RU2332999C2 - Терапевтические способы и применения сапогенинов и их производных - Google Patents

Терапевтические способы и применения сапогенинов и их производных Download PDF

Info

Publication number: RU2332999C2
Authority: RU; Russia
Prior art keywords: pharmaceutically acceptable; acceptable salts; glucose; disease; smilagenin
Prior art date: 2002-03-27

Application number

RU2004130281/15A

Other languages

English (en)

Russian (ru)

Other versions

RU2004130281A (ru

Inventor

Дарэл РИС

Фил Ганнинг

Антония Орси

Зонгкин Ксиа

Яар ХУ

Original Assignee

ФИТОФАРМ ПиЭлСи

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-27

Filing date

2003-03-27

Publication date

2008-09-10

2002-03-27 Priority claimed from ARP020101170A external-priority patent/AR033079A1/es

2003-03-27 Application filed by ФИТОФАРМ ПиЭлСи filed Critical ФИТОФАРМ ПиЭлСи

2006-01-20 Publication of RU2004130281A publication Critical patent/RU2004130281A/ru

2008-09-10 Application granted granted Critical

2008-09-10 Publication of RU2332999C2 publication Critical patent/RU2332999C2/ru

Links

NOSFTSSSIWJODY-UUTDFIMUSA-N CC(C[C@@H](CC1)C(C)=C)[C@@]1(C)[C@H](CC1)C[C@@H](C2)[C@@]1(C)[C@H]1[C@@H]2NCC1 Chemical compound CC(C[C@@H](CC1)C(C)=C)[C@@]1(C)[C@H](CC1)C[C@@H](C2)[C@@]1(C)[C@H]1[C@@H]2NCC1 NOSFTSSSIWJODY-UUTDFIMUSA-N 0.000 description 1

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Catalysts (AREA)

RU2004130281/15A 2002-03-27 2003-03-27 Терапевтические способы и применения сапогенинов и их производных RU2332999C2 (ru)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
ARP020101170A AR033079A1 (es)	2001-03-28	2002-03-27	Derivados de sapogeninas, sintesis y uso, y metodos en base a su uso
ARP020101170		2002-03-27
US36817802P	2002-03-28	2002-03-28
GBPCT/GB02/01578		2002-03-28
PCT/GB2002/001578 WO2002079221A2 (en)	2001-03-28	2002-03-28	Sapogenin derivatives, their synthesis and use
US60/368178		2002-03-28

Publications (2)

Publication Number	Publication Date
RU2004130281A RU2004130281A (ru)	2006-01-20
RU2332999C2 true RU2332999C2 (ru)	2008-09-10

Family

ID=30001210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU2004130281/15A RU2332999C2 (ru)	2002-03-27	2003-03-27	Терапевтические способы и применения сапогенинов и их производных

Country Status (10)

