RU2019113148A - BONE IMPLANT - Google Patents

BONE IMPLANT Download PDF

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Publication number
RU2019113148A
RU2019113148A RU2019113148A RU2019113148A RU2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A RU 2019113148 A RU2019113148 A RU 2019113148A
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RU
Russia
Prior art keywords
bone implant
mass
bioactive glass
film
microns
Prior art date
Application number
RU2019113148A
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Russian (ru)
Inventor
Фредрик ОЛЛИЛА
Нина ЛИНДФОРС
Роберт БЬЕРКЕНХЕЙМ
Густав СТРЕМБЕРГ
Лена ХУПА
Петер УППСТУ
Юкка ПАЯРИНЕН
Original Assignee
Бонэлайв Байоматириалс Ой
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Application filed by Бонэлайв Байоматириалс Ой filed Critical Бонэлайв Байоматириалс Ой
Publication of RU2019113148A publication Critical patent/RU2019113148A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30225—Flat cylinders, i.e. discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30322—The prosthesis having different structural features at different locations within the same prosthesis differing in surface structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30968—Sintering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00329—Glasses, e.g. bioglass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Claims (17)

1. Костный имплантат, который содержит1. A bone implant that contains пористое тело, содержащее частицы биоактивного стекла, имеющие размер частицы по меньшей мере 500 мкм, где композиция биоактивного стекла содержит 45-59% масс. SiO2, 18-25% масс. Na2O, 17-25% масс. CaO и 0,1-6% масс. P2O5, иa porous body containing particles of bioactive glass having a particle size of at least 500 microns, where the bioactive glass composition contains 45-59% of the mass. SiO 2 , 18-25% of the mass. Na 2 O, 17-25% of the mass. CaO and 0.1-6% of the mass. P 2 O 5 , and пленку толщиной 10-200 мкм, выполненную из биосовместимого полимера и расположенную по меньшей мере частично вокруг тела.a film with a thickness of 10-200 microns, made of a biocompatible polymer and located at least partially around the body. 2. Костный имплантат по п. 1, в котором пленку располагают вокруг тела так, чтобы покрывать часть тела, находящуюся в контакте с мышцей, фасцией или надкостницей, когда имплантат имплантируют в кость.2. The bone implant of claim 1, wherein the film is positioned around the body to cover the part of the body that is in contact with muscle, fascia, or periosteum when the implant is implanted into bone. 3. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором полимер выбирают из группы, состоящей из полилактида, полигликолида, сополимера (лактид-гликолид), поликапролактона, природных коллагеновых полимеров и их смесей с полиэтиленгликолем.3. A bone implant according to any of the preceding claims, wherein the polymer is selected from the group consisting of polylactide, polyglycolide, copolymer (lactide-glycolide), polycaprolactone, natural collagen polymers, and mixtures thereof with polyethylene glycol. 4. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором размер частиц биоактивного стекла составляет 500-3150 мкм.4. A bone implant according to any of the preceding claims, wherein the bioactive glass has a particle size of 500-3150 microns. 5. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором толщина пленки составляет 100-200 мкм.5. A bone implant according to any of the preceding claims, wherein the film thickness is 100-200 microns. 6. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором пленка содержит биоактивное стекло.6. A bone implant according to any of the preceding claims, wherein the film contains bioactive glass. 7. Костный имплантат по п. 6, в котором биоактивное стекло пленки имеет форму порошка, имеющего усредненный размер частицы меньше чем 45 мкм.7. A bone implant according to claim 6, wherein the bioactive glass of the film is in the form of a powder having an average particle size of less than 45 microns. 8. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором в состав биоактивного стекла входит 45-54% масс. SiO2, 22-25% масс. Na2O, 19-25% масс. CaO и 3,5-6% масс. P2O5.8. Bone implant in accordance with any of the preceding paragraphs, in which the composition of bioactive glass includes 45-54% of the mass. SiO 2 , 22-25% of the mass. Na 2 O, 19-25% of the mass. CaO and 3.5-6% of the mass. P 2 O 5 . 9. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором в состав биоактивного стекла входит 53% масс. SiO2, 23% масс. Na2O, 20% масс. CaO и 4% масс. P2O5.9. Bone implant in accordance with any of the preceding paragraphs, in which the composition of the bioactive glass includes 53% of the mass. SiO 2 , 23% of the mass. Na 2 O, 20% of the mass. CaO and 4% of the mass. P 2 O 5 . 10. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором тело имеет форму диска и пленку располагают вокруг сторон диска.10. A bone implant according to any of the preceding claims, wherein the body is in the shape of a disc and a film is placed around the sides of the disc. 11. Костный имплантат в соответствии с любым из предшествующих пунктов, в котором тело присутствует в форме спеченных биоактивных стеклянных частиц.11. A bone implant according to any of the preceding claims, wherein the body is in the form of sintered bioactive glass particles. 12. Костный имплантат в соответствии с любым из пп. 1-9, в котором тело присутствует в форме частиц биоактивного стекла, удерживаемых вместе биоразрушаемым полимером.12. Bone implant in accordance with any of paragraphs. 1-9, in which the body is present in the form of bioactive glass particles held together by a biodegradable polymer. 13. Костный имплантат по п. 12, в котором биоразрушаемый полимер выбирают из группы, состоящей из полилактида, полигликолида, сополимера (лактид-гликолид), поликапролактона, полиэтиленгликоля, коллагена и их смесей.13. The bone implant of claim 12, wherein the biodegradable polymer is selected from the group consisting of polylactide, polyglycolide, copolymer (lactide-glycolide), polycaprolactone, polyethylene glycol, collagen, and mixtures thereof. 14. Способ изготовления костного имплантата в соответствии с любым из пп. 1-13, который включает формирование пористого тела, содержащего частицы биоактивного стекла, размещение пленки, выполненной из биосовместимого полимера, по меньшей мере частично вокруг пористого тела и нагревание комбинации до температуры стеклования биосовместимого полимера.14. A method of manufacturing a bone implant in accordance with any of paragraphs. 1-13, which includes forming a porous body containing bioactive glass particles, placing a film made of a biocompatible polymer at least partially around the porous body, and heating the combination to the glass transition temperature of the biocompatible polymer. 15. Способ по п. 14, в котором пористое тело, содержащее частицы биоактивного стекла, изготавливают с использованием формы и либо спекания, либо полимерного соединительного материала.15. The method of claim. 14, wherein the porous body containing bioactive glass particles is made using a mold and either sintered or a polymeric joint material.
RU2019113148A 2016-10-05 2017-10-04 BONE IMPLANT RU2019113148A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16192500 2016-10-05
EP16192500.3 2016-10-05
PCT/FI2017/050693 WO2018065665A1 (en) 2016-10-05 2017-10-04 A bone implant

