RU42750U1 - DEVICE FOR DOSED SUBMISSION OF SUBSTANCES - Google Patents
DEVICE FOR DOSED SUBMISSION OF SUBSTANCESInfo
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- RU42750U1 RU42750U1 RU2004123193/22U RU2004123193U RU42750U1 RU 42750 U1 RU42750 U1 RU 42750U1 RU 2004123193/22 U RU2004123193/22 U RU 2004123193/22U RU 2004123193 U RU2004123193 U RU 2004123193U RU 42750 U1 RU42750 U1 RU 42750U1
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Abstract
Полезная модель относится к устройствам, используемым в физиологии, биохимии и экспериментальной медицине. Предложено устройство для дозированной подачи и забора веществ, содержащее двигатель, редуктор, микровинт с толкателем, держатель микрошприцев, планку крепления поршней микрошприцев и органы управления устройством, особенность которого состоит в том, что устройство снабжено муфтой для жесткого сочленения микровинта и толкателя поршней микрошприцев, причем передний конец толкателя подвижно соединен с планкой крепления поршней микрошприцев посредством подшипника, а задний конец толкателя выполнен в виде конуса, при этом планка крепления поршней микрошрицев снабжена ограничительными выступами с возможностью ее перемещения по направляющим пазам, выполненных на верхней панели корпуса устройства. Предложенное устройство обеспечивает дозированную плавную подачу веществ за счет введения электронной схемой управления скоростью вращения вала двигателя, выполненной на тринисторах. Устройство обеспечивает точный временной и визуальный контроль за объемом введенного вещества за счет того, что в электронную схему устройства включено реле времени, запускаемое автоматически с помощью кнопки, расположенной на панели управления, а держатель микрошприцев выполнен из прозрачного материала и оснащен системой подсвета шкалы микрошприцев.The utility model relates to devices used in physiology, biochemistry and experimental medicine. A device for the metered supply and intake of substances is proposed, comprising an engine, a gearbox, a microscrew with a pusher, a micro-syringe holder, a strap for attaching micro-syringe pistons and device controls, a feature of which is that the device is equipped with a coupling for rigidly connecting the micro-screw and pusher of micro-syringe pistons, moreover the front end of the pusher is movably connected to the mounting plate of the pistons of the micro syringes by means of a bearing, and the rear end of the pusher is made in the form of a cone, while the strap is stronger Ia pistons mikroshritsev restrictive projections provided with the ability to move along the guide grooves formed on the top panel of the unit case. The proposed device provides a dosed smooth flow of substances due to the introduction of an electronic circuit to control the speed of rotation of the motor shaft, made on trinistors. The device provides accurate time and visual control over the volume of the injected substance due to the fact that a time relay is activated in the electronic circuit of the device, which starts automatically using the button located on the control panel, and the micro-syringe holder is made of transparent material and equipped with a micro-syringe scale backlight system.
Description
Полезная модель относится к устройствам, используемым в физиологии, биохимии и экспериментальной медицине.The utility model relates to devices used in physiology, biochemistry and experimental medicine.
Известны устройства для ручной подачи химических и фармакологических веществ, содержащие микровинт с толкателем, держатель микрошприцев, планку крепления поршней микрошприцев и органы управления устройством (Swanson, Perez, Sharpe 1972; Veregge, Frost 1985).Known devices for the manual supply of chemical and pharmacological substances, containing a microscrew with a pusher, a holder for micro-syringes, a bar for attaching pistons for micro-syringes and device controls (Swanson, Perez, Sharpe 1972; Veregge, Frost 1985).
Известны также аналогичные микроинъекторы, снабженные двигателем и механическим редуктором, позволяющие ступенчато изменять скорость движения поршней микрошприцев (Stoelting 1995: прототип устройства). Similar microinjectors are also known, equipped with an engine and a mechanical gearbox, allowing stepwise changes in the speed of movement of the pistons of microsyringes (Stoelting 1995: prototype device).
Указанные устройства имеют следующие недостатки:These devices have the following disadvantages:
1. Устройства не позволяют наряду с инъекцией веществ осуществлять забор исследуемого вещества, например биологической жидкости (диализата) из тестируемого организма.1. The devices do not allow, along with the injection of substances, to take the test substance, for example, biological fluid (dialysate) from the test organism.
