RU2017134413A3 - - Google Patents

Download PDF

Info

Publication number
RU2017134413A3
RU2017134413A3 RU2017134413A RU2017134413A RU2017134413A3 RU 2017134413 A3 RU2017134413 A3 RU 2017134413A3 RU 2017134413 A RU2017134413 A RU 2017134413A RU 2017134413 A RU2017134413 A RU 2017134413A RU 2017134413 A3 RU2017134413 A3 RU 2017134413A3
Authority
RU
Russia
Application number
RU2017134413A
Other versions
RU2017134413A (ru
RU2698048C2 (ru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to RU2017134413A priority Critical patent/RU2698048C2/ru
Priority to TW107134501A priority patent/TWI758547B/zh
Priority to BR112020006795-4A priority patent/BR112020006795A2/pt
Priority to EA202090864A priority patent/EA202090864A1/ru
Priority to CN201880078306.5A priority patent/CN111788223A/zh
Priority to MA49607A priority patent/MA49607A1/fr
Priority to JOP/2020/0106A priority patent/JOP20200106A1/ar
Priority to MX2020004026A priority patent/MX2020004026A/es
Priority to AU2018346116A priority patent/AU2018346116A1/en
Priority to KR1020207012627A priority patent/KR20200058537A/ko
Priority to CA3078467A priority patent/CA3078467A1/en
Priority to JP2020519415A priority patent/JP7275117B2/ja
Priority to EP18864122.9A priority patent/EP3693388A4/en
Priority to PE2020000514A priority patent/PE20210466A1/es
Priority to US16/753,488 priority patent/US20200291121A1/en
Priority to PCT/RU2018/050118 priority patent/WO2019070164A1/ru
Priority to UY0001037914A priority patent/UY37914A/es
Priority to ARP180102863A priority patent/AR113343A1/es
Publication of RU2017134413A publication Critical patent/RU2017134413A/ru
Publication of RU2017134413A3 publication Critical patent/RU2017134413A3/ru
Application granted granted Critical
Publication of RU2698048C2 publication Critical patent/RU2698048C2/ru
Priority to CL2020000920A priority patent/CL2020000920A1/es
Priority to CONC2020/0004200A priority patent/CO2020004200A2/es
Priority to PH12020550218A priority patent/PH12020550218A1/en
Priority to ZA2020/02044A priority patent/ZA202002044B/en
Priority to ECSENADI202024551A priority patent/ECSP20024551A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
RU2017134413A 2017-10-03 2017-10-03 МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα RU2698048C2 (ru)

Priority Applications (23)

Application Number Priority Date Filing Date Title
RU2017134413A RU2698048C2 (ru) 2017-10-03 2017-10-03 МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα
TW107134501A TWI758547B (zh) 2017-10-03 2018-09-28 對IL-5Rα的單株抗體
PCT/RU2018/050118 WO2019070164A1 (ru) 2017-10-03 2018-10-02 МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα
CN201880078306.5A CN111788223A (zh) 2017-10-03 2018-10-02 抗IL-5Rα的单克隆抗体
MA49607A MA49607A1 (fr) 2017-10-03 2018-10-02 Anticorps monoclonal pour il-5ra
JOP/2020/0106A JOP20200106A1 (ar) 2017-10-03 2018-10-02 جسم مضاد أحادي النسيلة مضاد لـ il-5r?
MX2020004026A MX2020004026A (es) 2017-10-03 2018-10-02 Anticuerpo monoclonal anti-il-5ra.
AU2018346116A AU2018346116A1 (en) 2017-10-03 2018-10-02 Monoclonal antibody to IL-5Rα
KR1020207012627A KR20200058537A (ko) 2017-10-03 2018-10-02 IL-5Rα에 대한 단일클론 항체
CA3078467A CA3078467A1 (en) 2017-10-03 2018-10-02 Anti-il-5r.alpha. monoclonal antibody
JP2020519415A JP7275117B2 (ja) 2017-10-03 2018-10-02 抗IL-5Rαモノクローナル抗体
EP18864122.9A EP3693388A4 (en) 2017-10-03 2018-10-02 MONOCLONAL ANTIBODY FOR IL-5R
BR112020006795-4A BR112020006795A2 (pt) 2017-10-03 2018-10-02 anticorpo monoclonal anti-il-5ra
US16/753,488 US20200291121A1 (en) 2017-10-03 2018-10-02 ANTI-IL-5RAlpha MONOCLONAL ANTIBODY
EA202090864A EA202090864A1 (ru) 2017-10-03 2018-10-02 Моноклональное антитело к il-5r
PE2020000514A PE20210466A1 (es) 2017-10-03 2018-10-02 ANTICUERPO MONOCLONAL ANTI-IL-5Ralfa
UY0001037914A UY37914A (es) 2017-10-03 2018-10-03 Anticuerpo monoclonal contr il-5r
ARP180102863A AR113343A1 (es) 2017-10-03 2018-10-04 ANTICUERPO MONOCLONAL ANTI-IL-5Ra
CL2020000920A CL2020000920A1 (es) 2017-10-03 2020-04-03 Anticuerpo monoclonal anti-il-5ra.
CONC2020/0004200A CO2020004200A2 (es) 2017-10-03 2020-04-03 Anticuerpo monoclonal anti-il-5rα
PH12020550218A PH12020550218A1 (en) 2017-10-03 2020-04-03 MONOCLONAL ANTIBODY TO IL-5Ra
ZA2020/02044A ZA202002044B (en) 2017-10-03 2020-05-04 Monoclonal antibody to il-5rα
ECSENADI202024551A ECSP20024551A (es) 2017-10-03 2020-05-06 ANTICUERPO MONOCLONAL PARA IL-5Ra