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Publication Number Publication Date
RU2019113148A true RU2019113148A (en) 2020-11-06

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US (1) US20200038547A1 (en)
EP (1) EP3522944B1 (en)
JP (1) JP2019535338A (en)
KR (1) KR20190073349A (en)
CN (1) CN110099700A (en)
AU (1) AU2017339120A1 (en)
BR (1) BR112019005021B1 (en)
CA (1) CA3038608A1 (en)
CL (1) CL2019000792A1 (en)
CO (1) CO2019002492A2 (en)
MX (1) MX2019003946A (en)
PE (1) PE20190858A1 (en)
RU (1) RU2019113148A (en)
WO (1) WO2018065665A1 (en)

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BR112019005021A2 (en) 2019-06-04
MX2019003946A (en) 2019-06-10
EP3522944B1 (en) 2024-04-03
KR20190073349A (en) 2019-06-26
JP2019535338A (en) 2019-12-12
CO2019002492A2 (en) 2019-05-31
CN110099700A (en) 2019-08-06
EP3522944A1 (en) 2019-08-14
CL2019000792A1 (en) 2019-06-14
US20200038547A1 (en) 2020-02-06
BR112019005021B1 (en) 2023-01-10
WO2018065665A1 (en) 2018-04-12
PE20190858A1 (en) 2019-06-18
EP3522944A4 (en) 2020-06-17
CA3038608A1 (en) 2018-04-12
AU2017339120A1 (en) 2019-04-18

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