RU2109816C1 - Рекомбинантный полипептид, способ ингибирования агрегации тромбоцитов, рекомбинантная плазмидная днк (варианты), рекомбинантный штамм e.coli (варианты), способ получения полипептида - Google Patents

Рекомбинантный полипептид, способ ингибирования агрегации тромбоцитов, рекомбинантная плазмидная днк (варианты), рекомбинантный штамм e.coli (варианты), способ получения полипептида Download PDF

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Publication number
RU2109816C1
RU2109816C1 SU5053187A SU5053187A RU2109816C1 RU 2109816 C1 RU2109816 C1 RU 2109816C1 SU 5053187 A SU5053187 A SU 5053187A SU 5053187 A SU5053187 A SU 5053187A RU 2109816 C1 RU2109816 C1 RU 2109816C1
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RU
Russia
Prior art keywords
polypeptide
pvwf
plasmid
recombinant
factor
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Application number
SU5053187A
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English (en)
Russian (ru)
Inventor
Гарфинкель Леонард
Рихтер Тамар
Original Assignee
Био-Текнолоджи Дженерал Корп.
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Publication of RU2109816C1 publication Critical patent/RU2109816C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SU5053187A 1990-03-02 1991-03-01 Рекомбинантный полипептид, способ ингибирования агрегации тромбоцитов, рекомбинантная плазмидная днк (варианты), рекомбинантный штамм e.coli (варианты), способ получения полипептида RU2109816C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48776790A 1990-03-02 1990-03-02
US487,767 1990-03-02
PCT/US1991/001416 WO1991013093A1 (en) 1990-03-02 1991-03-01 CLONING AND PRODUCTION OF HUMAN VON WILLEBRAND FACTOR GPIb BINDING DOMAIN POLYPEPTIDES AND METHODS OF USING SAME

Publications (1)

Publication Number Publication Date
RU2109816C1 true RU2109816C1 (ru) 1998-04-27

Family

ID=23937035

Family Applications (1)

Application Number Title Priority Date Filing Date
SU5053187A RU2109816C1 (ru) 1990-03-02 1991-03-01 Рекомбинантный полипептид, способ ингибирования агрегации тромбоцитов, рекомбинантная плазмидная днк (варианты), рекомбинантный штамм e.coli (варианты), способ получения полипептида

Country Status (10)

Country Link
EP (1) EP0517826A4 (hu)
JP (1) JPH05506646A (hu)
CA (1) CA2077446A1 (hu)
FI (1) FI923935A0 (hu)
HU (1) HU216066B (hu)
IL (1) IL97399A0 (hu)
NO (1) NO923410L (hu)
NZ (1) NZ237244A (hu)
RU (1) RU2109816C1 (hu)
WO (1) WO1991013093A1 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2571660C2 (ru) * 2009-06-03 2015-12-20 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" Модуляторы гликопротеина vi, представляющие собой нуклеиновую кислоту

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900476A (en) * 1986-05-30 1999-05-04 The Scripps Research Institute Therapeutic domains of van Willebrand factor
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
FR2686901A1 (fr) * 1992-01-31 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
AU6169294A (en) * 1993-02-11 1994-08-29 Du Pont Merck Pharmaceutical Company, The 15-oxasterols as hypocholesterolemics
IL109383A0 (en) * 1993-04-23 1994-07-31 Bio Technology General Corp Method for enhancing thrombolysis
AT405403B (de) * 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
AT408443B (de) * 1998-02-27 2001-11-26 Immuno Ag Verfahren zur gewinnung von gereinigtem faktor viii:c/vwf-komplex
US6605222B1 (en) * 1998-05-20 2003-08-12 Baxter Aktiengesellschaft Method for producing a factor VIII/von Willebrand factor complex
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
GB201707139D0 (en) 2017-05-04 2017-06-21 Imp Innovations Ltd Polypeptides
CN110624105B (zh) * 2019-09-24 2021-06-11 苏州大学 血管性血友病因子的结构敏感多肽抗原的序列

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
EP0255206B1 (en) * 1986-05-30 1995-03-22 The Scripps Research Institute Peptides that inhibit von Willebrand factor binding

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Gujmuna et al.journal of Biol.Chem., 261, N 1, 381-385, 1986. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2571660C2 (ru) * 2009-06-03 2015-12-20 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" Модуляторы гликопротеина vi, представляющие собой нуклеиновую кислоту

Also Published As

Publication number Publication date
FI923935A (fi) 1992-09-02
NZ237244A (en) 1992-10-28
EP0517826A4 (en) 1993-05-26
IL97399A0 (en) 1992-06-21
HUT63183A (en) 1993-07-28
AU7496491A (en) 1991-09-18
WO1991013093A1 (en) 1991-09-05
HU9202821D0 (en) 1992-11-30
CA2077446A1 (en) 1991-09-03
AU645077B2 (en) 1994-01-06
FI923935A0 (fi) 1992-09-02
NO923410L (no) 1992-10-26
NO923410D0 (no) 1992-09-01
JPH05506646A (ja) 1993-09-30
HU216066B (hu) 1999-04-28
EP0517826A1 (en) 1992-12-16

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