RU2013122379A - METHOD FOR DROTAVERINE SYNTHESIS - Google Patents
METHOD FOR DROTAVERINE SYNTHESIS Download PDFInfo
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- RU2013122379A RU2013122379A RU2013122379/04A RU2013122379A RU2013122379A RU 2013122379 A RU2013122379 A RU 2013122379A RU 2013122379/04 A RU2013122379/04 A RU 2013122379/04A RU 2013122379 A RU2013122379 A RU 2013122379A RU 2013122379 A RU2013122379 A RU 2013122379A
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Abstract
1. Способ синтеза дротаверина, заключающийся введением ″этокси″ группы на стадии ТП-1.2. Способ по п.1, отличающийся от известных тем, что позволяет избежать на следующих стадиях ″жестких″ условий (растворитель - пиридин, температура 185°C, пары хлористого водорода).3. Способ по п.1 позволяет использовать стандартное н/ст и эмалированное оборудование.4. Способ по п.1 позволяет сократить число технологических стадий синтеза дротаверина на одну (на две, в случае использования в качестве исходного сырья ОДЭБ - орто-диэтокси бензола), тем самым сократить цикл производства на 120-130 ч, из 460 ч.1. The method of synthesis of drotaverine, which consists in the introduction of ″ ethoxy ″ group at the stage of TP-1.2. The method according to claim 1, which differs from the known ones in that it avoids the “hard” conditions in the following stages (the solvent is pyridine, a temperature of 185 ° C, hydrogen chloride vapors). The method according to claim 1 allows the use of standard n / a and enameled equipment. The method according to claim 1 allows to reduce the number of technological stages of the synthesis of drotaverine by one (by two, in the case of using ODEB - ortho-diethoxy benzene as a feedstock), thereby reducing the production cycle by 120-130 hours, from 460 hours
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Priority Applications (1)
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RU2013122379/04A RU2561489C2 (en) | 2013-05-14 | 2013-05-14 | Drotaverine synthesis method |
Applications Claiming Priority (1)
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RU2013122379/04A RU2561489C2 (en) | 2013-05-14 | 2013-05-14 | Drotaverine synthesis method |
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RU2013122379A true RU2013122379A (en) | 2014-11-20 |
RU2561489C2 RU2561489C2 (en) | 2015-08-27 |
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RU2013122379/04A RU2561489C2 (en) | 2013-05-14 | 2013-05-14 | Drotaverine synthesis method |
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RU (1) | RU2561489C2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111170847A (en) * | 2019-12-30 | 2020-05-19 | 江苏联环药业股份有限公司 | Novel method for preparing drotaverine hydrochloride intermediate |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2661150C9 (en) * | 2015-12-29 | 2018-11-13 | Открытое акционерное общество "Ирбитский химико-фармацевтический завод" | Method for preparation of drotaverine hydrochloride |
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AT234693B (en) * | 1961-08-30 | 1964-07-10 | Chinoin Gyogyszer Es Vegyeszet | Process for the preparation of new isoquinoline derivatives |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111170847A (en) * | 2019-12-30 | 2020-05-19 | 江苏联环药业股份有限公司 | Novel method for preparing drotaverine hydrochloride intermediate |
CN111170847B (en) * | 2019-12-30 | 2022-02-18 | 江苏联环药业股份有限公司 | Novel method for preparing drotaverine hydrochloride intermediate |
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RU2561489C2 (en) | 2015-08-27 |
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MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20160515 |