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2017134413A RU2698048C2 (ru) 2017-10-03 2017-10-03 МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα

Publications (3)

Publication Number Publication Date
RU2017134413A RU2017134413A (ru) 2019-04-03
RU2017134413A3 true RU2017134413A3 (ru) 2019-04-03
RU2698048C2 RU2698048C2 (ru) 2019-08-21

Family

ID=65994565

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017134413A RU2698048C2 (ru) 2017-10-03 2017-10-03 МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα

Country Status (23)

Country Link
US (1) US20200291121A1 (ru)
EP (1) EP3693388A4 (ru)
JP (1) JP7275117B2 (ru)
KR (1) KR20200058537A (ru)
CN (1) CN111788223A (ru)
AR (1) AR113343A1 (ru)
AU (1) AU2018346116A1 (ru)
BR (1) BR112020006795A2 (ru)
CA (1) CA3078467A1 (ru)
CL (1) CL2020000920A1 (ru)
CO (1) CO2020004200A2 (ru)
EA (1) EA202090864A1 (ru)
EC (1) ECSP20024551A (ru)
JO (1) JOP20200106A1 (ru)
MA (1) MA49607A1 (ru)
MX (1) MX2020004026A (ru)
PE (1) PE20210466A1 (ru)
PH (1) PH12020550218A1 (ru)
RU (1) RU2698048C2 (ru)
TW (1) TWI758547B (ru)
UY (1) UY37914A (ru)
WO (1) WO2019070164A1 (ru)
ZA (1) ZA202002044B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220035656A (ko) * 2020-09-14 2022-03-22 아주대학교산학협력단 인간 IL-5Rα에 결합하는 항체 및 이의 용도