Country	Link
KR (1)	KR20100093621A (zh)
CN (1)	CN1642558B (zh)
AT (1)	ATE424211T1 (zh)
IL (1)	IL164161A0 (zh)
NZ (2)	NZ547897A (zh)
PE (1)	PE20040306A1 (zh)
PL (1)	PL213697B1 (zh)
RU (1)	RU2332999C2 (zh)
TW (1)	TWI329016B (zh)
WO (1)	WO2003082893A2 (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6861788B2 (en) *	2003-06-03	2005-03-01	Motorola, Inc.	Switchable display/mirror method and apparatus
FR2868700B1 (fr) *	2004-04-09	2008-09-26	Michel Coisy	Utilisation de la dopamine ou de ses precurseurs biologiques contre l'algoneurodystrphie.
GB0409567D0 (en)	2004-04-28	2004-06-02	Phytopharm Plc	Chemical compounds
GB0424528D0 (en) *	2004-11-05	2004-12-08	Phytopharm Plc	Chemical compounds
WO2007049932A1 (en)	2005-10-28	2007-05-03	Sun-Yeou Kim	Extract of the family dioscoreaceae and composition for preventing or treating peripheral neuropathy comprising the same
WO2010084356A1 (en)	2009-01-24	2010-07-29	Phytopharm Plc	Treatment of neurotrophic factor mediated disorders
CA2805693A1 (en)	2010-07-20	2012-01-26	Phytopharm Plc	Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
LT2753632T (lt)	2011-09-08	2023-07-10	Sage Therapeutics, Inc.	Neuroaktyvieji steroidai, jų kompozicijos ir naudojimas
CU20110244A7 (es) *	2011-12-27	2013-08-29	Ct De Investigación Y Desarrollo De Medicamentos Cidem	Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
US11319338B2 (en)	2012-04-03	2022-05-03	Goldporp Pharma Limited	Timosaponin compounds
CN105246486B (zh)	2013-03-13	2020-11-03	萨奇治疗股份有限公司	神经活性甾类化合物
CN103232520A (zh) *	2013-05-13	2013-08-07	中国药科大学	一种螺甾类化合物、其制备方法及医药用途
EP3157528B1 (en)	2014-06-18	2023-09-13	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
MA42409A (fr)	2015-07-06	2018-05-16	Sage Therapeutics Inc	Oxystérols et leurs procédés d'utilisation
ES2884086T3 (es)	2015-07-06	2021-12-10	Sage Therapeutics Inc	Oxisteroles y sus procedimientos de uso
RS61718B1 (sr)	2015-07-06	2021-05-31	Sage Therapeutics Inc	Oksisteroli i postupci za njihovu upotrebu
RS63280B1 (sr)	2016-04-01	2022-06-30	Sage Therapeutics Inc	Oksisteroli i postupci za njihovu upotrebu
US10752653B2 (en)	2016-05-06	2020-08-25	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
PL3481846T3 (pl)	2016-07-07	2021-12-20	Sage Therapeutics, Inc.	11-podstawione 24-hydroksysterole do stosowania w leczeniu stanów związanych z NMDA
MA46351A (fr)	2016-09-30	2021-06-02	Sage Therapeutics Inc	Oxystérols substitués en c7 et procédés en tant que modulateurs nmda
RU2019115112A (ru)	2016-10-18	2020-11-24	Сейдж Терапьютикс, Инк.	Оксистеролы и способы их применения
IL266093B2 (en)	2016-10-18	2024-02-01	Sage Therapeutics Inc	Oxysterols and methods of using them
CN108264535A (zh)	2016-12-30	2018-07-10	中国科学院上海药物研究所	一种抗抑郁化合物及其制备方法和应用
RU2635485C1 (ru) *	2017-03-21	2017-11-13	Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации	Способ лечения атрофии зрительного нерва после черепно-мозговой травмы
CN109988218B (zh) *	2017-12-29	2022-11-25	中国科学院上海药物研究所	一种菝葜皂苷元衍生物及其制备方法和应用
EP3572085A1 (en) *	2018-05-25	2019-11-27	Neuro-Sys	Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound
CN112457362B (zh) *	2019-09-06	2023-09-19	上海青东生物科技有限公司	一种卤代四环三萜衍生物及其制备与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3416112A1 (de) *	1984-04-30	1985-10-31	Roecar Holdings (Netherlands Antilles) N.V., Willemstad, Curacao, Niederländische Antillen	Verwendung von sterolinen und spiroketalinen als lipoxygenaseregulatoren
US4680289A (en) *	1985-06-05	1987-07-14	Progenics, Inc.	Treatment of obesity and diabetes using sapogenins
JPH05246866A (ja) *	1992-03-06	1993-09-24	Ruibosuteii Japan:Kk	脳代謝促進・脳機能改善剤
DE4303214A1 (de) *	1993-02-04	1994-08-11	Wolfgang Marks	Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone
TW479061B (en) *	1993-12-24	2002-03-11	Mitsubishi Chem Corp	Sialic acid derivatives
JPH092956A (ja) *	1995-06-22	1997-01-07	Mitsubishi Chem Corp	神経障害の治療、予防薬
JPH092957A (ja) *	1995-06-22	1997-01-07	Mitsubishi Chem Corp	末梢性神経障害の治療、予防薬
US6046185A (en) *	1996-07-11	2000-04-04	Inflazyme Pharmaceuticals Ltd.	6,7-oxygenated steroids and uses related thereto
CN1131237C (zh) *	1997-09-26	2003-12-17	中国人民解放军军事医学科学院放射医学研究所	甾体皂甙防治老年性痴呆的用途及新的甾体皂甙
BR9909110A (pt) *	1998-03-26	2000-12-12	Phytopharm Plc	Usos de esmilagenina e anzurogenina d, compoisção farmacêutica tendo propriedades intensificadoras da função cognitiva, processo para intensificar a função cognitiva, e, composição para uso do mesmo
GB9923076D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
GB9923078D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
GB9923077D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
GB0000228D0 (en) *	2000-01-06	2000-03-01	Phytopharm Plc	Fluoro substituted sapogenins and their use
JP2002030096A (ja) *	2000-07-11	2002-01-29	Kyorin Pharmaceut Co Ltd	神経細胞突起再生剤及びその製造方法
AU2003218180B2 (en) *	2002-03-15	2008-03-20	Georgetown University	Neuroprotective spirostenol pharmaceutical compositions

