RU92004549A - HIGHLY DEFINED COLLAGENASE FORMS FOR EXTERNAL APPLICATION - Google Patents

HIGHLY DEFINED COLLAGENASE FORMS FOR EXTERNAL APPLICATION

Info

Publication number
RU92004549A
RU92004549A RU92004549/14A RU92004549A RU92004549A RU 92004549 A RU92004549 A RU 92004549A RU 92004549/14 A RU92004549/14 A RU 92004549/14A RU 92004549 A RU92004549 A RU 92004549A RU 92004549 A RU92004549 A RU 92004549A
Authority
RU
Russia
Prior art keywords
collagenase
forms
external application
highly defined
highly
Prior art date
Application number
RU92004549/14A
Other languages
Russian (ru)
Other versions
RU2129862C1 (en
Inventor
Гарольд Стерн
Давид Йн
Original Assignee
Адвансе Биофактюрес ОФ Кюракао, Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/963,995 external-priority patent/US5393792A/en
Application filed by Адвансе Биофактюрес ОФ Кюракао, Н.В. filed Critical Адвансе Биофактюрес ОФ Кюракао, Н.В.
Publication of RU92004549A publication Critical patent/RU92004549A/en
Application granted granted Critical
Publication of RU2129862C1 publication Critical patent/RU2129862C1/en

Links

Claims (1)

Предлагаемое изобретение представляет собой фармацевтическую композицию для наружного применения, содержащую высокие концентрации ферментной коллагеназы в неводных эксципиентах. Композиция содержит также конкретный эксципиент, декстран, который особенно пригоден для смешивания с коллагеназой и который может также с успехом применяться в сочетании с другими фармацевтически активными материалами.The present invention is a pharmaceutical composition for external use, containing high concentrations of enzyme collagenase in non-aqueous excipients. The composition also contains a specific excipient, dextran, which is particularly suitable for mixing with collagenase and which can also be successfully used in combination with other pharmaceutically active materials.
RU92004549A 1991-11-20 1992-11-19 Pharmaceutical composition for external using, method of treatment of wound or another body state RU2129862C1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US79591591A 1991-11-20 1991-11-20
US07/795915 1991-11-20
US07/795,915 1991-11-20
US07/963995 1992-10-29
US07/963,995 1992-10-29
US07/963,995 US5393792A (en) 1991-11-20 1992-10-29 High dosage topical forms of collagenase

Publications (2)

Publication Number Publication Date
RU92004549A true RU92004549A (en) 1995-02-10
RU2129862C1 RU2129862C1 (en) 1999-05-10

Family

ID=27121667

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92004549A RU2129862C1 (en) 1991-11-20 1992-11-19 Pharmaceutical composition for external using, method of treatment of wound or another body state

Country Status (12)

Country Link
US (3) US5393792A (en)
EP (1) EP0543521B1 (en)
JP (1) JPH0789871A (en)
AT (1) ATE179612T1 (en)
AU (1) AU654881B2 (en)
CA (1) CA2083333C (en)
DE (1) DE69229098T2 (en)
ES (1) ES2130162T3 (en)
HU (1) HUT62802A (en)
RU (1) RU2129862C1 (en)
SI (1) SI9200334A (en)
YU (1) YU98792A (en)

