RU2014147728A - DERIVATIVE TRANS-2-DECENIC ACID AND CONTAINING ITS MEDICINE - Google Patents
DERIVATIVE TRANS-2-DECENIC ACID AND CONTAINING ITS MEDICINE Download PDFInfo
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- RU2014147728A RU2014147728A RU2014147728A RU2014147728A RU2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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Abstract
1. Производное транс-2-деценовой кислоты, представленное следующей общей формулой (I') или его фармацевтически приемлемая соль:,где X' представляет собой:(a) 1-пирролидил, замещенный карбоксилом или алкоксикарбонилом,(b) 3-тиазолидил,(c) пиперидино, замещенный алкилом, оксо, гидрокси, алкокси, карбоксилом, алкоксикарбонилом, алкиламино, алкиламиноалкилом, фенилом, карбоксиалкилом, алкоксикарбонилалкилом, циано или галогенофенилом,(d) тиоморфолино,(e) 1-пиперазил, который может быть замещен алкилом, карбоксиалкилом, алкоксикарбонилалкилом, алкиламиноалкилом, циклоалкилом, пиперидиноалкилом, фенилалкилом, пиридилом, пиримидилом, карбоксифенилалкилом или алкоксикарбонилфенилалкилом,(f) 1-пиперазил, замещенный фенилом, который может быть замещен алкиламино, галогеном, алкокси, алкилом, гидрокси, карбоксиалкокси или алкоксикарбонилалкокси,(g) 1,4-диазепанил, который может быть замещен алкилом или алкиламиноалкилом, или(h) карбоксиморфолино.2. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 1-пирролидил, замещенный карбоксилом или алкоксикарбонилом.3. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 3-тиазолидил, тиоморфолино или карбоксиморфолино.4. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой пиперидино, замещенный алкилом, оксо, гидрокси, алкокси, карбоксилом, алкоксикарбонилом, алкиламино, алкиламиноалкилфенилом, карбоксиалкилом, алкоксикарбонилалкилом, циано или галогенофенилом.5. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' пре1. A trans-2-decenoic acid derivative represented by the following general formula (I ′) or a pharmaceutically acceptable salt thereof: wherein X ′ is: (a) 1-pyrrolidyl substituted with carboxyl or alkoxycarbonyl, (b) 3-thiazolidyl, (c) piperidino substituted with alkyl, oxo, hydroxy, alkoxy, carboxyl, alkoxycarbonyl, alkylamino, alkylaminoalkyl, phenyl, carboxyalkyl, alkoxycarbonylalkyl, cyano or halogenophenyl, (d) thiomorpholino, (e) 1-piperazyl, which may be substituted carboxyalkyl, alkoxycarbonylalkyl, alkyl n-alkyl, cycloalkyl, piperidinoalkyl, phenylalkyl, pyridyl, pyrimidyl, carboxyphenylalkyl or alkoxycarbonylphenylalkyl, (f) 1-piperazyl substituted by phenyl, which may be substituted by alkylamino, halogen, alkoxy, alkoxyalkylalkyl, alkyl -diazepanyl, which may be substituted by alkyl or alkylaminoalkyl, or (h) carboxymorpholino. 2. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof according to claim 1, wherein X 'is 1-pyrrolidyl substituted with carboxyl or alkoxycarbonyl. 3. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof according to claim 1, wherein X 'is 3-thiazolidyl, thiomorpholino or carboxymorpholino. 4. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof according to claim 1, wherein X ′ is piperidino substituted with alkyl, oxo, hydroxy, alkoxy, carboxyl, alkoxycarbonyl, alkylamino, alkylaminoalkylphenyl, carboxyalkyl, alkoxycarbonylalkyl, cyano or halo phenyl. . Derivative of trans-2-decenoic acid or its pharmaceutically acceptable salt according to claim 1, where X 'pre
Claims (16)
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PCT/JP2013/062373 WO2013161993A1 (en) | 2012-04-27 | 2013-04-26 | Trans-2-decenoic acid derivative and drug containing same |
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GB2321455A (en) | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
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