RU2000100955A - POWDERED COMPOSITIONS OF UNILAMELLAR LIPOS - Google Patents
POWDERED COMPOSITIONS OF UNILAMELLAR LIPOSInfo
- Publication number
- RU2000100955A RU2000100955A RU2000100955/14A RU2000100955A RU2000100955A RU 2000100955 A RU2000100955 A RU 2000100955A RU 2000100955/14 A RU2000100955/14 A RU 2000100955/14A RU 2000100955 A RU2000100955 A RU 2000100955A RU 2000100955 A RU2000100955 A RU 2000100955A
- Authority
- RU
- Russia
- Prior art keywords
- liposomes
- agent
- powder composition
- composition according
- gelling agents
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 24
- 239000003349 gelling agent Substances 0.000 claims 17
- 239000000843 powder Substances 0.000 claims 16
- 239000002502 liposome Substances 0.000 claims 14
- 150000002632 lipids Chemical class 0.000 claims 10
- 239000012071 phase Substances 0.000 claims 8
- 239000008346 aqueous phase Substances 0.000 claims 6
- 239000007864 aqueous solution Substances 0.000 claims 6
- 239000006185 dispersion Substances 0.000 claims 6
- 239000000499 gel Substances 0.000 claims 6
- 229920001353 Dextrin Polymers 0.000 claims 5
- 239000004375 Dextrin Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 235000019425 dextrin Nutrition 0.000 claims 5
- 229920001542 oligosaccharide Polymers 0.000 claims 5
- 150000002482 oligosaccharides Polymers 0.000 claims 5
- 239000003381 stabilizer Substances 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 238000002156 mixing Methods 0.000 claims 4
- 230000001105 regulatory Effects 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 229940067631 Phospholipids Drugs 0.000 claims 2
- 229920001525 carrageenan Polymers 0.000 claims 2
- 235000010418 carrageenan Nutrition 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 230000002441 reversible Effects 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 229940107161 Cholesterol Drugs 0.000 claims 1
- IECPWNUMDGFDKC-MZJAQBGESA-N Fusidic acid Chemical class O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 208000009576 Hypercholesterolemia Diseases 0.000 claims 1
- 208000006575 Hypertriglyceridemia Diseases 0.000 claims 1
- 210000004940 Nucleus Anatomy 0.000 claims 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- 102000003929 Transaminases Human genes 0.000 claims 1
- 108090000340 Transaminases Proteins 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 238000005354 coacervation Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 238000001599 direct drying Methods 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 1
- 230000000379 polymerizing Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000002588 toxic Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 239000004552 water soluble powder Substances 0.000 claims 1
Claims (21)
1) Приготовление дисперсии липосом с желатинированным внутренним ядром в водной фазе путем (а) приготовления раствора по меньшей мере одного подходящего гелеобразующего агента, в частности, смеси М гелеобразующих агентов G1 и G2, растворением названных гелеобразующих агентов при медленном перемешивании и при температуре, превышающей температуру фазового перехода гель-золь названных гелеобразующих агентов, в водном растворе, (b) введения липидов в полученный на стадии (а) раствор при медленном перемешивании смеси в течение менее 5 ч, преимущественно в вакууме, с образованием эмульсии, и (с) получения дисперсии липосом с желатинированным внутренним ядром в водной фазе, содержащей названные гелеобразующие агенты, при быстром перемешивании полученной на стадии (b) эмульсии, преимущественно в вакууме, и
2) Получение порошкового продукта путем проведенной подходящим образом непосредственной сушки полученной дисперсии.10. A method of obtaining a powder composition according to any one of claims 1 to 7, in which the outer shell of the particles contains a fraction of dewatered thermo-reversible aqueous gel, characterized in that it includes the following stages:
1) Preparing a dispersion of liposomes with a gelatinized inner core in the aqueous phase by (a) preparing a solution of at least one suitable gelling agent, in particular, a mixture of M gelling agents G1 and G2, by dissolving the mentioned gelling agents with slow stirring and at a temperature exceeding the temperature the gel-sol phase transition of the said gelling agents, in an aqueous solution, (b) introducing the lipids into the solution obtained in step (a) while slowly mixing the mixture for less than 5 hours, advantageously naturally in vacuum, to form an emulsion, and (c) obtain a liposome dispersion with a gelatinized inner core in an aqueous phase containing the mentioned gelling agents, with rapid mixing of the emulsion obtained in step (b), mainly in a vacuum, and
2) Preparation of a powder product by suitably direct-drying the obtained dispersion.
