanidides bearing perfluoroalkyl groups, process for their preparation, their use as a medicament or diagnostic, and medicament containing them |
DE4404183A1 (en) * | 1994-02-10 | 1995-08-17 | Merck Patent Gmbh | 4-amino-1-piperidylbenzoylguanidine |
DE4412334A1 (en) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituted N-heteroaroylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE4415873A1 (en) * | 1994-05-05 | 1995-11-09 | Hoechst Ag | Substituted bicyclic heteroaroylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them |
DE4421495A1 (en) * | 1994-06-20 | 1995-12-21 | Merck Patent Gmbh | Heterocyclyloxy-benzoylguanidines |
IL114670A0 (en) * | 1994-08-05 | 1995-11-27 | Fujisawa Pharmaceutical Co | Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4430213A1 (en) * | 1994-08-28 | 1996-02-29 | Merck Patent Gmbh | Arylbenzoylguanidine |
DE4430916A1 (en) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl benzoylguanidine derivatives |
DE4430861A1 (en) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidines |
DE4432101A1 (en) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Amino acid-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE4441880A1 (en) * | 1994-11-24 | 1996-05-30 | Hoechst Ag | Substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them |
TW372967B (en) * | 1994-12-27 | 1999-11-01 | Kanebo Ltd | 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof |
DE19527305A1 (en) * | 1995-07-26 | 1997-01-30 | Hoechst Ag | Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament or diagnostic agent and medicament containing them |
EP0765868A1 (en) * | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Substituted bezoyl guanidines, process for their preparation, their use as antiarrhythmics or diagnostic agent as well as pharmaceuticals containing them |
EP0765867A1 (en) * | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Substituted benzoyl guanidines, process for their preparation, their use as antiarrhythmics or diagnostic agent as well as pharmaceuticals containing them |
DE19540995A1 (en) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituted sulfonimidamides, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
DE19542306A1 (en) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
DE19546736A1 (en) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituted chromanylsulfonyl (thio) ureas, process for their preparation and their use in the manufacture of pharmaceutical preparations |
WO1998039300A1 (en) * | 1997-03-06 | 1998-09-11 | Toa Eiyo Ltd. | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME |
DE19737463A1 (en) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the treatment of diseases caused by protozoa |
DE19738604A1 (en) | 1997-09-04 | 1999-03-11 | Hoechst Marion Roussel De Gmbh | Use of Na<+>/H<+> exchange inhibitors |
DE19919349A1 (en) * | 1999-04-28 | 2000-11-02 | Merck Patent Gmbh | Process for the preparation of a benzoylguanidine derivative |
FR2842804B1 (en) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | N- [PHENYL (PIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2861071B1 (en) | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | N- [PHENYL (ALKYLPIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
FR2906251B1 (en) | 2006-09-22 | 2008-11-07 | Sanofi Aventis Sa | PYRROLIZINE, INDOLIZINE AND QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
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US3055882A (en) * | 1959-06-10 | 1962-09-25 | Ciba Geigy Corp | Reduction process for preparation of cyclic nitrogen compounds |
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
US3968243A (en) * | 1970-06-05 | 1976-07-06 | Burroughs Wellcome Co. | Substituted guanidine compounds in the treating of arrythmias |
DE2931735A1 (en) * | 1979-08-04 | 1981-02-19 | Beiersdorf Ag | NEW SUBSTITUTED PHENYLACETYLGUANIDINE AND METHOD FOR THE PRODUCTION THEREOF |
DE3360148D1 (en) * | 1982-02-10 | 1985-06-05 | Beecham Group Plc | Guanidine derivatives |
US5190976A (en) * | 1986-07-10 | 1993-03-02 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And University Of Oregon | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists |
DE3929582A1 (en) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | BENZOYLGUANIDINE, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINE AND THE MEDICINE CONTAINING IT |
US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
ATE139526T1 (en) * | 1992-02-15 | 1996-07-15 | Hoechst Ag | 3,5-SUBSTITUTED BENZOYLGUANIDINE, HAVING ANTIARRYTHMIC ACTION AND INHIBITING EFFECT ON CELL PROLIFERATIONS |
EP0556673B1 (en) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as medicaments containing them |
DK0603650T3 (en) * | 1992-12-16 | 1997-10-20 | Hoechst Ag | 3,5-Substituted aminobenzoylguanidines, their method of preparation, their use as a drug or diagnostic, and drug containing them. |
-
1992
- 1992-12-31 CZ CS924033A patent/CZ284456B6/en unknown
-
1993
- 1993-02-05 ES ES93101840T patent/ES2104971T3/en not_active Expired - Lifetime
- 1993-02-05 DK DK93101840.2T patent/DK0556672T3/en active
- 1993-02-05 TW TW082100767A patent/TW224455B/zh active
- 1993-02-05 EP EP93101840A patent/EP0556672B1/en not_active Expired - Lifetime
- 1993-02-05 DE DE59307039T patent/DE59307039D1/en not_active Expired - Lifetime
- 1993-02-05 AT AT93101840T patent/ATE156485T1/en not_active IP Right Cessation
- 1993-02-11 RO RO93-00173A patent/RO114131B1/en unknown
- 1993-02-11 US US08/016,535 patent/US5364868A/en not_active Expired - Lifetime
- 1993-02-11 FI FI930603A patent/FI930603A/en unknown
- 1993-02-12 AU AU33013/93A patent/AU658261B2/en not_active Ceased
- 1993-02-12 RU RU93004698/04A patent/RU2085555C1/en not_active IP Right Cessation
- 1993-02-12 NO NO930512A patent/NO302029B1/en not_active IP Right Cessation
- 1993-02-12 CA CA002089442A patent/CA2089442C/en not_active Expired - Fee Related
- 1993-02-12 JP JP02310993A patent/JP3321473B2/en not_active Expired - Lifetime
- 1993-02-12 HU HU9300368A patent/HU215851B/en not_active IP Right Cessation
- 1993-02-12 IL IL104715A patent/IL104715A/en not_active IP Right Cessation
- 1993-02-12 NZ NZ245896A patent/NZ245896A/en unknown
- 1993-02-12 ZA ZA93986A patent/ZA93986B/en unknown
- 1993-02-12 PH PH45720A patent/PH30940A/en unknown
- 1993-02-12 MA MA23090A patent/MA22798A1/en unknown
- 1993-02-12 MX MX9300784A patent/MX9300784A/en unknown
- 1993-02-15 KR KR1019930002037A patent/KR100275603B1/en not_active IP Right Cessation
-
1997
- 1997-09-16 GR GR970402375T patent/GR3024731T3/en unknown
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