2. Конструкция указанных устройств не позволяет исключить возможности передачи вращательного движения на поршень микрошприца, что может приводить к нагреву микрошприца и вводимого вещества и/или нарушению герметичности шприца.2. The design of these devices does not exclude the possibility of transmitting rotational motion to the piston of the microsyringe, which can lead to heating of the microsyringe and the injected substance and / or violation of the tightness of the syringe.
3. Устройства не обеспечивают возможности плавного изменения скорости подачи веществ в процессе опыта.3. Devices do not provide the possibility of a smooth change in the feed rate of substances in the experiment.
4. Устройства не обеспечивают оптимальных условий для визуального контроля за объемом введенного вещества.4. The devices do not provide optimal conditions for visual monitoring of the volume of the injected substance.
5. Устройства не обеспечивают автоматизированного введения заданного объема вещества в течение определенного промежутка времени. 5. Devices do not provide automated introduction of a given volume of a substance over a certain period of time.
Цель предлагаемой полезной модели заключается в повышении точности подачи веществ при расширении класса решаемых устройством задач. The purpose of the proposed utility model is to increase the accuracy of the supply of substances while expanding the class of tasks solved by the device.
Сущность заявляемого устройства для дозированной подачи веществ, содержащего двигатель, редуктор, микровинт с толкателем, держатель микрошприцев, The essence of the inventive device for a metered supply of substances containing an engine, gearbox, microscrew with a pusher, a holder of microsyringes,
планку крепления поршней микрошприцев и органы управления устройством заключается в том, что устройство снабжено муфтой для жесткого сочленения микровинта и толкателя поршней микрошприцев, причем передний конец толкателя подвижно соединен с планкой крепления поршней микрошприцев посредством подшипника, а задний конец толкателя выполнен в виде конуса, при этом планка крепления поршней микрошрицев снабжена ограничительными выступами с возможностью ее перемещения по направляющим пазам, выполненных на верхней панели корпуса устройства.the mounting bracket of the micro-syringe pistons and the device controls include the fact that the device is equipped with a sleeve for rigidly connecting the micro-screw and the pusher of the micro-syringe pistons, the front end of the plunger being movably connected to the mounting plate of the micro-syringe pistons by means of a bearing, and the rear end of the plunger is made in the form of a cone the mounting plate of the microspindle pistons is equipped with restrictive protrusions with the possibility of its movement along the guide grooves made on the top panel of the device casing a.
Сущность устройства состоит также в том, что устройство снабжено электронной схемой управления скоростью вращения вала двигателя, выполненной на тринисторах.The essence of the device also lies in the fact that the device is equipped with an electronic circuit for controlling the speed of rotation of the motor shaft, made on trinistors.
Сущность устройства состоит также в том, что держатель микрошприцев выполнен из прозрачного материала и оснащен системой подсвета шкал микрошприцев. The essence of the device also lies in the fact that the holder of the micro-syringes is made of transparent material and is equipped with a backlight system for the scales of micro-syringes.
Сущность устройства состоит также в том, что в состав электронной схемы устройства включено реле времени с органами управления для автоматизированного введения заданного объема вещества.The essence of the device also lies in the fact that the electronic circuit of the device includes a time relay with controls for the automated introduction of a given volume of substance.
На Фиг.1 изображена оптико-кинематическая схема устройства, гдеFigure 1 shows the optical-kinematic diagram of the device, where
1 - двигатель1 - engine
2 - микровинт2 - microscrew
3 - толкатель3 - pusher
4 - сквозное отверстие корпуса микровинта4 - through hole of the micro-screw housing
5 - шкив редуктора5 - gear pulley
6 - пассик6 - passik
7 - микрошприц7 - microsyringe
8 - планка крепления поршней микрошприцев8 - mounting plate of the pistons of the microsyringe
9 - подшипник9 - bearing
10 - коническая часть толкателя10 - conical part of the pusher
11 - проточки микровинта и задней части толкателя11 - grooves of the microscrew and the rear of the pusher
12 - муфта12 - coupling
13 - ограничительные упоры планки крепления поршней микрошприцев13 - restrictive stops of the mounting plate of the pistons of the micro syringes
14 - держатель микрошприцев14 - the holder of the microsyringe
15 - прижимная планка15 - clamping plate
16 - лампа подсвета шкалы микрошприцев16 - a lamp of illumination of a scale of microsyringes
17 - кожух лампы подсвета 17 - backlight cover