2003
- 2003-03-27 KR KR1020107017081A patent/KR20100093621A/ko active IP Right Grant
- 2003-03-27 RU RU2004130281/15A patent/RU2332999C2/ru not_active IP Right Cessation
- 2003-03-27 TW TW092106926A patent/TWI329016B/zh not_active IP Right Cessation
- 2003-03-27 NZ NZ547897A patent/NZ547897A/en unknown
- 2003-03-27 IL IL16416103A patent/IL164161A0/xx unknown
- 2003-03-27 CN CN038071886A patent/CN1642558B/zh not_active Expired - Fee Related
- 2003-03-27 NZ NZ547344A patent/NZ547344A/en unknown
- 2003-03-27 PE PE2003000315A patent/PE20040306A1/es not_active Application Discontinuation
- 2003-03-27 PL PL372941A patent/PL213697B1/pl not_active IP Right Cessation
- 2003-03-27 WO PCT/GB2003/001380 patent/WO2003082893A2/en active Application Filing
- 2003-03-27 AT AT03722713T patent/ATE424211T1/de active

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ХАРКЕВИЧ Д.А. Фармакология. - М.: Медицина, 1987, с.47-48. БЕЛИКОВ В.Г. Фармацевтическая химия. - М.: Высшая школа, 1993, т.1, с.43-47. *

Also Published As

Publication number	Publication date
PE20040306A1 (es)	2004-05-29
TWI329016B (en)	2010-08-21
WO2003082893A8 (en)	2003-12-31
NZ547344A (en)	2007-11-30
CN1642558A (zh)	2005-07-20
WO2003082893A2 (en)	2003-10-09
ATE424211T1 (de)	2009-03-15
RU2004130281A (ru)	2006-01-20
NZ547897A (en)	2008-02-29
PL213697B1 (pl)	2013-04-30
TW200400042A (en)	2004-01-01
CN1642558B (zh)	2012-05-30
PL372941A1 (en)	2005-08-08
WO2003082893A3 (en)	2004-04-15
KR20100093621A (ko)	2010-08-25
IL164161A0 (en)	2005-12-18

Legal Events

Date	Code	Title	Description
2010-08-20	MM4A	The patent is invalid due to non-payment of fees	Effective date: 20090328

Publication	Publication Date	Title
RU2332999C2 (ru)	2008-09-10	Терапевтические способы и применения сапогенинов и их производных
Melcangi et al.	2016	Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features
Luoma et al.	2012	Progesterone inhibition of neuronal calcium signaling underlies aspects of progesterone-mediated neuroprotection
WO2007133673A3 (en)	2008-01-17	Methods of treating a neurological disorder with creatine monohydrate
PH12020550631A1 (en)	2021-02-22	New catecholamine prodrugs for use in the treatment of parkinson`s disease
WO2004110389A3 (en)	2005-12-22	Sigma ligands for neuronal regeneration and functional recovery
US20110190249A1 (en)	2011-08-04	Therapeutic methods and uses of sapogenins and their derivatives
BR112012007580A2 (pt)	2016-08-16	conjunto para um dispositivo de distribuição de fármaco
MX2011013258A (es)	2012-02-28	Proteinas de fusion para entrega de gdnf y bdnf al sistema nervioso central.
CA2986891C (en)	2022-01-04	Compositions for use in treating parkinson's disease and related disorders
EA200800767A1 (ru)	2008-08-29	Средство для коррекции стресс-индуцируемых нейромедиаторных, нейроэндокринных и метаболических нарушений, а также способ профилактики и лечения сопутствующих им патологических состояний
Garcia et al.	2011	Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation
EP1255556A4 (en)	2003-07-02	USES FOR NEUROPROTECTIVE, ANTITHROMBOTIC AND ANTI-INFLAMMATORY PURPOSES OF ACTIVATED PROTEIN C
EP2774661A3 (de)	2014-11-05	Vorderbacken für eine Skitourenbindung
BR112015021333A2 (pt)	2017-07-18	conjunto para um dispositivo de aplicação de fármaco
BR112021021184A8 (pt)	2023-02-28	Fármaco terapêutico para discinesia
PT98427A (pt)	1992-05-29	Metodo para tratamento de doencas do sistema nervoso central com compostos amino-alcoois heterociclicos
US20050130948A1 (en)	2005-06-16	Therapeutic methods and uses of sapogenins and their derivatives
AT517278A1 (de)	2016-12-15	Fahrwerkslösung mit aerodynamischer Verkleidung/ Einhausung, Radabdeckung der gelenkten Räder
RU2008110392A (ru)	2009-09-27	Терапевтические способы и применения сапогенинов и их производных
CA2477787A1 (en)	2003-10-09	Therapeutic methods and uses of sapogenins and their derivatives
BR112015020816A2 (pt)	2017-07-18	conjunto para um dispositivo de aplicação de fármaco
DE60118418T2 (de)	2007-01-11	Maurotoxin, pi1 und hstx1 derivate
DE60004473T2 (de)	2004-07-08	Verwendung von gaba-b rezeptor liganden zur herstellungen von medikamenten zur behandlung von neurodegenerativen erkrankungen
Martać et al.	2010	Evaluation of the neurotoxical effect of aluminum on the Wistar rat