RU2019133312A - Method for early preclinical diagnosis of Parkinson's disease by the concentration of catecholamines in the patient's lacrimal fluid - Google Patents

Method for early preclinical diagnosis of Parkinson's disease by the concentration of catecholamines in the patient's lacrimal fluid Download PDF

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RU2019133312A
RU2019133312A RU2019133312A RU2019133312A RU2019133312A RU 2019133312 A RU2019133312 A RU 2019133312A RU 2019133312 A RU2019133312 A RU 2019133312A RU 2019133312 A RU2019133312 A RU 2019133312A RU 2019133312 A RU2019133312 A RU 2019133312A
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concentration
patient
parkinson
disease
catecholamines
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RU2019133312A
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Russian (ru)
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RU2775261C2 (en
RU2019133312A3 (en
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Михаил Вениаминович Угрюмов
Александр Робертович Ким
Марина Романовна Нодель
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Общество с ограниченной ответственностью "Центр ранней диагностики нейродегенеративных заболеваний (НДЗ)"
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Способ ранней доклинической диагностики болезни Паркинсона, предусматривающий следующие стадии:A method for early preclinical diagnosis of Parkinson's disease, which includes the following stages: а) измерение в слезной жидкости у пациента без нарушения двигательной функции концентрации одного или нескольких биомаркеров, выбранных из норадреналина, адреналина и дофамина, иa) measuring the concentration of one or more biomarkers selected from norepinephrine, adrenaline and dopamine in the tear fluid of a patient without impairment of motor function, and б) сравнение измеренной концентрации одного или нескольких биомаркеров с соответствующим пациенту возрастным контролем,b) comparison of the measured concentration of one or more biomarkers with the age control corresponding to the patient, причем значимое повышение концентрации норадреналина и/или снижение концентрации адреналина и/или повышение концентрации дофамина в слезной жидкости пациента по сравнению с контролем позволяет диагностировать у пациента раннюю доклиническую стадию болезни Паркинсона.moreover, a significant increase in the concentration of norepinephrine and / or a decrease in the concentration of adrenaline and / or an increase in the concentration of dopamine in the lacrimal fluid of the patient in comparison with the control allows the patient to be diagnosed with an early preclinical stage of Parkinson's disease.
RU2019133312A 2019-10-21 Method for early preclinical diagnostics of parkinson's disease by concentration of catecholamines in patient's lacrimal fluid RU2775261C2 (en)

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RU2019133312A true RU2019133312A (en) 2021-04-21
RU2019133312A3 RU2019133312A3 (en) 2021-04-21
RU2775261C2 RU2775261C2 (en) 2022-06-28

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