1) Приготовление дисперсии липосом с желатинированным внутренним ядром в водной фазе путем (а) приготовления раствора по меньшей мере одного подходящего гелеобразующего агента, в частности, смеси М гелеобразующих агентов G1 и G2, растворением названных гелеобразующих агентов при медленном перемешивании и при температуре, превышающей температуру фазового перехода гель-золь названных гелеобразующих агентов, в водном растворе, (b) введения липидов в полученный на стадии (а) раствор при медленном перемешивании смеси в течение менее 5 час, преимущественно в вакууме, с образованием эмульсии, и (с) получения дисперсии липосом с желатинированными внутренним ядром в жидкой водной фазе, содержащей названные гелеобразующие агенты, при быстром перемешивании полученной на стадии (b) эмульсии, преимущественно в вакууме,
2) удаление по меньшей мере части жидкой водной фазы, содержащей указанные гелеобразующие агенты и в которой диспергированы указанные липосомы,
3) добавление по меньшей мере одного подходящего декстрина, и
4) получение порошкового продукта сушкой распылением полученного в (3) продукта.14. A method of obtaining a powder composition according to any one of claims 1 to 7, in which the outer shell of the particles contains a fraction of a thermally reversible aqueous gel and / or dextrin, characterized in that it includes the following stages:
1) Preparing a dispersion of liposomes with a gelatinized inner core in the aqueous phase by (a) preparing a solution of at least one suitable gelling agent, in particular, a mixture of M gelling agents G1 and G2, by dissolving the mentioned gelling agents with slow stirring and at a temperature exceeding the temperature the gel-sol phase transition of the said gelling agents, in an aqueous solution, (b) the introduction of lipids into the solution obtained in step (a) while slowly mixing the mixture for less than 5 hours, substantially under vacuum, with the formation of an emulsion, and (c) obtaining a dispersion of liposomes with a gelatinized internal core in a liquid aqueous phase containing the mentioned gelling agents, with rapid mixing of the emulsion obtained in step (b), mainly in vacuum,
2) removing at least a portion of the liquid aqueous phase containing said gelling agents and in which said liposomes are dispersed,
3) adding at least one suitable dextrin, and
4) obtaining a powder product by spray drying the product obtained in (3).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9707254 | 1997-06-11 | ||
FR9707254A FR2764507B1 (en) | 1997-06-11 | 1997-06-11 | PULVERULENT COMPOSITIONS OF SINGLEAMELLAR LIPOSOMES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS AS NUTRITIONAL SUPPLEMENTS AND AS NUTRITIONAL SUPPLEMENTS AND AS MEDICINAL PRODUCTS |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2000100955A true RU2000100955A (en) | 2001-10-20 |
RU2214231C2 RU2214231C2 (en) | 2003-10-20 |
Family
ID=9507867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2000100955/14A RU2214231C2 (en) | 1997-06-11 | 1998-06-11 | Powder-like compositions of unilamellar liposomes |
Country Status (12)
Country | Link |
---|---|
US (1) | US6331315B1 (en) |
EP (1) | EP0998268A1 (en) |
JP (1) | JP2002511077A (en) |
