RU2012125827A - Применение аналога тестостерона и агониста 5-нт1а для лечения сексуальной дисфункции - Google Patents
Применение аналога тестостерона и агониста 5-нт1а для лечения сексуальной дисфункции Download PDFInfo
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- RU2012125827A RU2012125827A RU2012125827/15A RU2012125827A RU2012125827A RU 2012125827 A RU2012125827 A RU 2012125827A RU 2012125827/15 A RU2012125827/15 A RU 2012125827/15A RU 2012125827 A RU2012125827 A RU 2012125827A RU 2012125827 A RU2012125827 A RU 2012125827A
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- ht1a
- testosterone
- analogue
- testosterone analogue
- sexual dysfunction
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- 201000001880 Sexual dysfunction Diseases 0.000 title claims abstract 8
- 231100000872 sexual dysfunction Toxicity 0.000 title claims abstract 8
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 150000003515 testosterones Chemical class 0.000 claims abstract 20
- 239000003723 serotonin 1A agonist Substances 0.000 claims abstract 11
- 239000000203 mixture Substances 0.000 claims abstract 10
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 10
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims abstract 9
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims abstract 9
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 claims abstract 8
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 claims abstract 8
- 230000001568 sexual effect Effects 0.000 claims abstract 8
- 239000003814 drug Substances 0.000 claims abstract 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 4
- 206010057671 Female sexual dysfunction Diseases 0.000 claims abstract 2
- 206010057672 Male sexual dysfunction Diseases 0.000 claims 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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Abstract
1. Применение аналога тестостерона и агониста 5-HT1A для изготовления лекарственного средства для лечения сексуальной дисфункции, где указанный 5-HT1A высвобождается по существу за один час и указанный аналог тестостерона - за 3,5-5,5 часов до сексуальной активности.2. Применение аналога тестостерона, ингибитора ФДЭ5 и агониста 5-HT1A для изготовления лекарственного средства для лечения сексуальной дисфункции, где указанный 5-HT1A высвобождается по существу за один час, указанный ингибитор ФДЭ5 за 1-2 ч и указанный аналог тестостерона - за 3,5-5,5 ч до сексуальной активности.3. Применение по п.1 или 2, где указанная сексуальная дисфункция представляет собой женскую сексуальную дисфункцию.4. Фармацевтическая композиция, включающая аналог тестостерона и агонист 5-HT1A, где указанная композиция предназначена для высвобождения по существу указанного 5-HT1A за один час и указанного аналога тестостерона - за 3,5-5,5 ч до сексуальной активности.5. Фармацевтическая композиция, включающая аналог тестостерона, ингибитор ФДЭ5 и агонист 5-HT1A, где указанная композиция предназначена для высвобождения по существу указанного 5-HT1A за один час, указанного ингибитора ФДЭ5 - за 1-2 ч и указанного аналога тестостерона - за 3,5-5,5 ч до сексуальной активности.6. Набор, включающий, по меньшей мере, одну фармацевтическую композицию, включающую аналог тестостерона и, по меньшей мере, одну композицию, включающую агонист 5-НТ1А, где указанный набор дополнительно включает инструкции по введению указанных композиций.7. Набор, включающий, по меньшей мере, одну фармацевтическую композицию, которая включает аналог тестостерона, по меньшей мере, одну фармацевтическую композици�
Claims (8)
1. Применение аналога тестостерона и агониста 5-HT1A для изготовления лекарственного средства для лечения сексуальной дисфункции, где указанный 5-HT1A высвобождается по существу за один час и указанный аналог тестостерона - за 3,5-5,5 часов до сексуальной активности.
2. Применение аналога тестостерона, ингибитора ФДЭ5 и агониста 5-HT1A для изготовления лекарственного средства для лечения сексуальной дисфункции, где указанный 5-HT1A высвобождается по существу за один час, указанный ингибитор ФДЭ5 за 1-2 ч и указанный аналог тестостерона - за 3,5-5,5 ч до сексуальной активности.
3. Применение по п.1 или 2, где указанная сексуальная дисфункция представляет собой женскую сексуальную дисфункцию.
4. Фармацевтическая композиция, включающая аналог тестостерона и агонист 5-HT1A, где указанная композиция предназначена для высвобождения по существу указанного 5-HT1A за один час и указанного аналога тестостерона - за 3,5-5,5 ч до сексуальной активности.
5. Фармацевтическая композиция, включающая аналог тестостерона, ингибитор ФДЭ5 и агонист 5-HT1A, где указанная композиция предназначена для высвобождения по существу указанного 5-HT1A за один час, указанного ингибитора ФДЭ5 - за 1-2 ч и указанного аналога тестостерона - за 3,5-5,5 ч до сексуальной активности.
6. Набор, включающий, по меньшей мере, одну фармацевтическую композицию, включающую аналог тестостерона и, по меньшей мере, одну композицию, включающую агонист 5-НТ1А, где указанный набор дополнительно включает инструкции по введению указанных композиций.
7. Набор, включающий, по меньшей мере, одну фармацевтическую композицию, которая включает аналог тестостерона, по меньшей мере, одну фармацевтическую композицию, которая включает ингибитор ФДЭ5, и, по меньшей мере, одну композицию, которая включает агонист 5-НТ1А, где указанный набор дополнительно включает инструкции по введению указанных композиций.
