RS63899B1 - Benzotiadiazepinska jedinjenja i njihova upotreba kao modulatora žučnih kiselina - Google Patents
Benzotiadiazepinska jedinjenja i njihova upotreba kao modulatora žučnih kiselinaInfo
- Publication number
- RS63899B1 RS63899B1 RS20230040A RSP20230040A RS63899B1 RS 63899 B1 RS63899 B1 RS 63899B1 RS 20230040 A RS20230040 A RS 20230040A RS P20230040 A RSP20230040 A RS P20230040A RS 63899 B1 RS63899 B1 RS 63899B1
- Authority
- RS
- Serbia
- Prior art keywords
- bile acid
- acid modulators
- benzothiadiazepine
- compounds
- benzothiadiazepine compounds
- Prior art date
Links
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
- KAOYLRLQZXRRBD-UHFFFAOYSA-N 1,2,3-benzothiadiazepine Chemical class S1N=NC=CC2=CC=CC=C12 KAOYLRLQZXRRBD-UHFFFAOYSA-N 0.000 title 1
- 239000003613 bile acid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201911004690 | 2019-02-06 | ||
| SE1950464 | 2019-04-12 | ||
| IN201911049981 | 2019-12-04 | ||
| EP20705305.9A EP3921028B1 (en) | 2019-02-06 | 2020-02-06 | Benzothiadiazepine compounds and their use as bile acid modulators |
| PCT/EP2020/052942 WO2020161217A1 (en) | 2019-02-06 | 2020-02-06 | Benzothiadiazepine compounds and their use as bile acid modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS63899B1 true RS63899B1 (sr) | 2023-02-28 |
Family
ID=69591608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20230040A RS63899B1 (sr) | 2019-02-06 | 2020-02-06 | Benzotiadiazepinska jedinjenja i njihova upotreba kao modulatora žučnih kiselina |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20230406832A1 (sr) |
| EP (1) | EP3921028B1 (sr) |
| JP (1) | JP2022519370A (sr) |
| KR (1) | KR20210126053A (sr) |
| CN (1) | CN113677398A (sr) |
| AU (1) | AU2020218908A1 (sr) |
| BR (1) | BR112021015060A2 (sr) |
| CA (1) | CA3127568A1 (sr) |
| CL (1) | CL2021001934A1 (sr) |
| CO (1) | CO2021010400A2 (sr) |
| CR (1) | CR20210458A (sr) |
| DK (1) | DK3921028T3 (sr) |
| EC (1) | ECSP21056710A (sr) |
| ES (1) | ES2937153T3 (sr) |
| FI (1) | FI3921028T3 (sr) |
| HR (1) | HRP20230039T1 (sr) |
| HU (1) | HUE060905T2 (sr) |
| IL (1) | IL284983B1 (sr) |
| LT (1) | LT3921028T (sr) |
| MX (1) | MX2021008981A (sr) |
| PE (1) | PE20212251A1 (sr) |
| PL (1) | PL3921028T3 (sr) |
| PT (1) | PT3921028T (sr) |
| RS (1) | RS63899B1 (sr) |
| SG (1) | SG11202108566VA (sr) |
| SI (1) | SI3921028T1 (sr) |
| TW (1) | TW202045483A (sr) |
| UA (1) | UA127911C2 (sr) |
| WO (1) | WO2020161217A1 (sr) |
| ZA (1) | ZA202106472B (sr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2637668T1 (sl) | 2010-11-08 | 2016-11-30 | Albiero Ab | IBAT inhibitorji za zdravljenje jetrnih bolezni |
| KR20220082931A (ko) | 2014-06-25 | 2022-06-17 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| WO2019245449A1 (en) | 2018-06-20 | 2019-12-26 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| AR120683A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| WO2021110887A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| AR120676A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| JP2023504644A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CR20220315A (es) | 2019-12-04 | 2022-10-26 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| TW202134221A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻二氮呯化合物及其作為膽酸調節劑之用途 |
| CA3158181A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2021110883A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
