RU92004509A - SUBSTITUTED PHENYLPHENOL COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD OF OBTAINING - Google Patents

SUBSTITUTED PHENYLPHENOL COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD OF OBTAINING

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Publication number
RU92004509A
RU92004509A RU92004509/04A RU92004509A RU92004509A RU 92004509 A RU92004509 A RU 92004509A RU 92004509/04 A RU92004509/04 A RU 92004509/04A RU 92004509 A RU92004509 A RU 92004509A RU 92004509 A RU92004509 A RU 92004509A
Authority
RU
Russia
Prior art keywords
obtaining
pharmaceutical composition
substituted
antagonists
leukotriene
Prior art date
Application number
RU92004509/04A
Other languages
Russian (ru)
Other versions
RU2095340C1 (en
Inventor
Ричард Бейкер Стефен
Дилэйн Диллард Роберт
Эдвард Флоренсиг Поль
Скотт Сойер Джейсон
Джозеф София Майкл
Эндри Шмиттлинг Элизабет
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of RU92004509A publication Critical patent/RU92004509A/en
Application granted granted Critical
Publication of RU2095340C1 publication Critical patent/RU2095340C1/en

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Claims (1)

Антагонисты, имеющие замещенные фенилфенольные или замещенные фенольно-дифенильные структуры и их различные производные, являются специфическими антагонистами лейкотриенов. Описано их строение, использование и синтез. Раскрыты также фармацевтические композиции, используемые для лечения заболеваний и состояний, характеризующихся избыточным освобождением лейкотриена B4, одного из метаболитов арахидоновой кислоты. Первичные структуры антагонистов лейкотриена B4 представлены формулой:
Figure 00000001

в которой R1, R2, R3, R4, X, Y, Z и A подробно охарактеризованы в описании к заявке на изобретение. Изобретение предусматривает также способ получения промежуточных соединений формулы.Antagonists having substituted phenylphenol or substituted phenol-diphenyl structures and their various derivatives are specific leukotriene antagonists. Their structure, use and synthesis are described. Pharmaceutical compositions used to treat diseases and conditions characterized by the excessive release of leukotriene B 4 , one of the arachidonic acid metabolites, are also disclosed. The primary structures of leukotriene B 4 antagonists are represented by the formula:
Figure 00000001

in which R 1 , R 2 , R 3 , R 4 , X, Y, Z and A are described in detail in the description of the application for invention. The invention also provides a method for preparing intermediates of the formula.
RU9292004509A 1991-11-25 1992-11-24 Substituted phenyl phenol compounds, pharmaceutically acceptable salts thereof, intermediate compounds, and pharmaceutical composition RU2095340C1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US79764691A 1991-11-25 1991-11-25
US79752291A 1991-11-25 1991-11-25
US07/797.646 1991-11-25
US07/797.522 1991-11-25
US07/797522 1991-11-25
US07/797646 1991-11-25

Publications (2)

Publication Number Publication Date
RU92004509A true RU92004509A (en) 1995-03-27
RU2095340C1 RU2095340C1 (en) 1997-11-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU9292004509A RU2095340C1 (en) 1991-11-25 1992-11-24 Substituted phenyl phenol compounds, pharmaceutically acceptable salts thereof, intermediate compounds, and pharmaceutical composition

Country Status (22)

Country Link
EP (1) EP0544488B1 (en)
JP (1) JP3417582B2 (en)
KR (1) KR100266893B1 (en)
AT (1) ATE163914T1 (en)
AU (1) AU658023B2 (en)
BR (1) BR9204527A (en)
CA (1) CA2083639C (en)
CZ (2) CZ280133B6 (en)
DE (1) DE69224708T2 (en)
DK (1) DK0544488T3 (en)
ES (1) ES2116324T3 (en)
FI (1) FI925330A (en)
GR (1) GR3026749T3 (en)
HU (2) HU222486B1 (en)
IL (3) IL116942A (en)
MX (1) MX9206746A (en)
MY (1) MY141472A (en)
NO (1) NO180044C (en)
RU (1) RU2095340C1 (en)
TW (1) TW232684B (en)
YU (2) YU49008B (en)
ZA (1) ZA929051B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
ES2079997A1 (en) * 1993-06-15 1996-01-16 Lilly Co Eli Leucotriene-antagonist substituted phenyl phenol compounds, process for their preparation and pharmaceutical formulations thereof
CA2198752A1 (en) 1994-08-31 1996-03-07 Jason Scott Sawyer Methods for identifying and treating resistant tumors
US5543428A (en) * 1994-08-31 1996-08-06 Eli Lilly And Company Method for treating resistant tumors
EP0743064A1 (en) * 1995-05-17 1996-11-20 Eli Lilly And Company Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease
UA47505C2 (en) * 1996-12-13 2002-07-15 Елі Ліллі Енд Компані A method for treatment a flat-cell cancer of mouth cavity by means of leicotrien antagonists
CZ290693B6 (en) 1998-06-19 2002-09-11 Vúfb, A. S. Derivatives of hydroxyphenyl mercaptobenzoic and hydroxyphenyl mercaptoarylacetic acids exhibiting anti-leukotriene activity
CA2388479A1 (en) 1999-10-22 2001-05-03 Shionogi & Co., Ltd. Preventives or remedies for arrhythmia
CN1387518A (en) * 1999-11-11 2002-12-25 伊莱利利公司 Heterocyclic substd, diphenyl leukotriene antagonists
US6797723B1 (en) 1999-11-11 2004-09-28 Eli Lilly And Company Heterocycle substituted diphenyl leukotriene antagonists
WO2001034197A2 (en) * 1999-11-11 2001-05-17 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
MXPA03002694A (en) * 2000-09-26 2003-06-24 Tanabe Seiyaku Co 5-phenylbenzylamine compounds, process for their production and intermediates for their synthesis.
US6921752B2 (en) 2002-03-26 2005-07-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of LTB4 antagonists in veterinary medicine
DE10213350A1 (en) * 2002-03-26 2003-10-16 Boehringer Ingelheim Pharma Use of LTB¶4¶ antagonists in veterinary medicine
EP1790338A4 (en) * 2004-09-13 2007-12-12 Santen Pharmaceutical Co Ltd Therapeutic agent for keratoconjunctiva disorder
EP2272817A4 (en) * 2008-04-11 2011-12-14 Inst Med Molecular Design Inc Pai-1 inhibitor
US20110112193A1 (en) * 2008-05-14 2011-05-12 Peter Nilsson Bis-aryl compounds for use as medicaments
US8088936B2 (en) * 2009-03-23 2012-01-03 Hoffman-La Roche Inc. Leukotriene B4 inhibitors
BR112012020603A2 (en) * 2010-02-25 2017-07-11 Colgate Palmolive Co synthesis of magnolol and its analogous compounds.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives
US3755603A (en) * 1970-07-01 1973-08-28 Syntex Corp Biphenylyloxyacetic acids in pharmaceutical compositions
ES494769A0 (en) * 1979-09-05 1981-07-16 Glaxo Group Ltd A PROCEDURE FOR THE PRE-PARATION OF PHENOXIALCOXIFENIL- DERIVATIVES.
ES537023A0 (en) * 1983-10-27 1985-12-01 Merck Frosst Canada Inc A PROCEDURE FOR THE PREPARATION OF NEW LEUCOTRENE ANTAGONISTS.

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