8. Применение по п.1 или 2, где указанная сексуальная дисфункция представляет собой мужскую сексуальную дисфункцию.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06076976A EP1925307A1 (en) | 2006-11-03 | 2006-11-03 | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| EP06076976.7 | 2006-11-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009120990/15A Division RU2463054C2 (ru) | 2006-11-03 | 2007-11-02 | Применение тестостерона и агониста 5-нт1a для лечения сексуальной дисфункции |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012125827A true RU2012125827A (ru) | 2013-12-27 |
| RU2646447C2 RU2646447C2 (ru) | 2018-03-05 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009120990/15A RU2463054C2 (ru) | 2006-11-03 | 2007-11-02 | Применение тестостерона и агониста 5-нт1a для лечения сексуальной дисфункции |
| RU2009120992/15A RU2491073C2 (ru) | 2006-11-03 | 2007-11-02 | Применение 3-андростандиола, необязательно в сочетании с агонистом 5-ht1а для лечения сексуальной дисфункции |
| RU2009120988/15A RU2464027C2 (ru) | 2006-11-03 | 2007-11-02 | Применение 3-альфа-андростендиола, необязательно в сочетании с ингибитором фосфодиэстеразы 5, при лечении половой дисфункции |
| RU2012125827A RU2646447C2 (ru) | 2006-11-03 | 2012-06-20 | ПРИМЕНЕНИЕ АНАЛОГА ТЕСТОСТЕРОНА И АГОНИСТА 5-НТ1а ДЛЯ ЛЕЧЕНИЯ СЕКСУАЛЬНОЙ ДИСФУНКЦИИ |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009120990/15A RU2463054C2 (ru) | 2006-11-03 | 2007-11-02 | Применение тестостерона и агониста 5-нт1a для лечения сексуальной дисфункции |
| RU2009120992/15A RU2491073C2 (ru) | 2006-11-03 | 2007-11-02 | Применение 3-андростандиола, необязательно в сочетании с агонистом 5-ht1а для лечения сексуальной дисфункции |
| RU2009120988/15A RU2464027C2 (ru) | 2006-11-03 | 2007-11-02 | Применение 3-альфа-андростендиола, необязательно в сочетании с ингибитором фосфодиэстеразы 5, при лечении половой дисфункции |
Country Status (28)
| Country | Link |
|---|---|
| US (10) | US8575139B2 (ru) |
| EP (5) | EP1925307A1 (ru) |
| JP (8) | JP2010509211A (ru) |
| KR (6) | KR20150099620A (ru) |
| CN (6) | CN101563086B (ru) |
| AU (3) | AU2007314736B2 (ru) |
| BR (3) | BRPI0718396A2 (ru) |
| CA (3) | CA2668317C (ru) |
| CY (1) | CY1117191T1 (ru) |
| DK (1) | DK2086544T3 (ru) |
| ES (1) | ES2561946T3 (ru) |
| HK (1) | HK1135038A1 (ru) |
| HR (1) | HRP20160108T1 (ru) |
| HU (1) | HUE026752T2 (ru) |
| IL (5) | IL198459A (ru) |
| ME (1) | ME02410B (ru) |
| MX (3) | MX2009004696A (ru) |
| NO (3) | NO20092145L (ru) |
| NZ (3) | NZ577390A (ru) |
| PH (2) | PH12014501440A1 (ru) |
| PL (1) | PL2086544T3 (ru) |
| PT (1) | PT2086544E (ru) |
| RS (1) | RS54541B1 (ru) |
| RU (4) | RU2463054C2 (ru) |
| SI (1) | SI2086544T1 (ru) |
| UA (4) | UA103592C2 (ru) |
| WO (3) | WO2008054213A2 (ru) |
| ZA (3) | ZA200903836B (ru) |
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| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| EP2266568A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of LHRH antagonists in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
| EP2266567A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
| AU2012256501B2 (en) * | 2011-05-13 | 2017-04-06 | Eb Ip Hybritabs B.V. | Drug delivery system |
| HRP20211377T1 (hr) | 2011-11-23 | 2022-01-07 | Therapeuticsmd, Inc. | Prirodne kombinirane hormonske supstitucijske formulacije i terapije |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| JP5828923B2 (ja) | 2014-01-30 | 2015-12-09 | 国立大学法人高知大学 | ニッケル粉の製造方法 |
| JP5936783B2 (ja) | 2014-02-21 | 2016-06-22 | 国立大学法人高知大学 | ニッケル粉の製造方法 |
| JP6406613B2 (ja) | 2014-04-15 | 2018-10-17 | 住友金属鉱山株式会社 | 含有する炭素及び硫黄の濃度を低減するニッケル粉の製造方法 |
| CN103947533B (zh) * | 2014-05-15 | 2015-12-16 | 青岛理工大学 | 生长环境可控的磁化水工厂化豆芽菜生产*** |
| RU2600845C2 (ru) | 2014-07-04 | 2016-10-27 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Применение производных оксатриазолий-5-олата для лечения сексуальных расстройств |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
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