| EP4255565A1 (en) | 2020-12-04 | 2023-10-11 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2023164179A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164186A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164181A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164183A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| US20230338392A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
| WO2023237728A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250524A (en) | 1990-12-06 | 1993-10-05 | Hoechst Aktiengesellschaft | Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals |
| ES2087422T3 (es) | 1991-12-20 | 1996-07-16 | Hoechst Ag | Polimeros y oligomeros de derivados de acidos biliares, procedimiento para su preparacion y su empleo como medicamento. |
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| DE59307759D1 (de) | 1992-06-12 | 1998-01-15 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| ZA941003B (en) | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
| EP0624593A3 (de) | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| TW289021B (sr) | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| TW289757B (sr) | 1993-05-08 | 1996-11-01 | Hoechst Ag | |
| TW289020B (sr) | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| WO1996008484A1 (en) | 1994-09-13 | 1996-03-21 | Monsanto Company | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| GB9423172D0 (en) | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
| CN1515567A (zh) | 1996-03-11 | 2004-07-28 | G.D.ɪ����˾ | 具有作为回肠胆汁酸转运和牛磺胆酸盐吸收抑制剂活性的新的苯并噻庚因 |
| EP0912861B1 (de) | 1996-07-24 | 2000-11-29 | Zumtobel Staff GmbH | Adapter für ein haltemittel, welches zum befestigen einer einbauleuchte in einer einbauöffnung bestimmt ist, oder haltemittel oder einbauleuchte mit einem solchen adapter |
| DE19633268A1 (de) | 1996-08-19 | 1998-02-26 | Hoechst Ag | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
| GB9704208D0 (en) * | 1997-02-28 | 1997-04-16 | Glaxo Group Ltd | Chemical compounds |
| HUP0002395A3 (en) | 1997-03-11 | 2002-12-28 | G D Searle & Co Chicago | Combined pharmaceutical compositions containing ileal bile acid transport inhibiting benzothiepines and hmg co-a reductase inhibitors |
| ES2198613T3 (es) | 1997-03-14 | 2004-02-01 | Aventis Pharma Deutschland Gmbh | 1,4-benzotiazepina-1,1-dioxidos hipolipidemicos. |
| GB9800428D0 (en) | 1998-01-10 | 1998-03-04 | Glaxo Group Ltd | Chemical compounds |
| DE19825804C2 (de) | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| PL348581A1 (en) | 1998-12-23 | 2002-06-03 | Searle Llc | Combinations of ileal bile acid transport inhibitors and nicotinic acid derivatives for cardiovascular indications |
| IL143944A0 (en) | 1998-12-23 | 2002-04-21 | Searle Llc | Combinations for cardiovascular indications |
| NZ512537A (en) | 1998-12-23 | 2003-11-28 | G | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
| BR9916486A (pt) | 1998-12-23 | 2002-02-05 | Searle Llc | Combinações de inibidores do transporte de ácidos biliares no ìleo e inibidores da proteìna de transferência do ester colesteril para indicações cardiovasculares |
| DK1140190T3 (da) | 1998-12-23 | 2002-12-23 | Searle Llc | Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer |
| KR20020000139A (ko) | 1999-02-12 | 2002-01-04 | 추후제출 | 회장 담즙산 수송 및 타우로콜산염 흡수의 억제제로서의활성을 보유하는 신규한 1,2-벤조티아제핀 |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| WO2001068096A2 (en) | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| CN1582151A (zh) | 2001-09-08 | 2005-02-16 | 阿斯特拉曾尼卡有限公司 | 用于治疗高脂血症、具有回肠胆汁酸转运(ibat)抑制活性的苯并硫氮杂䓬和苯并硫杂二氮杂䓬衍生物 |
| GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0209467D0 (en) * | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
| CA2497345C (en) | 2002-08-28 | 2008-10-14 | Asahi Kasei Pharma Corporation | Novel quaternary ammonium compounds |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| US20050215882A1 (en) | 2004-03-23 | 2005-09-29 | The Regents Of The University Of Michigan | Noninvasive method to determine fat content of tissues using MRI |
| DE102005033099A1 (de) | 2005-07-15 | 2007-01-18 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung |
| DE102005033100B3 (de) | 2005-07-15 | 2007-01-25 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung |
| US9295677B2 (en) | 2008-02-26 | 2016-03-29 | Qing Bile Therapeutics Inc. | Polyhydroxylated bile acids for treatment of biliary disorders |
| JO3131B1 (ar) | 2010-04-27 | 2017-09-20 | Glaxosmithkline Llc | مركبات كيميائية |
| CA2939833A1 (en) | 2014-02-27 | 2015-09-03 | Nusirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| KR20160061492A (ko) | 2014-11-21 | 2016-06-01 | 삼성디스플레이 주식회사 | 휴대용 먼지 센서 및 이를 이용한 휴대전화 |
| CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| JP6954927B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| US11350844B2 (en) | 2016-11-23 | 2022-06-07 | Mayo Foundation For Medical Education And Research | System and method for generating nonalcoholic fatty liver disease activity score (NAS) using magnetic resonance elastography |
| CN110996915B (zh) | 2017-08-09 | 2023-10-03 | 阿尔比里奥公司 | 考来烯胺丸粒、口服考来烯胺制剂及其用途 |
| CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
-
2020
- 2020-02-06 AU AU2020218908A patent/AU2020218908A1/en active Pending
- 2020-02-06 CN CN202080012140.4A patent/CN113677398A/zh active Pending
- 2020-02-06 PE PE2021001268A patent/PE20212251A1/es unknown
- 2020-02-06 UA UAA202104946A patent/UA127911C2/uk unknown
- 2020-02-06 JP JP2021545897A patent/JP2022519370A/ja active Pending
- 2020-02-06 MX MX2021008981A patent/MX2021008981A/es unknown
- 2020-02-06 IL IL284983A patent/IL284983B1/en unknown
- 2020-02-06 CR CR20210458A patent/CR20210458A/es unknown
- 2020-02-06 DK DK20705305.9T patent/DK3921028T3/da active
- 2020-02-06 PL PL20705305.9T patent/PL3921028T3/pl unknown
- 2020-02-06 SI SI202030140T patent/SI3921028T1/sl unknown
- 2020-02-06 PT PT207053059T patent/PT3921028T/pt unknown
- 2020-02-06 RS RS20230040A patent/RS63899B1/sr unknown
- 2020-02-06 SG SG11202108566VA patent/SG11202108566VA/en unknown
- 2020-02-06 WO PCT/EP2020/052942 patent/WO2020161217A1/en unknown
- 2020-02-06 KR KR1020217028378A patent/KR20210126053A/ko active Search and Examination
- 2020-02-06 ES ES20705305T patent/ES2937153T3/es active Active
- 2020-02-06 FI FIEP20705305.9T patent/FI3921028T3/fi active
- 2020-02-06 CA CA3127568A patent/CA3127568A1/en active Pending
- 2020-02-06 HR HRP20230039TT patent/HRP20230039T1/hr unknown
- 2020-02-06 EP EP20705305.9A patent/EP3921028B1/en active Active
- 2020-02-06 TW TW109103758A patent/TW202045483A/zh unknown
- 2020-02-06 LT LTEPPCT/EP2020/052942T patent/LT3921028T/lt unknown
- 2020-02-06 BR BR112021015060-9A patent/BR112021015060A2/pt unknown
- 2020-02-06 HU HUE20705305A patent/HUE060905T2/hu unknown
-
2021
- 2021-07-22 CL CL2021001934A patent/CL2021001934A1/es unknown
- 2021-07-30 EC ECSENADI202156710A patent/ECSP21056710A/es unknown
- 2021-08-06 CO CONC2021/0010400A patent/CO2021010400A2/es unknown