На фиг.2 показана принципиальная электронная схема устройства, гдеFigure 2 shows a schematic electronic circuit of the device, where
18 - 5-диапазонный регулятор скорости подачи веществ (выделен пунктиром),18 - 5-range regulator of the speed of supply of substances (highlighted by a dotted line),
19 - регулятор мощности на тринисторах (выделен пунктиром). Применение регулятора мощности на тринисторах дает удобную возможность управлять скоростью вращения асинхронных двигателей с сетевым питанием, мощность которых достаточна для привода передаточной системы поршней микрошприцев и создания необходимого избыточного давления для инъекции веществ. Низкое напряжение управляющего сигнала позволило осуществить ступенчатое и плавное изменение скорости вращения вала двигателя с помощью делителя напряжения, собранного на многооборотных прецизионных потенциометрах и тем самым значительно повысить точность регулировки скорости подачи веществ. Реле времени включено в электронную схему устройства через гнезда РВ. 19 - power regulator on trinistors (highlighted by a dotted line). The use of a power regulator on trinistors provides a convenient opportunity to control the speed of rotation of asynchronous motors with mains supply, the power of which is sufficient to drive the transmission system of micro-syringe pistons and create the necessary excess pressure for the injection of substances. The low voltage of the control signal allowed for a stepwise and smooth change in the speed of rotation of the motor shaft using a voltage divider assembled on multi-turn precision potentiometers and thereby significantly increase the accuracy of adjusting the feed rate of substances. The time relay is included in the electronic circuit of the device through the RV sockets.
На фиг.3 изображен общий вид устройства в собранном виде, гдеFigure 3 shows a General view of the device in assembled form, where
20 - направляющие пазы20 - guide grooves
21 - кожух редуктора двигателя21 - a casing of a reducer of the engine
На передней панели устройства расположены органы управления устройством.The device’s controls are located on the front of the device.
На фиг.1 и 3 показана конструкция устройства, содержащее двигатель 1, микровинт 2 с толкателем 3, закрепленным с возможностью передвижения в сквозном отверстии 4 корпуса микровинта и редуктором, состоящим из сменных шкивов 5, связанных пассиком 6 и сидящих на валу двигателя 1 и штоке микровинта 2, и микрошприцев 7. Передний конец толкателя 3 подвижно соединен с планкой 8 крепления поршней микрошприцев 7 посредством подшипника 9, а задний конец толкателя выполнен в виде конуса 10, при этом на штоке микровинта 2 и заднем конце толкателя сделаны посадочные проточки 11 для установки муфты 1 and 3 show the design of the device containing the engine 1, a microscrew 2 with a pusher 3, mounted with the possibility of movement in the through hole 4 of the microscrew housing and a gearbox consisting of interchangeable pulleys 5 connected by a passer 6 and sitting on the shaft of the engine 1 and the rod microscrew 2, and microsyringe 7. The front end of the pusher 3 is movably connected to the plate 8 of the pistons of the microsyring 7 by means of the bearing 9, and the rear end of the pusher is made in the form of a cone 10, while on the rod of the microscrew 2 and the rear end of the pusher ny grooves 11 for installation of the coupling
12 в виде втулки с штифтами (на схеме показана пунктиром), которая обеспечивает возможность их жесткого сочленения. Планка 7 крепления поршней микрошприцев снизу имеет ограничительные выступы 13 с возможностью ее перемещения по направляющим пазам, выполненных на верхней панели корпуса устройства. Микрошприцы 7 размещены в ложах на верхней грани держателя 14 микрошприцев, выполненном из бруска прозрачного оргстекла, и закреплены с помощью прижимных планок 15. На задней стенке держателя установлена лампа 16 для подсвета шкалы микрошприцев, закрытая светонепроницаемым кожухом 17. Верхняя грань держателя 14 микрошприцев выполнена матовой, а остальные грани - полированными для отражения от них лучей лампы 16, последующим их рассеиванием на верхней матовой грани держателя и равномерным подсветом шкалы микрошприцев. 12 in the form of a sleeve with pins (dotted in the diagram), which makes it possible to rigidly join them. The bottom 7 of the mounting of the pistons of the microsyring from the bottom has restrictive protrusions 13 with the possibility of its movement along the guide grooves made on the upper panel of the device. Micro syringes 7 are placed in the boxes on the upper face of the micro syringe holder 14, made of a transparent plexiglass bar, and are fixed with clamping strips 15. A lamp 16 is installed on the back wall of the holder to illuminate the micro syringe scale, closed by a lightproof casing 17. The upper face of the micro syringe holder 14 is made opaque and the remaining faces are polished to reflect the rays of the lamp 16 from them, their subsequent dispersion on the upper matte face of the holder and uniform illumination of the micro syringe scale.