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US6958150B2 (en) 1994-12-15 2005-10-25 Advance Biofactures Of Curacao, N.V. Reduction of adipose tissue
CA2165271C (en) * 1994-12-15 2010-06-29 Edwin H. Wegman Reduction of adipose tissue
DE19503338C2 (en) * 1995-02-02 1998-07-30 Lohmann Therapie Syst Lts Pharmaceutical form for delivering collagenase to wounds and process for their production and their use
US5718897A (en) * 1995-06-07 1998-02-17 Trustees Of Tufts College Enhancing keratinocyte migration and proliferation
US5851522A (en) * 1995-06-07 1998-12-22 Trustees Of Tufts College Enhancing keratinocyte migration
DE19521829A1 (en) * 1995-06-16 1996-12-19 Knoll Ag New use of collagenase
US6086872A (en) * 1997-03-27 2000-07-11 Advance Biofactures Of Curacao, Nv Amelioration of dupuytren's disease
AU3954199A (en) * 1998-06-03 1999-12-20 Hwa Seong Kim Adhesion / fixation / cooling remedies for burn and therapeutic method for relieving burn scar
DE19825794A1 (en) * 1998-06-10 1999-12-16 Knoll Ag Collagenase application form
IL127209A0 (en) * 1998-11-23 1999-09-22 Bio Silk Ltd Composition and method for treatment of hypertrophic skin accumulations and their prevention
US20030198631A1 (en) * 2002-04-18 2003-10-23 Healthpoint, Ltd. Thermolysin enzymatic wound debrider
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US20050220821A1 (en) * 2004-03-31 2005-10-06 Allergan, Inc. Pressure sore treatment
ZA200701233B (en) * 2004-07-13 2008-10-29 Mediwound Ltd Compositions and methods for dermatological wound healing
US20070224184A1 (en) * 2006-02-22 2007-09-27 The Research Foundation Of The State University Of New York Method for treating cellulite
ITPD20050207A1 (en) * 2005-07-07 2007-01-08 Fidia Farmaceutici NEW PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID AND COLLAGENAS IN THE TOPIC TREATMENT OF WOUNDS, BURNS AND ULCERS
CN1935262B (en) * 2005-09-23 2010-12-29 沈阳胜宝康生物制药有限公司 Use of red Nocardia cyto skeleton for preparing anti human papillomavirus medicine
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8323642B2 (en) * 2006-12-13 2012-12-04 Depuy Mitek, Inc. Tissue fusion method using collagenase for repair of soft tissue
US10071143B1 (en) 2007-05-03 2018-09-11 The Research Foundation For The State University Of New York Methods for non-surgical treatment of carpal tunnel syndrome
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
WO2010050980A1 (en) * 2008-10-31 2010-05-06 Laboratory Skin Care, Inc. Topical formulations comprising hydroxyapatite particles for stimulation and maintenance of collagen fibers
ES2613495T3 (en) 2009-12-08 2017-05-24 Smith & Nephew Orthopaedics Ag Enzymatic wound debridement compositions with enhanced enzyme activity
WO2012125948A1 (en) 2011-03-16 2012-09-20 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
NZ766918A (en) 2012-01-12 2023-03-31 Auxilium Int Holdings Inc Clostridium histolyticum enzymes and methods for the use thereof
WO2013125276A1 (en) * 2012-02-21 2013-08-29 株式会社 東芝 X-ray ct device, image display device, and image display method
US9636385B2 (en) 2012-10-24 2017-05-02 The Research Foundation For The State University Of New York Use of collagenase to treat glaucoma
ES2909565T3 (en) 2016-01-31 2022-05-09 Mediwound Ltd Debriding composition for the treatment of wounds
AU2017252085B2 (en) 2016-04-18 2021-09-16 Mediwound Ltd Methods of debridement of chronic wounds
US11123280B2 (en) 2017-03-01 2021-09-21 Endo Ventures Limited Method of assessing and treating cellulite
US11473074B2 (en) 2017-03-28 2022-10-18 Endo Global Aesthetics Limited Method of producing collagenase
US20220362327A1 (en) * 2021-05-13 2022-11-17 Nasser Diab Compositions and methods for wound healing

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CH437641A (en) * 1961-05-30 1967-06-15 Bernburg Serum Werk Veb Process for the production of fat-free ointment bases
US3392161A (en) * 1964-10-15 1968-07-09 Gen Tire & Rubber Co Gel-free halogenated polybutadiene rubber-resins
US3705083A (en) * 1966-07-08 1972-12-05 Agricultural Biolog Corp Process for producing collagenase
US3792161A (en) * 1970-05-18 1974-02-12 Research Corp Burn ointment comprising silver sulfadiazine and collagenase
US3678158A (en) * 1971-05-11 1972-07-18 Worthington Bio Chem Corp Treatment of herniated intervertebral discs of mammals
US4089333A (en) * 1972-10-28 1978-05-16 Nippi, Incorporated Method of treating a wound or burn
US3876501A (en) * 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
US4174389A (en) * 1977-05-13 1979-11-13 Cope Louise A Ophthalmic use of collagenase
US4338300A (en) * 1981-02-05 1982-07-06 The Regents Of The University Of California Use of purified clostridial collangenase in the treatment of Peyronie's disease
US4485088A (en) * 1982-03-26 1984-11-27 Bio-Products, Inc. Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs
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GB2150833B (en) * 1983-12-08 1987-04-15 Ceskoslovenska Akademie Ved Proteolytic wounds dressing
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