- 2021-09-03 ZA ZA2021/06472A patent/ZA202106472B/en unknown
-
2023
- 2023-02-03 US US18/164,185 patent/US20230406832A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP21056710A (es) | 2021-08-31 |
| PL3921028T3 (pl) | 2023-02-13 |
| HUE060905T2 (hu) | 2023-04-28 |
| FI3921028T3 (fi) | 2023-01-31 |
| AU2020218908A1 (en) | 2021-08-26 |
| EP3921028A1 (en) | 2021-12-15 |
| IL284983B1 (en) | 2024-03-01 |
| IL284983A (en) | 2021-09-30 |
| DK3921028T3 (da) | 2023-01-23 |
| US20230406832A1 (en) | 2023-12-21 |
| SI3921028T1 (sl) | 2023-02-28 |
| CO2021010400A2 (es) | 2021-08-19 |
| CA3127568A1 (en) | 2020-08-13 |
| UA127911C2 (uk) | 2024-02-07 |
| MX2021008981A (es) | 2021-09-08 |
| CL2021001934A1 (es) | 2022-04-01 |
| WO2020161217A1 (en) | 2020-08-13 |
| CN113677398A (zh) | 2021-11-19 |
| ES2937153T3 (es) | 2023-03-24 |
| EP3921028B1 (en) | 2022-11-09 |
| TW202045483A (zh) | 2020-12-16 |
| JP2022519370A (ja) | 2022-03-23 |
| CR20210458A (es) | 2021-11-04 |
| PE20212251A1 (es) | 2021-11-24 |
| PT3921028T (pt) | 2023-02-15 |
| KR20210126053A (ko) | 2021-10-19 |
| SG11202108566VA (en) | 2021-09-29 |
| LT3921028T (lt) | 2023-02-10 |
| HRP20230039T1 (hr) | 2023-06-09 |
| ZA202106472B (en) | 2023-04-26 |
| BR112021015060A2 (pt) | 2021-10-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202106472B (en) | Benzothiadiazepine compounds and their use as bile acid modulators | |
| FI4069360T3 (fi) | Bentsotia(di)atsepiinin yhdisteet ja niiden käyttö sappihapon modulaattoreina | |
| PT4069360T (pt) | Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar | |
| EP3873923A4 (en) | MULTIVALENT REGULATORY T-CELL MODULATORS | |
| IL292156A (en) | Transduced azacils as trmp8 modulators | |
| EP3310336A4 (en) | Storage stable compositions and methods for the treatment of refractive errors of the eye | |
| EP3710036A4 (en) | STABLE ASCORBIC ACID COMPOSITIONS AND METHOD FOR THEIR USE | |
| EP3581185A4 (en) | COMPOSITION CONTAINING URSODESOXYCHOLIC ACID FOR THE PREVENTION OR TREATMENT OF VISUAL IMPAIRMENT | |
| EP3481819A4 (en) | CONNECTIONS AND THE USE THEREOF TO REDUCE THE URIC ACID LEVEL | |
| IL289861A (en) | trex1 modulators | |
| IL232384A0 (en) | Use of preparations containing halofanate or halophanic acid to treat gout | |
| EP3998110A4 (en) | LIQUID COSMETIC COMPOSITION | |
| EP3192512A4 (en) | Novel pharmaceutical composition for urinary incontinence prevention and/or treatment | |
| ZA202101836B (en) | Compositions containing linoleic acid | |
| EP3597198A4 (en) | COMPOSITION FOR TREATMENT OF JOINT DISEASES AND KIT WITH IT | |
| KR102096391B9 (en) | -3- Omega-3-fatty acid composition forming liquid crystal structures | |
| GB201918404D0 (en) | Compounds and their use for the treatment of aplha1-antitrypsin deficiency | |
| IL288307A (en) | Preparations for use in the treatment of insulin deficiency conditions | |
| EP3533437A4 (en) | COMPOSITIONS WITH LINOLIC ACID | |
| EP3475442A4 (en) | 12 (S) -HYDROXYEICOSATRIENOIC ACID COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | |
| IL287684A (en) | trex1 modulators | |
| EP3366292A4 (en) | COMPOSITION FOR THE PREVENTION OR TREATMENT OF OBESITY CONTAINING ALPHA-LIPOIC ACID AND N-ACETYLCYSTEINE AS ACTIVE SUBSTANCES | |
| EP3156040A4 (en) | Cosmetic composition containing 3-o-alkyl-l-ascorbic acid or salt thereof | |
| EP3768274A4 (en) | COMPOSITION FOR USE IN THE TREATMENT OF CONDITIONS CAUSED BY CALCIUM DEFICIENCY | |
| GB2589174B (en) | Electro-optic modulator |