Устройство работает следующим образом (см. фиг.1, 2, 3):The device operates as follows (see figures 1, 2, 3):
Рабочими органами управления устройством являются: тумблер включения питания S1 «вкл»; кнопка S7 «подсвет шкалы»; кнопочный переключатель S2-S6 диапазонов скоростей (5 положений); ручки потенциометров плавной регулировки скорости подачи R15-R19; кнопка включения реле времени S11 «авто»; ручка установки параметров времени инъекции «реле»; тумблер обратного хода штока микровинта S9 «реверс».The device’s working controls are: power switch S1 “on”; S7 button “backlight of the scale”; button switch S2-S6 speed ranges (5 positions); potentiometer knobs for infinitely variable feed rate R15-R19; button to turn on the time switch S11 "auto"; knob for setting the parameters of the “relay” injection time; S9 micro-screw reverse reverse toggle switch.
Инъекцию веществ производят в следующем порядке: заполняют канюлю, соединительный трубопровод и выбранный микрошприц (1, 10, 50 мкл) требуемым препаратом или буферным веществом; проверяют стыковку передаточных звеньев привода поршня микрошприца и отсутствие сочленяющей их муфты; выбирают необходимую скорость подачи вещества (при необходимости устанавливают на валу двигателя и оси микровинта шкивы с нужным коэффициентом редукции); вводят канюлю в исследуемый объект; включают тумблер питания S1; нажатием на выбранную клавишу переключателя S2-S6 запускают процесс подачи вещества. Экспериментатору следует помнить, что потенциометры R15-R19 позволяет также плавно регулировать скорость подачи веществ в ходе опыта.Injection of substances is carried out in the following order: fill the cannula, the connecting pipe and the selected microsyringe (1, 10, 50 μl) with the required preparation or buffer substance; check the coupling of the transmission links of the piston of the microsyringe and the absence of a coupling coupling them; select the required feed rate of the substance (if necessary, set pulleys with the desired reduction coefficient on the motor shaft and the axis of the micro-screw); introduce a cannula into the test object; include power switch S1; by pressing the selected switch button S2-S6, the substance supply process is started. The experimenter should remember that the potentiometers R15-R19 also allow you to smoothly control the feed rate of substances during the experiment.
Контроль за объемом введенного препарата осуществляется по шкале микрошприца путем включения кнопки подсвета S7. Система подсвета микрошприцев также обеспечивает визуальный контроль процесса точного (без воздушных пузырьков) заполнения микрошприпев и соединительного трубопровода при подготовке к работе с устройством. Для окончания процесса подачи вещества фиксированную клавишу переключателя S2-S6 возвращают в исходное положение. Для осуществления забора тестируемого вещества производят установку муфты, обеспечивающую жесткое сочленения микровинта и толкателя поршней микрошприцев. Направление вращения вала двигателя определяется положением тумблера S9. При необходимости подачи, или забора веществ в автоматическом режиме, а также в условиях длительного введения препарата контроль за временем подачи вещества осуществляет реле времени, подключенное к соответствующим гнездам устройства. Запуск реле производится автоматически путем нажатия кнопки S 11. Monitoring the volume of the injected drug is carried out on the scale of the microsyringe by turning on the backlight button S7. The micro-syringe illumination system also provides visual control of the process of precise (without air bubbles) filling the micro-sprays and the connecting pipe in preparation for working with the device. To complete the supply process, the fixed key of the switch S2-S6 is returned to its original position. To carry out the sampling of the test substance, a coupling is installed that provides a rigid joint of the microscrew and the piston pusher of the microsyringes. The direction of rotation of the motor shaft is determined by the position of the toggle switch S9. If it is necessary to supply or withdraw substances in automatic mode, as well as in conditions of prolonged administration of the drug, the time relay of the substance is controlled by a time relay connected to the corresponding sockets of the device. The relay starts automatically by pressing the S 11 button.
ПРЕИМУЩЕСТВА ПОЛЕЗНОЙ МОДЕЛИADVANTAGES OF A USEFUL MODEL
1. Устройство позволяет, наряду с инъекцией веществ, осуществлять забор исследуемого вещества, например биологической жидкости (диализата) тестируемого объекта. Указанное преимущество достигается за счет установки муфты, обеспечивающей режим жесткого сочленения микровинта и толкателя поршней микрошприцев.1. The device allows, along with the injection of substances, to take the test substance, for example biological fluid (dialysate) of the test object. This advantage is achieved through the installation of the coupling, providing a rigid joint of the microscrew and pusher piston microsyringe.