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL47062A (en) 1975-04-10 1979-07-25 Yeda Res & Dev Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4665077A (en) 1979-03-19 1987-05-12 The Upjohn Company Method for treating rejection of organ or skin grafts with 6-aryl pyrimidine compounds
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
WO1986005807A1 (en) 1985-04-01 1986-10-09 Celltech Limited Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
IL85746A (en) 1988-03-15 1994-05-30 Yeda Res & Dev Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
FI891226A (fi) 1988-04-28 1989-10-29 Univ Leland Stanford Junior Reseptordeterminanter i anti-t-celler foer behandling av autoimmunsjukdom.
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
WO1990008187A1 (en) 1989-01-19 1990-07-26 Dana Farber Cancer Institute Soluble two domain cd2 protein
DE69006018T3 (de) 1989-03-21 2004-01-15 Immune Response Corp Inc Impfung und methoden gegen krankheiten, die von pathologischen reaktionen der spezifischen t-zellen abstammen.
DE69029036T2 (de) 1989-06-29 1997-05-22 Medarex Inc Bispezifische reagenzien für die aids-therapie
DK0552142T3 (da) 1989-07-19 1998-09-07 Connetics Corp T-cellereceptorpeptider og terapeutika til autoimmune og maligne sygdomme
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
JPH06500011A (ja) 1990-06-29 1994-01-06 ラージ スケール バイオロジー コーポレイション 形質転換された微生物によるメラニンの製造
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
ES2206447T3 (es) 1991-06-14 2004-05-16 Genentech, Inc. Anticuerpo humanizado para heregulina.
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
JP3946256B2 (ja) 1995-09-11 2007-07-18 協和醗酵工業株式会社 ヒトインターロイキン5受容体α鎖に対する抗体
DE19544393A1 (de) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistische herbizide Mischungen
FR2783326B1 (fr) * 1998-09-10 2000-12-01 Immunotech Sa Procede de detection ou de quantification des basophiles et des eosinophiles
US6517529B1 (en) 1999-11-24 2003-02-11 Radius International Limited Partnership Hemodialysis catheter
WO2002022805A2 (en) * 2000-09-14 2002-03-21 Beth Israel Deaconess Medical Center, Inc. Modulation of il-2- and il-15-mediated t cell responses
ES2327830T3 (es) * 2002-03-29 2009-11-04 Schering Corporation Anticuerpos monoclonales humanos anti-interleuquina-5 y metodos y composiciones que los contienen.
US20050226867A1 (en) * 2003-10-08 2005-10-13 Kyowa Hakko Kogyo Co., Ltd. IL-5R-specific antibody composition
AU2004279740A1 (en) * 2003-10-08 2005-04-21 Kyowa Hakko Kirin Co., Ltd. Antibody composition specifically binding to IL-5 receptor
EP2068927B1 (en) 2007-05-14 2015-10-21 MedImmune, LLC Methods of reducing eosinophil levels
TR201802772T4 (tr) * 2010-11-17 2018-03-21 Chugai Pharmaceutical Co Ltd Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül.
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
WO2015172800A1 (en) 2014-05-12 2015-11-19 Numab Ag Novel multispecific molecules and novel treatment methods based on such multispecific molecules
SG11201600481UA (en) * 2013-08-12 2016-02-26 Medimmune Llc Methods for reducing exacerbation rates of asthma using benralizumab
WO2015058861A1 (en) * 2013-10-25 2015-04-30 Numab Ag Bispecific constructs and their use in the treatment of various diseases

Also Published As

Publication number Publication date
PE20210466A1 (es) 2021-03-08
US20200291121A1 (en) 2020-09-17
EA202090864A1 (ru) 2020-06-29
RU2017134413A (ru) 2019-04-03
EP3693388A4 (en) 2021-06-23
TWI758547B (zh) 2022-03-21
ECSP20024551A (es) 2020-06-30
MX2020004026A (es) 2020-08-13
AU2018346116A1 (en) 2020-05-14
JP2021501568A (ja) 2021-01-21
KR20200058537A (ko) 2020-05-27
RU2698048C2 (ru) 2019-08-21
MA49607A1 (fr) 2021-03-31
CL2020000920A1 (es) 2020-10-16
EP3693388A1 (en) 2020-08-12
JP7275117B2 (ja) 2023-05-17
PH12020550218A1 (en) 2021-02-15
WO2019070164A1 (ru) 2019-04-11
JOP20200106A1 (ar) 2020-05-06
CA3078467A1 (en) 2019-04-11
AR113343A1 (es) 2020-04-22
CO2020004200A2 (es) 2020-04-24
UY37914A (es) 2019-04-30
BR112020006795A2 (pt) 2020-10-06
TW201922789A (zh) 2019-06-16
CN111788223A (zh) 2020-10-16
ZA202002044B (en) 2022-08-31

Similar Documents

Publication Publication Date Title
BR122021024397A2 (ru)
BR122021023687A2 (ru)
BR122022003521A2 (ru)
BR122021000189A2 (ru)
BR112020006084A8 (ru)
BR122021014832A2 (ru)
BR112020008820A2 (ru)
BR202017025154U2 (ru)
BR202017021228U2 (ru)
BR202017020981U2 (ru)
BR202017017068U2 (ru)
BR202017016984U2 (ru)
BR202017016924U2 (ru)
BR202017012548U2 (ru)
BR202017011220U2 (ru)
BR202017010814U2 (ru)
BR202017010373U2 (ru)
BR202017009870U2 (ru)
BR202017004898U2 (ru)
BR202017002937U2 (ru)
BR202017002826U2 (ru)
CN304089699S (ru)
CN303993372S (ru)
CN303993196S (ru)
CN303994191S (ru)