RU2013122379A - METHOD FOR DROTAVERINE SYNTHESIS - Google Patents

METHOD FOR DROTAVERINE SYNTHESIS Download PDF

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Publication number
RU2013122379A
RU2013122379A RU2013122379/04A RU2013122379A RU2013122379A RU 2013122379 A RU2013122379 A RU 2013122379A RU 2013122379/04 A RU2013122379/04 A RU 2013122379/04A RU 2013122379 A RU2013122379 A RU 2013122379A RU 2013122379 A RU2013122379 A RU 2013122379A
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RU
Russia
Prior art keywords
drotaverine
synthesis
hours
allows
stages
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RU2013122379/04A
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Russian (ru)
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RU2561489C2 (en
Inventor
Вадим Петрович Бахарев
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Вадим Петрович Бахарев
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Priority to RU2013122379/04A priority Critical patent/RU2561489C2/en
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Abstract

1. Способ синтеза дротаверина, заключающийся введением ″этокси″ группы на стадии ТП-1.2. Способ по п.1, отличающийся от известных тем, что позволяет избежать на следующих стадиях ″жестких″ условий (растворитель - пиридин, температура 185°C, пары хлористого водорода).3. Способ по п.1 позволяет использовать стандартное н/ст и эмалированное оборудование.4. Способ по п.1 позволяет сократить число технологических стадий синтеза дротаверина на одну (на две, в случае использования в качестве исходного сырья ОДЭБ - орто-диэтокси бензола), тем самым сократить цикл производства на 120-130 ч, из 460 ч.1. The method of synthesis of drotaverine, which consists in the introduction of ″ ethoxy ″ group at the stage of TP-1.2. The method according to claim 1, which differs from the known ones in that it avoids the “hard” conditions in the following stages (the solvent is pyridine, a temperature of 185 ° C, hydrogen chloride vapors). The method according to claim 1 allows the use of standard n / a and enameled equipment. The method according to claim 1 allows to reduce the number of technological stages of the synthesis of drotaverine by one (by two, in the case of using ODEB - ortho-diethoxy benzene as a feedstock), thereby reducing the production cycle by 120-130 hours, from 460 hours

Claims (4)

1. Способ синтеза дротаверина, заключающийся введением ″этокси″ группы на стадии ТП-1.1. The method of synthesis of drotaverine, which consists in the introduction of ″ ethoxy ″ group at the stage of TP-1. 2. Способ по п.1, отличающийся от известных тем, что позволяет избежать на следующих стадиях ″жестких″ условий (растворитель - пиридин, температура 185°C, пары хлористого водорода).2. The method according to claim 1, which differs from the known ones in that it avoids the “hard” conditions in the following stages (the solvent is pyridine, temperature 185 ° C, hydrogen chloride vapors). 3. Способ по п.1 позволяет использовать стандартное н/ст и эмалированное оборудование.3. The method according to claim 1 allows the use of standard n / a and enameled equipment. 4. Способ по п.1 позволяет сократить число технологических стадий синтеза дротаверина на одну (на две, в случае использования в качестве исходного сырья ОДЭБ - орто-диэтокси бензола), тем самым сократить цикл производства на 120-130 ч, из 460 ч. 4. The method according to claim 1 allows to reduce the number of technological stages of the synthesis of drotaverine by one (by two, in the case of using ODEB - ortho-diethoxy benzene as a feedstock), thereby reducing the production cycle by 120-130 hours, from 460 hours
RU2013122379/04A 2013-05-14 2013-05-14 Drotaverine synthesis method RU2561489C2 (en)

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RU2013122379/04A RU2561489C2 (en) 2013-05-14 2013-05-14 Drotaverine synthesis method

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RU2013122379/04A RU2561489C2 (en) 2013-05-14 2013-05-14 Drotaverine synthesis method

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RU2013122379A true RU2013122379A (en) 2014-11-20
RU2561489C2 RU2561489C2 (en) 2015-08-27

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111170847A (en) * 2019-12-30 2020-05-19 江苏联环药业股份有限公司 Novel method for preparing drotaverine hydrochloride intermediate

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2661150C9 (en) * 2015-12-29 2018-11-13 Открытое акционерное общество "Ирбитский химико-фармацевтический завод" Method for preparation of drotaverine hydrochloride

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Publication number Priority date Publication date Assignee Title
AT234693B (en) * 1961-08-30 1964-07-10 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of new isoquinoline derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111170847A (en) * 2019-12-30 2020-05-19 江苏联环药业股份有限公司 Novel method for preparing drotaverine hydrochloride intermediate
CN111170847B (en) * 2019-12-30 2022-02-18 江苏联环药业股份有限公司 Novel method for preparing drotaverine hydrochloride intermediate

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RU2561489C2 (en) 2015-08-27

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Effective date: 20160515