2. Устройство позволяет блокировать возможность передачи вращательного движения на поршень микрошприца, что исключает возможность нагрева микро-шприца и вводимого вещества и/или нарушение герметичности шприца. Указанное преимущество достигается за счет того, что задний конец толкателя выполнен в виде конуса, передний конец толкателя подвижно соединен с планкой крепления поршней микрошприцев посредством подшипника, а планка крепления поршней микрошрицев снабжена ограничительными выступами с возможностью прямолинейного перемещения по направляющим пазам, выполненных на верхней панели корпуса устройства.2. The device allows you to block the possibility of transmitting rotational motion to the piston of the microsyringe, which eliminates the possibility of heating the micro-syringe and the injected substance and / or violation of the tightness of the syringe. This advantage is achieved due to the fact that the rear end of the pusher is made in the form of a cone, the front end of the pusher is movably connected to the fastening plate of the micro syringe pistons by means of a bearing, and the fastening plate of the micro syringe pistons is provided with restrictive protrusions with the possibility of rectilinear movement along guide grooves made on the upper panel of the housing devices.
3. Устройство обеспечивает возможность плавного изменения скорости 3. The device provides the ability to smoothly change speed
подачи веществ в ходе опыта. Укачанное преимущество достигается за счет того. что устройство снабжено электронной схемой управления скоростью вращения вала двигателя, выполненной на тринисторах.supply of substances during the experiment. The specified advantage is achieved due to the fact. that the device is equipped with an electronic circuit for controlling the speed of rotation of the motor shaft, made on trinistors.
4. Устройство обеспечивает возможность автоматизированного введения заданного объема вещества в течение определенного промежутка времени. Указанное преимущество достигается за счет включения в электронную схему устройства реле времени, запускаемою автоматически с помощью кнопки, расположенной на панели управления устройством.4. The device provides the ability to automatically introduce a given volume of a substance over a certain period of time. This advantage is achieved by including a time relay in the electronic circuitry of the device, which is started automatically using the button located on the device control panel.
5. Устройство обеспечивает оптимальные условия для визуального контроля за объемом введенного вещества. Указанное преимущество достигается за счет того, что держатель микрошприцев выполнен из прозрачного материала и оснащен безартефактной системой подсвета шкалы микрошприцев.5. The device provides optimal conditions for visual control of the volume of the injected substance. This advantage is achieved due to the fact that the holder of the micro syringes is made of a transparent material and is equipped with an artifact-free illumination system for the scale of the micro syringes.
6. Устройство экономично, несложно в изготовлении и настройке и отличается высокой надежностью в эксплуатации. Указанное преимущество достигается за счет разработки оригинальных оптико-механической и электронной схем устройства, оптимально адаптированных к применению недорогих и доступных элементов, выпускаемых отечественной промышленностью.6. The device is economical, easy to manufacture and configure, and is highly reliable in operation. This advantage is achieved through the development of original optical-mechanical and electronic circuits of the device, optimally adapted to the use of inexpensive and affordable elements manufactured by the domestic industry.
ИСТОЧНИКИ ИНФОРМАЦИИSOURCES OF INFORMATION
1. Swanson L.W., Perez V.J., Sharpe L.G. Accurate and reliable intracerebral delivery of minute volumes of drug solutions. J. of Appl. Physiol, 1972, 33, pp.247-249.1. Swanson L.W., Perez V.J., Sharpe L.G. Accurate and reliable intracerebral delivery of minute volumes of drug solutions. J. of Appl. Physiol, 1972, 33, pp. 247-249.
2. Stoelting Crp. Catalogue. Motorized microsyringe pump. 1995, p.26. (прототип)2. Stoelting Crp. Catalog Motorized microsyringe pump. 1995, p. 26. (prototype)
3. Veregge S., Frost J.D. A simple, inexpensive, hydraulic microdrive for recording neo-cortical unit activity in the rats. EEC & Clin. NeurophysioL, 1985, 61, pp.94-97.3. Veregge S., Frost J.D. A simple, inexpensive, hydraulic microdrive for recording neo-cortical unit activity in the rats. EEC & Clin. NeurophysioL, 1985, 61, pp. 94-97.
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