RU2017102307A - Способ получения синтетического пентапептида - Google Patents

Способ получения синтетического пентапептида Download PDF

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Publication number
RU2017102307A
RU2017102307A RU2017102307A RU2017102307A RU2017102307A RU 2017102307 A RU2017102307 A RU 2017102307A RU 2017102307 A RU2017102307 A RU 2017102307A RU 2017102307 A RU2017102307 A RU 2017102307A RU 2017102307 A RU2017102307 A RU 2017102307A
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RU
Russia
Prior art keywords
compound
salt
producing synthetic
synthetic pentapeptide
pentapeptide
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RU2017102307A
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English (en)
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RU2664545C2 (ru
RU2017102307A3 (ru
Inventor
Асами МУРАЯМА
Такааки КАНО
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Маруиси Фармасьютикал Ко., Лтд.
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Publication of RU2017102307A3 publication Critical patent/RU2017102307A3/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Claims (8)

1. Соединение, представленное следующей формулой (1), или его соль:
Figure 00000001
где R1 представляет собой алкильную группу или аралкильную группу.
2. Соединение или его соль по п.1, где R1 представляет собой алкильную группу.
3. Соединение или его соль по п.1 или 2, где соединение или его соль представляет собой кислотно-аддитивную соль данного соединения.
4. Способ получения соединения, представленного формулой (A), или его соли:
Figure 00000002
,
включающий гидролиз соединения или его соли по любому из пп.1-3.
RU2017102307A 2014-06-26 2014-12-19 Способ получения синтетического пентапептида RU2664545C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014130891 2014-06-26
JP2014-130891 2014-06-26
PCT/JP2014/083651 WO2015198505A1 (ja) 2014-06-26 2014-12-19 合成ペンタペプチドの製造法

Publications (3)

Publication Number Publication Date
RU2017102307A3 RU2017102307A3 (ru) 2018-07-26
RU2017102307A true RU2017102307A (ru) 2018-07-26
RU2664545C2 RU2664545C2 (ru) 2018-08-20

Family

ID=54937619

Family Applications (1)

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RU2017102307A RU2664545C2 (ru) 2014-06-26 2014-12-19 Способ получения синтетического пентапептида

Country Status (12)

Country Link
US (1) US10035767B2 (ru)
EP (1) EP3162810B1 (ru)
KR (1) KR102303092B1 (ru)
CN (1) CN106459150B (ru)
AU (1) AU2014398345B2 (ru)
CA (1) CA2953653C (ru)
ES (1) ES2715082T3 (ru)
MX (1) MX2016016479A (ru)
RU (1) RU2664545C2 (ru)
SA (1) SA516380521B1 (ru)
TR (1) TR201902611T4 (ru)
WO (1) WO2015198505A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109563133B (zh) 2016-09-27 2020-09-11 四川科伦博泰生物医药股份有限公司 多酰胺化合物及其用途
EP3722286B1 (en) * 2017-12-06 2022-06-22 Jiangsu Hengrui Medicine Co., Ltd. Salt of a phenylpropionamide derivative and preparation method therefor
CN111479800A (zh) * 2018-02-12 2020-07-31 四川科伦博泰生物医药股份有限公司 一种中间体化合物及其制备方法，及以该中间体化合物制备多肽的固相合成方法
CN115884963A (zh) * 2020-06-25 2023-03-31 人福医药美国公司 用于治疗医学病症的肽
WO2024015106A1 (en) * 2022-07-11 2024-01-18 Humanwell Pharmacuetical Us Peptides for treatment of medical disorders

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* Cited by examiner, † Cited by third party
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US5965701A (en) * 1997-12-23 1999-10-12 Ferring Bv Kappa receptor opioid peptides
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
CN101627049B (zh) 2006-11-10 2012-09-05 卡拉治疗学股份有限公司 合成酞酰胺
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
AU2008298694A1 (en) * 2007-09-12 2009-03-19 Dr. Reddy's Laboratories Ltd. Bortezomib and process for producing same
CN102924569A (zh) * 2012-09-14 2013-02-13 烟台海安多肽药物研发技术有限公司 一种依替巴肽的液相合成方法

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Publication number Publication date
RU2664545C2 (ru) 2018-08-20
KR102303092B1 (ko) 2021-09-15
CA2953653C (en) 2021-02-16
TR201902611T4 (tr) 2019-03-21
KR20170020808A (ko) 2017-02-24
CN106459150B (zh) 2020-01-24
SA516380521B1 (ar) 2020-04-26
AU2014398345B2 (en) 2019-01-17
US20170183307A1 (en) 2017-06-29
US10035767B2 (en) 2018-07-31
EP3162810A1 (en) 2017-05-03
WO2015198505A1 (ja) 2015-12-30
EP3162810A4 (en) 2018-01-24
AU2014398345A1 (en) 2017-02-16
ES2715082T3 (es) 2019-05-31
CN106459150A (zh) 2017-02-22
RU2017102307A3 (ru) 2018-07-26
CA2953653A1 (en) 2015-12-30
MX2016016479A (es) 2017-04-10
EP3162810B1 (en) 2019-02-13

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