KR (1) | KR20010013664A (en) |
CN (1) | CN1264296A (en) |
AU (1) | AU738238C (en) |
BR (1) | BR9810104A (en) |
FR (1) | FR2764507B1 (en) |
HU (1) | HUP0002066A3 (en) |
PL (1) | PL337782A1 (en) |
RU (1) | RU2214231C2 (en) |
WO (1) | WO1998056351A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102475683B (en) * | 2010-11-30 | 2013-10-30 | 沈阳药科大学 | Liposome which is prepared by ion-exchange fiber and has internal and external water phase gradient difference and application thereof |
US20140127287A1 (en) * | 2011-05-11 | 2014-05-08 | Wisconsin Alumni Research Foundation (Warf) | Liposome-encapsulated hydrogels for use in a drug delivery system |
KR101356796B1 (en) * | 2011-07-29 | 2014-01-28 | (주)모아캠 | Liposome Collecting Kaempferitrin and Coating Carrageenan and Method of The Same |
JP2013136038A (en) * | 2011-12-28 | 2013-07-11 | Miyoshi Oil & Fat Co Ltd | Liposome and method of manufacturing the same |
KR102009909B1 (en) * | 2015-10-07 | 2019-08-21 | 주식회사 엘지화학 | Measuring method of rupture strength of a superabsorbent resin particle |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU200698B (en) * | 1984-05-25 | 1990-08-28 | Vestar Inc | Process for stabilizing micellar particles |
GB8522963D0 (en) * | 1985-09-17 | 1985-10-23 | Biocompatibles Ltd | Microcapsules |
DE3815473A1 (en) * | 1988-05-06 | 1989-11-16 | Karl Heinz Prof Dr Dr Schmidt | System of active substances for lipid exchange with target structures |
DE4018767A1 (en) * | 1990-06-12 | 1991-12-19 | Braun Melsungen Ag | ACTIVE LIPOSOMES FOR THE TREATMENT OF ATHEROSCLEROSIS |
US5464629A (en) * | 1993-11-16 | 1995-11-07 | Georgetown University | Method of forming hydrogel particles having a controlled size using liposomes |
AU1751795A (en) * | 1994-03-04 | 1995-09-18 | University Of British Columbia, The | Liposome compositions and methods for the treatment of atherosclerosis |
FR2718369B1 (en) * | 1994-04-12 | 1996-06-21 | Lipogel Sarl | Gelled microspheres, their preparation process and their applications. |
AU4424797A (en) * | 1996-09-18 | 1998-04-14 | Dragoco Inc. | Liposome encapsulated active agent dry powder composition |
DE29704822U1 (en) * | 1997-03-17 | 1997-05-15 | Lucas Meyer GmbH & Co, 20539 Hamburg | Proliposomal compositions for making beverages |
-
1997
- 1997-06-11 FR FR9707254A patent/FR2764507B1/en not_active Expired - Fee Related
-
1998
- 1998-06-11 US US09/445,441 patent/US6331315B1/en not_active Expired - Fee Related
- 1998-06-11 BR BR9810104-8A patent/BR9810104A/en not_active IP Right Cessation
- 1998-06-11 WO PCT/FR1998/001203 patent/WO1998056351A1/en not_active Application Discontinuation
- 1998-06-11 CN CN98807282A patent/CN1264296A/en active Pending
- 1998-06-11 KR KR19997011676A patent/KR20010013664A/en not_active Application Discontinuation
- 1998-06-11 PL PL98337782A patent/PL337782A1/en unknown
- 1998-06-11 JP JP50178399A patent/JP2002511077A/en not_active Ceased
- 1998-06-11 EP EP98930819A patent/EP0998268A1/en not_active Withdrawn
- 1998-06-11 AU AU81122/98A patent/AU738238C/en not_active Ceased
- 1998-06-11 RU RU2000100955/14A patent/RU2214231C2/en not_active IP Right Cessation
- 1998-06-11 HU HU0002066A patent/HUP0002066A3/en unknown
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