RU2016118008A - Применение ингибиторов бромодомена свр/ер300 для иммунотерапии рака - Google Patents
Применение ингибиторов бромодомена свр/ер300 для иммунотерапии рака Download PDFInfo
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- RU2016118008A RU2016118008A RU2016118008A RU2016118008A RU2016118008A RU 2016118008 A RU2016118008 A RU 2016118008A RU 2016118008 A RU2016118008 A RU 2016118008A RU 2016118008 A RU2016118008 A RU 2016118008A RU 2016118008 A RU2016118008 A RU 2016118008A
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Claims (22)
1. Способ лечения или замедления прогрессирования рака у пациента, включающий введение пациенту эффективного количества ингибитора бромодомена CBP/EP300.
2. Способ усиления иммунной функции у пациента, имеющего рак, включающий введение пациенту эффективного количества ингибитора бромодомена CBP/EP300.
3. Способ по п. 1 или 2, где T-клетки CD8 у пациента имеют усиленную активность примирования, активационную, пролиферативную и/или цитолитическую активность до введения ингибитора бромодомена CBP/EP300.
4. Способ по п.3, где количество T-клеток CD8 повышено относительно до введения ингибитора бромодомена CBP/EP300.
5. Способ по любому из пп.3 и 4, где T-клетки CD8 являются анитиген-специфическими T-клетками CD8.
6. Способ по любому из пп.1-5, где рак имеет повышенный уровень T-клеточной инфильтрации.
7. Способ по любому из пп. 1-6, где рак ассоциирован с увеличенной внутриопухолевой плотностью Treg клеток.
8. Способ по любому из пп.1-7, где рак выбирают из невриномы слухового нерва, острого лейкоза, острого лимфоцитарного лейкоза, острого миелоцитарного лейкоза, острого t-клеточного лейкоза, базальноклеточной карциномы, карциномы желчных протоков, рака мочевого пузыря, рака головного мозга, рака молочной железы, бронхогенной карциномы, рака шейки матки, хондросаркомы, хордомы, хориокарциномы, хронического лейкоза, хронического лимфоцитарного лейкоза, хронического миелоцитарного лейкоза, хронического миелогенного лейкоза, рака ободочной кишки, колоректальногог рака, краниофарингеомы, цистаденокарциномы, диффузной крупно B-клеточной лимфомы, диспролиферативных изменений, эмбриональной карциномы, рака эндометрия, эндотелиосаркомы, эпендимомы, эпителиальной карциномы, эритролейкемии, рака пищевода, рака молочной железы, положительного по эстрогеновым рецепторам, эссенциальной тромбоцитемии, опухоли Юинга, фибросаркомы, фолликулярной лимфомы, рака зародышевых клеток яичек, глиомы, глиобластомы, глиосаркомы, болезни тяжелых цепей, рака головы и шеи, гемангиобластомы, гепатомы, печеночно-клеточного рака, гормон-нечувствительного рака предстательной железы, лейомиосаркомы, лейкоза, липосаркомы, рака легкого, лимфангиоэндотелиосаркомы, лимфангиосаркомы, лимфобластного лейкоза, лимфомы, лимфоидных злокачественных новообразований T-клеточного или B-клеточного происхождения, медуллярной карциномы, медуллобластомы, меланомы, менингиомы, мезотелиомы, множественной миеломы, миелогенного лейкоза, миеломы, миксосаркомы, нейробластомы карциномы срединной линии NUT (NMC), немелкоклеточного рака легкого (NSCLC), олигодендроглиомы, рака полости рта, остеогенной саркомы, рака яичника, рака поджелудочной железы, папиллярных аденокарцином, капиллярной карциномы, пинеаломы, истинной полицитемии, рака предстательной железы, рака прямой кишки, почечно-клеточной карциномы, ретинобластомы, рабдомиосаркомы, саркомы, карциномы сальных желез, семиномы, рака кожи, мелкоклеточной карциномы легкого, солидных опухолей (карцином и сарком), мелкоклеточного рака легкого, рака желудка, плоскоклеточной карциномы, синовиомы, карциномы потовых желез, рака щитовидной железы, макроглобулинемии Вальденстрема, опухолей яичек, рака матки и опухоли Вильмса.
9. Способ по любому из пп. 1-8, где раком является меланома, NSCLC, рак почки, яичника, ободочной кишки, поджелудочной железы, печеночно-клеточный рак или рак молочной железы.
10. Способ по любому из пп. 1-9, где раком является рак NSCLC, яичника, поджелудочной железы, печеночно-клеточный рак или рак молочной железы.
11. Способ по любому из пп. 1-8, где раком является меланома, NSCLC, или почечно-клеточная карцинома.
12. Способ по любому из пп. 1-11, где ингибитор бромодомена CBP/EP300 ингибирует CBP.
13. Способ по любому из пп. 1-11, где ингибитор бромодомена CBP/EP300 ингибирует EP300.
14. Способ по любому из пп. 1-13, где способ подавляет функцию Treg.
15. Способ по любому из пп. 1-14, где способ снижает Т-клеточное истощение T-клеток CD8+.
16. Способ по любому из пп. 1-15, где ингибитор бромодомена CBP/EP300 не связывается с доменом HAT CBP и/или EP300.
17. Способ по любому из пп. 1-16, где пациентом является человек.
18. Ингибитор бромодомена CBP/EP300 для применения в лечении или диагностике в медицине, включая терапию и/или лечение рака.
19. Способ выбора противоракового соединения, включающий определение, является ли тестируемое соединение соединением ингибитором бромодоменa CBP/EP300, где тестируемое соединение, которое является соединением ингибитором бромодомена CBP/EP300, выбирают в качестве противоракового соединения.
20. Способ по п.19, дополнительно включающий определение того, связывается ли тестируемое соединение с HAT доменом CBP и/или EP300, где тестируемое соединение, которое не связывается с HAT доменом CBP и/или EP300, выбирают в качестве противоракового соединения.
21. Способ по п.19 или 20, дополнительно включающий определение, подавляет ли тестируемое соединение Treg функцию, где тестируемое соединение, которое подавляет Treg функцию, выбирают в качестве противоракового соединения.
22. Способ по любому из пп.19-21, дополнительно включающий определение, снижает ли тестируемое соединение T-клеточное истощение T-клеток CD8+, где тестируемое соединение, которое снижает T-клеточное истощение T-клеток CD8+, выбирают в качестве противоракового соединения.
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| CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
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| CN105849110B (zh) | 2013-11-08 | 2019-08-02 | 达纳-法伯癌症研究所有限公司 | 使用溴结构域和额外终端(bet)蛋白抑制剂的用于癌症的组合疗法 |
| SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
| UA122130C2 (uk) | 2014-10-27 | 2020-09-25 | Тенша Терапеутікс, Інк. | Інгібітори бромодомену |
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| EP3892284B1 (en) * | 2015-05-29 | 2024-05-22 | Merck Sharp & Dohme LLC | Combination of a pd-1 antagonist and a cpg-c type oligonucleotide for treating cancer |
| WO2017059319A2 (en) * | 2015-10-02 | 2017-04-06 | Dana-Farber Cancer Institute, Inc. | Combination therapy of bromodomain inhibitors and checkpoint blockade |
| WO2017078049A1 (ja) * | 2015-11-04 | 2017-05-11 | アステラス製薬株式会社 | ジアミノヘテロ環カルボキサミド化合物を有効成分とするがん免疫治療用、及び／又は、免疫活性化用医薬組成物 |
| EP3487993A1 (en) | 2016-07-25 | 2019-05-29 | Epizyme, Inc. | Crebbp related cancer therapy |
| WO2019161157A1 (en) * | 2018-02-16 | 2019-08-22 | Constellation Pharmceuticals, Inc. | P300/cbp hat inhibitors |
| CN112218857B (zh) * | 2018-02-16 | 2023-11-21 | 星座制药公司 | P300/cbp hat抑制剂及其使用方法 |
| TW202028222A (zh) * | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| WO2020257278A2 (en) * | 2019-06-18 | 2020-12-24 | Dana-Farber Cancer Institute, Inc. | Small molecule target bromo/acetyl proteins and uses thereof |
| CN110170052B (zh) * | 2019-06-21 | 2020-07-10 | 复旦大学 | Cbp-p300抑制剂在肠道损伤疾病中的应用 |
| CN110938630B (zh) * | 2019-12-20 | 2023-07-28 | 中国人民解放军第四军医大学 | 人b3gnt5基因的用途及相关产品 |
| CA3183982A1 (en) * | 2020-06-25 | 2021-12-30 | Stefanie Fluckiger-Mangual | A combination of a cbp/p300 bromodomain inhibitor and an egfr inhibitor for use in treating egfr-mutant nsclc |
| WO2022184664A1 (en) | 2021-03-02 | 2022-09-09 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
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| US8476458B2 (en) * | 2007-06-21 | 2013-07-02 | The Wistar Institute | Methods and compositions for modulating P300/CBP activity |
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| WO2013033420A1 (en) * | 2011-08-30 | 2013-03-07 | Whitehead Institute For Biomedical Research | Methods of downregulating translocated oncogene expression using bromodomain inhibitors |
| EP2861255B1 (en) * | 2012-06-19 | 2019-10-09 | The Broad Institute, Inc. | Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy |
| CN107073125A (zh) * | 2014-09-19 | 2017-08-18 | 基因泰克公司 | Cbp/ep300和bet抑制剂用于治疗癌症的用途 |
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| IL245016A0 (en) | 2016-05-31 |
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| WO2015054642A9 (en) | 2016-04-28 |
| KR20160060765A (ko) | 2016-05-30 |
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| US20160317632A1 (en) | 2016-11-03 |
| EP3054966A4 (en) | 2017-04-19 |
| MX2016004570A (es) | 2016-09-08 |
| SG11201602815YA (en) | 2016-05-30 |
| CA2926946A1 (en) | 2015-04-16 |
| WO2015054642A2 (en) | 2015-04-16 |
| CN105979958A (zh) | 2016-09-28 |
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